Article
Chemistry, Multidisciplinary
Xinyu Liu, Zhongxing Chen, Jieyi Bai, Xin Li, Xin Chen, Zheng Li, Hongxian Pan, Siheng Li, Qingyi Gao, Nan Zhao, Aodong Chen, Huilin Xu, Yinuo Wen, Lan Du, Mei Yang, Xingtao Zhou, Jinhai Huang
Summary: In this study, multifunctional hydrogel eye drops were developed for the synergistic treatment of uveitis. These eye drops offer improved ocular bioavailability and unexpected anti-inflammatory efficacy. By mitigating the ophthalmic inflammatory reaction and suppressing inflammatory cytokines, the eye drops demonstrated superior efficacy in treating endotoxin-induced uveitis.
Review
Chemistry, Multidisciplinary
Yi Chen, Mingju Shui, Qin Yuan, Chi Teng Vong, Zhengming Yang, Zhejie Chen, Shengpeng Wang
Summary: The etiology of inflammatory bowel disease (IBD) is complex and involves an excessive immune response leading to the release of reactive oxygen species (ROS) and chronic inflammation. Targeting excess ROS for inflammatory suppression has been recognized as a feasible strategy for treating IBD. Additionally, overexpression of ROS can trigger drug release from novel drug delivery systems to alleviate IBD symptoms.
JOURNAL OF CONTROLLED RELEASE
(2023)
Review
Medicine, Research & Experimental
Omar A. Abed, Younes Attlassy, Jin Xu, Kai Han, James J. Moon
Summary: Inflammatory bowel disease (IBD) is a chronic inflammation that affects almost 7 million people worldwide. Current treatments are effective in managing symptoms, but fail to target the root cause. Self-assembled nanoparticles have shown great potential as drug delivery systems for treating IBD by surviving harsh gastric conditions and reaching inflamed areas of the gastrointestinal tract. These nanoparticles can localize drugs to the affected regions, reduce off-target toxicities, and restore symbiotic microbes while reducing harmful ones. However, challenges such as scale-up synthesis, potential side effects, and financial obstacles in clinical trials need to be addressed. Research on nanoparticles is crucial for the development of more effective therapeutics for IBD.
MOLECULAR PHARMACEUTICS
(2022)
Article
Biotechnology & Applied Microbiology
Bosong Zhang, Yufang Zhao, Kai Guo, Hui Tian, Cao Wang, Ruiqi Wang, Yue Chen, Xiongbiao Chen, Hongxia Zheng, Bingxin Gao, Jieyi Shen, Weiming Tian
Summary: Prevention and early intervention are crucial in treating Alzheimer's disease (AD). This study investigates the use of nanoparticles composed of resveratrol and oligomeric proanthocyanidin grafted with hyaluronic acid to address the issue of ROS accumulation in early AD. The results demonstrate that these nanoparticles are effective in scavenging ROS, reducing brain inflammation, and improving cognitive function in AD mice.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Jianfeng Guo, Zhuo Yu, Dandan Sun, Yifang Zou, Yun Liu, Leaf Huang
Summary: This study demonstrates the concept of successful FOLFOX-associated CRC and HCC therapies through the combination of two nano delivery systems. Further optimization in dosing and timing has the potential to enhance the clinical efficacy of this combination strategy.
Review
Chemistry, Multidisciplinary
Chi-Pin James Wang, Min Ji Byun, Se-Na Kim, Wooram Park, Hee Ho Park, Tae-Hyung Kim, Jung Seung Lee, Chun Gwon Park
Summary: Inflammatory bowel diseases (IBDs) are gastrointestinal inflammatory disorders featuring chronic intestinal inflammation. Novel biomaterial-based platforms have been developed to deliver drugs to damaged sites with increased efficacy and reduced side effects in IBD treatments.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Engineering, Biomedical
Qian-Xiao Huang, Jun-Long Liang, Chi-Hui Yang, Ke Li, Mei-Ting Niu, Jin-Xuan Fan, Xian-Zheng Zhang
Summary: In this study, a stimulation-responsive mucoadhesive probiotic Lac@HDP was constructed for specific adhesion and ROS depletion in colitis. The results showed that the Lac@HDP probiotics were more effective in alleviating colitis symptoms and increasing the abundance of intestinal flora compared to antioxidants and probiotics alone. This provides a promising clinical application for the future.
