Status and Challenges for Vaccination against Avian H9N2 Influenza Virus in China

The molecular determinants of antigenic drift in a novel avian influenza A (H9N2) variant virus

(2022) Yiqing Zheng et al.   Virology Journal

Molecular and Antigenic Characterization of Avian H9N2 Viruses in Southern China

(2022) Wanwan Yan et al.   Microbiology Spectrum

Mucosal immune responses to infection and vaccination in the respiratory tract

(2022) Robert C. Mettelman et al.   IMMUNITY

A single-shot vaccine approach for the universal influenza A vaccine candidate M2e

(2022) Ranmali Kavishna et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antigenic Evolution Characteristics and Immunological Evaluation of H9N2 Avian Influenza Viruses from 1994–2019 in China

(2022) Qingzheng Liu et al.   Viruses-Basel

Intranasal Immunization with a Recombinant Avian Paramyxovirus Serotypes 2 Vector-Based Vaccine Induces Protection against H9N2 Avian Influenza in Chicken

(2022) Wenhao Yang et al.   Viruses-Basel

An epitope-optimized human H3N2 influenza vaccine induces broadly protective immunity in mice and ferrets

(2022) Brianna L. Bullard et al.   npj Vaccines

Epigraph hemagglutinin vaccine induces broad cross-reactive immunity against swine H3 influenza virus

(2021) Brianna L. Bullard et al.   Nature Communications

A Live Attenuated H9N2 Avian Influenza Vaccine Prevents the Viral Reassortment by Exchanging the HA and NS1 Packaging Signals

(2021) Sujuan Chen et al.   Frontiers in Microbiology

Highly pathogenic avian influenza A/Guangdong/17SF003/2016 is immunogenic and induces cross-protection against antigenically divergent H7N9 viruses

(2021) Peter Radvak et al.   npj Vaccines

HIV mRNA Vaccines—Progress and Future Paths

(2021) Zekun Mu et al.   Vaccines

Reassortment with Dominant Chicken H9N2 Influenza Virus Contributed to the Fifth H7N9 Virus Human Epidemic

(2021) Juan Pu et al.   JOURNAL OF VIROLOGY

Novel Vaccine Technologies in Veterinary Medicine: A Herald to Human Medicine Vaccines

(2021) Virginia Aida et al.   Frontiers in Veterinary Science

Generation and Evaluation of Recombinant Thermostable Newcastle Disease Virus Expressing the HA of H9N2 Avian Influenza Virus

(2021) Xiaorong Zhang et al.   Viruses-Basel

Establishment of Recombinant Eimeria acervulina Expressing Multi-Copies M2e Derived from Avian Influenza Virus H9N2

(2021) Sixin Zhang et al.   Vaccines

Recombinant HA1-ΔfliC enhances adherence to respiratory epithelial cells and promotes the superiorly protective immune responses against H9N2 influenza virus in chickens

(2021) Tong Wang et al.   VETERINARY MICROBIOLOGY

H9N2 virus-derived M1 protein promotes H5N6 virus release in mammalian cells: Mechanism of avian influenza virus inter-species infection in humans

(2021) Fangtao Li et al.   PLoS Pathogens

Development of a Novel Avian Vaccine Vector Derived From the Emerging Fowl Adenovirus 4

(2021) Qing Pan et al.   Frontiers in Microbiology

Avian influenza overview September – December 2021

(2021) et al.   EFSA Journal

Control of avian influenza in China: Strategies and lessons

(2020) Shuo Liu et al.   Transboundary and Emerging Diseases

Human‐infecting influenza A (H9N2) virus: A forgotten potential pandemic strain?

(2020) Wenjun Song et al.   Zoonoses and Public Health

Modified mRNA/lipid nanoparticle-based vaccines expressing respiratory syncytial virus F protein variants are immunogenic and protective in rodent models of RSV infection

(2020) Amy S. Espeseth et al.   npj Vaccines

Dendrigraft poly-L-lysines delivery of DNA vaccine effectively enhances the immunogenic responses against H9N2 avian influenza virus infection in chickens

(2020) Kai Zhao et al.   Nanomedicine-Nanotechnology Biology and Medicine

Recent Progress on the Versatility of Virus-Like Particles

(2020) Ciying Qian et al.   Vaccines

Newcastle Disease Virus as a Vaccine Vector for 20 Years: A Focus on Maternally Derived Antibody Interference

(2020) Zenglei Hu et al.   Vaccines

SARS-CoV-2 mRNA vaccine design enabled by prototype pathogen preparedness

(2020) Kizzmekia S. Corbett et al.   NATURE

Assessing the efficacy of a recombinant H9N2 avian influenza virus–inactivated vaccine

