A macrocyclic molecule with multiple antioxidative activities protects the lens from oxidative damage

Ferroptosis: mechanisms, biology and role in disease

(2021) Xuejun Jiang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Aging lens epithelium is susceptible to ferroptosis

(2021) Zongbo Wei et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mechanistic Insights into Iron-Catalyzed C–H Bond Activation and C–C Coupling

(2021) Samantha M. Brewer et al.   ORGANOMETALLICS

Oxidative Stress and Cancer Development: Are Noncoding RNAs the Missing Links?

(2020) Leonard Clinton D'Souza et al.   ANTIOXIDANTS & REDOX SIGNALING

Ferroptosis: past, present and future

(2020) Jie Li et al.   Cell Death & Disease

Nrf2 activation through the PI3K/GSK-3 axis protects neuronal cells from Aβ-mediated oxidative and metabolic damage

(2020) Krystal Sotolongo et al.   Alzheimers Research & Therapy

Iron Metabolism in Ferroptosis

(2020) Xin Chen et al.   Frontiers in Cell and Developmental Biology

Ferroptosis: molecular mechanisms and health implications

(2020) Daolin Tang et al.   CELL RESEARCH

Oxidative stress mitigation by antioxidants - An overview on their chemistry and influences on health status

(2020) Aurelia Magdalena Pisoschi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Inonotus obliquus polysaccharides protect against Alzheimer's disease by regulating Nrf2 signaling and exerting antioxidative and antiapoptotic effects

(2019) Yanqiu Han et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

NRF2/ARE pathway negatively regulates BACE1 expression and ameliorates cognitive deficits in mouse Alzheimer’s models

(2019) Gahee Bahn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Enhancement of the Antioxidant Activity and Neurotherapeutic Features through Pyridol Addition to Tetraazamacrocyclic Molecules

(2019) Hannah M. Johnston et al.   INORGANIC CHEMISTRY

Hydrotropic function of ATP in the crystalline lens

(2019) Jack V. Greiner et al.   EXPERIMENTAL EYE RESEARCH

microRNAs Tune Oxidative Stress in Cancer Therapeutic Tolerance and Resistance

(2019) Wen Cai Zhang   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Increase of Direct C–C Coupling Reaction Yield by Identifying Structural and Electronic Properties of High-Spin Iron Tetra-azamacrocyclic Complexes

(2018) Samantha M. Brewer et al.   INORGANIC CHEMISTRY

Nrf2 mediates the expression of BAG3 and autophagy cargo adaptor proteins and tau clearance in an age-dependent manner

(2018) Maoping Tang et al.   NEUROBIOLOGY OF AGING

Pharmacological targeting of GSK-3 and NRF2 provides neuroprotection in a preclinical model of tauopathy

(2018) Antonio Cuadrado et al.   Redox Biology

CuATSM Protects Against the In Vitro Cytotoxicity of Wild-Type-Like Copper–Zinc Superoxide Dismutase Mutants but not Mutants That Disrupt Metal Binding

(2018) Natalie E. Farrawell et al.   ACS Chemical Neuroscience

Solar ultraviolet radiation cataract

(2017) Stefan Löfgren   EXPERIMENTAL EYE RESEARCH

Targeting iron metabolism in drug discovery and delivery

(2017) Bart J. Crielaard et al.   NATURE REVIEWS DRUG DISCOVERY

Zeroing in on neurodegenerative α-synuclein

(2017) Katie Kingwell   NATURE REVIEWS DRUG DISCOVERY

Copper delivery to the CNS by CuATSM effectively treats motor neuron disease in SODG93A mice co-expressing the Copper-Chaperone-for-SOD

(2016) Jared R. Williams et al.   NEUROBIOLOGY OF DISEASE

Targeting Oxidative Stress in Central Nervous System Disorders

(2016) Manisha Patel   TRENDS IN PHARMACOLOGICAL SCIENCES

Alzheimer’s Next Chapter

(2015)   CHEMICAL & ENGINEERING NEWS

Today’s oxidative stress markers

(2015) Marta Czerska et al.   MEDYCYNA PRACY

Oxidative Stress in Neurodegenerative Diseases

(2015) Ewa Niedzielska et al.   MOLECULAR NEUROBIOLOGY

Biogen's early Alzheimer's data raise hopes, some eyebrows

(2015) Mark Ratner   NATURE BIOTECHNOLOGY

Increased oxidative stress is related to disease severity in the ALS motor cortex: A PET study

(2015) M. Ikawa et al.   NEUROLOGY

Oxidative and pro-inflammatory impact of regular and denicotinized cigarettes on blood brain barrier endothelial cells: is smoking reduced or nicotine-free products really safe?

