Efficacy and Safety of a Brain-Penetrant Biologic TNF-α Inhibitor in Aged APP/PS1 Mice

Full- versus Sub-Regional Quantification of Amyloid-Beta Load on Mouse Brain Sections

(2022) Yuu Ohno et al.   Jove-Journal of Visualized Experiments

Microglia use TAM receptors to detect and engulf amyloid β plaques

(2021) Youtong Huang et al.   NATURE IMMUNOLOGY

Multimodal, label-free fluorescence and Raman imaging of amyloid deposits in snap-frozen Alzheimer’s disease human brain tissue

(2021) Benjamin Lochocki et al.   Communications Biology

Blood–Brain Barrier Breakdown: An Emerging Biomarker of Cognitive Impairment in Normal Aging and Dementia

(2021) Basharat Hussain et al.   Frontiers in Neuroscience

Nonclinical safety evaluation of pabinafusp alfa, an anti-human transferrin receptor antibody and iduronate-2-sulfatase fusion protein, for the treatment of neuronopathic mucopolysaccharidosis type II

(2021) Ryuji Yamamoto et al.   Molecular Genetics and Metabolism Reports

Biologic TNF-α inhibitors reduce microgliosis, neuronal loss, and tau phosphorylation in a transgenic mouse model of tauopathy

(2021) Weijun Ou et al.   Journal of Neuroinflammation

A 3′UTR modification of the TNF-α mouse gene increases peripheral TNF-α and modulates the Alzheimer-like phenotype in 5XFAD mice

(2020) Nikoleta Kalovyrna et al.   Scientific Reports

A Phase 2/3 Trial of Pabinafusp Alfa, IDS Fused with Anti-Human Transferrin Receptor Antibody, Targeting Neurodegeneration in MPS-II

(2020) Torayuki Okuyama et al.   MOLECULAR THERAPY

Acute and Chronic Dosing of a High-Affinity Rat/Mouse Chimeric Transferrin Receptor Antibody in Mice

(2020) Demi M. Castellanos et al.   Pharmaceutics

Neuroinflammation and microglial activation in Alzheimer disease: where do we go from here?

(2020) Fangda Leng et al.   Nature Reviews Neurology

Modulation of β-Amyloid Fibril Formation in Alzheimer’s Disease by Microglia and Infection

(2020) Madeleine R. Brown et al.   Frontiers in Molecular Neuroscience

Blood–brain barrier breakdown is an early biomarker of human cognitive dysfunction

(2019) Daniel A. Nation et al.   NATURE MEDICINE

Human cerebrospinal fluid 6E10-immunoreactive protein species contain amyloid precursor protein fragments

(2019) Marianne K. O. Grant et al.   PLoS One

Modulating the antibody density changes the uptake and transport at the blood-brain barrier of both transferrin receptor-targeted gold nanoparticles and liposomal cargo

(2019) Kasper Bendix Johnsen et al.   JOURNAL OF CONTROLLED RELEASE

Imaging and Spectral Characteristics of Amyloid Plaque Autofluorescence in Brain Slices from the APP/PS1 Mouse Model of Alzheimer’s Disease

(2019) Yunling Gao et al.   Neuroscience Bulletin

Genetic Deletion of Tumor Necrosis Factor-α Attenuates Amyloid-β Production and Decreases Amyloid Plaque Formation and Glial Response in the 5XFAD Model of Alzheimer’s Disease

(2017) Evi Paouri et al.   JOURNAL OF ALZHEIMERS DISEASE

Characterization of an ‘Amyloid Only’ Transgenic (B6C3-Tg(APPswe,PSEN1dE9)85Dbo/Mmjax) Mouse Model of Alzheimer's Disease

(2017) G.S. Finnie et al.   JOURNAL OF COMPARATIVE PATHOLOGY

Blood–Brain Barrier Penetrating Biologic TNF-α Inhibitor for Alzheimer’s Disease

(2017) Rudy Chang et al.   MOLECULAR PHARMACEUTICS

Targeting transferrin receptors at the blood-brain barrier improves the uptake of immunoliposomes and subsequent cargo transport into the brain parenchyma

