Repeated inhibition of sigma-1 receptor suppresses GABAA receptor expression and long-term depression in the nucleus accumbens leading to depressive-like behaviors

Physiological role for GABAA receptor desensitization in the induction of long-term potentiation at inhibitory synapses

(2021) Martin Field et al.   Nature Communications

α2-containing γ-aminobutyric acid type A receptors promote stress resiliency in male mice

(2021) Rebecca S. Benham et al.   NEUROPSYCHOPHARMACOLOGY

Sigma-1 receptor increases intracellular calcium in cultured astrocytes and contributes to mechanical allodynia in a model of neuropathic pain

(2021) Jae-Gyun Choi et al.   BRAIN RESEARCH BULLETIN

Dopaminergic afferents from midbrain to dorsolateral bed nucleus of stria terminalis inhibit release and expression of corticotropin‐releasing hormone in paraventricular nucleus

(2020) Tingting Di et al.   JOURNAL OF NEUROCHEMISTRY

Ventral-hippocampal afferents to nucleus accumbens encode both latent vulnerability and stress-induced susceptibility

(2020) Jessie Muir et al.   BIOLOGICAL PSYCHIATRY

Chronic mild stress alters synaptic plasticity in the nucleus accumbens through GSK3β-dependent modulation of Kv4.2 channels

(2020) Giuseppe Aceto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of sigma-1 receptors substantially modulates GABA and glutamate transport in presynaptic nerve terminals

(2020) Pozdnyakova Natalia et al.   EXPERIMENTAL NEUROLOGY

Depression and Social Defeat Stress Are Associated with Inhibitory Synaptic Changes in the Nucleus Accumbens

(2020) Mitra Heshmati et al.   JOURNAL OF NEUROSCIENCE

Dopamine D1 receptor in the NAc shell is involved in delayed emergence from isoflurane anesthesia in aged mice

(2020) Yi Zhang et al.   Brain and Behavior

Cortical GABAergic Dysfunction in Stress and Depression: New Insights for Therapeutic Interventions

(2019) Manoela V. Fogaça et al.   Frontiers in Cellular Neuroscience

Acute Cocaine Enhances Dopamine D2R Recognition and Signaling and Counteracts D2R Internalization in Sigma1R-D2R Heteroreceptor Complexes

(2019) Dasiel O. Borroto-Escuela et al.   MOLECULAR NEUROBIOLOGY

Novel radioligands for imaging sigma-1 receptor in brain using positron emission tomography (PET)

(2019) Yu Lan et al.   Acta Pharmaceutica Sinica B

The sigma-1 receptor as key common factor in cocaine and food seeking behaviors

(2019) David Aguinaga et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

OSU-6162, a Sigma1R Ligand in Low Doses, Can Further Increase the Effects of Cocaine Self-Administration on Accumbal D2R Heteroreceptor Complexes

(2019) Dasiel O. Borroto-Escuela et al.   NEUROTOXICITY RESEARCH

Cocaine engages a non-canonical, dopamine-independent, mechanism that controls neuronal excitability in the nucleus accumbens

(2018) Ilse Delint-Ramirez et al.   MOLECULAR PSYCHIATRY

Defective GABAergic neurotransmission in the nucleus tractus solitarius in Mecp2 -null mice, a model of Rett syndrome

(2018) Chao-Yin Chen et al.   NEUROBIOLOGY OF DISEASE

The sigma-1 receptor mediates the beneficial effects of pridopidine in a mouse model of Huntington disease

(2017) Daniel Ryskamp et al.   NEUROBIOLOGY OF DISEASE

Sigma-1 receptor deficiency reduces GABAergic inhibition in the basolateral amygdala leading to LTD impairment and depressive-like behaviors

(2017) Baofeng Zhang et al.   NEUROPHARMACOLOGY

Isolation and characterization of alternatively spliced variants of the mouse sigma1 receptor gene, Sigmar1

(2017) Ling Pan et al.   PLoS One

MPTP-Induced Dopamine Depletion in Basolateral Amygdala via Decrease of D2R Activation Suppresses GABAA Receptors Expression and LTD Induction Leading to Anxiety-Like Behaviors

(2017) Tingting Zhang et al.   Frontiers in Molecular Neuroscience

Hyperactivity of Hypothalamic-Pituitary-Adrenal Axis Due to Dysfunction of the Hypothalamic Glucocorticoid Receptor in Sigma-1 Receptor Knockout Mice