Review
Biochemistry & Molecular Biology
Katarzyna Dziabowska-Grabias, Malgorzata Sztanke, Przemyslaw Zajac, Michal Celejewski, Katarzyna Kurek, Stanislaw Szkutnicki, Patryk Korga, Wlodzimierz Bulikowski, Krzysztof Sztanke
Summary: Inflammatory bowel diseases (IBD) are chronic, incurable diseases of the digestive tract with unclear etiology, resulting in significant impact on patients' quality of life. The incidence and prevalence of IBD are continuously increasing worldwide, becoming a significant public health burden. Current pharmaceutical management options often have side effects and may not provide sufficient disease control, leading to research on antioxidant and anti-inflammatory substances as potential treatment options.
Article
Chemistry, Multidisciplinary
Yeon Su Choi, Kang Moo Huh, Min Suk Shim, In Suh Park, Yong-Yeon Cho, Joo Young Lee, Hye Suk Lee, Han Chang Kang
Summary: This study investigates the release of therapeutics in the cytosol using a diselenide-based drug carrier, identifying GSH as the major trigger for diselenide cleavage and demonstrating synergistic anticancer effects when combining the carrier with an anticancer drug. The research shows that the combined use of diselenide-based drug carrier and drug has a significant inhibitory effect on tumor growth in vivo.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Engineering, Biomedical
Cong Zhang, Qingrong Li, Jie Shan, Jianghao Xing, Xiaoyan Liu, Yan Ma, Haisheng Qian, Xulin Chen, Xianwen Wang, Lian-Ming Wu, Yue Yu
Summary: The overexpression of reactive oxygen and nitrogen species (RONS) in the colonic mucosa destroys the mucosa and its barrier, accelerating the occurrence of inflammatory bowel disease (IBD). The elimination of RONS from the inflammatory colon has proven effective in alleviating IBD. Bi2Se3 nanodiscs modified with PVP were developed as a multifunctional nanozyme for the treatment of IBD. The nanodiscs can eliminate multiple RONS, enhance cellular survival, alleviate intestinal inflammation, and regulate intestinal flora.
ACTA BIOMATERIALIA
(2023)
Review
Biotechnology & Applied Microbiology
Jiaxue Liu, Boyan Jia, Zhibo Li, Wenliang Li
Summary: Applying reactive polymer materials sensitive to biological stimuli has attracted extensive research interest. The application of reactive oxygen species (ROS)-responsive polymers as drug-delivery systems in organisms has received much attention due to the special physiological effects of ROS on tumors or inflammation. The research progress of ROS-responsive polymers and their application in recent years were summarized and analyzed in this paper. From the perspective of nanoparticle drug delivery systems, multi-responsive delivery systems, and ROS-responsive hydrogels, the future development trends in this field were discussed.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Review
Engineering, Biomedical
Yinfeng Zhang, Tingting Wang, Meng Sun, Yueyue Song, Xinyuan Huang, Shutian Zhang, Jun Yang, Jinfeng Zhang
Summary: Inflammatory bowel disease (IBD) is a chronic and recurrent gastrointestinal inflammatory disorder with a rapidly increasing incidence, posing a global healthcare challenge. Efficient cure for IBD is lacking due to its elusive etiology and pathogenesis. Nanotherapeutic strategies utilizing advanced nanomaterials show promise in achieving positive clinical efficacy and reduced side effects. This review provides an overview of the characteristics of healthy and inflammatory intestinal microenvironments, discusses different administration routes and targeting strategies of nanotherapeutics for IBD treatment, explores nanotherapeutic treatments based on different IBD pathogenesis, and presents future challenges and perspectives.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Pharmacology & Pharmacy
Dan Yan, Haili Zhang, Zhongrui Li
Summary: With the development of precision medicine, a self-assembly theranostic nanosystem (MWNs) was designed for enhanced cell apoptosis and guided cancer therapy. This intelligent nanosystem provides information on tumor location, instructs the appropriate treatment time, and enables precise cancer therapy.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Miao Hu, Yuyang Huang, Xiaoqian Du, Guannan Liu, Baokun Qi, Yang Li
Summary: Indicates the typical substances with synergistic effects, mainly used in the treatment of related diseases, but limited by their instability and low bioavailability. Therefore, researchers encapsulated these substances in hydrogel beads with sodium alginate and soybean protein isolate to improve their stability and bioavailability. The anti-inflammatory effect and molecular mechanism of action of these substances in inflammatory bowel disease were also investigated.
