The next step in translational research: lessons learned from the first preclinical randomized controlled trial

Neuroprotective therapies: Preclinical reproducibility is only part of the problem

(2015) Michael Tymianski   Science Translational Medicine

Results of a preclinical randomized controlled multicenter trial (pRCT): Anti-CD49d treatment for acute brain ischemia

(2015) Gemma Llovera et al.   Science Translational Medicine

A combined pre-clinical meta-analysis and randomized confirmatory trial approach to improve data validity for therapeutic target validation

(2015) Pamela WM. Kleikers et al.   Scientific Reports

Biomedical research: increasing value, reducing waste

(2014) Malcolm R Macleod et al.   LANCET

Increasing value and reducing waste in research design, conduct, and analysis

(2014) John P A Ioannidis et al.   LANCET

Preclinical research: Make mouse studies work

(2014) Steve Perrin   NATURE

The Quality of Reporting Methods and Results in Network Meta-Analyses: An Overview of Reviews and Suggestions for Improvement

(2014) Brian Hutton et al.   PLoS One

Journals unite for reproducibility

(2014) M. McNutt   SCIENCE

Distinguishing between Exploratory and Confirmatory Preclinical Research Will Improve Translation

(2014) Jonathan Kimmelman et al.   PLOS BIOLOGY

Remote control—triggering of brain autoimmune disease in the gut

(2013) Hartmut Wekerle et al.   CURRENT OPINION IN IMMUNOLOGY

Facilitating reproducibility

(2013)   Nature Chemical Biology

Bringing rigour to translational medicine

(2013) David W. Howells et al.   Nature Reviews Neurology

Power failure: why small sample size undermines the reliability of neuroscience

(2013) Katherine S. Button et al.   NATURE REVIEWS NEUROSCIENCE

Quantifying Reproducibility in Computational Biology: The Case of the Tuberculosis Drugome

(2013) Daniel Garijo et al.   PLoS One

Stroke Treatment Academic Industry Roundtable

(2013) Jeffrey L. Saver et al.   STROKE

A Concerted Appeal for International Cooperation in Preclinical Stroke Research

(2013) Ulrich Dirnagl et al.   STROKE

Evaluation of Excess Significance Bias in Animal Studies of Neurological Diseases

(2013) Konstantinos K. Tsilidis et al.   PLOS BIOLOGY

Phenotypic Changes in Immune Cell Subsets Reflect Increased Infarct Volume in Male vs. Female Mice

(2013) Anirban Banerjee et al.   Translational Stroke Research

Postischemic Brain Infiltration of Leukocyte Subpopulations Differs among Murine Permanent and Transient Focal Cerebral Ischemia Models

(2012) Wei Zhou et al.   BRAIN PATHOLOGY

Do stroke models model stroke?

(2012) P. Mergenthaler et al.   Disease Models & Mechanisms

Improving the Efficiency of the Development of Drugs for Stroke

(2012) David W. Howells et al.   International Journal of Stroke

International, Multicenter Randomized Preclinical Trials in Translational Stroke Research: It's Time to Act

(2012) Ulrich Dirnagl et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Gait analysis as a method for assessing neurological outcome in a mouse model of stroke

(2012) Susann Hetze et al.   JOURNAL OF NEUROSCIENCE METHODS

Raise standards for preclinical cancer research

(2012) C. Glenn Begley et al.   NATURE

The interplay between the intestinal microbiota and the brain

(2012) Stephen M. Collins et al.   NATURE REVIEWS MICROBIOLOGY

Development of an NIH Consortium for PreclinicAl AssESsment of CARdioprotective Therapies (CAESAR): A Paradigm Shift in Studies of Infarct Size Limitation

(2011) David J. Lefer et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS

Believe it or not: how much can we rely on published data on potential drug targets?

(2011) Florian Prinz et al.   NATURE REVIEWS DRUG DISCOVERY

Modeling Stroke in Mice - Middle Cerebral Artery Occlusion with the Filament Model

(2011) Odilo Engel et al.   Jove-Journal of Visualized Experiments

Different Strokes for Different Folks: The Rich Diversity of Animal Models of Focal Cerebral Ischemia

(2010) David W Howells et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Emulating Multicentre Clinical Stroke Trials: A New Paradigm for Studying Novel Interventions in Experimental Models of Stroke

(2009) P. M. W. Bath et al.   International Journal of Stroke

Potential Animal Models of Lacunar Stroke

(2009) Emma L. Bailey et al.   STROKE

Translational research: Crossing the valley of death

(2008) Declan Butler   NATURE

Empirical Evidence of Bias in the Design of Experimental Stroke Studies

(2008) Nicolas A. Crossley et al.   STROKE