Star Polymer Nanomedicines─Challenges and Future Perspectives

Aerosol delivery of star polymer-siRNA nanoparticles as a therapeutic strategy to inhibit lung tumor growth

(2022) Z. Ma et al.   BIOMATERIALS

Sustained endosomal release of a neurokinin-1 receptor antagonist from nanostars provides long-lasting relief of chronic pain

(2022) Rocco Latorre et al.   BIOMATERIALS

Amphiphilic Core Cross-Linked Star Polymers for the Delivery of Hydrophilic Drugs from Hydrophobic Matrices

(2021) Katarzyna Somszor et al.   BIOMACROMOLECULES

Cancer-associated fibroblasts in pancreatic ductal adenocarcinoma determine response to SLC7A11 inhibition

(2021) George Sharbeen et al.   CANCER RESEARCH

Does the Microenvironment Hold the Hidden Key for Functional Precision Medicine in Pancreatic Cancer?

(2021) John Kokkinos et al.   Cancers

Design and synthesis of targeted star-shaped micelle for guided delivery of camptothecin: In vitro and in vivo evaluation

(2021) Mehrdad Sahranavard et al.   Materials Science & Engineering C-Materials for Biological Applications

Life of RISC: Formation, action, and degradation of RNA-induced silencing complex

(2021) Hiro-oki Iwakawa et al.   MOLECULAR CELL

Enabling peristalsis of human colon tumor organoids on microfluidic chips

(2021) Guocheng Fang et al.   Biofabrication

Preferentially released miR-122 from cyclodextrin-based star copolymer nanoparticle enhances hepatoma chemotherapy by apoptosis induction and cytotoxics efflux inhibition

(2021) Qingqing Xiong et al.   Bioactive Materials

Polymer nanomedicines based on micelle-forming amphiphilic or water-soluble polymer-doxorubicin conjugates: Comparative study of in vitro and in vivo properties related to the polymer carrier structure, composition, and hydrodynamic properties

(2020) Alena Braunová et al.   JOURNAL OF CONTROLLED RELEASE

The entry of nanoparticles into solid tumours

(2020) Shrey Sindhwani et al.   NATURE MATERIALS

Targeting the undruggable in pancreatic cancer using nano-based gene silencing drugs

(2020) John Kokkinos et al.   BIOMATERIALS

Design and preclinical evaluation of nanostars for the passive pretargeting of tumor tissue

(2020) Jeroen A.C.M. Goos et al.   NUCLEAR MEDICINE AND BIOLOGY

Matrix metalloprotein-triggered, cell penetrating peptide-modified star-shaped nanoparticles for tumor targeting and cancer therapy

(2020) Fangyuan Guo et al.   JOURNAL OF NANOBIOTECHNOLOGY

Human organoids: model systems for human biology and medicine

(2020) Jihoon Kim et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Adaptive methodology to determine hydrophobicity of nanomaterials in situ

(2020) Lauren E. Crandon et al.   PLoS One

Cellular Interactions of Liposomes and PISA Nanoparticles during Human Blood Flow in a Microvascular Network

(2020) Mai N. Vu et al.   Small

Intranasal Delivery of Targeted Nanoparticles Loaded With miR-132 to Brain for the Treatment of Neurodegenerative Diseases

(2020) Yu Su et al.   Frontiers in Pharmacology

Miktoarm Star Polymers: Branched Architectures in Drug Delivery

(2020) Victor Lotocki et al.   Pharmaceutics

A novel small molecule that kills a subset of MLL-rearranged leukemia cells by inducing mitochondrial dysfunction

(2019) Klaartje Somers et al.   ONCOGENE

The current state and future directions of RNAi-based therapeutics

(2019) Ryan L. Setten et al.   NATURE REVIEWS DRUG DISCOVERY

Miktoarm Stars via Grafting-Through Copolymerization: Self-Assembly and the Star-to-Bottlebrush Transition

(2019) Adam E. Levi et al.   MACROMOLECULES

Elaboration and characterization of curcumin-loaded Tri-CL-mPEG three-arm copolymeric nanoparticles by a microchannel technology

(2019) Wenchao Wu et al.   International Journal of Nanomedicine

Survey of Clinical Translation of Cancer Nanomedicines—Lessons Learned from Successes and Failures

(2019) Hongliang He et al.   ACCOUNTS OF CHEMICAL RESEARCH

A pH-responsive nanoparticle targets the neurokinin 1 receptor in endosomes to prevent chronic pain

