Two nanoformulations induce reactive oxygen species and immunogenetic cell death for synergistic chemo-immunotherapy eradicating colorectal cancer and hepatocellular carcinoma

Icaritin Exacerbates Mitophagy and Synergizes with Doxorubicin to Induce Immunogenic Cell Death in Hepatocellular Carcinoma

(2020) Zhuo Yu et al.   ACS Nano

Nano Codelivery of Oxaliplatin and Folinic Acid Achieves Synergistic Chemo-Immunotherapy with 5-Fluorouracil for Colorectal Cancer and Liver Metastasis

(2020) Jianfeng Guo et al.   ACS Nano

Membrane-core nanoparticles for cancer nanomedicine

(2020) Jianfeng Guo et al.   ADVANCED DRUG DELIVERY REVIEWS

FOLFOX Chemotherapy Ameliorates CD8 T Lymphocyte Exhaustion and Enhances Checkpoint Blockade Efficacy in Colorectal Cancer

(2020) Yue Guan et al.   Frontiers in Oncology

Tackling TAMs for Cancer Immunotherapy: It’s Nano Time

(2020) Yishun Yang et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Nanoparticle-Enhanced Radiotherapy to Trigger Robust Cancer Immunotherapy

(2019) Qian Chen et al.   ADVANCED MATERIALS

Approaches to treat immune hot, altered and cold tumours with combination immunotherapies

(2019) Jérôme Galon et al.   NATURE REVIEWS DRUG DISCOVERY

Anisamide-targeted PEGylated gold nanoparticles designed to target prostate cancer mediate: Enhanced systemic exposure of siRNA, tumour growth suppression and a synergistic therapeutic response in combination with paclitaxel in mice

(2019) Xue Luan et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Immunostimulatory nanomedicines synergize with checkpoint blockade immunotherapy to eradicate colorectal tumors

(2019) Xiaopin Duan et al.   Nature Communications

Relaxin gene delivery mitigates liver metastasis and synergizes with check point therapy

(2019) Mengying Hu et al.   Nature Communications

Engineering nanoparticles to locally activate T cells in the tumor microenvironment

(2019) Dangge Wang et al.   Science Immunology

Smart cancer nanomedicine

(2019) Roy van der Meel et al.   Nature Nanotechnology

Relaxin-FOLFOX-IL-12 triple combination therapy engages memory response and achieves long-term survival in colorectal cancer liver metastasis

(2019) Mengying Hu et al.   JOURNAL OF CONTROLLED RELEASE

Fluorouracil-Loaded Gold Nanoparticles for the Treatment of Skin Cancer: Development, in Vitro Characterization, and in Vivo Evaluation in a Mouse Skin Cancer Xenograft Model

(2018) Mohamed A. Safwat et al.   MOLECULAR PHARMACEUTICS

Synergistic and low adverse effect cancer immunotherapy by immunogenic chemotherapy and locally expressed PD-L1 trap

(2018) Wantong Song et al.   Nature Communications

Potential immune priming of the tumor microenvironment with FOLFOX chemotherapy in locally advanced rectal cancer

(2018) Campbell S. Roxburgh et al.   OncoImmunology

Local Blockade of Interleukin 10 and C-X-C Motif Chemokine Ligand 12 with Nano-Delivery Promotes Antitumor Response in Murine Cancers

(2018) Limei Shen et al.   ACS Nano

Trapping of Lipopolysaccharide to Promote Immunotherapy against Colorectal Cancer and Attenuate Liver Metastasis

(2018) Wantong Song et al.   ADVANCED MATERIALS

DNA Mismatch Repair Deficiency and Immune Checkpoint Inhibitors in Gastrointestinal Cancers

(2018) Juan Ruiz-Bañobre et al.   GASTROENTEROLOGY

Nanoparticle Delivery of RIG-I Agonist Enables Effective and Safe Adjuvant Therapy in Pancreatic Cancer

(2018) Manisit Das et al.   MOLECULAR THERAPY

An inflammatory-CCRK circuitry drives mTORC1-dependent metabolic and immunosuppressive reprogramming in obesity-associated hepatocellular carcinoma

(2018) Hanyong Sun et al.   Nature Communications

Exosomes from M1-Polarized Macrophages Potentiate the Cancer Vaccine by Creating a Pro-inflammatory Microenvironment in the Lymph Node

(2017) Lifang Cheng et al.   MOLECULAR THERAPY

Inactivation of DNA repair triggers neoantigen generation and impairs tumour growth

(2017) Giovanni Germano et al.   NATURE

PEGylation as a strategy for improving nanoparticle-based drug and gene delivery

(2016) Jung Soo Suk et al.   ADVANCED DRUG DELIVERY REVIEWS

Cancer nanomedicines: oversold or underappreciated?

