Article
Multidisciplinary Sciences
Jun-Ha Hwang, Kyung Min Kim, Ho Taek Oh, Gi Don Yoo, Mi Gyeong Jeong, Hyun Lee, Joori Park, Kwon Jeong, Yoon Ki Kim, Young-Gyu Ko, Eun Sook Hwang, Jeong-Ho Hong
Summary: This study reveals that TAZ is a novel stimulator for mitochondrial biogenesis and exercise-induced muscle adaptation. TAZ stimulates the translation of mitochondrial transcription factor A via the Rheb/Rhebl1-mTOR pathway. The knockout of TAZ in mice results in decreased mitochondrial biogenesis, respiratory metabolism, and exercise ability.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Mikhail Dubinin, Vlada S. Starinets, Eugeny Yu Talanov, Irina B. Mikheeva, Natalia Belosludtseva, Konstantin N. Belosludtsev
Summary: The study demonstrates that the calcium-dependent mitochondrial permeability transition (MPT) pore inhibitor alisporivir can alleviate inflammation in mdx mice, improve muscle function, improve mitochondrial ultrastructure, normalize respiration and oxidative phosphorylation. The therapy suppresses MPT pore opening, improves calcium homeostasis, but also inhibits mitochondrial biogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Trace Thome, Kyoungrae Kim, Gengfu Dong, Terence E. E. Ryan
Summary: Chronic kidney disease (CKD) affects 700 million people worldwide and leads to the loss of muscle mass and function. Mitochondrial and redox alterations have been found to be involved in CKD-associated myopathy, but the underlying mechanisms are not well understood. Effective treatments to improve muscle health in CKD are still lacking.
ANTIOXIDANTS & REDOX SIGNALING
(2023)
Review
Cell Biology
James Sligar, Danielle A. DeBruin, Nicholas J. Saner, Ashleigh M. Philp, Andrew Philp
Summary: Mitochondria, as the main energy-producing organelles of the cell, play a crucial role in various biological processes in skeletal muscle. Age-related deterioration in skeletal muscle functional capacity is partly driven by a decrease in oxidative capacity and fatigue resistance, which are caused by mitochondrial dysfunction due to alterations in mitochondrial quality control (MQC). Recent research has shown that manipulating MQC may hold great therapeutic potential in preventing mitochondrial dysfunction during aging.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Article
Endocrinology & Metabolism
Stephen P. Ashcroft, Gareth Fletcher, Ashleigh M. Philp, Carl Jenkinson, Shatarupa Das, Philip M. Hansbro, Philip J. Atherton, Andrew Philp
Summary: The study found that diet-induced vitamin D deficiency reduced skeletal muscle mitochondrial respiration in C57BL/6J mice, indicating a potential role of vitamin D in regulating muscle fatigue and performance deficits.
JOURNAL OF ENDOCRINOLOGY
(2021)
Article
Nutrition & Dietetics
Frederic Nicolas Daussin, Alexane Cuillerier, Julianne Touron, Samir Bensaid, Bruno Melo, Ali Al Rewashdy, Goutham Vasam, Keir J. Menzies, Mary-Ellen Harper, Elsa Heyman, Yan Burelle
Summary: The study found that cocoa flavanols supplementation can improve mitochondrial function and whole-body metabolism, particularly by stimulating NAD metabolism and enhancing the function of Sirt3. These findings suggest that cocoa flavanols may help improve metabolic efficiency in the body.
Review
Physiology
Christine M. Latham, Camille R. Brightwell, Alexander R. Keeble, Brooke D. Munson, Nicholas T. Thomas, Alyaa M. Zagzoog, Christopher S. Fry, Jean L. Fry
Summary: Vitamin D plays a crucial role in muscle regeneration and maintenance, protecting muscle structure and mitochondrial function, and promoting the activity of muscle stem cells.
FRONTIERS IN PHYSIOLOGY
(2021)
Review
Neurosciences
Ashleigh M. Philp, Nicholas J. Saner, Michael Lazarou, Ian G. Ganley, Andrew Philp
Summary: Mitochondria are dynamic organelles designed to meet cellular energy demands, exhibiting high plasticity in response to alterations in energy demand. Aerobic exercise is a potent stimulus for skeletal muscle remodelling, leading to changes in mitochondrial quality control. There is a rapidly advancing understanding of mitochondrial quality control in skeletal muscle and the regulatory role of aerobic exercise on this process.
JOURNAL OF PHYSIOLOGY-LONDON
(2021)
Article
Clinical Neurology
M. Scott Binder, Ricardo H. Roda, Andrea M. Corse, Sunjeet Sidhu, Sarah Stewart, Andreas S. Barth
Summary: This study investigated the prevalence of cardiac conduction disease and structural heart disease in patients with mitochondrial abnormalities found in skeletal muscle biopsy. The results showed a higher prevalence of cardiovascular diseases in these patients compared to control populations, suggesting the importance of routine cardiac screening for patients with mitochondrial abnormalities.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2021)
Review
Physiology
Rachel M. Handy, Graham P. Holloway
Summary: Impairments in peripheral tissue insulin signaling, caused by a high-lipid environment and increased mitochondrial reactive oxygen species production, are believed to contribute to insulin resistance and type 2 diabetes. However, physical inactivity can also promote insulin resistance through alternative mechanisms, such as a reduction in protein synthesis. Mitochondrial biology plays a crucial role in the interaction between physical (in)activity, lipid metabolism, and insulin signaling.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Multidisciplinary Sciences
Charlotte Gineste, Sonia Youhanna, Sabine U. Vorrink, Sara Henriksson, Andres Hernandez, Arthur J. Cheng, Thomas Chaillou, Andreas Buttgereit, Dominik Schneidereit, Oliver Friedrich, Kjell Hultenby, Joseph D. Bruton, Niklas Ivarsson, Linda Sandblad, Volker M. Lauschke, Hakan Westerblad
Summary: This study investigated the effects of extracellular matrix (ECM) disruption on cellular and mitochondrial morphology, gene expression, and Ca2+ handling in skeletal muscle fibers. The results showed that enzymatic dissociation of fibers resulted in myopathic phenotypes, shorter and less branched mitochondria, and prolonged mitochondrial Ca2+ accumulation during repeated contractions. However, this accumulation was concealed with enzymatic dissociation, making it an ambiguous method in studies of native intracellular Ca2+ fluxes.
Article
Neurosciences
Joseph J. Bass, Abid A. Kazi, Colleen S. Deane, Asif Nakhuda, Stephen P. Ashcroft, Matthew S. Brook, Daniel J. Wilkinson, Bethan E. Phillips, Andrew Philp, Janelle Tarum, Fawzi Kadi, Ditte Andersen, Amadeo Munoz Garcia, Ken Smith, Iain J. Gallagher, Nathaniel J. Szewczyk, Mark E. Cleasby, Philip J. Atherton
Summary: Reduced vitamin D receptor (VDR) expression leads to skeletal muscle atrophy through the induction of autophagy, without affecting muscle protein synthesis or anabolic signaling. VDR knockdown impairs mitochondrial function and myogenic regulation, highlighting its crucial role in maintaining muscle mass and limiting autophagy. These findings suggest a fundamental regulatory role of VDR in myogenesis and muscle mass regulation.
JOURNAL OF PHYSIOLOGY-LONDON
(2021)
Article
Agriculture, Dairy & Animal Science
Victoria Favorit, Wendy R. Hood, Andreas N. Kavazis, Patricia Villamediana, Kang Nian Yap, Hailey A. Parry, Amy L. Skibiel
Summary: Lactation requires increased nutrient and energy usage. Mitochondrial efficiency and biogenesis in the liver are positively associated with milk yield, while skeletal muscle mitochondrial efficiency remains consistent but experiences oxidative damage.
Article
Nutrition & Dietetics
Gianluca Gortan Cappellari, Aneta Aleksova, Matteo Dal Ferro, Antonio Cannata, Annamaria Semolic, Alberto Guarnaccia, Michela Zanetti, Mauro Giacca, Gianfranco Sinagra, Rocco Barazzoni
Summary: Skeletal muscle derangements in chronic heart failure (CHF), such as mitochondrial dysfunction and high reactive oxygen species (ROS) generation, lead to muscle wasting and reduced exercise capacity. 8-week n-3-PUFA dietary replacement normalizes mitochondrial dynamics, reduces oxidative stress, and preserves skeletal muscle mass in CHF.
Article
Endocrinology & Metabolism
Emily J. King, Simon T. Bond, Christine Yang, Yingying Liu, Anna C. Calkin, Darren C. Henstridge, Brian G. Drew
Summary: This study investigated the impact of muscle-specific deletion of TRIM28 on obesity, glucose tolerance, and insulin resistance. Although alterations in mitochondrial activity and autophagy markers were observed, no major impacts on most metabolic measures were observed.