(2019) Paulina D. Ramírez-García et al.   Nature Nanotechnology

HPMA-based star polymer biomaterials with tuneable structure and biodegradability tailored for advanced drug delivery to solid tumours

(2019) Libor Kostka et al.   BIOMATERIALS

Thiol-Reactive Star Polymers Functionalized with Short Ethoxy-Containing Moieties Exhibit Enhanced Uptake in Acute Lymphoblastic Leukemia Cells

(2019) Narges Bayat et al.   International Journal of Nanomedicine

Regulation of microRNA function in animals

(2018) Luca F. R. Gebert et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Nano-Star-Shaped Polymers for Drug Delivery Applications

(2017) Da-Peng Yang et al.   MACROMOLECULAR RAPID COMMUNICATIONS

Doxorubicin induces cardiotoxicity through upregulation of death receptors mediated apoptosis in cardiomyocytes

(2017) Liqun Zhao et al.   Scientific Reports

A Rationally Optimized Nanoparticle System for the Delivery of RNA Interference Therapeutics into Pancreatic Tumors in Vivo

(2016) Joann Teo et al.   BIOMACROMOLECULES

Star Polymers

(2016) Jing M. Ren et al.   CHEMICAL REVIEWS

The Pharmacokinetics and Biodistribution of a 64 kDa PolyPEG Star Polymer After Subcutaneous and Pulmonary Administration to Rats

(2016) Song Yang Khor et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Nanoparticle-Based Medicines: A Review of FDA-Approved Materials and Clinical Trials to Date

(2016) Daniel Bobo et al.   PHARMACEUTICAL RESEARCH

Towards controlled polymer brushes via a self-assembly-assisted-grafting-to approach

(2016) Tian Zhou et al.   Nature Communications

Stimuli-Responsive Polymers: Design, Synthesis, Characterization, and Applications

(2016) Dong Wang et al.   International Journal of Polymer Science

Positron Emission Tomography Based Elucidation of the Enhanced Permeability and Retention Effect in Dogs with Cancer Using Copper-64 Liposomes

(2015) Anders E. Hansen et al.   ACS Nano

Molecular weight (hydrodynamic volume) dictates the systemic pharmacokinetics and tumour disposition of PolyPEG star polymers

(2015) Song Yang Khor et al.   Nanomedicine-Nanotechnology Biology and Medicine

G Protein-Coupled Receptors: Dynamic Machines for Signaling Pain and Itch

(2015) Pierangelo Geppetti et al.   NEURON

Therapeutic targeting of polo-like kinase 1 using RNA-interfering nanoparticles (iNOPs) for the treatment of non-small cell lung cancer

(2015) Joshua A. McCarroll et al.   Oncotarget

Multimodal Polymer Nanoparticles with Combined 19F Magnetic Resonance and Optical Detection for Tunable, Targeted, Multimodal Imaging in Vivo

(2014) Barbara E. Rolfe et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Drug delivery: Beyond active tumour targeting

(2014) Sharon M. Sagnella et al.   Nanomedicine-Nanotechnology Biology and Medicine

Nanoparticles Based on Star Polymers as Theranostic Vectors: Endosomal-Triggered Drug Release Combined with MRI Sensitivity

(2014) Yang Li et al.   Advanced Healthcare Materials

Effective Delivery of siRNA into Cancer Cells and Tumors Using Well-Defined Biodegradable Cationic Star Polymers

(2013) Cyrille Boyer et al.   MOLECULAR PHARMACEUTICS

A novel cyclodextrin-containing pH-responsive star polymer for nanostructure fabrication and drug delivery

(2013) Mingming Zhang et al.   Polymer Chemistry

Effectively Delivering a Unique Hsp90 Inhibitor Using Star Polymers

(2013) Seong Jong Kim et al.   ACS Medicinal Chemistry Letters

Synthesis of Functional Core, Star Polymers via RAFT Polymerization for Drug Delivery Applications

(2012) Jinna Liu et al.   MACROMOLECULAR RAPID COMMUNICATIONS

Biodegradable star HPMA polymer–drug conjugates: Biodegradability, distribution and anti-tumor efficacy

(2011) Tomáš Etrych et al.   JOURNAL OF CONTROLLED RELEASE

Intranasal delivery to the brain

(2011) Robert I Henkin   NATURE BIOTECHNOLOGY