Article
Agricultural Engineering
Jingze Sun, Jianan Wang, Yun Jia, Shujuan Zhuang, Yujiao Xie, Xiaoyan Yin, Yuan Zhang, Rongrong Zhao, Hongzi Tan, Lihong Wang, Feng Song, Hongyou Cui
Summary: This study investigated the free radical depolymerization of lignin using three model compounds and peroxymonosulfate (PMS). The results showed that the reaction pathway and selectivity of monomer products can be regulated by adjusting the pH value and temperature. The presence of hydroxyl and methoxy groups can enhance the reactivity of lignin model compounds and promote the directional generation of monomer products.
BIOMASS & BIOENERGY
(2023)
Article
Chemistry, Multidisciplinary
Ge Meng, Wu Lan, Lilong Zhang, Shibin Wang, Tanhao Zhang, Shuo Zhang, Ming Xu, Yu Wang, Jian Zhang, Fengxia Yue, Yulong Wu, Dingsheng Wang
Summary: A synergistic catalyst (Mo1Al/MgO) combining atomically dispersed Mo centers and Al Lewis acid sites on a MgO substrate was designed for the depolymerization of Eucalyptus lignin. The Mo1Al/MgO achieved a near-theoretical monophenol yield of 46% and a high selectivity of 92% for coniferyl and sinapyl methyl ether, with good cycling durability, in an inert N-2 atmosphere. This study confirms the feasibility of designing better-performing catalysts with synergistic multiactive sites for the efficient and selective disassembly of complex renewable biopolymers into highly value-added products with lower cost and greater security.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Jiali Yang, Mengyun Peng, Shaochong Tan, Shengchan Ge, Li Xie, Tonghai Zhou, Wei Liu, Kaixiang Zhang, Zhenzhong Zhang, Junjie Liu, Jinjin Shi
Summary: Calcium tungstate microgel selectively disrupts the ecological niche occupied by abnormally expanded Enterobacteriaceae during colitis, promoting probiotic colonization. The use of a calcium tungste microgel-based oral probiotic delivery system improves the delivery and colonization of probiotics. The synergistic reduction of Enterobacteriaceae and increase in probiotic colonization results in effective treatment for colitis.
ACS CENTRAL SCIENCE
(2023)
Article
Nanoscience & Nanotechnology
Yale Yue, Hejia Li, Xinwei Wang, Baohua Zhang, Yao Li, Yiting Liu, Xiaotu Ma, Guangna Liu, Xiao Zhao, Jinjin Shi
Summary: This study proposes an intelligent responsive nanoparticle triggered by near-infrared light, which can have a prolonged blood circulation half-life and improved tumor enrichment, and easily penetrate deep tumor tissues. The results show that this intelligent nanoparticle successfully integrates photothermal therapy and chemotherapy, effectively inhibiting tumor cell growth.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Xiu Zhao, Hui Cheng, Qiongwei Wang, Weimin Nie, Yue Yang, Xinyuan Yang, Kaixiang Zhang, Jinjin Shi, Junjie Liu
Summary: This study reports a photosensitizer metabolism-regulating strategy using ALA/DNAzyme-co-loaded nanoparticles (ALA & Dz@ZIF-PEG) for mitochondria-targeting photodynamic immunotherapy. The nanoparticles release zinc ions (Zn2+) in tumor cells, which promotes the conversion of ALA to PpIX and enhances the accumulation of PpIX in mitochondria, leading to improved photodynamic therapy outcomes.