(2014) Pooja Naik et al.   BMC NEUROSCIENCE

Diabetic cardiomyopathy is associated with defective myocellular copper regulation and both defects are rectified by divalent copper chelation

(2014) Shaoping Zhang et al.   Cardiovascular Diabetology

Salvianolic acid A protects RPE cells against oxidative stress through activation of Nrf2/HO-1 signaling

(2014) Hui Zhang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Glutaredoxin 2 (Grx2) Gene Deletion Induces Early Onset of Age-dependent Cataracts in Mice

(2014) Hongli Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Discovery of Vinyl Sulfones as a Novel Class of Neuroprotective Agents toward Parkinson’s Disease Therapy

(2014) Seo Yeon Woo et al.   JOURNAL OF MEDICINAL CHEMISTRY

Role of Nrf2 in Oxidative Stress and Toxicity

(2013) Qiang Ma   Annual Review of Pharmacology and Toxicology

A potent antioxidant small molecule aimed at targeting metal-based oxidative stress in neurodegenerative disorders

(2013) Kimberly M. Lincoln et al.   CHEMICAL COMMUNICATIONS

Long-Term Effects of Vitamins C and E, β-Carotene, and Zinc on Age-related Macular Degeneration

(2013) Emily Y. Chew et al.   OPHTHALMOLOGY

Mitochondrial oxidative stress drives tumor progression and metastasis: should we use antioxidants as a key component of cancer treatment and prevention?

(2011) Federica Sotgia et al.   BMC Medicine

Metformin and Incident Breast Cancer among Diabetic Women: A Population-Based Case-Control Study in Denmark

(2011) J. L. F. Bosco et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Vitamin Supplement Use During Breast Cancer Treatment and Survival: A Prospective Cohort Study

(2011) S. Nechuta et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Age-Related Retinopathy in NRF2-Deficient Mice

(2011) Zhenyang Zhao et al.   PLoS One

Metformin and Cancer Risk in Diabetic Patients: A Systematic Review and Meta-analysis

(2010) A. DeCensi et al.   Cancer Prevention Research

Complications of cataract surgery

(2010) Elsie Chan et al.   Clinical and Experimental Optometry

Nrf2-encoding NFE2L2 haplotypes influence disease progression but not risk in Alzheimer's disease and age-related cataract

(2010) Malin von Otter et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Vegetarian diets: what do we know of their effects on common chronic diseases?

(2009) Gary E Fraser   AMERICAN JOURNAL OF CLINICAL NUTRITION

Use of Oral N-Acetylcysteine for Protection of Melanocytic Nevi against UV-Induced Oxidative Stress: Towards a Novel Paradigm for Melanoma Chemoprevention

(2009) A. G. Goodson et al.   CLINICAL CANCER RESEARCH

A copper(II)-selective chelator ameliorates left-ventricular hypertrophy in type 2 diabetic patients: a randomised placebo-controlled study

(2009) G. J. S. Cooper et al.   DIABETOLOGIA

Nrf2:INrf2 (Keap1) signaling in oxidative stress

(2009) James W. Kaspar et al.   FREE RADICAL BIOLOGY AND MEDICINE

Glutaredoxin systems

(2008) Christopher Horst Lillig et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Safety, efficacy, and biomarker findings of PBT2 in targeting Aβ as a modifying therapy for Alzheimer's disease: a phase IIa, double-blind, randomised, placebo-controlled trial

(2008) Lars Lannfelt et al.   LANCET NEUROLOGY