(2017) Kasper Bendix Johnsen et al.   Scientific Reports

Neuroinflammation in Alzheimer's disease: Current evidence and future directions

(2016) Valeria Calsolaro et al.   Alzheimers & Dementia

Infliximab ameliorates AD-associated object recognition memory impairment

(2016) Dong Hyun Kim et al.   BEHAVIOURAL BRAIN RESEARCH

The amyloid hypothesis of Alzheimer's disease at 25 years

(2016) Dennis J Selkoe et al.   EMBO Molecular Medicine

Nuclear Receptors License Phagocytosis by Trem2+ Myeloid Cells in Mouse Models of Alzheimer's Disease

(2015) J. C. Savage et al.   JOURNAL OF NEUROSCIENCE

Behavioral abnormalities in APPSwe/PS1dE9 mouse model of AD-like pathology: comparative analysis across multiple behavioral domains

(2015) Christopher Janus et al.   NEUROBIOLOGY OF AGING

Etanercept in Alzheimer disease: A randomized, placebo-controlled, double-blind, phase 2 trial

(2015) J. Butchart et al.   NEUROLOGY

Oral TNFα Modulation Alters Neutrophil Infiltration, Improves Cognition and Diminishes Tau and Amyloid Pathology in the 3xTgAD Mouse Model

(2015) S. Prasad Gabbita et al.   PLoS One

The amyloid state and its association with protein misfolding diseases

(2014) Tuomas P. J. Knowles et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Peripheral administration of an anti-TNF-α receptor fusion protein counteracts the amyloid induced elevation of hippocampal TNF-α levels and memory deficits in mice

(2014) E.R. Detrait et al.   NEUROCHEMISTRY INTERNATIONAL

Characterization and comparison of commercially available TNF receptor 2-Fc fusion protein products

(2013) Brian Hassett et al.   mAbs

Pharmacokinetics and Brain Uptake of an IgG-TNF Decoy Receptor Fusion Protein Following Intravenous, Intraperitoneal, and Subcutaneous Administration in Mice

(2013) Rachita K. Sumbria et al.   MOLECULAR PHARMACEUTICS

Addressing Safety Liabilities of TfR Bispecific Antibodies That Cross the Blood-Brain Barrier

(2013) J. A. Couch et al.   Science Translational Medicine

Amyloid β-protein oligomers and Alzheimer’s disease

(2013) Eric Y Hayden et al.   Alzheimers Research & Therapy

The Classification of Microglial Activation Phenotypes on Neurodegeneration and Regeneration in Alzheimer’s Disease Brain

(2012) Megan M. Varnum et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

COGNITIVE IMPROVEMENT WITH INTRATHECAL ADMINISTRATION OF INFLIXIMAB IN A WOMAN WITH ALZHEIMER'S DISEASE

(2011) Jian-Quan Shi et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

Anti-TNF-α reduces amyloid plaques and tau phosphorylation and induces CD11c-positive dendritic-like cell in the APP/PS1 transgenic mouse brains

(2010) Jian-Quan Shi et al.   BRAIN RESEARCH

Brain-Penetrating Tumor Necrosis Factor Decoy Receptor in the Mouse

(2010) Q.-H. Zhou et al.   DRUG METABOLISM AND DISPOSITION

Selective targeting of a TNFR decoy receptor pharmaceutical to the primate brain as a receptor-specific IgG fusion protein

(2010) Ruben J. Boado et al.   JOURNAL OF BIOTECHNOLOGY

Pharmacokinetics and Brain Uptake of a Genetically Engineered Bifunctional Fusion Antibody Targeting the Mouse Transferrin Receptor

(2009) Ruben J. Boado et al.   MOLECULAR PHARMACEUTICS

Engineering and expression of a chimeric transferrin receptor monoclonal antibody for blood-brain barrier delivery in the mouse

(2008) Ruben J. Boado et al.   BIOTECHNOLOGY AND BIOENGINEERING