(2016) Roy van der Meel et al.   Expert Opinion on Drug Delivery

The delivery of therapeutic oligonucleotides

(2016) Rudolph L. Juliano   NUCLEIC ACIDS RESEARCH

A Review of the Evolution of Systemic Chemotherapy in the Management of Colorectal Cancer

(2015) Bengt Gustavsson et al.   Clinical Colorectal Cancer

Turning a water and oil insoluble cisplatin derivative into a nanoparticle formulation for cancer therapy

(2014) Shutao Guo et al.   BIOMATERIALS

Immunomic, genomic and transcriptomic characterization of CT26 colorectal carcinoma

(2014) John C Castle et al.   BMC GENOMICS

Combinational delivery of c-myc siRNA and nucleoside analogs in a single, synthetic nanocarrier for targeted cancer therapy

(2013) Yuan Zhang et al.   BIOMATERIALS

Randomized, Multicenter, Open-Label Study of Oxaliplatin Plus Fluorouracil/Leucovorin Versus Doxorubicin As Palliative Chemotherapy in Patients With Advanced Hepatocellular Carcinoma From Asia

(2013) Shukui Qin et al.   JOURNAL OF CLINICAL ONCOLOGY

Turning an antiviral into an anticancer drug: Nanoparticle delivery of acyclovir monophosphate

(2013) Jing Yao et al.   JOURNAL OF CONTROLLED RELEASE

Codelivery of VEGF siRNA and Gemcitabine Monophosphate in a Single Nanoparticle Formulation for Effective Treatment of NSCLC

(2013) Yuan Zhang et al.   MOLECULAR THERAPY

Immunogenic Cell Death in Cancer Therapy

(2012) Guido Kroemer et al.   Annual Review of Immunology

Anisamide-targeted cyclodextrin nanoparticles for siRNA delivery to prostate tumours in mice

(2012) Jianfeng Guo et al.   BIOMATERIALS

Molecular Pathways: Microsatellite Instability in Colorectal Cancer: Prognostic, Predictive, and Therapeutic Implications

(2012) F. A. Sinicrope et al.   CLINICAL CANCER RESEARCH

Cytokine-Mediated Programmed Proliferation of Virus-Specific CD8+ Memory T Cells

(2012) Hans-Peter Raué et al.   IMMUNITY

Bevacizumab in Stage II-III Colon Cancer: 5-Year Update of the National Surgical Adjuvant Breast and Bowel Project C-08 Trial

(2012) Carmen J. Allegra et al.   JOURNAL OF CLINICAL ONCOLOGY

Randomized, Phase III Trial of Panitumumab With Infusional Fluorouracil, Leucovorin, and Oxaliplatin (FOLFOX4) Versus FOLFOX4 Alone As First-Line Treatment in Patients With Previously Untreated Metastatic Colorectal Cancer: The PRIME Study

(2010) Jean-Yves Douillard et al.   JOURNAL OF CLINICAL ONCOLOGY

Apoptosis and glutathione: beyond an antioxidant

(2009) R Franco et al.   CELL DEATH AND DIFFERENTIATION

S-1: a promising new oral fluoropyrimidine derivative

(2009) Muhammad Wasif Saif et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Biodegradable calcium phosphate nanoparticle with lipid coating for systemic siRNA delivery

(2009) Jun Li et al.   JOURNAL OF CONTROLLED RELEASE

Immunogenic death of colon cancer cells treated with oxaliplatin

(2009) A Tesniere et al.   ONCOGENE

Pharmacokinetic characteristics and anticancer effects of 5-Fluorouracil loaded nanoparticles

(2008) Su Li et al.   BMC CANCER

Effect of new hydrophobic modification of hyaluronan on its solution properties: evaluation of self-aggregation

(2008) Martin Chytil et al.   CARBOHYDRATE POLYMERS

Regulation of glutathione synthesis

(2008) Shelly C. Lu   MOLECULAR ASPECTS OF MEDICINE