(2020) Cai Liang Song et al.   POULTRY SCIENCE

Lactobacillus plantarum surface-displayed influenza antigens (NP-M2) with FliC flagellin stimulate generally protective immune responses against H9N2 influenza subtypes in chickens

(2020) Qiong-Yan Li et al.   VETERINARY MICROBIOLOGY

Anti-Influenza Protective Efficacy of a H6 Virus-Like Particle in Chickens

(2020) Wan-Zhen Zhu et al.   Vaccines

Polyethylenimine-coated PLGA nanoparticles-encapsulated Angelica sinensis polysaccharide as an adjuvant for H9N2 vaccine to improve immune responses in chickens compared to Alum and oil-based adjuvants

(2020) Pengfei Gu et al.   VETERINARY MICROBIOLOGY

CD83 expression regulates antibody production in response to influenza A virus infection

(2020) Madhav Akauliya et al.   Virology Journal

Dominant subtype switch in avian influenza viruses during 2016–2019 in China

(2020) Yuhai Bi et al.   Nature Communications

Novel Approaches for The Development of Live Attenuated Influenza Vaccines

(2019) Pilar Blanco-Lobo et al.   Viruses-Basel

Recombinant turkey herpesvirus expressing H9 hemagglutinin providing protection against H9N2 avian influenza

(2019) Litao Liu et al.   VIROLOGY

Enhanced cross-lineage protection induced by recombinant H9N2 avian influenza virus inactivated vaccine

(2019) Zeyuan Wang et al.   VACCINE

mRNA vaccines against H10N8 and H7N9 influenza viruses of pandemic potential are immunogenic and well tolerated in healthy adults in phase 1 randomized clinical trials

(2019) Robert A. Feldman et al.   VACCINE

Immune responses of mice inoculated with recombinant Lactobacillus plantarum NC8 expressing the fusion gene HA2 and 3M2e of the influenza virus and protection against different subtypes of influenza virus

(2019) Feng Bo et al.   VIRUS RESEARCH

Highly conserved influenza T cell epitopes induce broadly protective immunity

(2019) Christopher S. Eickhoff et al.   VACCINE

Influenza virus-specific CD4+ and CD8+ T cell-mediated immunity induced by infection and vaccination

(2019) Janina M. Jansen et al.   JOURNAL OF CLINICAL VIROLOGY

Mucosal vaccines: Strategies and challenges

(2019) Miao Li et al.   IMMUNOLOGY LETTERS

Neuraminidase as an influenza vaccine antigen: a low hanging fruit, ready for picking to improve vaccine effectiveness

(2018) Maryna C Eichelberger et al.   CURRENT OPINION IN IMMUNOLOGY

IL-1β as mucosal vaccine adjuvant: the specific induction of tissue-resident memory T cells improves the heterosubtypic immunity against influenza A viruses

(2018) D. Lapuente et al.   Mucosal Immunology

Examination of the effects of virus inactivation methods on the induction of antibody- and cell-mediated immune responses against whole inactivated H9N2 avian influenza virus vaccines in chickens

(2018) Jake Astill et al.   VACCINE

Enhanced infection of avian influenza virus H9N2 with infectious laryngeotracheitis vaccination in chickens

(2018) Nagah Arafat et al.   VETERINARY MICROBIOLOGY

Chimeric Newcastle disease virus-vectored vaccine protects chickens against H9N2 avian influenza virus in the presence of pre-existing NDV immunity

(2018) Jingjing Liu et al.   ARCHIVES OF VIROLOGY

A novel recombinant attenuated Newcastle disease virus expressing H9 subtype hemagglutinin protected chickens from challenge by genotype VII virulent Newcastle disease virus and H9N2 avian influenza virus

(2018) Xiaohong Xu et al.   VETERINARY MICROBIOLOGY

Generation of highly productive and mammalian nonpathogenic recombinant H9N2 avian influenza viruses by optimization of 3’end promoter and NS genome

(2018) Se-Hee An et al.   VETERINARY MICROBIOLOGY

The molecular basis of antigenic variation among A(H9N2) avian influenza viruses

(2018) Thomas P. Peacock et al.   Emerging Microbes & Infections

A brief summary of the epidemiology and genetic relatedness of avian influenza H9N2 virus in birds and mammals in the Middle East and North Africa

(2017) A. NAGY et al.   EPIDEMIOLOGY AND INFECTION

Influenza virus-like particles harboring H9N2 HA and NA proteins induce a protective immune response in chicken

