Interferon-γ blocks signalling through PDGFRβ in human brain pericytes

Cerebral microvascular pericytes and neurogliovascular signaling in health and disease

(2015) Turgay Dalkara et al.   BRAIN RESEARCH

Establishment and Dysfunction of the Blood-Brain Barrier

(2015) Zhen Zhao et al.   CELL

Dysfunction of brain pericytes in chronic neuroinflammation

(2015) Yuri Persidsky et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Interferon-γ regulates cellular metabolism and mRNA translation to potentiate macrophage activation

(2015) Xiaodi Su et al.   NATURE IMMUNOLOGY

Increased central microglial activation associated with peripheral cytokine levels in premanifest Huntington's disease gene carriers

(2015) Marios Politis et al.   NEUROBIOLOGY OF DISEASE

Blood-Brain Barrier Breakdown in the Aging Human Hippocampus

(2015) Axel Montagne et al.   NEURON

An anti-inflammatory role for C/EBPδ in human brain pericytes

(2015) Justin Rustenhoven et al.   Scientific Reports

Traumatic brain injury results in rapid pericyte loss followed by reactive pericytosis in the cerebral cortex

(2015) Christoph M. Zehendner et al.   Scientific Reports

Inflammation and insulin/IGF-1 resistance as the possible link between obesity and neurodegeneration

(2014) Lindsay J. Spielman et al.   JOURNAL OF NEUROIMMUNOLOGY

A role for human brain pericytes in neuroinflammation

(2014) Deidre Jansson et al.   Journal of Neuroinflammation

Age-associated dysregulation of microglial activation is coupled with enhanced blood-brain barrier permeability and pathology in APP/PS1 mice

(2014) Aedín M. Minogue et al.   NEUROBIOLOGY OF AGING

Tumor necrosis factor-α-stimulated brain pericytes possess a unique cytokine and chemokine release profile and enhance microglial activation

(2014) Junichi Matsumoto et al.   NEUROSCIENCE LETTERS

Blood-spinal cord barrier disruption contributes to early motor-neuron degeneration in ALS-model mice

(2014) E. A. Winkler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuroprotective intervention by interferon-γ blockade prevents CD8+T cell–mediated dendrite and synapse loss

(2013) Mario Kreutzfeldt et al.   JOURNAL OF EXPERIMENTAL MEDICINE

TNF-α promotes cerebral pericyte remodeling in vitro, via a switch from α1 to α2 integrins

(2013) Ulrich Tigges et al.   Journal of Neuroinflammation

Mutations in the gene encoding PDGF-B cause brain calcifications in humans and mice

(2013) Annika Keller et al.   NATURE GENETICS

Development, maintenance and disruption of the blood-brain barrier

(2013) Birgit Obermeier et al.   NATURE MEDICINE

Inhibitory Effects of Resveratrol on PDGF-BB-Induced Retinal Pigment Epithelial Cell Migration via PDGFRβ, PI3K/Akt and MAPK pathways

(2013) Chi-Ming Chan et al.   PLoS One

Pleiotropic Actions of Insulin Resistance and Inflammation in Metabolic Homeostasis

(2013) J. I. Odegaard et al.   SCIENCE

Blood–spinal cord barrier breakdown and pericyte reductions in amyotrophic lateral sclerosis

(2012) Ethan A. Winkler et al.   ACTA NEUROPATHOLOGICA

Impaired blood–brain/spinal cord barrier in ALS patients

(2012) Svitlana Garbuzova-Davis et al.   BRAIN RESEARCH

Metabolic syndrome, mild cognitive impairment and Alzheimer's disease—The emerging role of systemic low-grade inflammation and adiposity

(2012) Blazej Misiak et al.   BRAIN RESEARCH BULLETIN

PDGF Receptor β Signaling in Pericytes Following Ischemic Brain Injury

(2012) Koichi Arimura et al.   CURRENT NEUROVASCULAR RESEARCH

Blood–Spinal Cord Barrier Pericyte Reductions Contribute to Increased Capillary Permeability