JOURNAL OF ENDOCRINOLOGY
(2023)
Article
Cell Biology
Dechao Wu, Chongshu Jian, Qi Peng, Tingting Hou, Keling Wu, Bizhi Shang, Minglei Zhao, Yanru Wang, Wen Zheng, Qi Ma, Chuan-Yun Li, Heping Cheng, Xianhua Wang, Ling Zhao
CELL DEATH & DISEASE
(2020)
Review
Neurosciences
Shiyuan Chen, Zichen Wang, Dong Zhang, Aiming Wang, Liangyi Chen, Heping Cheng, Runlong Wu
NEUROSCIENCE BULLETIN
(2020)
Letter
Cardiac & Cardiovascular Systems
Fujian Lu, Yan Zhao, Wenjun Xie, Qianjin Guo, Shi-Qiang Wang, Xianhua Wang, Heping Cheng
Article
Biochemical Research Methods
Weijian Zong, Runlong Wu, Shiyuan Chen, Junjie Wu, Hanbin Wang, Zhe Zhao, Guoqing Chen, Rui Tu, Danlei Wu, Yanhui Hu, Yangyang Xu, Yao Wang, Zhuoli Duan, Haitao Wu, Yunfeng Zhang, Jue Zhang, Aimin Wang, Liangyi Chen, Heping Cheng
Summary: Our miniature two-photon microscope, equipped with an axial scanning mechanism and a long-working-distance miniature objective, enables multi-plane imaging within a small animal's body, aiding in deciphering neuronal mechanisms.
Article
Multidisciplinary Sciences
Fan Jiang, Kunlun Yin, Kun Wu, Mingmin Zhang, Shiqiang Wang, Heping Cheng, Zhou Zhou, Bailong Xiao
Summary: The Piezo1 channel serves as a key cardiac mechanotransducer for converting mechanical stretch of cardiomyocytes into Ca2+ and ROS signaling to maintain normal heart function.
NATURE COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Feihong Dong, Jian An, Jiabin Zhang, Jingyi Yin, Wenyu Guo, Di Wang, Feng Feng, Shuo Huang, Jue Zhang, Heping Cheng
Summary: The novel acoustic contrast agent called Blinking Acoustic Nanodroplets (BANDs) is ideal for super-resolution ultrasound imaging, enabling high-resolution vascular imaging through reversible vaporization and reliquefaction. By utilizing sparse activation and high-density mixtures, BANDs allow for fast and accurate imaging of vasculature in live animals, promising to greatly enhance the application of super-resolution ultrasound in both basic science and clinical settings.
Review
Biochemistry & Molecular Biology
Fujian Lu, Yunzhan Li, Shengchen Lin, Heping Cheng, Shengyu Yang
Summary: SOCE is a critical mechanism for cells to replenish depleted Ca2+ stores and its dysregulation has been implicated in metastatic cancers. It plays a role in promoting cell migration and invasion by remodeling the actin cytoskeleton and cell adhesion dynamics. Additionally, recent evidence suggests that SOCE is essential for spatial and temporal coding of Ca2+ signals in cells.
BIOCHEMICAL SOCIETY TRANSACTIONS
(2021)
Article
Neurosciences
Chaoyi Zhang, Hong Zhu, Zheyi Ni, Qiuhong Xin, Tingting Zhou, Runlong Wu, Guangping Gao, Zhihua Gao, Huan Ma, Haohong Li, Miao He, Jue Zhang, Heping Cheng, Hailan Hu
Summary: This study reveals the crucial role of VIP and PV neuron activation in regulating winning behavior in social competition. The study also uncovers the sequential calcium activities initiated by VIP in the dmPFC microcircuit and the delayed activation of PV neurons.
Article
Chemistry, Multidisciplinary
Jian An, Jiabin Zhang, Feihong Dong, Jingyi Yin, Feng Feng, Wenyu Guo, Shuo Huang, Di Wang, Jie Dang, Jue Zhang, Heping Cheng
Summary: This study develops a noninvasive arterial labeling ultrasound subtraction angiography (ALUSA) technique based on new nanodroplets, which allows high-resolution observation of vascular structures and perfusion. It has been successfully applied in rabbit kidneys and mouse breast tumors.
Article
Multidisciplinary Sciences
Fujian Lu, Qing Ma, Wenjun Xie, Carter L. Liou, Donghui Zhang, Mason E. Sweat, Blake D. Jardin, Francisco J. Naya, Yuxuan Guo, Heping Cheng, William T. Pu
Summary: This study uncovers the role of CMYA5 in organizing and regulating the subcellular structures in cardiomyocytes, highlighting its importance in cardiac development, function, and tolerance to pressure overload.
NATURE COMMUNICATIONS
(2022)
Article
Developmental Biology
Daniel Medina-Cano, Emily K. Corrigan, Rachel A. Glenn, Mohammed T. Islam, Yuan Lin, Juliet Kim, Hyunwoo Cho, Thomas Vierbuchen
Summary: Directed differentiation of pluripotent stem cells provides a powerful model system for studying embryonic development. Current protocols for mouse PSCs require improvement, but new protocols for generating nearly pure definitive endoderm and neural organoids present potential opportunities for research.