(2017) Xin Li et al.   Influenza and Other Respiratory Viruses

Modified mRNA-Based Vaccines Elicit Robust Immune Responses and Protect Guinea Pigs From Ebola Virus Disease

(2017) Michelle Meyer et al.   JOURNAL OF INFECTIOUS DISEASES

Vaccine Efficacy of Inactivated, Chimeric Hemagglutinin H9/H5N2 Avian Influenza Virus and Its Suitability for the Marker Vaccine Strategy

(2017) Se Mi Kim et al.   JOURNAL OF VIROLOGY

M Gene Reassortment in H9N2 Influenza Virus Promotes Early Infection and Replication: Contribution to Rising Virus Prevalence in Chickens in China

(2017) Juan Pu et al.   JOURNAL OF VIROLOGY

Targeting antigens to Dec-205 on dendritic cells induces a higher immune response in chickens: Hemagglutinin of avian influenza virus example

(2017) David Jáuregui-Zúñiga et al.   RESEARCH IN VETERINARY SCIENCE

Virus-like particles displaying H5, H7, H9 hemagglutinins and N1 neuraminidase elicit protective immunity to heterologous avian influenza viruses in chickens

(2017) Peter Pushko et al.   VIROLOGY

Increased humoral immunity by DNA vaccination using an α-tocopherol-based adjuvant

(2017) Ingrid Karlsson et al.   Human Vaccines & Immunotherapeutics

Efficacy of Live-Attenuated H9N2 Influenza Vaccine Candidates Containing NS1 Truncations against H9N2 Avian Influenza Viruses

(2017) Sujuan Chen et al.   Frontiers in Microbiology

Single Dose of Consensus Hemagglutinin-Based Virus-Like Particles Vaccine Protects Chickens against Divergent H5 Subtype Influenza Viruses

(2017) Peipei Wu et al.   Frontiers in Immunology

Mucosal and Systemic Immune Responses to Influenza H7N9 Antigen HA1–2 Co-Delivered Intranasally with Flagellin or Polyethyleneimine in Mice and Chickens

(2017) Li Song et al.   Frontiers in Immunology

Enhancing vaccine antibody responses by targeting Clec9A on dendritic cells

(2017) Hae-Young Park et al.   npj Vaccines

Evaluation of the Protective Efficacy of Poly I:C as an Adjuvant for H9N2 Subtype Avian Influenza Inactivated Vaccine and Its Mechanism of Action in Ducks

(2017) Aiguo Zhang et al.   PLoS One

Chimeric virus-like particles containing influenza HA antigen and GPI-CCL28 induce long-lasting mucosal immunity against H3N2 viruses

(2017) Teena Mohan et al.   Scientific Reports

Construction of a recombinant duck enteritis virus vaccine expressing hemagglutinin of H9N2 avian influenza virus and evaluation of its efficacy in ducks

(2016) Ying Sun et al.   ARCHIVES OF VIROLOGY

Genesis, Evolution and Prevalence of H5N6 Avian Influenza Viruses in China

(2016) Yuhai Bi et al.   Cell Host & Microbe

Characterization of Clade 7.2 H5 Avian Influenza Viruses That Continue To Circulate in Chickens in China

(2016) Liling Liu et al.   JOURNAL OF VIROLOGY

Rearrangement of Influenza Virus Spliced Segments for the Development of Live-Attenuated Vaccines

(2016) Aitor Nogales et al.   JOURNAL OF VIROLOGY

Highly Pathogenic Avian Influenza H5N6 Viruses Exhibit Enhanced Affinity for Human Type Sialic Acid Receptor and In-Contact Transmission in Model Ferrets

(2016) Honglei Sun et al.   JOURNAL OF VIROLOGY

Generation of influenza A viruses as live but replication-incompetent virus vaccines

(2016) L. Si et al.   SCIENCE

Evaluation of the attenuation, immunogenicity, and efficacy of a live virus vaccine generated by codon-pair bias de-optimization of the 2009 pandemic H1N1 influenza virus, in ferrets

(2016) Andrew J. Broadbent et al.   VACCINE

Recombinant Newcastle disease virus expressing H9 HA protects chickens against heterologous avian influenza H9N2 virus challenge

(2016) Abdou Nagy et al.   VACCINE

Antigenic evolution of H9N2 chicken influenza viruses isolated in China during 2009–2013 and selection of a candidate vaccine strain with broad cross-reactivity

(2016) Yandi Wei et al.   VETERINARY MICROBIOLOGY

Lactobacillus plantarum vaccine vector expressing hemagglutinin provides protection against H9N2 challenge infection