(2012) Ethan A Winkler et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The immunology of traumatic brain injury: a prime target for Alzheimer’s disease prevention

(2012) Brian Giunta et al.   Journal of Neuroinflammation

Infection and upregulation of proinflammatory cytokines in human brain vascular pericytes by human cytomegalovirus

(2012) Donald J Alcendor et al.   Journal of Neuroinflammation

Neuroinflammation: A Common Pathway in CNS Diseases as Mediated at the Blood-Brain Barrier

(2012) Michelle A. Erickson et al.   NEUROIMMUNOMODULATION

Adult Human Brain Neural Progenitor Cells (NPCs) and Fibroblast-Like Cells Have Similar Properties In Vitro but Only NPCs Differentiate into Neurons

(2012) Thomas In-Hyeup Park et al.   PLoS One

Extended results of the Alzheimer’s disease anti-inflammatory prevention trial

(2011) John C. Breitner et al.   Alzheimers & Dementia

PDGFR-β as a Positive Regulator of Tissue Repair in a Mouse Model of Focal Cerebral Ischemia

(2011) Jie Shen et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Systemic inflammatory challenges compromise survival after experimental stroke via augmenting brain inflammation, blood- brain barrier damage and brain oedema independently of infarct size

(2011) Ádám Dénes et al.   Journal of Neuroinflammation

Brain microvascular pericytes are immunoactive in culture: cytokine, chemokine, nitric oxide, and LRP-1 expression in response to lipopolysaccharide

(2011) Andrej Kovac et al.   Journal of Neuroinflammation

Disruption of neurovascular unit prior to motor neuron degeneration in amyotrophic lateral sclerosis

(2011) Kazunori Miyazaki et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Cannabinoid Receptor 1 trafficking and the role of the intracellular pool: Implications for therapeutics

(2010) Natasha L. Grimsey et al.   BIOCHEMICAL PHARMACOLOGY

Dimerization drives PDGF receptor endocytosis through a C-terminal hydrophobic motif shared by EGF receptor

(2010) Justin Pahara et al.   EXPERIMENTAL CELL RESEARCH

Interferon-γ-mediated Inhibition of Serum Response Factor-dependent Smooth Muscle-specific Gene Expression

(2010) Zengdun Shi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pericyte-specific expression of PDGF beta receptor in mouse models with normal and deficient PDGF beta receptor signaling

(2010) Ethan A Winkler et al.   Molecular Neurodegeneration

Pericytes regulate the blood–brain barrier

(2010) Annika Armulik et al.   NATURE

Pericytes Control Key Neurovascular Functions and Neuronal Phenotype in the Adult Brain and during Brain Aging

(2010) Robert D. Bell et al.   NEURON

Dystrophic (senescent) rather than activated microglial cells are associated with tau pathology and likely precede neurodegeneration in Alzheimer’s disease

(2009) Wolfgang J. Streit et al.   ACTA NEUROPATHOLOGICA

Two Different PDGF β-Receptor Cohorts in Human Pericytes Mediate Distinct Biological Endpoints

(2009) Christian Sundberg et al.   AMERICAN JOURNAL OF PATHOLOGY

The blood-brain barrier in neurodegenerative disease: a rhetorical perspective

(2009) Paul M. Carvey et al.   JOURNAL OF NEUROCHEMISTRY

Neuroinflammation in Parkinson's disease: a target for neuroprotection?

(2009) Etienne C Hirsch et al.   LANCET NEUROLOGY

IRS1-Independent Defects Define Major Nodes of Insulin Resistance

(2008) Kyle L. Hoehn et al.   Cell Metabolism

A NOVEL HIGH-THROUGHPUT ASSAY FOR THE QUANTITATIVE ASSESSMENT OF RECEPTOR TRAFFICKING

(2008) Natasha L Grimsey et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

ALS-causing SOD1 mutants generate vascular changes prior to motor neuron degeneration

(2008) Zhihui Zhong et al.   NATURE NEUROSCIENCE

The Blood-Brain Barrier in Health and Chronic Neurodegenerative Disorders

(2008) Berislav V. Zlokovic   NEURON