Platycodin D sensitizes KRAS-mutant colorectal cancer cells to cetuximab by inhibiting the PI3K/Akt signaling pathway

GANT61 suppresses cell survival, invasion and epithelial-mesenchymal transition through inactivating AKT/mTOR and JAK/STAT3 pathways in anaplastic thyroid carcinoma

(2022) Haoji Gao et al.   CANCER BIOLOGY & THERAPY

C2orf40 inhibits metastasis and regulates chemo-resistance and radio-resistance of nasopharyngeal carcinoma cells by influencing cell cycle and activating the PI3K/AKT/mTOR signaling pathway

(2022) Zuozhong Xie et al.   Journal of Translational Medicine

Combined Anti-Cancer Effects of Platycodin D and Sorafenib on Androgen-Independent and PTEN-Deficient Prostate Cancer

(2021) Zongliang Lu et al.   Frontiers in Oncology

Activation of cGMP-Dependent Protein Kinase Restricts Melanoma Growth and Invasion by Interfering with the EGF/EGFR Pathway

(2021) Marika Quadri et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The Role of Akt in Acquired Cetuximab Resistant Head and Neck Squamous Cell Carcinoma: An In Vitro Study on a Novel Combination Strategy

(2021) Hannah Zaryouh et al.   Frontiers in Oncology

Chronic exposure to FGF2 converts iPSCs into cancer stem cells with an enhanced integrin/focal adhesion/PI3K/AKT axis

(2021) Mona Sheta et al.   CANCER LETTERS

Resistance to anti-EGFR therapies in metastatic colorectal cancer: underlying mechanisms and reversal strategies

(2021) Jing Zhou et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Resveratrol Sensitizes Colorectal Cancer Cells to Cetuximab by Connexin 43 Upregulation-Induced Akt Inhibition

(2020) Yijia Wang et al.   Frontiers in Oncology

Platycodin D suppresses cisplatin‐induced cytotoxicity by suppressing ROS‐mediated oxidative damage, apoptosis, and inflammation in HEK‐293 cells

(2020) Jun‐nan Hu et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Effects of Platycodin D on apoptosis, migration, invasion and cell cycle arrest of gallbladder cancer cells

(2020) Xiaoyu Zhang et al.   Oncology Letters

Platycodin D reverses histone deacetylase inhibitor resistance in hepatocellular carcinoma cells by repressing ERK1/2-mediated cofilin-1 phosphorylation

(2020) Wei-Chung Hsu et al.   PHYTOMEDICINE

Comprehensive characterization of RAS mutations in colon and rectal cancers in old and young patients

(2019) Ilya G. Serebriiskii et al.   Nature Communications

Nicotine promotes lymph node metastasis and cetuximab resistance in head and neck squamous cell carcinoma

(2018) Rieko Shimizu et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Platycodin D, a triterpenoid saponin from Platycodon grandiflorum , suppresses the growth and invasion of human oral squamous cell carcinoma cells via the NF-κB pathway

(2017) Zhiyong Zhang et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

pH-Sensitive Nano-Complexes Overcome Drug Resistance and Inhibit Metastasis of Breast Cancer by Silencing Akt Expression

(2017) Jieying Yin et al.   Theranostics

Platycodin D induces apoptosis and triggers ERK- and JNK-mediated autophagy in human hepatocellular carcinoma BEL-7402 cells

(2015) Ting Li et al.   ACTA PHARMACOLOGICA SINICA

Platycodin-D Induced Autophagy in Non-Small Cell Lung Cancer Cells via PI3K/Akt/mTOR and MAPK Signaling Pathways

(2015) Ruolin Zhao et al.   Journal of Cancer

The dual PI3K/mTOR inhibitor PKI-587 enhances sensitivity to cetuximab in EGFR-resistant human head and neck cancer models

(2014) V D'Amato et al.   BRITISH JOURNAL OF CANCER

Effects of Platycodin D on Proliferation, Apoptosis and PI3K/Akt Signal Pathway of Human Glioma U251 Cells

(2014) Chong Xu et al.   MOLECULES

Platycodin D from Platycodonis Radix enhances the anti-proliferative effects of doxorubicin on breast cancer MCF-7 and MDA-MB-231 cells

(2014) Zheng-Hai Tang et al.   Chinese Medicine

Platycodin D inhibits migration, invasion, and growth of MDA-MB-231 human breast cancer cells via suppression of EGFR-mediated Akt and MAPK pathways

(2013) Jaemoo Chun et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Combination treatment with platycodin D and osthole inhibits cell proliferation and invasion in mammary carcinoma cell lines

(2013) Yiyi Ye et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Platycodin D, a triterpenoid saponin from Platycodon grandiflorum, induces G2/M arrest and apoptosis in human hepatoma HepG2 cells by modulating the PI3K/Akt pathway

(2013) Hua Qin et al.   TUMOR BIOLOGY

Anti-atherosclerotic Activity of Platycodin D Derived from Roots of Platycodon grandiflorum in Human Endothelial Cells

(2012) Jingtao Wu et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Lack of AKT activation in lung cancer cells with EGFR mutation is a novel marker of cetuximab sensitivity

(2012) Miyako Takata et al.   CANCER BIOLOGY & THERAPY

Platycodin D induces anoikis and caspase-mediated apoptosis via p38 MAPK in AGS human gastric cancer cells

(2012) Jaemoo Chun et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Dasatinib sensitizes KRAS mutant colorectal tumors to cetuximab

(2010) E F Dunn et al.   ONCOGENE

Platycodin D inhibits adipogenesis of 3T3-L1 cells by modulating kruppel-like factor 2 and peroxisome proliferator-activated receptor γ

(2009) Haeyong Lee et al.   PHYTOTHERAPY RESEARCH

The biological properties of cetuximab

(2008) Bruno Vincenzi et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Platycodin D2 is a potential less hemolytic saponin adjuvant eliciting Th1 and Th2 immune responses

(2008) Yong Xie et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Platycodin D induces mitotic arrestin vitro, leading to endoreduplication, inhibition of proliferation and apoptosis in leukemia cells

(2008) Mun-Ock Kim et al.   INTERNATIONAL JOURNAL OF CANCER