(2016) Shao-Hua Shi et al.   VIRUS RESEARCH

Recombinant Marek’s Disease Virus as a Vector-Based Vaccine against Avian Leukosis Virus Subgroup J in Chicken

(2016) Yongzhen Liu et al.   Viruses-Basel

Evaluation of Antihemagglutinin and Antineuraminidase Antibodies as Correlates of Protection in an Influenza A/H1N1 Virus Healthy Human Challenge Model

(2016) Matthew J. Memoli et al.   mBio

Heterosubtypic T-Cell Immunity to Influenza in Humans: Challenges for Universal T-Cell Influenza Vaccines

(2016) Saranya Sridhar   Frontiers in Immunology

Antigenic mapping of an H9N2 avian influenza virus reveals two discrete antigenic sites and a novel mechanism of immune escape

(2016) Thomas Peacock et al.   Scientific Reports

Recombinant Marek’s disease virus type 1 provides full protection against very virulent Marek’s and infectious bursal disease viruses in chickens

(2016) Kai Li et al.   Scientific Reports

Molecular mechanisms for enhanced DNA vaccine immunogenicity

(2015) Lei Li et al.   Expert Review of Vaccines

CpG Oligodeoxynucleotides Facilitate Delivery of Whole Inactivated H9N2 Influenza Virus via Transepithelial Dendrites of Dendritic Cells in Nasal Mucosa

(2015) Tao Qin et al.   JOURNAL OF VIROLOGY

Immunogenicity and protective efficacy of the norovirus P particle-M2e chimeric vaccine in chickens

(2015) M. Elaish et al.   VACCINE

Identification and characterization of a novel antigenic epitope in the hemagglutinin of the escape mutants of H9N2 avian influenza viruses

(2015) Yinbiao Zhu et al.   VETERINARY MICROBIOLOGY

Development of high-yield influenza A virus vaccine viruses

(2015) Jihui Ping et al.   Nature Communications

Evaluation of Immune Response Against Inactivated Avian Influenza (H9N2) Vaccine, by Using Chitosan Nanoparticles

(2015) Iraj Khalili et al.   Jundishapur Journal of Microbiology

Bursin-like peptide (BLP) enhances H9N2 influenza vaccine induced humoral and cell mediated immune responses

(2014) Chen Wang et al.   CELLULAR IMMUNOLOGY

Genesis of the novel human-infecting influenza A(H10N8) virus and potential genetic diversity of the virus in poultry, China

(2014) W Qi et al.   Eurosurveillance

Comparative transcriptional activity of five promoters in BAC-cloned MDV for the expression of the hemagglutinin gene of H9N2 avian influenza virus

(2014) Chengtai Ma et al.   JOURNAL OF VIROLOGICAL METHODS

Molecular Mechanism of the Airborne Transmissibility of H9N2 Avian Influenza A Viruses in Chickens

(2014) L. Zhong et al.   JOURNAL OF VIROLOGY

Antigenic Mapping of the Hemagglutinin of an H9N2 Avian Influenza Virus Reveals Novel Critical Amino Acid Positions in Antigenic Sites

(2014) Z. Wan et al.   JOURNAL OF VIROLOGY

Clinical and epidemiological characteristics of a fatal case of avian influenza A H10N8 virus infection: a descriptive study

(2014) HaiYing Chen et al.   LANCET

Poultry carrying H9N2 act as incubators for novel human avian influenza viruses

(2014) Di Liu et al.   LANCET

CpG DNA assists the whole inactivated H9N2 influenza virus in crossing the intestinal epithelial barriers via transepithelial uptake of dendritic cell dendrites

(2014) Y Yin et al.   Mucosal Immunology

Glycan Masking of Hemagglutinin for Adenovirus Vector and Recombinant Protein Immunizations Elicits Broadly Neutralizing Antibodies against H5N1 Avian Influenza Viruses

(2014) Shih-Chang Lin et al.   PLoS One

Evolution of the H9N2 influenza genotype that facilitated the genesis of the novel H7N9 virus

(2014) Juan Pu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immunoprotection against influenza virus H9N2 by the oral administration of recombinant Lactobacillus plantarum NC8 expressing hemagglutinin in BALB/c mice

(2014) Shao-Hua Shi et al.   VIROLOGY

H9N2 influenza virus in China: a cause of concern

(2014) Yipeng Sun et al.   Protein & Cell

Background paper to the recommendation for the preferential use of live-attenuated influenza vaccine in children aged 2–6 years in Germany

(2013) G. Falkenhorst et al.   Bundesgesundheitsblatt-Gesundheitsforschung-Gesundheitsschutz

