Targeting GRP78 suppresses oncogenic KRAS protein expression and reduces viability of cancer cells bearing various KRAS mutations

RAS-mediated tumor stress adaptation and the targeting opportunities it presents

(2022) Alexandra Redding et al.   Disease Models & Mechanisms

The hydroxyquinoline analog YUM70 inhibits GRP78 to induce ER stress-mediated apoptosis in pancreatic cancer

(2021) Soma Samanta et al.   CANCER RESEARCH

Targeting eIF4A Dependent Translation of KRAS Signaling Molecules

(2021) Kamini Singh et al.   CANCER RESEARCH

Endoplasmic reticulum chaperone GRP78/BiP is critical for mutant Kras-driven lung tumorigenesis

(2021) Daisy Flores Rangel et al.   ONCOGENE

KRAS Inhibitors– yes but what next? Direct targeting of KRAS– vaccines, adoptive T cell therapy and beyond

(2021) Misako Nagasaka et al.   CANCER TREATMENT REVIEWS

Suppression of ER-stress induction of GRP78 as an anti-neoplastic mechanism of the cardiac glycoside Lanatoside C in pancreatic cancer

(2021) Dat P. Ha et al.   NEOPLASIA

Mechanisms, regulation and functions of the unfolded protein response

(2020) Claudio Hetz et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

KRASG12C Inhibition with Sotorasib in Advanced Solid Tumors

(2020) David S. Hong et al.   NEW ENGLAND JOURNAL OF MEDICINE

KRAS Oncoprotein Expression Is Regulated by a Self-Governing eIF5A-PEAK1 Feed-Forward Regulatory Loop

(2018) Ken Fujimura et al.   CANCER RESEARCH

Endoplasmic reticulum stress activates SRC, relocating chaperones to the cell surface where GRP78/CD109 blocks TGF-β signaling

(2018) Yuan-Li Tsai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Suppression of stress induction of the 78-kilodalton glucose regulated protein (GRP78) in cancer by IT-139, an anti-tumor ruthenium small molecule inhibitor

(2018) Suzanne J. Bakewell et al.   Oncotarget

GRP78 haploinsufficiency suppresses acinar-to-ductal metaplasia, signaling, and mutantKras-driven pancreatic tumorigenesis in mice

(2017) Jieli Shen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evaluation of the selectivity and sensitivity of isoform- and mutation-specific RAS antibodies

(2017) Andrew M. Waters et al.   Science Signaling

Evaluation of the selectivity and sensitivity of isoform- and mutation-specific RAS antibodies

(2017) Andrew M. Waters et al.   Science Signaling

GRP78 at the Centre of the Stage in Cancer and Neuroprotection

(2017) Caty Casas   Frontiers in Neuroscience

Compounds Triggering ER Stress Exert Anti-Melanoma Effects and Overcome BRAF Inhibitor Resistance

(2016) Michaël Cerezo et al.   CANCER CELL

Genetics and biology of pancreatic ductal adenocarcinoma

(2016) Haoqiang Ying et al.   GENES & DEVELOPMENT

Expression of GRP78, Master Regulator of the Unfolded Protein Response, Increases Chemoresistance in Pancreatic Ductal Adenocarcinoma

(2016) J. B. Gifford et al.   MOLECULAR CANCER THERAPEUTICS

Upregulation of Glucose-Regulated Protein 78 in Metastatic Cancer Cells Is Necessary for Lung Metastasis Progression

(2016) Michael M. Lizardo et al.   NEOPLASIA

GRP78/BiP/HSPA5/Dna K is a universal therapeutic target for human disease

(2015) Laurence Booth et al.   JOURNAL OF CELLULAR PHYSIOLOGY

KRAS Protein Stability Is Regulated through SMURF2: UBCH5 Complex-Mediated β-TrCP1 Degradation

(2015) Shirish Shukla et al.   NEOPLASIA

P42 Ebp1 regulates the proteasomal degradation of the p85 regulatory subunit of PI3K by recruiting a chaperone-E3 ligase complex HSP70/CHIP

(2014) H R Ko et al.   Cell Death & Disease

Monoclonal Antibody against Cell Surface GRP78 as a Novel Agent in Suppressing PI3K/AKT Signaling, Tumor Growth, and Metastasis

(2013) R. Liu et al.   CLINICAL CANCER RESEARCH

Cancer Cells Resistant to Therapy Promote Cell Surface Relocalization of GRP78 Which Complexes with PI3K and Enhances PI(3,4,5)P3 Production

(2013) Yi Zhang et al.   PLoS One

UPR-inducible miRNAs contribute to stressful situations

(2013) Nilesh Chitnis et al.   TRENDS IN BIOCHEMICAL SCIENCES

A Comprehensive Survey of Ras Mutations in Cancer

(2012) I. A. Prior et al.   CANCER RESEARCH

The critical roles of endoplasmic reticulum chaperones and unfolded protein response in tumorigenesis and anticancer therapies

(2012) B Luo et al.   ONCOGENE

Oncogenic and Wild-type Ras Play Divergent Roles in the Regulation of Mitogen-Activated Protein Kinase Signaling

(2012) Amy Young et al.   Cancer Discovery

Inducible knockout of GRP78/BiP in the hematopoietic system suppresses Pten-null leukemogenesis and AKT oncogenic signaling

(2011) S. Wey et al.   BLOOD

Knockdown of Oncogenic KRAS in Non-Small Cell Lung Cancers Suppresses Tumor Growth and Sensitizes Tumor Cells to Targeted Therapy

(2011) N. Sunaga et al.   MOLECULAR CANCER THERAPEUTICS

Role of the Unfolded Protein Response Regulator GRP78/BiP in Development, Cancer, and Neurological Disorders

(2009) Miao Wang et al.   ANTIOXIDANTS & REDOX SIGNALING

GRP78: A Multifunctional Receptor on the Cell Surface

(2009) Mario Gonzalez–Gronow et al.   ANTIOXIDANTS & REDOX SIGNALING

Pten null prostate tumorigenesis and AKT activation are blocked by targeted knockout of ER chaperone GRP78/BiP in prostate epithelium

(2008) Y. Fu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA