Photobiomodulation for the treatment of neuroinflammation: A systematic review of controlled laboratory animal studies

Non-invasive photobiomodulation treatment in an Alzheimer Disease-like transgenic rat model

(2022) Luodan Yang et al.   Theranostics

Transcranial photobiomodulation (808 nm) attenuates pentylenetetrazole-induced seizures by suppressing hippocampal neuroinflammation, astrogliosis, and microgliosis in peripubertal rats

(2022) Chung-Min Tsai et al.   Neurophotonics

Effects of Chronic Photobiomodulation with Transcranial Near-Infrared Laser on Brain Metabolomics of Young and Aged Rats

(2021) Fabrízio dos Santos Cardoso et al.   MOLECULAR NEUROBIOLOGY

Transcranial laser stimulation: Mitochondrial and cerebrovascular effects in younger and older healthy adults

(2021) Celeste L. Saucedo et al.   Brain Stimulation

Improved Spatial Memory And Neuroinflammatory Profile Changes in Aged Rats Submitted to Photobiomodulation Therapy

(2021) Fabrízio dos Santos Cardoso et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Transcranial low‐level laser therapy in an in vivo model of stroke: Relevance to the brain infarct, microglia activation and neuroinflammation

(2021) Débora D. S. Vogel et al.   Journal of Biophotonics

Photobiomodulation for the aging brain

(2021) Fabrízio dos Santos Cardoso et al.   AGEING RESEARCH REVIEWS

Photobiomodulation Therapy Attenuates Anxious-Depressive-Like Behavior in the TgF344 Rat Model

(2021) Luodan Yang et al.   JOURNAL OF ALZHEIMERS DISEASE

NIR Laser Photobiomodulation Induces Neuroprotection in an In Vitro Model of Cerebral Hypoxia/Ischemia

(2021) Elisabetta Gerace et al.   MOLECULAR NEUROBIOLOGY

Transcranial Laser Photobiomodulation Improves Intracellular Signaling Linked to Cell Survival, Memory and Glucose Metabolism in the Aged Brain: A Preliminary Study

(2021) Fabrízio dos Santos Cardoso et al.   Frontiers in Cellular Neuroscience

Photoactivation of TGFβ/SMAD signaling pathway ameliorates adult hippocampal neurogenesis in Alzheimer’s disease model

(2021) Xiaolei Wu et al.   Stem Cell Research & Therapy

Photobiomodulation inhibits the activation of neurotoxic microglia and astrocytes by inhibiting Lcn2/JAK2-STAT3 crosstalk after spinal cord injury in male rats

(2021) Xuankang Wang et al.   Journal of Neuroinflammation

Effect of transcranial near-infrared photobiomodulation on cognitive outcomes in D-galactose/AlCl3 induced brain aging in BALB/c mice

(2021) Leila Hosseini et al.   LASERS IN MEDICAL SCIENCE

Photobiomodulation Improves the Inflammatory Response and Intracellular Signaling Proteins Linked to Vascular Function and Cell Survival in the Brain of Aged Rats

(2021) Fabrízio dos Santos Cardoso et al.   MOLECULAR NEUROBIOLOGY

Inflammation-related plasma and CSF biomarkers for multiple sclerosis

(2020) Jesse Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Photobiomodulation and Coenzyme Q10 Treatments Attenuate Cognitive Impairment Associated With Model of Transient Global Brain Ischemia in Artificially Aged Mice

(2019) Farzad Salehpour et al.   Frontiers in Cellular Neuroscience

Effect of Photobiomodulation in Rescuing Lipopolysaccharide-Induced Dopaminergic Cell Loss in the Male Sprague–Dawley Rat

(2019) O’Brien et al.   Biomolecules

Cognitive Enhancement by Transcranial Photobiomodulation Is Associated With Cerebrovascular Oxygenation of the Prefrontal Cortex

(2019) Emma Holmes et al.   Frontiers in Neuroscience

Photobiomodulation therapy promotes neurogenesis by improving post-stroke local microenvironment and stimulating neuroprogenitor cells

(2018) Luodan Yang et al.   EXPERIMENTAL NEUROLOGY

Nano-Pulsed Laser Therapy Is Neuroprotective in a Rat Model of Blast-Induced Neurotrauma

(2018) Rinat O. Esenaliev et al.   JOURNAL OF NEUROTRAUMA

Spinal Cord Injury Scarring and Inflammation: Therapies Targeting Glial and Inflammatory Responses

(2018) Michael B. Orr et al.   Neurotherapeutics

Mitochondrial Damage-Associated Molecular Patterns: From Inflammatory Signaling to Human Diseases

(2018) Serge Grazioli et al.   Frontiers in Immunology

Near-infrared photobiomodulation combined with coenzyme Q10 for depression in a mouse model of restraint stress: reduction in oxidative stress, neuroinflammation, and apoptosis