Evidence of avian-like H9N2 influenza A virus among dogs in Guangxi, China

(2013) Xiangxiang Sun et al.   INFECTION GENETICS AND EVOLUTION

Chimeric Hemagglutinin Influenza Virus Vaccine Constructs Elicit Broadly Protective Stalk-Specific Antibodies

(2013) F. Krammer et al.   JOURNAL OF VIROLOGY

The genesis and source of the H7N9 influenza viruses causing human infections in China

(2013) Tommy Tsan-Yuk Lam et al.   NATURE

Deliberate reduction of hemagglutinin and neuraminidase expression of influenza virus leads to an ultraprotective live vaccine in mice

(2013) Chen Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intranasal vaccination with H5, H7 and H9 hemagglutinins co-localized in a virus-like particle protects ferrets from multiple avian influenza viruses

(2013) Irina Tretyakova et al.   VIROLOGY

Immunization of chickens with an agonistic monoclonal anti-chicken CD40 antibody–hapten complex: Rapid and robust IgG response induced by a single subcutaneous injection

(2012) Chang-Hsin Chen et al.   JOURNAL OF IMMUNOLOGICAL METHODS

A Triclade DNA Vaccine Designed on the Basis of a Comprehensive Serologic Study Elicits Neutralizing Antibody Responses against All Clades and Subclades of Highly Pathogenic Avian Influenza H5N1 Viruses

(2012) F. Zhou et al.   JOURNAL OF VIROLOGY

A Replication-Incompetent PB2-Knockout Influenza A Virus Vaccine Vector

(2012) Sylvia T. Victor et al.   JOURNAL OF VIROLOGY

Broader Neutralizing Antibodies against H5N1 Viruses Using Prime-Boost Immunization of Hyperglycosylated Hemagglutinin DNA and Virus-Like Particles

(2012) Shih-Chang Lin et al.   PLoS One

Chinese and Global Distribution of H9 Subtype Avian Influenza Viruses

(2012) Wenming Jiang et al.   PLoS One

Protection conferred by a recombinant Marek’s disease virus that expresses the spike protein from infectious bronchitis virus in specific pathogen-free chicken

(2012) Xiaorong Zhang et al.   Virology Journal

Mapping of H3N2 influenza antigenic evolution in China reveals a strategy for vaccine strain recommendation

(2012) Xiangjun Du et al.   Nature Communications

Immune responses of chickens inoculated with a recombinant fowlpox vaccine coexpressing HA of H9N2 avain influenza virus and chicken IL-18

(2011) Hong-Ying Chen et al.   ANTIVIRAL RESEARCH

Bursopentine as a Novel Immunoadjuvant Enhances both Humoral and Cell-Mediated Immune Responses to Inactivated H9N2 Avian Influenza Virus in Chickens

(2011) Deyuan Li et al.   Clinical and Vaccine Immunology

The NS1 protein of influenza A virus suppresses interferon-regulated activation of antigen-presentation and immune-proteasome pathways

(2011) J. R. Tisoncik et al.   JOURNAL OF GENERAL VIROLOGY

Evaluation of the protective efficacy of a commercial vaccine against different antigenic groups of H9N2 influenza viruses in chickens

(2011) Yipeng Sun et al.   VETERINARY MICROBIOLOGY

Molecular and antigenic characterization of H9N2 avian influenza virus isolates from chicken flocks between 1998 and 2007 in China

(2011) Yi Zhang et al.   VETERINARY MICROBIOLOGY

Live attenuated influenza virus vaccines by computer-aided rational design

(2010) Steffen Mueller et al.   NATURE BIOTECHNOLOGY

Protection of chickens, with or without maternal antibodies, against IBDV infection by a recombinant IBDV-VP2 protein

(2010) Xuemei Zhou et al.   VACCINE

Genotypic evolution and antigenic drift of H9N2 influenza viruses in China from 1994 to 2008

(2010) Yipeng Sun et al.   VETERINARY MICROBIOLOGY

Genetic Evolution of H9 Subtype Influenza Viruses from Live Poultry Markets in Shanghai, China

(2009) F.-F. Ge et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Antigenic structure of the hemagglutinin of H9N2 influenza viruses

(2008) Masatoshi Okamatsu et al.   ARCHIVES OF VIROLOGY

Virus Attenuation by Genome-Scale Changes in Codon Pair Bias

(2008) J. R. Coleman et al.   SCIENCE

Genetic characterization and protective immunity of cold-adapted attenuated avian H9N2 influenza vaccine

(2008) Joo Sub Lee et al.   VACCINE