Article
Chemistry, Multidisciplinary
Danyu Wang, Hua Yi, Shizhen Geng, Chuanmei Jiang, Jingwen Liu, Jie Duan, Zhenzhong Zhang, Jinjin Shi, Haiwei Song, Zhenzhen Guo, Kaixiang Zhang
Summary: Multidrug resistance (MDR) is a major cause of chemotherapy failure in oncology, and gene therapy is an excellent measure to reverse MDR. However, conventional gene therapy only modulates the expression of MDR-associated proteins but hardly affects their existing function, thus limiting the efficiency of tumor treatment. Therefore, we designed a photoactivated DNA nanodrug (MCD@TMPyP4@DOX) to improve tumor chemosensitivity through the downregulation of MDR-related genes and mitochondria-targeted photodynamic therapy (PDT).
Article
Chemistry, Multidisciplinary
Yan Liang, Jingge Zhang, Chenlu Xu, Jinjin Wang, Wenshuai Han, Jiali Yang, Sixuan Wu, Jingyi An, Junjie Liu, Zhenzhong Zhang, Jinjin Shi, Kaixiang Zhang
Summary: The researchers have developed an all-in-one biomimetic mineralized CRISPR/Cas9 RNA delivery system, which achieves efficient multiplex gene editing by editing multiple genomic loci. The system allows for precise control over the coencapsulation ratio between Cas9 mRNA and multiple sgRNAs, with a high RNA loading capacity. It also enhances the storage stability of RNA at 4°C and enables precise targeting of RNA nanoparticles in vivo. The system successfully achieved significant gene editing and inhibited tumor growth without off-target effects in liver tissue.
Correction
Chemistry, Multidisciplinary
Jingyi An, Kaixiang Zhang, Binghua Wang, Sixuan Wu, Yifei Wang, Hongling Zhang, Zhenzhong Zhang, Junjie Liu, Jinjin Shi
Review
Chemistry, Analytical
Qinghua Cao, Wenjun Chen, Ying Zhong, Xing Ma, Bo Wang
Summary: Hydrogel, a material with outstanding biocompatibility and shape deformation ability, has attracted attention as a hot topic for researchers due to its stimulus responsiveness. This study discusses the different responsive deformation mechanisms in hydrogels, introduces preparation techniques and structural designs, and highlights the potential of hydrogel micro-nano robots in biomedical applications.
Article
Chemistry, Multidisciplinary
Xiaoxia Liu, Yong Wang, Yixin Peng, Jinjin Shi, Wenjun Chen, Wei Wang, Xing Ma
Summary: Enzyme-catalyzed micro/nanomotors (MNMs) have great potential for biological isolation and sensing due to their biocompatibility, versatility, and easy access to biofuel. However, the flow field generated by enzyme-catalyzed reactions can significantly affect the performance of surface-linked functional moieties. In this study, enzymatic micromotors with spatially selective distribution of urease were developed to enable independent operation of various modules and facilitate the capture and sensing of exosomes. The integration of urease into the motors' cavity reduced the impact of the flow field on the exterior surface, resulting in enhanced binding efficiency of target cargos, such as exosomes, compared to static counterparts and moving micromotors with externally modified urease. The trapped exosomes can be transferred to a clean environment for Raman signal detection and identification using the surface Raman enhancement scattering (SERS) effect of gold nanoshell coating. The biocatalytic micromotors, with spatial separation between driving module and function module, hold considerable promise for the future design of multifunctional MNMs in biomedicine and diagnostics.
Correction
Chemistry, Multidisciplinary
Xiu Zhao, Hui Cheng, Qiongwei Wang, Weimin Nie, Yue Yang, Xinyuan Yang, Kaixiang Zhang, Jinjin Shi, Junjie Liu
Article
Chemistry, Multidisciplinary
Sixuan Wu, Yongbin Wei, Yang Wang, Zhenzhong Zhang, Dejun Liu, Shangshang Qin, Jinjin Shi, Jianzhong Shen
Summary: This study presents a pathogen-primed liposomal antibiotic booster that uses bismuth nanoclusters as a storage tank for Bi(III) to remove zinc ions. By fusing with the bacterial outer membrane, the booster facilitates drug delivery and zinc ion replacement, effectively treating NDMs-producing bacterial infections and slowing down their transmission.
