β-sitosterol inhibits trimethylamine production by regulating the gut microbiota and attenuates atherosclerosis in ApoE–/– mice

Atherosclerosis amelioration by allicin in raw garlic through gut microbiota and trimethylamine-N-oxide modulation

(2022) Suraphan Panyod et al.   npj Biofilms and Microbiomes

Integrated metagenomics identifies a crucial role for trimethylamine-producing Lachnoclostridium in promoting atherosclerosis

(2022) Yuan-Yuan Cai et al.   npj Biofilms and Microbiomes

Hawthorn fruit extract reduced trimethylamine-N-oxide (TMAO)-exacerbated atherogenesis in mice via anti-inflammation and anti-oxidation

(2021) Zouyan He et al.   Nutrition & Metabolism

Lactobacillus paracasei DTA81, a cholesterol‐lowering strain having immunomodulatory activity, reveals gut microbiota regulation capability in BALB/c mice receiving high‐fat diet

(2021) Armin Tarrah et al.   JOURNAL OF APPLIED MICROBIOLOGY

β-Sitosterol Circumvents Obesity Induced Inflammation and Insulin Resistance by down-Regulating IKKβ/NF-κB and JNK Signaling Pathway in Adipocytes of Type 2 Diabetic Rats

(2021) Selvaraj Jayaraman et al.   MOLECULES

Berberine attenuates choline-induced atherosclerosis by inhibiting trimethylamine and trimethylamine-N-oxide production via manipulating the gut microbiome

(2021) Xingxing Li et al.   npj Biofilms and Microbiomes

The Role of Gut Microbiota on Cholesterol Metabolism in Atherosclerosis

(2021) Margaret Vourakis et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

β-Sitosterol Ameliorates Endometrium Receptivity in PCOS-Like Mice: The Mediation of Gut Microbiota

(2021) Yanyan Yu et al.   Frontiers in Nutrition

Bio-Mechanism Inhibitory Prediction of β-Sitosterol from Kemangi (Ocimum basilicum L.) as an Inhibitor of MurA Enzyme of Oral Bacteria: In vitro and in silico Study

(2021) Ida Ayu Evangelina et al.   Advances and Applications in Bioinformatics and Chemistry

Gut Metabolite Trimethylamine-N-Oxide in Atherosclerosis: From Mechanism to Therapy

(2021) BingYu Wang et al.   Frontiers in Cardiovascular Medicine

β-Sitosterol Attenuates High Grain Diet-Induced Inflammatory Stress and Modifies Rumen Fermentation and Microbiota in Sheep

(2020) Guangliang Xia et al.   Animals

Medicinal Plants as a Potential and Successful Treatment Option in the Context of Atherosclerosis

(2020) Tatiana V. Kirichenko et al.   Frontiers in Pharmacology

Identification of choline-degrading bacteria from healthy human feces and used for screening of trimethylamine (TMA)-lyase inhibitors

(2020) Xing Heng et al.   MICROBIAL PATHOGENESIS

Intestinal Bacteria Interplay With Bile and Cholesterol Metabolism: Implications on Host Physiology

(2019) Natalia Molinero et al.   Frontiers in Physiology

Nobiletin Prevents Trimethylamine Oxide-Induced Vascular Inflammation via Inhibition of the NF-κB/MAPK Pathways

(2019) Guliang Yang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Trimethylamine N-oxide attenuates high-fat high-cholesterol diet-induced steatohepatitis by reducing hepatic cholesterol overload in rats

(2019) Ze-Hua Zhao et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Fish Oil Is More Potent than Flaxseed Oil in Modulating Gut Microbiota and Reducing Trimethylamine-N-oxide-Exacerbated Atherogenesis

(2019) Zouyan He et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Lipid Management for the Prevention of Atherosclerotic Cardiovascular Disease

(2019) Erin D. Michos et al.   NEW ENGLAND JOURNAL OF MEDICINE

Trimethylamine N-oxide promotes atherosclerosis via CD36-dependent MAPK/JNK pathway

(2018) Jin Geng et al.   BIOMEDICINE & PHARMACOTHERAPY

A review of probiotic supplementation in healthy adults: helpful or hype?

