Ablation of P2X7 receptor exacerbates gliosis and motoneuron death in the SOD1-G93A mouse model of amyotrophic lateral sclerosis

The NADPH Oxidase Pathway Is Dysregulated by the P2X7 Receptor in the SOD1-G93A Microglia Model of Amyotrophic Lateral Sclerosis

(2013) S. Apolloni et al.   JOURNAL OF IMMUNOLOGY

Peroxiredoxin I is a ROS/p38 MAPK-dependent inducible antioxidant that regulates NF-κB-mediated iNOS induction and microglial activation

(2013) Sun-Uk Kim et al.   JOURNAL OF NEUROIMMUNOLOGY

The mitochondrial calcium regulator cyclophilin D is an essential component of oestrogen-mediated neuroprotection in amyotrophic lateral sclerosis

(2012) Hyun Jeong Kim et al.   BRAIN

P2X7 Receptors: Channels, Pores and More

(2012) C. Volonte et al.   CNS & Neurological Disorders-Drug Targets

Transformation from a neuroprotective to a neurotoxic microglial phenotype in a mouse model of ALS

(2012) Bing Liao et al.   EXPERIMENTAL NEUROLOGY

Role of P2X7 Receptor-Mediated IL-18/IL-18R Signaling in Morphine Tolerance: Multiple Glial-Neuronal Dialogues in the Rat Spinal Cord

(2012) Meng-Ling Chen et al.   JOURNAL OF PAIN

The JNK/c-Jun signaling axis contributes to the TDP-43-induced cell death

(2012) Hiroaki Suzuki et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Prolonged survival and milder impairment of motor function in the SOD1 ALS mouse model devoid of fibroblast growth factor 2

(2012) Nadine Thau et al.   NEUROBIOLOGY OF DISEASE

Regulatory T lymphocytes from ALS mice suppress microglia and effector T lymphocytes through different cytokine-mediated mechanisms

(2012) Weihua Zhao et al.   NEUROBIOLOGY OF DISEASE

Ablation of Proliferating Cells in the CNS Exacerbates Motor Neuron Disease Caused by Mutant Superoxide Dismutase

(2012) Jean-Nicolas Audet et al.   PLoS One

Effect of genetic background on phenotype variability in transgenic mouse models of amyotrophic lateral sclerosis: A window of opportunity in the search for genetic modifiers

(2011) Terry D. Heiman-Patterson et al.   Amyotrophic Lateral Sclerosis

Purinergic signalling at the plasma membrane: a multipurpose and multidirectional mode to deal with amyotrophic lateral sclerosis and multiple sclerosis

(2011) Susanna Amadio et al.   JOURNAL OF NEUROCHEMISTRY

Amyotrophic lateral sclerosis

(2011) Matthew C Kiernan et al.   LANCET

Neuroinflammation in amyotrophic lateral sclerosis: role of glial activation in motor neuron disease

(2011) Thomas Philips et al.   LANCET NEUROLOGY

Lack of neuroprotection in the absence of P2X7 receptors in toxin-induced animal models of Parkinson's disease

(2011) Zsuzsanna Hracskó et al.   Molecular Neurodegeneration

Clinical diagnosis and management of amyotrophic lateral sclerosis

(2011) Orla Hardiman et al.   Nature Reviews Neurology

Spatiotemporal and anatomical analyses of P2X receptor-mediated neuronal and glial processing of sensory signals in the rat dorsal horn

(2011) Ryoma Aoyama et al.   PAIN

ALS: Focus on purinergic signalling

(2011) Cinzia Volonté et al.   PHARMACOLOGY & THERAPEUTICS

Physiology of Microglia

(2011) Helmut Kettenmann et al.   PHYSIOLOGICAL REVIEWS

Guidelines for preclinical animal research in ALS/MND: A consensus meeting

(2010) Albert C. Ludolph et al.   Amyotrophic Lateral Sclerosis

Significance of behavioural tests in a transgenic mouse model of amyotrophic lateral sclerosis (ALS)

(2010) Sarah Knippenberg et al.   BEHAVIOURAL BRAIN RESEARCH

Pathological roles of MAPK signaling pathways in human diseases

(2010) Eun Kyung Kim et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Neuroinflammation modulates distinct regional and temporal clinical responses in ALS mice

(2010) David R. Beers et al.   BRAIN BEHAVIOR AND IMMUNITY

Interaction and interrelation of P2X7 and P2X4 receptor complexes in mouse lung epithelial cells

(2010) Karina Weinhold et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Effects of gender in amyotrophic lateral sclerosis

(2010) Pamela A. McCombe et al.   Gender Medicine

Skeletal muscle-restricted expression of human SOD1 causes motor neuron degeneration in transgenic mice

(2010) Margaret Wong et al.   HUMAN MOLECULAR GENETICS

Microglia: Proliferation and activation driven by the P2X7 receptor

(2010) Mastura Monif et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

The “Dying-Back” Phenomenon of Motor Neurons in ALS

(2010) Michal Dadon-Nachum et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Extracellular ATP and the P2X7 receptor in astrocyte-mediated motor neuron death: implications for amyotrophic lateral sclerosis

(2010) Mandi Gandelman et al.   Journal of Neuroinflammation

Involvement of Spinal Microglial P2X7 Receptor in Generation of Tolerance to Morphine Analgesia in Rats

(2010) D. Zhou et al.   JOURNAL OF NEUROSCIENCE

Astrocytes: biology and pathology

(2009) Michael V. Sofroniew et al.   ACTA NEUROPATHOLOGICA

XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy

(2009) C. Hetz et al.   GENES & DEVELOPMENT

Non–cell autonomous toxicity in neurodegenerative disorders: ALS and beyond

(2009) Hristelina Ilieva et al.   JOURNAL OF CELL BIOLOGY

The Proinflammatory Action of Microglial P2 Receptors Is Enhanced in SOD1 Models for Amyotrophic Lateral Sclerosis

(2009) N. D'Ambrosi et al.   JOURNAL OF IMMUNOLOGY

Microglia in ALS: The Good, The Bad, and The Resting

(2009) Jenny S. Henkel et al.   Journal of Neuroimmune Pharmacology

Reduced VGLUT2 expression increases motor neuron viability in Sod1G93A mice

(2009) Hanna Wootz et al.   NEUROBIOLOGY OF DISEASE

Cellular localization of P2X7 receptor mRNA in the rat brain

(2008) Yong Yu et al.   BRAIN RESEARCH

Human mesenchymal stem cell transplantation extends survival, improves motor performance and decreases neuroinflammation in mouse model of amyotrophic lateral sclerosis

(2008) A. Vercelli et al.   NEUROBIOLOGY OF DISEASE

CD4+ T cells support glial neuroprotection, slow disease progression, and modify glial morphology in an animal model of inherited ALS

(2008) D. R. Beers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

T lymphocytes potentiate endogenous neuroprotective inflammation in a mouse model of ALS

(2008) I. M. Chiu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transgenics, toxicity and therapeutics in rodent models of mutant SOD1-mediated familial ALS

(2008) B TURNER et al.   PROGRESS IN NEUROBIOLOGY