Article
Physiology
Junjie Wang, Zhen Zhen, Yanqing Wang, Runlong Wu, Yanhui Hu, Qiang Fu, Yongzhi Li, Bingmu Xin, Jinping Song, Jianwei Li, Yafei Ren, Lishuang Feng, Heping Cheng, Aimin Wang, Liming Hu, Shukuan Ling, Yingxian Li
Summary: Spaceflight poses various challenges to astronauts, including radiation, microgravity, isolation, and other hazards. This study found that skin autofluorescence signals can reflect changes in human oxidant status during space missions.
FRONTIERS IN PHYSIOLOGY
(2022)
Letter
Neurosciences
Zhuoran Zhang, Shihe Jiang, Kaibin Shi, Yan Li, Wei-Na Jin, Qiang Liu, Ting Zhao, Heping Cheng, Fu-Dong Shi
NEUROSCIENCE BULLETIN
(2022)
Article
Multidisciplinary Sciences
Zhe Zhao, Fengqingyang Zeng, Hanbin Wang, Runlong Wu, Liping Chen, Yan Wu, Shen Li, Jingyuan Shao, Yao Wang, Junjie Wu, Zhiheng Feng, Weizheng Gao, Yanhui Hu, Aimin Wang, Heping Cheng, Jue Zhang, Liangyi Chen, Haitao Wu
Summary: This study used miniature two-photon microscopy to investigate the neural activity associated with social behaviors in freely behaving mice. The researchers found that the activity of GABAergic neurons was more correlated with social behaviors than glutamatergic neurons. Suppressing the activity of GABAergic neurons in the prelimbic area disrupted social novelty behaviors, while restoring the MeCP2 levels in these neurons rescued the deficits. Additionally, the study identified and characterized two types of GABAergic interneurons responsible for new and old mouse exploration in the prelimbic area.
Article
Cell Biology
Di Wu, Wenfeng Qi, Wei Nie, Zhengyuan Lu, Yongxin Ye, Jinghang Li, Tao Sun, Yufei Zhu, Heping Cheng, Xianhua Wang
Summary: This study reveals an exquisite bacterial acid-resistance mechanism in which proton leak triggers a preemptive response. The proton leak leads to a quantal electrochemical excitation, BacFlash, which protects bacteria by activating transcription of key AR genes.
Article
Cardiac & Cardiovascular Systems
Andrew B. Harvey, Renelyn A. Woltes, Raymond N. Deepe, Hannah G. Tarolli, Jenna R. Drummond, Allison Trouten, Auva Zandi, Jeremy L. Barth, Rupak Mukherjee, Martin J. Romeo, Silvia G. Vaena, Ge Tao, Robin Muise-Helmericks, Paula S. Ramos, Russell A. Norris, Andy Wessels
Summary: This study highlights the importance of SOX9 in the regulation of epicardial cell invasion and emphasizes the role of EPDCs in regulating atrioventricular valve development and homeostasis. It also reports a novel expression profile of Cd109, a gene with previously unknown relevance in heart development.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)
Review
Cardiac & Cardiovascular Systems
MariaSanta C. Mangione, Jinhua Wen, Dian J. Cao
Summary: mTOR, a mechanistic target of rapamycin, is an evolutionarily conserved pathway that plays a fundamental role in nutrient sensing, growth, metabolism, lifespan, and aging. Recent studies have highlighted the regulatory role of mTOR in innate immune responses and its involvement in the pathogenesis of cardiovascular diseases, especially in acute inflammation and atherosclerotic cardiovascular disease. This review also discusses mTOR's role in trained immunity, immune senescence, and clonal hematopoiesis, as well as its architecture and regulatory complexes.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Junlin Li, Yajun Gong, Yiren Wang, Huihui Huang, Huan Du, Lianying Cheng, Cui Ma, Yongxiang Cai, Hukui Han, Jianhong Tao, Gang Li, Panke Cheng
Summary: Myocardial ischemia-reperfusion injury is closely related to the final infarct size in acute myocardial infarction. Regulatory T cells play an important role in the inflammatory response after AMI, but different subtypes of Tregs have different effects on the injury.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Yuxin Chu, Yutao Hua, Lihao He, Jin He, Yunxi Chen, Jing Yang, Ismail Mahmoud, Fanfang Zeng, Xiaochang Zeng, Gloria A. Benavides, Victor M. Darley-Usmar, Martin E. Young, Scott W. Ballinger, Sumanth D. Prabhu, Cheng Zhang, Min Xie
Summary: This study demonstrates that administering beta-hydroxybutyrate (beta-OHB) at the time of reperfusion can reduce infarct size and preserve cardiac function by activating autophagy and preserving mitochondrial homeostasis, potentially through mTOR inhibition.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)