(2018) Saman Khalesi et al.   EUROPEAN JOURNAL OF CLINICAL NUTRITION

Gut flora-dependent metabolite Trimethylamine-N-oxide accelerates endothelial cell senescence and vascular aging through oxidative stress

(2018) Yilang Ke et al.   FREE RADICAL BIOLOGY AND MEDICINE

Intake of stigmasterol and β-sitosterol alters lipid metabolism and alleviates NAFLD in mice fed a high-fat western-style diet

(2018) Simin Feng et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Short-Chain Fatty Acids Manifest Stimulative and Protective Effects on Intestinal Barrier Function Through the Inhibition of NLRP3 Inflammasome and Autophagy

(2018) Yanhai Feng et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Gut Colonization with Methanogenic Archaea Lowers Plasma Trimethylamine N-oxide Concentrations in Apolipoprotein e−/− Mice

(2018) Ali Ramezani et al.   Scientific Reports

First Report of Plant-Derived β-Sitosterol with Antithrombotic, in Vivo Anticoagulant, and Thrombus-Preventing Activities in a Mouse Model

(2018) Debananda Gogoi et al.   JOURNAL OF NATURAL PRODUCTS

Trimethylamine-N-oxide (TMAO)-induced atherosclerosis is associated with bile acid metabolism

(2018) Lin Ding et al.   Lipids in Health and Disease

Gut microbiota functions: metabolism of nutrients and other food components

(2017) Ian Rowland et al.   EUROPEAN JOURNAL OF NUTRITION

Gut Microbiota Metabolites and Risk of Major Adverse Cardiovascular Disease Events and Death: A Systematic Review and Meta‐Analysis of Prospective Studies

(2017) Yoriko Heianza et al.   Journal of the American Heart Association

Trimethylamine‐N‐Oxide Induces Vascular Inflammation by Activating the NLRP3 Inflammasome Through the SIRT3‐SOD2‐mtROS Signaling Pathway

(2017) Ming‐liang Chen et al.   Journal of the American Heart Association

Beneficial effects of β-sitosterol on type 1 cholecystokinin receptor dysfunction induced by elevated membrane cholesterol

(2016) Aditya J. Desai et al.   CLINICAL NUTRITION

The role of the intestinal microbiota in type 1 diabetes mellitus

(2016) Mikael Knip et al.   Nature Reviews Endocrinology

The role of the gut microbiota in NAFLD

(2016) Christopher Leung et al.   Nature Reviews Gastroenterology & Hepatology

microRNA-185 modulates low density lipoprotein receptor expression as a key posttranscriptional regulator

(2015) Huajun Jiang et al.   ATHEROSCLEROSIS

Chinese Yam Extracts Containing β-Sitosterol and Ethyl Linoleate Protect against Atherosclerosis in Apolipoprotein E-Deficient Mice and Inhibit Muscular Expression of VCAM-1In Vitro

(2014) Hyun Jung Koo et al.   JOURNAL OF FOOD SCIENCE

Intestinal microbiota metabolism of l-carnitine, a nutrient in red meat, promotes atherosclerosis

(2013) Robert A Koeth et al.   NATURE MEDICINE

Oxidative Stress and Antioxidant Defense

(2012) Esra Birben et al.   World Allergy Organization Journal

Residual Cardiovascular Risk Despite Optimal LDL Cholesterol Reduction with Statins: The Evidence, Etiology, and Therapeutic Challenges

(2011) Uchechukwu K. Sampson et al.   Current Atherosclerosis Reports

Inflammatory cytokines in vascular dysfunction and vascular disease

(2009) Alexander H. Sprague et al.   BIOCHEMICAL PHARMACOLOGY

Cytokines and atherosclerosis: a comprehensive review of studies in mice

(2008) R. Kleemann et al.   CARDIOVASCULAR RESEARCH