PU.1 downregulation in murine radiation-induced acute myeloid leukaemia (AML): from molecular mechanism to human AML

Total body irradiation causes long-term mouse BM injury via induction of HSC premature senescence in an Ink4a- and Arf-independent manner

(2014) L. Shao et al.   BLOOD

The Runx-PU.1 pathway preserves normal and AML/ETO9a leukemic stem cells

(2014) P. B. Staber et al.   BLOOD

Pre-leukemic evolution of hematopoietic stem cells: the importance of early mutations in leukemogenesis

(2014) M R Corces-Zimmerman et al.   LEUKEMIA

Leukemogenesis in HeterozygousPU.1Knockout Mice

(2014) Paula C. Genik et al.   RADIATION RESEARCH

Live cell detection of chromosome 2 deletion and Sfpi1/PU1 loss in radiation-induced mouse acute myeloid leukaemia

(2013) C.-H. Olme et al.   LEUKEMIA RESEARCH

Sustained PU.1 Levels Balance Cell-Cycle Regulators to Prevent Exhaustion of Adult Hematopoietic Stem Cells

(2013) Philipp B. Staber et al.   MOLECULAR CELL

Frequency of acute myeloid leukaemia-associated mouse chromosome 2 deletions in X-ray exposed immature haematopoietic progenitors and stem cells

(2013) C.-H. Olme et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Genomic and Epigenomic Landscapes of Adult De Novo Acute Myeloid Leukemia

(2013)   NEW ENGLAND JOURNAL OF MEDICINE

Aggressive acute myeloid leukemia in PU.1/p53 double-mutant mice

(2013) P Basova et al.   ONCOGENE

The Incidence of Leukemia, Lymphoma and Multiple Myeloma among Atomic Bomb Survivors: 1950–2001

(2013) Wan-Ling Hsu et al.   RADIATION RESEARCH

Positive Feedback Between PU.1 and the Cell Cycle Controls Myeloid Differentiation

(2013) H. Y. Kueh et al.   SCIENCE

The Origin and Evolution of Mutations in Acute Myeloid Leukemia

(2012) John S. Welch et al.   CELL

Flt3-ITD mutations in a mouse model of radiation-induced acute myeloid leukaemia

(2012) R Finnon et al.   LEUKEMIA

5-Azacitidine in aggressive myelodysplastic syndromes regulates chromatin structure at PU.1 gene and cell differentiation capacity

(2012) N Curik et al.   LEUKEMIA

Molecular characterisation of murine acute myeloid leukaemia induced by 56Fe ion and 137Cs gamma ray irradiation

(2012) L. S. Steffen et al.   MUTAGENESIS

The Transcription Factor PU.1 is a Critical Regulator of Cellular Communication in the Immune System

(2011) Shereen A. Turkistany et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

Cell Surface Marker Phenotypes and Gene Expression Profiles of Murine Radiation-Induced Acute Myeloid Leukemia Stem Cells are Similar to Those of Common Myeloid Progenitors

(2011) Tokuhisa Hirouchi et al.   RADIATION RESEARCH

The impact of therapy-related acute myeloid leukemia (AML) on outcome in 2853 adult patients with newly diagnosed AML

(2010) S. Kayser et al.   BLOOD

Hematopoietic Stem Cell Quiescence Promotes Error-Prone DNA Repair and Mutagenesis

(2010) Mary Mohrin et al.   Cell Stem Cell

The Transcription Factor PU.1 Controls Dendritic Cell Development and Flt3 Cytokine Receptor Expression in a Dose-Dependent Manner

(2010) Sebastian Carotta et al.   IMMUNITY

Identification and Characterization of Enhancers Controlling the Inflammatory Gene Expression Program in Macrophages

(2010) Serena Ghisletti et al.   IMMUNITY

Sfpi1/PU.1 mutations in mouse radiation-induced acute myeloid leukaemias affect mRNA and protein abundance and associate with disrupted transcription

(2010) N.L. Brown et al.   LEUKEMIA RESEARCH

Simple Combinations of Lineage-Determining Transcription Factors Prime cis-Regulatory Elements Required for Macrophage and B Cell Identities

(2010) Sven Heinz et al.   MOLECULAR CELL

A two-mutation model of radiation-induced acute myeloid leukemia using historical mouse data

(2010) Fieke Dekkers et al.   RADIATION AND ENVIRONMENTAL BIOPHYSICS

Heterozygous deletion of the PU.1 locus in human AML

(2009) N. Bonadies et al.   BLOOD

Implication of replicative stress-related stem cell ageing in radiation-induced murine leukaemia

(2009) N Ban et al.   BRITISH JOURNAL OF CANCER

PU.1 is regulated by NF-κB through a novel binding site in a 17 kb upstream enhancer element

(2009) N Bonadies et al.   ONCOGENE

Radiation Leukemogenesis in Mice: Loss ofPU.1on Chromosome 2 in CBA and C57BL/6 Mice after Irradiation with 1 GeV/nucleon56Fe Ions, X Rays or γ Rays. Part I. Experimental Observations

(2009) Yuanlin Peng et al.   RADIATION RESEARCH

Upregulation of c-myc gene accompanied by PU.1 deficiency in radiation-induced acute myeloid leukemia in mice

(2008) Tokuhisa Hirouchi et al.   EXPERIMENTAL HEMATOLOGY

Sustained expression of microRNA-155 in hematopoietic stem cells causes a myeloproliferative disorder

(2008) Ryan M. O'Connell et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Genetics of therapy-related myelodysplasia and acute myeloid leukemia

(2008) J Pedersen-Bjergaard et al.   LEUKEMIA

Dose-dependent repression of T-cell and natural killer cell genes by PU.1 enforces myeloid and B-cell identity

(2008) M B Kamath et al.   LEUKEMIA