(2018) Farzad Salehpour et al.   BRAIN RESEARCH BULLETIN

Low-level laser therapy modulates demyelination in mice

(2018) Katherine Chuere Nunes Duarte et al.   JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY

Photobiomodulation using a low-level light-emitting diode improves cognitive dysfunction in the 5XFAD mouse model of Alzheimer’s disease

(2018) Gwang Moo Cho et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Microglia in Central Nervous System Inflammation and Multiple Sclerosis Pathology

(2018) Sofie Voet et al.   TRENDS IN MOLECULAR MEDICINE

Low-level light emitting diode (LED) therapy suppresses inflammasome-mediated brain damage in experimental ischemic stroke

(2017) Hae In Lee et al.   Journal of Biophotonics

Up-regulation of cerebral cytochrome-c-oxidase and hemodynamics by transcranial infrared laser stimulation: A broadband near-infrared spectroscopy study

(2017) Xinlong Wang et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Low-level laser therapy for beta amyloid toxicity in rat hippocampus

(2017) Yujiao Lu et al.   NEUROBIOLOGY OF AGING

Impact of heat on metabolic and hemodynamic changes in transcranial infrared laser stimulation measured by broadband near-infrared spectroscopy

(2017) Xinlong Wang et al.   Neurophotonics

Treatment of traumatic brain injury with anti-inflammatory drugs

(2016) Peter J. Bergold   EXPERIMENTAL NEUROLOGY

Neuroinflammation pathways: a general review

(2016) Tara Shabab et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Photobiomodulation reduces abdominal adipose tissue inflammatory infiltrate of diet-induced obese and hyperglycemic mice

(2016) Tania Mateus Yoshimura et al.   Journal of Biophotonics

Craniofacial Wound Healing with Photobiomodulation Therapy

(2016) P.R. Arany   JOURNAL OF DENTAL RESEARCH

Neuroinflammation: the devil is in the details

(2016) Damon J. DiSabato et al.   JOURNAL OF NEUROCHEMISTRY

HSP60 plays a regulatory role in IL-1β-induced microglial inflammation via TLR4-p38 MAPK axis

(2016) Shalini Swaroop et al.   Journal of Neuroinflammation

Transcranial laser stimulation improves human cerebral oxygenation

(2016) Fenghua Tian et al.   LASERS IN SURGERY AND MEDICINE

Role of neuroinflammation in neurodegenerative diseases (Review)

(2016) WEI-WEI CHEN et al.   Molecular Medicine Reports

Light-emitting diode therapy reduces persistent inflammatory pain: Role of interleukin 10 and antioxidant enzymes

(2016) D.F. Martins et al.   NEUROSCIENCE

Pre-conditioning with transcranial low-level light therapy reduces neuroinflammation and protects blood-brain barrier after focal cerebral ischemia in mice

(2016) Hae In Lee et al.   RESTORATIVE NEUROLOGY AND NEUROSCIENCE

Low-level laser therapy ameliorates disease progression in a mouse model of multiple sclerosis

(2015) Elaine D. Gonçalves et al.   AUTOIMMUNITY

Sequential activation of microglia and astrocyte cytokine expression precedes increased iba-1 or GFAP immunoreactivity following systemic immune challenge

(2015) Diana M. Norden et al.   GLIA

Low-Level Light/Laser Therapy Versus Photobiomodulation Therapy

(2015) Juanita J. Anders et al.   PHOTOMEDICINE AND LASER SURGERY

Immunity and Inflammation in Epilepsy

(2015) Annamaria Vezzani et al.   Cold Spring Harbor Perspectives in Medicine

Superpulsed (Ga-As, 904 nm) low-level laser therapy (LLLT) attenuates inflammatory response and enhances healing of burn wounds

(2014) Asheesh Gupta et al.   Journal of Biophotonics

Low-Level Laser Therapy Effectively Prevents Secondary Brain Injury Induced by Immediate Early Responsive Gene X-1 Deficiency

(2014) Qi Zhang et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Low-level laser therapy (LLLT) reduces the COX-2 mRNA expression in both subplantar and total brain tissues in the model of peripheral inflammation induced by administration of carrageenan

(2014) Antonio Carlos Guimarães Prianti et al.   LASERS IN MEDICAL SCIENCE

Neurological and psychological applications of transcranial lasers and LEDs

(2013) Julio C. Rojas et al.   BIOCHEMICAL PHARMACOLOGY

Gene expression patterns following unilateral traumatic brain injury reveals a local pro-inflammatory and remote anti-inflammatory response

(2013) Todd E White et al.   BMC GENOMICS

The p38  MAPK Regulates Microglial Responsiveness to Diffuse Traumatic Brain Injury

