Reduction of kinesin I heavy chain decreases tau hyperphosphorylation, aggregation, and memory impairment in Alzheimer’s disease and tauopathy models

Current directions in tau research: Highlights from Tau 2020

(2021) Claire Sexton et al.   Alzheimers & Dementia

Protopine promotes the proteasomal degradation of pathological tau in Alzheimer's disease models via HDAC6 inhibition

(2021) Sravan Gopalkrishnashetty Sreenivasmurthy et al.   PHYTOMEDICINE

Qingyangshen mitigates amyloid-β and Tau aggregate defects involving PPARα-TFEB activation in transgenic mice of Alzheimer's disease

(2021) Ashok Iyaswamy et al.   PHYTOMEDICINE

Specific depletion of the motor protein KIF5B leads to deficits in dendritic transport, synaptic plasticity and memory

(2020) Junjun Zhao et al.   eLife

Amyloid beta-mediated KIF5A deficiency disrupts anterograde axonal mitochondrial movement

(2019) Qi Wang et al.   NEUROBIOLOGY OF DISEASE

Functional connectivity associated with tau levels in ageing, Alzheimer’s, and small vessel disease

(2019) Nicolai Franzmeier et al.   BRAIN

A small molecule transcription factor EB activator ameliorates beta‐amyloid precursor protein and Tau pathology in Alzheimer's disease models

(2019) Ju‐Xian Song et al.   AGING CELL

Tau burden and the functional connectome in Alzheimer’s disease and progressive supranuclear palsy

(2018) Thomas E Cope et al.   BRAIN

Recent developments with tau-based drug discovery

(2018) Khalid Iqbal et al.   Expert Opinion on Drug Discovery

Molecular Pathogenesis of the Tauopathies

(2018) Jürgen Götz et al.   Annual Review of Pathology-Mechanisms of Disease

A new role of anterograde motor Kif5b in facilitating large clathrin-coated vesicle mediated endocytosis via regulating clathrin uncoating

(2018) Yan-Xiang Ni et al.   Cell Discovery

Overexpression of Kinesin Superfamily Motor Proteins in Alzheimer’s Disease

(2017) Kelly Hares et al.   JOURNAL OF ALZHEIMERS DISEASE

Extracellular Tau Oligomers Induce Invasion of Endogenous Tau into the Somatodendritic Compartment and Axonal Transport Dysfunction

(2017) Eric Swanson et al.   JOURNAL OF ALZHEIMERS DISEASE

Entorhinal Tau Pathology, Episodic Memory Decline, and Neurodegeneration in Aging

(2017) Anne Maass et al.   JOURNAL OF NEUROSCIENCE

A small-molecule activator of kinesin-1 drives remodeling of the microtubule network

(2017) Thomas S. Randall et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Axonal Degeneration in Tauopathies: Disease Relevance and Underlying Mechanisms

(2017) Andrew Kneynsberg et al.   Frontiers in Neuroscience

Analysis of isoform-specific tau aggregates suggests a common toxic mechanism involving similar pathological conformations and axonal transport inhibition

(2016) Kristine Cox et al.   NEUROBIOLOGY OF AGING

Tau-driven 26S proteasome impairment and cognitive dysfunction can be prevented early in disease by activating cAMP-PKA signaling

(2015) Natura Myeku et al.   NATURE MEDICINE

Tau in physiology and pathology

(2015) Yipeng Wang et al.   NATURE REVIEWS NEUROSCIENCE

Connecting the dots between tau dysfunction and neurodegeneration

(2015) Bess Frost et al.   TRENDS IN CELL BIOLOGY

Memory deficits correlate with tau and spine pathology in P301SMAPTtransgenic mice

(2014) Hong Xu et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Abundant kif21b is associated with accelerated progression in neurodegenerative diseases

(2014) Karim L Kreft et al.   Acta Neuropathologica Communications

Axonal degeneration in Alzheimer's disease: When signaling abnormalities meet the axonal transport system

(2012) Nicholas M. Kanaan et al.   EXPERIMENTAL NEUROLOGY

Autophagosomes initiate distally and mature during transport toward the cell soma in primary neurons

(2012) Sandra Maday et al.   JOURNAL OF CELL BIOLOGY

Berberine ameliorates β-amyloid pathology, gliosis, and cognitive impairment in an Alzheimer's disease transgenic mouse model

(2012) Siva Sundara Kumar Durairajan et al.   NEUROBIOLOGY OF AGING

Tau-Mediated Nuclear Depletion and Cytoplasmic Accumulation of SFPQ in Alzheimer's and Pick's Disease

(2012) Yazi Ke et al.   PLoS One

Reduced Axonal Transport and Increased Excitotoxic Retinal Ganglion Cell Degeneration in Mice Transgenic for Human Mutant P301S Tau

(2012) Natalie D. Bull et al.   PLoS One

The Nucleotide-binding State of Microtubules Modulates Kinesin Processivity and the Ability of Tau to Inhibit Kinesin-mediated Transport

(2011) Derrick P. McVicker et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lysosomal Proteolysis Inhibition Selectively Disrupts Axonal Transport of Degradative Organelles and Causes an Alzheimer's-Like Axonal Dystrophy

(2011) S. Lee et al.   JOURNAL OF NEUROSCIENCE

Kinesin-1 transport reductions enhance human tau hyperphosphorylation, aggregation and neurodegeneration in animal models of tauopathies

(2010) Tomás L. Falzone et al.   HUMAN MOLECULAR GENETICS

Molecular Motors in Neurons: Transport Mechanisms and Roles in Brain Function, Development, and Disease

(2010) Nobutaka Hirokawa et al.   NEURON

Multimodal techniques for diagnosis and prognosis of Alzheimer's disease

(2009) Richard J. Perrin et al.   NATURE

Pathogenic huntingtin inhibits fast axonal transport by activating JNK3 and phosphorylating kinesin

(2009) Gerardo A Morfini et al.   NATURE NEUROSCIENCE

Role of Axonal Transport in Neurodegenerative Diseases

(2008) Kurt J. De Vos et al.   Annual Review of Neuroscience

Phosphorylation of tau regulates its axonal transport by controlling its binding to kinesin

(2008) Inmaculada Cuchillo-Ibanez et al.   FASEB JOURNAL

The amino terminus of tau inhibits kinesin-dependent axonal transport: Implications for filament toxicity

(2008) Nichole E. LaPointe et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Parkinsonism and impaired axonal transport in a mouse model of frontotemporal dementia

(2008) L. M. Ittner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential Regulation of Dynein and Kinesin Motor Proteins by Tau

(2008) R. Dixit et al.   SCIENCE