(2017) Tingting Di et al.   Frontiers in Molecular Neuroscience

Quinpirole Increases Melatonin-Augmented Pentobarbital Sleep via Cortical ERK, p38 MAPK, and PKC in Mice

(2016) Sa-Ik Hong et al.   Biomolecules & Therapeutics

Cholinergic, Glutamatergic, and GABAergic Neurons of the Pedunculopontine Tegmental Nucleus Have Distinct Effects on Sleep/Wake Behavior in Mice

(2016) Daniel Kroeger et al.   JOURNAL OF NEUROSCIENCE

Activation of Sigma-1 Receptor Alleviates Postpartum Estrogen Withdrawal-Induced “Depression” Through Restoring Hippocampal nNOS-NO-CREB Activities in Mice

(2016) Suyun Zhang et al.   MOLECULAR NEUROBIOLOGY

BDNF rescues BAF53b-dependent synaptic plasticity and cocaine-associated memory in the nucleus accumbens

(2016) André O. White et al.   Nature Communications

Sex-related neurogenesis decrease in hippocampal dentate gyrus with depressive-like behaviors in sigma-1 receptor knockout mice

(2015) Sha Sha et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Ventral hippocampal afferents to the nucleus accumbens regulate susceptibility to depression

(2015) Rosemary C. Bagot et al.   Nature Communications

Lack of seipin in neurons results in anxiety- and depression-like behaviors via down regulation of PPARγ

(2014) Libin Zhou et al.   HUMAN MOLECULAR GENETICS

Alterations of GABAergic and dopaminergic systems in mutant mice with disruption of exons 2 and 3 of the Disc1 gene

(2014) Tsuyoshi Nakai et al.   NEUROCHEMISTRY INTERNATIONAL

proBDNF Negatively Regulates Neuronal Remodeling, Synaptic Transmission, and Synaptic Plasticity in Hippocampus

(2014) Jianmin Yang et al.   Cell Reports

Sigma-1 Receptor Knockout Impairs Neurogenesis in Dentate Gyrus of Adult HippocampusViaDown-Regulation of NMDA Receptors

(2013) Sha Sha et al.   CNS Neuroscience & Therapeutics

Dopamine D2 Receptors Regulate Collateral Inhibition between Striatal Medium Spiny Neurons

(2013) R. R. Lalchandani et al.   JOURNAL OF NEUROSCIENCE

Patterns of mRNA and protein expression for 12 GABAA receptor subunits in the mouse brain

(2013) H. Hörtnagl et al.   NEUROSCIENCE

Improving bioscience research reporting: the ARRIVE guidelines for reporting animal research

(2012) C. Kilkenny et al.   OSTEOARTHRITIS AND CARTILAGE

Involvement of Cannabinoid CB1 Receptor in Associative Learning and in Hippocampal CA3-CA1 Synaptic Plasticity

(2011) N. Madronal et al.   CEREBRAL CORTEX

Targeting ligand-operated chaperone sigma-1 receptors in the treatment of neuropsychiatric disorders

(2011) Teruo Hayashi et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

D2 receptor overexpression in the striatum leads to a deficit in inhibitory transmission and dopamine sensitivity in mouse prefrontal cortex

(2011) Y.-C. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antidepressant-like properties of α2-containing GABAA receptors

(2010) Isabel Vollenweider et al.   BEHAVIOURAL BRAIN RESEARCH

Pregnenolone sulfate enhances survival of adult-generated hippocampal granule cells via sustained presynaptic potentiation

(2010) Rong Yang et al.   NEUROPHARMACOLOGY

Deficiency in Endocannabinoid Signaling in the Nucleus Accumbens Induced by Chronic Unpredictable Stress

(2010) Wei Wang et al.   NEUROPSYCHOPHARMACOLOGY

Regulation of  -1 Receptors and Endoplasmic Reticulum Chaperones in the Brain of Methamphetamine Self-Administering Rats

(2009) T. Hayashi et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Cortico-Basal Ganglia Reward Network: Microcircuitry

(2009) Susan R Sesack et al.   NEUROPSYCHOPHARMACOLOGY

Sigma-1 receptor knockout mice display a depressive-like phenotype

(2008) Valentina Sabino et al.   BEHAVIOURAL BRAIN RESEARCH

Dopamine and Ethanol Cause Translocation of  PKC Associated with  RACK: Cross-Talk between cAMP-Dependent Protein Kinase A and Protein Kinase C Signaling Pathways

(2008) L. Yao et al.   MOLECULAR PHARMACOLOGY