Insights into the Small Molecule Targeting of Biologically Relevant G-Quadruplexes: An Overview of NMR and Crystal Structures

Nuclear magnetic resonance footprint of Wharton Jelly mesenchymal stem cells death mechanisms and distinctive in‐cell biophysical properties in vitro

(2022) Artur T. Krzyżak et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Identification of G-quadruplex DNA sequences in SARS-CoV2

(2022) Amit K. Maiti   IMMUNOGENETICS

Ruthenium Polypyridyl Complex Bound to a Unimolecular Chair-Form G-Quadruplex

(2022) Kane T. McQuaid et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Affinity Chromatography‐Based Assays for the Screening of Potential Ligands Selective for G‐Quadruplex Structures

(2022) Chiara Platella et al.   ChemistryOpen

Major Achievements in the Design of Quadruplex-Interactive Small Molecules

(2022) Eduarda Mendes et al.   Pharmaceuticals

Phen‐DC 3 Induces Refolding of Human Telomeric DNA into a Chair‐Type Antiparallel G‐Quadruplex through Ligand Intercalation

(2022) Anirban Ghosh et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Selectivity and Targeting of G‐quadruplex Binders Activated by Adaptive Binding and Controlled by Chemical Kinetics

(2021) Bo-Chen Zhu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Disentangling the Structure–Activity Relationships of Naphthalene Diimides as Anticancer G-Quadruplex-Targeting Drugs

(2021) Chiara Platella et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structural recognition of the MYC promoter G-quadruplex by a quinoline derivative: insights into molecular targeting of parallel G-quadruplexes

(2021) Jonathan Dickerhoff et al.   NUCLEIC ACIDS RESEARCH

Towards Profiling of the G-Quadruplex Targeting Drugs in the Living Human Cells Using NMR Spectroscopy

(2021) Daniel Krafčík et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Unlocking G-Quadruplexes as Antiviral Targets

(2021) Ardavan Abiri et al.   PHARMACOLOGICAL REVIEWS

G-Quadruplexes and Their Ligands: Biophysical Methods to Unravel G-Quadruplex/Ligand Interactions

(2021) Tiago Santos et al.   Pharmaceuticals

G-Quadruplex Targeting in the Fight against Viruses: An Update

(2021) Emanuela Ruggiero et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Berberine Molecular Recognition of the Parallel MYC G-Quadruplex in Solution

(2021) Jonathan Dickerhoff et al.   JOURNAL OF MEDICINAL CHEMISTRY

Solution Structure of Ternary Complex of Berberine Bound to a dGMP–Fill-In Vacancy G-Quadruplex Formed in the PDGFR-β Promoter

(2021) Kai-Bo Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

G4LDB 2.2: a database for discovering and studying G-quadruplex and i-Motif ligands

(2021) Yu-Huan Wang et al.   NUCLEIC ACIDS RESEARCH

ONQUADRO: a database of experimentally determined quadruplex structures

(2021) Tomasz Zok et al.   NUCLEIC ACIDS RESEARCH

Single-cell mapping of DNA G-quadruplex structures in human cancer cells

(2021) Winnie W. I. Hui et al.   Scientific Reports

Structural basis for stabilization of human telomeric G-quadruplex [d-(TTAGGGT)]4 by anticancer drug adriamycin

(2020) Ritu Barthwal et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

PDGFR-β Promoter Forms a Vacancy G-Quadruplex that Can be Filled-in by dGMP: Solution Structure and Molecular Recognition of Guanine Metabolites and Drugs

(2020) Kai-Bo Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Pyridine Derivative of the Natural Alkaloid Berberine as Human Telomeric G4-DNA Binder: A Solution and Solid-State Study

(2020) Francesco Papi et al.   ACS Medicinal Chemistry Letters

Content Detection of G‐Quadruplex DNA in Live Cells Based on Photon Counts and Complex Structures

(2020) Liu-Yi Liu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

G-quadruplex in cancer biology and drug discovery

(2020) Chuya Nakanishi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Trifunctionalized Naphthalene Diimides and Dimeric Analogues as G-Quadruplex-Targeting Anticancer Agents Selected by Affinity Chromatography

(2020) Chiara Platella et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Native de novo structural determinations of non-canonical nucleic acid motifs by X-ray crystallography at long wavelengths

(2020) Yashu Zhang et al.   NUCLEIC ACIDS RESEARCH

Going Platinum to the Tune of a Remarkable Guanine Quadruplex Binder: Solution‐ and Solid‐State Investigations.

