Review
Oncology
Cecilia Herraiz, Idoya Martinez-Vicente, Vittoria Maresca
Summary: The MC1R receptor is involved in driving eumelanogenesis and also has the ability to cope with oxidative insults and DNA damage. Polymorphic variants associated with melanoma risk represent important clinical relevance.
PIGMENT CELL & MELANOMA RESEARCH
(2021)
Article
Dermatology
Qiuying Chen, Dalee Zhou, Zalfa Abdel-Malek, Fengli Zhang, Philip S. Goff, Elena Sviderskaya, Kazumasa Wakamatsu, Shosuke Ito, Steven S. Gross, Jonathan H. Zippin
Summary: A new method was developed to actively measure the synthesis of both eumelanin and pheomelanin using liquid chromatography-mass spectrometry, shedding new light on melanin synthesis and revealing new insights into the mechanisms of melanogenesis.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Article
Dermatology
Maftuna Yusupova, Dalee Zhou, Jaewon You, Jeydi Gonzalez-Guzman, Megha B. Ghanta, Hong Pu, Zalfa Abdel-Malek, Qiuying Chen, Steven S. Gross, John D'Orazio, Shosuke Ito, Kazumasa Wakamatsu, Melissa L. Harris, Jonathan H. Zippin
Summary: cAMP signaling pathways, including transmembrane adenylyl cyclase and soluble adenylyl cyclase (sAC), regulate melanin synthesis by affecting melanosomal pH and gene expression. Loss of function MC1R does not affect melanosomal pH, indicating that sAC pathway is the only one that regulates melanosomal pH. sAC loss of function has no effect on melanin synthesis in MC1R nonfunctional human and mouse melanocytes or skin and hair melanin in e/e mice. However, activation of transmembrane adenylyl cyclases increases eumelanin production in sAC-knockout mice.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Article
Anatomy & Morphology
Shelly Aono, John C. Dennis, Shan He, Wei Wang, Ya-Xiong Tao, Edward E. Morrison
Summary: Canine beta-defensin 103 (cBD103) and its variant cBD103 Delta G23 are multitasking polypeptides that play a role in antimicrobial defense in the nasal cavity. The Delta G23 mutation does not significantly affect the antimicrobial activity of cBD103, and both forms of cBD103 can cause ultrastructural changes in Escherichia coli and Staphylococcus aureus. Additionally, cBD103 has cell-degrading effects in nutrient-rich or salt-added minimal media.
ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY
(2021)
Article
Chemistry, Organic
Meng-Cheng Zhang, Dong-Chao Wang, Gui-Rong Qu, Hai-Ming Guo
Summary: The first catalytic asymmetric route to synthesize chiral thiohydantoins containing a quaternary stereogenic center has been established using a chiral phosphoric acid catalyst, achieving high yields and excellent enantioselectivities. This reaction also allows for the construction of two C-N bonds.
ORGANIC CHEMISTRY FRONTIERS
(2022)
Article
Plant Sciences
Hwang-Ju Jeon, Kyeongnam Kim, Chaeeun Kim, Myoung-Jin Kim, Tae-Oh Kim, Sung-Eun Lee
Summary: Melanogenesis is a complex process that produces melanin, a protective skin pigment, and determines skin color. Gedunin has been shown to effectively inhibit melanin production, making it a promising candidate for anti-melanogenesis agents.
Article
Mycology
Pedro Goes Mesquita, Laiza Magalhaes de Araujo, Francisco de Assis Rocha Neves, Maria de Fatima Borin
Summary: Diabetes is a metabolic disorder linked to oxidative stress and inflammation. Endophytic fungi can produce natural products with antioxidant activities, and some extracts show activity on PPAR receptors. Studying this relationship may provide insights into the mechanism of action of antioxidants in treating diabetes and its complications.
FRONTIERS IN FUNGAL BIOLOGY
(2022)
Article
Geriatrics & Gerontology
Yang Na, Lin Ke, Zhang Jie, Wang Jinping, Meng Tao, Zhu Jie, Yang Liu, Zhou Yueqin
Summary: This study investigated the effect of LXR agonist TO901317 on the cognitive function of AD transgenic mice fed with a cholesterol-rich diet (CRD), and explored the underlying mechanisms. The results showed that TO901317 improved the impaired learning, memory, and spatial exploration ability of the mice. It decreased the levels of cholesterol, LDL, and Aβ42 in the serum and brain, while increasing the level of HDL. Furthermore, TO901317 regulated the expression of LXR-beta, RXR-alpha, ABCA1, caveolin-1, APP, and BACE1. These findings suggest that TO901317 attenuates the cognitive impairment in AD mice induced by CRD, possibly through the activation of the LXR-beta/RXR-alpha/ABCA1 transmembrane transport system and the reduction of Aβ42 in the brain.
EXPERIMENTAL AGING RESEARCH
(2023)
Article
Engineering, Biomedical
Britani N. Blackstone, Megan M. Malara, Molly E. Baumann, Kevin L. McFarland, Dorothy M. Supp, Heather M. Powella
ACTA BIOMATERIALIA
(2020)
Article
Dermatology
Danielle M. DeBruler, Molly E. Baumann, Jacob Zbinden, Britani N. Blackstone, John Kevin Bailey, Dorothy M. Supp, Heather M. Powell
ADVANCES IN WOUND CARE
(2020)
Article
Critical Care Medicine
Molly E. Baumann, Danielle M. DeBruler, Britani N. Blackstone, Rebecca A. Coffey, Steven T. Boyce, Dorothy M. Supp, J. Kevin Bailey, Heather M. Powell
Summary: Assessing scar properties quantitatively with non-invasive instruments is more reliable and efficient than using scar scales, with color and biomechanics measurements taking less than 90 s per measurement and providing high sensitivity over time or treatment.
