Journal
JOURNAL OF BIOPHOTONICS
Volume 8, Issue 6, Pages 489-501Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/jbio.201400058
Keywords
Burns; hypoxia inducible factor-1 alpha; nuclear factor-kappa B; low-level laser (light) therapy (LLLT); photobiomodulation; superpulsed laser (904 nm)
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Funding
- Defence Research and Development Organization (DRDO), Ministry of Defence, Government of India
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Low-level laser therapy (LLLT) using superpulsed near-infrared light can penetrate deeper in the injured tissue and could allow non-pharmacological treatment for chronic wound healing. This study investigated the effects of superpulsed laser (Ga-As 904 nm, 200 ns pulse width; 100 Hz; 0.7 mW mean output power; 0.4 mW/cm(2) average irradiance; 0.2 J/cm(2) total fluence) on the healing of burn wounds in rats, and further explored the probable associated mechanisms of action. Irradiated group exhibited enhanced DNA, total protein, hydroxyproline and hexosamine contents compared to the control and silver sulfadiazine (reference care) treated groups. LLLT exhibited decreased TNF-alpha level and NF-kappa B, and up-regulated protein levels of VEGF, FGFR-1, HSP-60, HSP-90, HIF-1 alpha and matrix metalloproteinases-2 and 9 compared to the controls. In conclusion, LLLT using superpulsed 904 nm laser reduced the inflammatory response and was able to enhance cellular proliferation, collagen deposition and wound contraction in the repair process of burn wounds.
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