Efficacy of idebenone in the Treatment of iRBD into Synucleinopathies (EITRS): rationale, design, and methodology of a randomized, double-blind, multi-center clinical study

Risk Factors for Phenoconversion in Rapid Eye Movement Sleep Behavior Disorder

(2022) Hui Zhang et al.   ANNALS OF NEUROLOGY

Idebenone Regulates Aβ and LPS-Induced Neurogliosis and Cognitive Function Through Inhibition of NLRP3 Inflammasome/IL-1β Axis Activation

(2022) Hyun-ju Lee et al.   Frontiers in Immunology

Idebenone improves motor dysfunction, learning and memory by regulating mitophagy in MPTP-treated mice

(2022) Junqiang Yan et al.   Cell Death Discovery

Parkinson's disease peripheral immune biomarker profile: a multicentre, cross-sectional and longitudinal study

(2022) Yuanyuan Li et al.   Journal of Neuroinflammation

Increased free water in the substantia nigra in idiopathic REM sleep behaviour disorder

(2021) Liche Zhou et al.   BRAIN

Idebenone-Activating Autophagic Degradation of α-Synuclein via Inhibition of AKT-mTOR Pathway in a SH-SY5Y-A53T Model of Parkinson’s Disease: A Network Pharmacological Approach

(2021) Pei Kun He et al.   Evidence-based Complementary and Alternative Medicine

Effectiveness of idebenone nanorod formulations in the treatment of Alzheimer's disease

(2021) Yuying Huang et al.   JOURNAL OF CONTROLLED RELEASE

Biomarkers of conversion to α-synucleinopathy in isolated rapid-eye-movement sleep behaviour disorder

(2021) Mitchell G Miglis et al.   LANCET NEUROLOGY

Neuropathology and molecular diagnosis of Synucleinopathies

(2021) Shunsuke Koga et al.   Molecular Neurodegeneration

SNCA Hypomethylation in Rapid Eye Movement Sleep Behavior Disorder Is a Potential Biomarker for Parkinson’s Disease

(2020) Aonan Zhao et al.   Journal of Parkinsons Disease

Altered structure and functional connectivity of the central autonomic network in idiopathic rapid eye movement sleep behaviour disorder

(2020) Guanglu Li et al.   JOURNAL OF SLEEP RESEARCH

Hypomethylation of SNCA in Idiopathic REM Sleep Behavior Disorder Associated With Phenoconversion

(2020) Yuan Li et al.   MOVEMENT DISORDERS

Idebenone Ameliorates Rotenone-Induced Parkinson’s Disease in Rats Through Decreasing Lipid Peroxidation

(2020) Bahattin Avcı et al.   NEUROCHEMICAL RESEARCH

Mitochondrial Dysfunction and Mitophagy in Parkinson’s Disease: From Mechanism to Therapy

(2020) Ana Belen Malpartida et al.   TRENDS IN BIOCHEMICAL SCIENCES

Idebenone: When an antioxidant is not an antioxidant

(2020) Nuri Gueven et al.   Redox Biology

Idebenone Alleviates Neuroinflammation and Modulates Microglial Polarization in LPS-Stimulated BV2 Cells and MPTP-Induced Parkinson’s Disease Mice

(2019) Aijuan Yan et al.   Frontiers in Cellular Neuroscience

Risk and predictors of dementia and parkinsonism in idiopathic REM sleep behaviour disorder: a multicentre study

(2019) Ronald B Postuma et al.   BRAIN

Melatonin for Rapid Eye Movement Sleep Behavior Disorder in Parkinson's Disease: A Randomised Controlled Trial

(2019) Moran Gilat et al.   MOVEMENT DISORDERS

Abnormal intrinsic brain activity of the putamen is correlated with dopamine deficiency in idiopathic rapid eye movement sleep behavior disorder

(2019) Guanglu Li et al.   SLEEP MEDICINE

REM sleep behaviour disorder

(2018) Yves Dauvilliers et al.   Nature Reviews Disease Primers

The risk of neurodegeneration in REM sleep behavior disorder: A systematic review and meta-analysis of longitudinal studies

(2018) Andrea Galbiati et al.   SLEEP MEDICINE REVIEWS

REM Sleep Behavior Disorder: Diagnosis, Clinical Implications, and Future Directions

(2017) Erik K. St Louis et al.   MAYO CLINIC PROCEEDINGS

REMSleep Behavior Disorder in Parkinson's Disease and Other Synucleinopathies

(2017) Erik K. St Louis et al.   MOVEMENT DISORDERS

Degeneration of rapid eye movement sleep circuitry underlies rapid eye movement sleep behavior disorder

(2017) Dillon McKenna et al.   MOVEMENT DISORDERS

Idiopathic REM sleep behaviour disorder and neurodegeneration — an update

(2017) Birgit Högl et al.   Nature Reviews Neurology

REM Sleep EEG Instability in REM Sleep Behavior Disorder and Clonazepam Effects

(2017) Raffaele Ferri et al.   SLEEP

REM Sleep EEG Instability in REM Sleep Behavior Disorder and Clonazepam Effects

(2017) Raffaele Ferri et al.   SLEEP

REM sleep behaviour disorder: prodromal and mechanistic insights for Parkinson's disease

(2016) Anand Tekriwal et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Idiopathic rapid eye movement sleep behaviour disorder: diagnosis, management, and the need for neuroprotective interventions

(2016) Alex Iranzo et al.   LANCET NEUROLOGY

Efficacy of idebenone on respiratory function in patients with Duchenne muscular dystrophy not using glucocorticoids (DELOS): a double-blind randomised placebo-controlled phase 3 trial

(2015) Gunnar M Buyse et al.   LANCET

Melatonin therapy for REM sleep behavior disorder: a critical review of evidence

(2015) Ian R. McGrane et al.   SLEEP MEDICINE

Rapid Eye Movement Sleep Behavior Disorder and Neurodegenerative Disease

(2015) Michael Joseph Howell et al.   JAMA Neurology

Border between natural product and drug: Comparison of the related benzoquinones idebenone and coenzyme Q10

(2015) Nuri Gueven et al.   Redox Biology

Breakdown in REM sleep circuitry underlies REM sleep behavior disorder

(2014) John Peever et al.   TRENDS IN NEUROSCIENCES

Mitochondrial Enhancement for Neurodegenerative Movement Disorders: A Systematic Review of Trials Involving Creatine, Coenzyme Q10, Idebenone and Mitoquinone

(2013) Jia Liu et al.   CNS DRUGS

Idebenone Induces Apoptotic Cell Death in the Human Dopaminergic Neuroblastoma SHSY-5Y Cells

(2011) Kwok-Keung Tai et al.   NEUROTOXICITY RESEARCH

The clinical and pathophysiological relevance of REM sleep behavior disorder in neurodegenerative diseases

(2009) Alex Iranzo et al.   SLEEP MEDICINE REVIEWS