Article
Cell & Tissue Engineering
Megan M. Malara, Britani N. Blackstone, Molly E. Baumann, J. Kevin Bailey, Dorothy M. Supp, Heather M. Powell
TISSUE ENGINEERING PART A
(2020)
Letter
Critical Care Medicine
Heather M. Powell, Dorothy M. Supp, J. Kevin Bailey, Molly E. Baumann
Article
Critical Care Medicine
Angela L. F. Gibson, Bonnie C. Carney, Leila Cuttle, Christine J. Andrews, Christine J. Kowalczewski, Aiping Liu, Heather M. Powell, Randolph Stone, Dorothy M. Supp, Adam J. Singer, Jeffrey W. Shupp, Lily Stalter, Lauren T. Moffatt
Summary: Deep partial thickness burns are commonly seen in clinical practice but are hard to diagnose. Accurate animal models are crucial for developing methods to assess burn depth and therapies to treat these burns. Inconsistencies in evaluation approaches among different laboratories were found, leading to the development of a scoring rubric that improved reliability in assessing burn injury depth in pig models.
JOURNAL OF BURN CARE & RESEARCH
(2021)
Article
Multidisciplinary Sciences
Mariana L. Stevens, Zhonghua Zhang, Elisabet Johansson, Samriddha Ray, Amrita Jagpal, Brandy P. Ruff, Arjun Kothari, Hua He, Lisa J. Martin, Hong Ji, Kathryn Wikenheiser-Brokamp, Matthew T. Weirauch, Dorothy M. Supp, Jocelyn M. Biagini Myers, Gurjit K. Khurana Hershey
NATURE COMMUNICATIONS
(2020)
Article
Cell & Tissue Engineering
Sonya Ruiz-Torres, Marion G. Brusadelli, David P. Witte, Kathryn A. Wikenheiser-Brokamp, Sharon Sauter, Adam S. Nelson, Mathieu Sertorio, Timothy M. Chlon, Adam Lane, Parinda A. Mehta, Kasiani C. Myers, Mary C. Bedard, Bidisha Pal, Dorothy M. Supp, Paul F. Lambert, Kakajan Komurov, Melinda Butsch Kovacic, Stella M. Davies, Susanne Wells
Summary: The study found that genetic mutations in Fanconi anemia (FA) patients can affect cell structure and function, accelerating the process of cancer development. This provides a new direction for exploring SCC prevention.
Article
Cell Biology
Jennifer M. Hahn, Kevin L. McFarland, Kelly A. Combs, Meridith C. Anness, Dorothy M. Supp
Summary: Keloids are fibroproliferative lesions resulting from abnormal wound healing, with different expression of HOX genes in keloid and normal skin cells potentially playing a role in keloid development. However, the differential expression of HOX genes may be due to positional identity differences between keloid and normal fibroblasts rather than body site-specific factors.
WOUND REPAIR AND REGENERATION
(2021)
Article
Multidisciplinary Sciences
Christian B. Bergmann, Bruce D. Hammock, Debin Wan, Falk Gogolla, Holly Goetzman, Charles C. Caldwell, Dorothy M. Supp
Summary: The study demonstrated that TPPU administration can decrease DHET levels post-burn, leading to reduced IL-6 concentrations. 14,15-DHET was found to modulate neutrophil functionality and mRNA expression, indicating its role in regulating inflammation in burn injury.
SCIENTIFIC REPORTS
(2021)
Article
Critical Care Medicine
David M. Burmeister, Dorothy M. Supp, Richard A. Clark, Edward E. Tredget, Heather M. Powell, Perenlei Enkhbaatar, Julia K. Bohannon, Leopoldo C. Cancio, David M. Hill, Rachel M. Nygaard
Summary: This article introduces the use of multiple animal species and approaches for modeling burn care and discusses the pros and cons of using small and large animal models for research. Researchers believe that using pigs as large animal models can better simulate human skin, while sheep models are suitable for studying inhalation injury. However, these models are expensive and technically demanding. Therefore, by improving small animal models, questions related to burns can be addressed.
JOURNAL OF BURN CARE & RESEARCH
(2022)
Article
Cell Biology
Jennifer M. Hahn, Kelly A. Combs, Heather M. Powell, Dorothy M. Supp
Summary: Keloids are challenging to treat and have high recurrence rates. The genetic causes and molecular mechanisms of keloid formation are not fully understood. Dark-skinned individuals, who are at higher risk of keloids, may also have lower vitamin D levels, suggesting a potential role for vitamin D in keloid pathology. Studies have found reduced vitamin D receptor expression in keloid lesions, indicating a possible therapeutic role for vitamin D in suppressing keloid fibrosis.
WOUND REPAIR AND REGENERATION
(2023)
Article
Biochemical Research Methods
Dorothy M. Supp, Jennifer M. Hahn, Kelly A. Combs, Kevin L. Mcfarland, Heather M. Powell
Summary: A method has been developed to isolate four types of primary cells from a single human skin sample without using murine feeder cells. These isolated cells contain stem cell populations and are capable of forming functional skin tissue.
Meeting Abstract
Cell Biology
Dorothy M. Supp, Jennifer M. Hahn, Kevin L. McFarland, Kelly A. Combs, Meridith Anness
WOUND REPAIR AND REGENERATION
(2021)
Meeting Abstract
Critical Care Medicine
Christian B. Bergmann, Bruce D. Hammock, Debin Wan, Dorothy M. Supp, Charles Caldwell