(2013) A. D. Bachstetter et al.   JOURNAL OF NEUROSCIENCE

Neuroinflammation: The role and consequences

(2013) Monty Lyman et al.   NEUROSCIENCE RESEARCH

Neurobiology of Major Depressive Disorder

(2013) Rosa Villanueva   NEURAL PLASTICITY

The Role of Markers of Inflammation in Traumatic Brain Injury

(2013) Thomas Woodcock et al.   Frontiers in Neurology

Light-Induced Vasodilation of Coronary Arteries and Its Possible Clinical Implication

(2012) Christian A. Plass et al.   ANNALS OF THORACIC SURGERY

Neuroinflammation after traumatic brain injury: Opportunities for therapeutic intervention

(2012) Alok Kumar et al.   BRAIN BEHAVIOR AND IMMUNITY

Microglia in the developing brain: A potential target with lifetime effects

(2012) G. Jean Harry et al.   NEUROTOXICOLOGY

Low-Level Laser Therapy and Sodium Diclofenac in Acute Inflammatory Response Induced by Skeletal Muscle Trauma: Effects in Muscle Morphology and mRNA Gene Expression of Inflammatory Markers

(2012) Patrícia de Almeida et al.   PHOTOCHEMISTRY AND PHOTOBIOLOGY

Amelioration of Experimental Autoimmune Encephalomyelitis in C57BL/6 Mice by Photobiomodulation Induced by 670 nm Light

(2012) Kamaldeen A. Muili et al.   PLoS One

Brain inflammation as a biomarker in epilepsy

(2011) Annamaria Vezzani et al.   Biomarkers in Medicine

Kaempferol acts through mitogen-activated protein kinases and protein kinase B/AKT to elicit protection in a model of neuroinflammation in BV2 microglial cells

(2011) SE Park et al.   BRITISH JOURNAL OF PHARMACOLOGY

Interleukin (IL)-6, tumour necrosis factor alpha (TNF-α) and soluble interleukin-2 receptors (sIL-2R) are elevated in patients with major depressive disorder: A meta-analysis and meta-regression

(2011) Yang Liu et al.   JOURNAL OF AFFECTIVE DISORDERS

Low-Level Laser Light Therapy Improves Cognitive Deficits and Inhibits Microglial Activation after Controlled Cortical Impact in Mice

(2011) Jugta Khuman et al.   JOURNAL OF NEUROTRAUMA

Mechanisms Underlying Inflammation in Neurodegeneration

(2010) Christopher K. Glass et al.   CELL

Inflammation induced by LPS enhances epileptogenesis in immature rat and may be partially reversed by IL1RA

(2010) Stéphane Auvin et al.   EPILEPSIA

Dysregulated neuronal–microglial cross-talk during aging, stress and inflammation

(2010) Heidi A. Jurgens et al.   EXPERIMENTAL NEUROLOGY

Role of CCL2 (MCP-1) in Traumatic Brain Injury (TBI): Evidence from Severe TBI Patients and CCL2−/− Mice

(2010) Bridgette D Semple et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Neural mechanisms of ageing and cognitive decline

(2010) Nicholas A. Bishop et al.   NATURE

In animal models, psychosocial stress-induced (neuro)inflammation, apoptosis and reduced neurogenesis are associated to the onset of depression

(2010) Marta Kubera et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement

(2010) David Moher et al.   International Journal of Surgery

Biphasic Dose Response in Low Level Light Therapy

(2009) Ying-Ying Huang et al.   Dose-Response

Age and Neuroinflammation: A Lifetime of Psychoneuroimmune Consequences

(2009) Jonathan P. Godbout et al.   IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA

In Situ Detection of Inflammatory Mediators in Post Mortem Human Brain Tissue after Traumatic Injury

(2009) Tony Frugier et al.   JOURNAL OF NEUROTRAUMA

Effect of phototherapy with low intensity laser on local and systemic immunomodulation following focal brain damage in rat

(2009) Maria Stella Moreira et al.   JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY

The Role of Hippocampal GluR1 and GluR2 Receptors in Manic-Like Behavior

(2008) J. Du et al.   JOURNAL OF NEUROSCIENCE

Interleukin Converting Enzyme inhibition impairs kindling epileptogenesis in rats by blocking astrocytic IL-1β production

(2008) Teresa Ravizza et al.   NEUROBIOLOGY OF DISEASE

Cell adhesion molecules and ischemic stroke

(2008) Gokhan Yilmaz et al.   NEUROLOGICAL RESEARCH

Effect of endotoxin treatment on the expression and localization of spinal cyclooxygenase, prostaglandin synthases, and PGD2receptors

(2007) Magdalena Grill et al.   JOURNAL OF NEUROCHEMISTRY

Role of interleukin-1β and tumor necrosis factor-α-dependent expression of cyclooxygenase-2 mRNA in thermal hyperalgesia induced by chronic inflammation in mice

(2007) M. Narita et al.   NEUROSCIENCE