5-Azacitidine in aggressive myelodysplastic syndromes regulates chromatin structure at PU.1 gene and cell differentiation capacity

Two distinct auto-regulatory loops operate at the PU.1 locus in B cells and myeloid cells

(2011) M. Leddin et al.   BLOOD

A Large Gene Network in Immature Erythroid Cells Is Controlled by the Myeloid and B Cell Transcriptional Regulator PU.1

(2011) Sandeep N. Wontakal et al.   PLoS Genetics

Prolonged survival with improved tolerability in higher-risk myelodysplastic syndromes: azacitidine compared with low dose ara-C

(2010) Pierre Fenaux et al.   BRITISH JOURNAL OF HAEMATOLOGY

Chromatin Remodeling Is Required for Gene Reactivation after Decitabine-Mediated DNA Hypomethylation

(2010) J. Si et al.   CANCER RESEARCH

5-azacytidine treatment reorganizes genomic histone modification patterns

(2010) Vitalina M. Komashko et al.   Epigenetics

Practical use of azacitidine in higher-risk myelodysplastic syndromes: An expert panel opinion

(2010) Pierre Fenaux et al.   LEUKEMIA RESEARCH

Decitabine Maintains Hematopoietic Precursor Self-Renewal by Preventing Repression of Stem Cell Genes by a Differentiation-Inducing Stimulus

(2010) Z. Hu et al.   MOLECULAR CANCER THERAPEUTICS

Therapy with azanucleosides for myelodysplastic syndromes

(2010) Alfonso Quintás-Cardama et al.   Nature Reviews Clinical Oncology

Efficacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes: a randomised, open-label, phase III study

(2009) Pierre Fenaux et al.   LANCET ONCOLOGY

Many are called MDS cell lines: One is chosen

(2009) Hans G. Drexler et al.   LEUKEMIA RESEARCH

PU.1 Activation Relieves GATA-1-Mediated Repression of Cebpa and Cbfb during Leukemia Differentiation

(2009) P. Burda et al.   MOLECULAR CANCER RESEARCH

Sustained expression of microRNA-155 in hematopoietic stem cells causes a myeloproliferative disorder

(2008) Ryan M. O'Connell et al.   JOURNAL OF EXPERIMENTAL MEDICINE

p21WAF1/CIP1 induction by 5-azacytosine nucleosides requires DNA damage

(2008) A Jiemjit et al.   ONCOGENE