(2020) Caitlin E. Miron et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Structural basis for stabilization of human telomeric G-quadruplex [d-(TTAGGGT)]4 by anticancer drug epirubicin

(2020) Ritu Barthwal et al.   BIOORGANIC & MEDICINAL CHEMISTRY

On the binding of naphthalene diimides to a human telomeric G-quadruplex multimer model

(2020) Valentina Pirota et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Biophysical and X-ray structural studies of the (GGGTT)3GGG G-quadruplex in complex with N-methyl mesoporphyrin IX

(2020) Linda Yingqi Lin et al.   PLoS One

Telomeres and telomerase: three decades of progress

(2019) Jerry W. Shay et al.   NATURE REVIEWS GENETICS

Recent Progress of Targeted G-Quadruplex-Preferred Ligands Toward Cancer Therapy

(2019) Sefan Asamitsu et al.   MOLECULES

Structural studies reveal the enantiospecific recognition of a DNA G-quadruplex by a ruthenium polypyridyl complex

(2019) Kane McQuaid et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Solution Structures of a G-Quadruplex Bound to Linear- and Cyclic-Dinucleotides

(2019) Fernaldo Richtia Winnerdy et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structures of 1:1 and 2:1 complexes of BMVC and MYC promoter G-quadruplex reveal a mechanism of ligand conformation adjustment for G4-recognition

(2019) Wenting Liu et al.   NUCLEIC ACIDS RESEARCH

Molecular Recognition of the Hybrid-2 Human Telomeric G-Quadruplex by Epiberberine: Insights into Conversion of Telomeric G-Quadruplex Structures

(2018) Clement Lin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Solution structures of multiple G-quadruplex complexes induced by a platinum(II)-based tripod reveal dynamic binding

(2018) Wenting Liu et al.   Nature Communications

Chemical and structural studies provide a mechanistic basis for recognition of the MYC G-quadruplex

(2018) David R. Calabrese et al.   Nature Communications

NMR Structure of a Triangulenium-Based Long-Lived Fluorescence Probe Bound to a G-Quadruplex

(2016) Anita Kotar et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Determinants for Tight and Selective Binding of a Medicinal Dicarbene Gold(I) Complex to a Telomeric DNA G-Quadruplex: a Joint ESI MS and XRD Investigation

(2016) Carla Bazzicalupi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Multivalent Interactions between an Aromatic Helical Foldamer and a DNA G-Quadruplex in the Solid State

(2016) Pradeep K. Mandal et al.   CHEMBIOCHEM

Solution and Solid-State Analysis of Binding of 13-Substituted Berberine Analogues to Human Telomeric G-quadruplexes

(2016) Marta Ferraroni et al.   Chemistry-An Asian Journal

Structural Insight into the interaction of Flavonoids with Human Telomeric Sequence

(2015) Arpita Tawani et al.   Scientific Reports

Selective Lighting Up of Epiberberine Alkaloid Fluorescence by Fluorophore-Switching Aptamer and Stoichiometric Targeting of Human Telomeric DNA G-Quadruplex Multimer

(2014) Lihua Zhang et al.   ANALYTICAL CHEMISTRY

Solution Structure of a G-quadruplex Bound to the Bisquinolinium Compound Phen-DC3

(2013) Wan Jun Chung et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Structural Studies on Dinuclear Ruthenium(II) Complexes That Bind Diastereoselectively to an Antiparallel Folded Human Telomere Sequence

(2013) Tom Wilson et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structure-Based Design and Evaluation of Naphthalene Diimide G-Quadruplex Ligands As Telomere Targeting Agents in Pancreatic Cancer Cells

(2013) Marialuisa Micco et al.   JOURNAL OF MEDICINAL CHEMISTRY

Solution Structure of an Intramolecular (3 + 1) Human Telomeric G-Quadruplex Bound to a Telomestatin Derivative

(2013) Wan Jun Chung et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Flavonoids from Achyrocline satureioides: promising biomolecules for anticancer therapy

(2013) Juliana Poglia Carini et al.   RSC Advances

Optimized End-Stacking Provides Specificity of N-Methyl Mesoporphyrin IX for Human Telomeric G-Quadruplex DNA

(2012) John M. Nicoludis et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structural Basis for Telomeric G-Quadruplex Targeting by Naphthalene Diimide Ligands

(2012) Gavin W. Collie et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

DNA secondary structures: stability and function of G-quadruplex structures

(2012) Matthew L. Bochman et al.   NATURE REVIEWS GENETICS

The crystal structure of human telomeric DNA complexed with berberine: an interesting case of stacked ligand to G-tetrad ratio higher than 1:1

(2012) Carla Bazzicalupi et al.   NUCLEIC ACIDS RESEARCH

G4LDB: a database for discovering and studying G-quadruplex ligands

(2012) Qian Li et al.   NUCLEIC ACIDS RESEARCH

The high-resolution crystal structure of a parallel intermolecular DNA G-4 quadruplex/drug complex employing syn glycosyl linkages

(2012) George R. Clark et al.   NUCLEIC ACIDS RESEARCH

Methods for investigating G-quadruplex DNA/ligand interactions

(2011) Pierre Murat et al.   CHEMICAL SOCIETY REVIEWS

Molecular Basis of Structure–Activity Relationships between Salphen Metal Complexes and Human Telomeric DNA Quadruplexes

(2011) Nancy H. Campbell et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structural Basis of Telomeric RNA Quadruplex−Acridine Ligand Recognition

(2011) Gavin W. Collie et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Solution Structure of a 2:1 Quindoline–c-MYC G-Quadruplex: Insights into G-Quadruplex-Interactive Small Molecule Drug Design

(2011) Jixun Dai et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Fluorine in medicinal chemistry: β-fluorination of peripheral pyrrolidines attached to acridine ligands affects their interactions with G-quadruplex DNA

(2011) Nancy H. Campbell et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Structural insights into G-quadruplexes: towards new anticancer drugs

(2010) Danzhou Yang et al.   Future Medicinal Chemistry

Structural and Conformational Requisites in DNA Quadruplex Groove Binding: Another Piece to the Puzzle

(2010) Sandro Cosconati et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Differentiating quadruplexes: binding preferences of a luminescent dinuclear ruthenium(ii) complex with four-stranded DNA structures

(2010) Tom Wilson et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Selectivity in Ligand Recognition of G-Quadruplex Loops†

(2009) Nancy H. Campbell et al.   BIOCHEMISTRY

Human telomeric G-quadruplex: structures of DNA and RNA sequences

(2009) Anh Tuân Phan   FEBS Journal

Structure of Propeller-Type Parallel-Stranded RNA G-Quadruplexes, Formed by Human Telomeric RNA Sequences in K+Solution

(2009) Herry Martadinata et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Tri- and tetra-substituted naphthalene diimides as potent G-quadruplex ligands

(2008) Francisco Cuenca et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Topology Conservation and Loop Flexibility in Quadruplex–Drug Recognition: Crystal Structures of Inter- and Intramolecular Telomeric DNA Quadruplex–Drug Complexes

(2008) Gary N. Parkinson et al.   JOURNAL OF MOLECULAR BIOLOGY

Structural Basis of DNA Quadruplex Recognition by an Acridine Drug

(2008) Nancy H. Campbell et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Conserved elements with potential to form polymorphic G-quadruplex structures in the first intron of human genes

(2008) Johanna Eddy et al.   NUCLEIC ACIDS RESEARCH

G-quadruplexes: the beginning and end of UTRs

(2008) Julian Leon Huppert et al.   NUCLEIC ACIDS RESEARCH