Targeting ligand-operated chaperone sigma-1 receptors in the treatment of neuropsychiatric disorders

Antidepressant-like effect of PRE-084, a selective σ1 receptor agonist, in Albino Swiss and C57BL/6J mice

(2014) Grażyna Skuza et al.   Pharmacological Reports

Sigma nonopioid intracellular receptor 1 mutations cause frontotemporal lobar degeneration-motor neuron disease

(2010) Agnes A. Luty et al.   ANNALS OF NEUROLOGY

Sigma-1 receptors amplify dopamine D1 receptor signaling at presynaptic sites in the prelimbic cortex

(2010) Yingmei Fu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Molecular mechanisms involving sigma receptor-mediated induction of MCP-1: implication for increased monocyte transmigration

(2010) H. Yao et al.   BLOOD

Dendritic vulnerability in neurodegenerative disease: insights from analyses of cortical pyramidal neurons in transgenic mouse models

(2010) Jennifer I. Luebke et al.   Brain Structure & Function

Synapse Pathology in Psychiatric and Neurologic Disease

(2010) Myrrhe van Spronsen et al.   Current Neurology and Neuroscience Reports

Targeting sigma-1 receptor with fluvoxamine ameliorates pressure-overload-induced hypertrophy and dysfunctions

(2010) Md. Shenuarin Bhuiyan et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Synthesis and Resolution ofcis-(±)-Methyl (1R,2S/1S,2R)-2-[(4-Hydroxy-4-phenylpiperidin-1-yl)methyl]-1-(4-methylphenyl)cyclopropanecarboxylate [(±)-PPCC)]: New σ Receptor Ligands with Neuroprotective Effect

(2010) Orazio Prezzavento et al.   JOURNAL OF MEDICINAL CHEMISTRY

Metals, oxidative stress and neurodegenerative disorders

(2010) Klaudia Jomova et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Detergent-Resistant Microdomains Determine the Localization of  -1 Receptors to the Endoplasmic Reticulum-Mitochondria Junction

(2010) T. Hayashi et al.   MOLECULAR PHARMACOLOGY

DHEA prevents Aβ25–35-impaired survival of newborn neurons in the dentate gyrus through a modulation of PI3K-Akt-mTOR signaling

(2010) Liang Li et al.   NEUROPHARMACOLOGY

An increase in spinal dehydroepiandrosterone sulfate (DHEAS) enhances NMDA-induced pain via phosphorylation of the NR1 subunit in mice: Involvement of the sigma-1 receptor

(2010) Seo-Yeon Yoon et al.   NEUROPHARMACOLOGY

The sigma-1 receptor is enriched in postsynaptic sites of C-terminals in mouse motoneurons. An anatomical and behavioral study

(2010) T.A. Mavlyutov et al.   NEUROSCIENCE

Sigma-1 receptor-induced increase in murine spinal NR1 phosphorylation is mediated by the PKCα and ɛ, but not the PKCζ, isoforms

(2010) Dae-Hyun Roh et al.   NEUROSCIENCE LETTERS

Glutamate receptors, neurotoxicity and neurodegeneration

(2010) Anthony Lau et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Sigma receptors: Potential targets for a new class of antidepressant drug

(2010) James A. Fishback et al.   PHARMACOLOGY & THERAPEUTICS

Endoplasmic Reticulum Protein Targeting of Phospholamban: A Common Role for an N-Terminal Di-Arginine Motif in ER Retention?

(2010) Parveen Sharma et al.   PLoS One

Direct involvement of  -1 receptors in the dopamine D1 receptor-mediated effects of cocaine

(2010) G. Navarro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fluvoxamine improved cognitive impairments in a patient with schizophrenia

(2010) Tomihisa Niitsu et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists

(2010) N. Li et al.   SCIENCE

The sigma-1 receptor chaperone as an inter-organelle signaling modulator

(2010) Tsung-Ping Su et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Synaptic Adaptations of CA1 Pyramidal Neurons Induced by a Highly Effective Combinational Antidepressant Therapy

(2009) Cristina Marchetti et al.   BIOLOGICAL PSYCHIATRY

Neuropeptide and Sigma Receptors as Novel Therapeutic Targets for the Pharmacotherapy of Depression

(2009) Konstantinos A. Paschos et al.   CNS DRUGS

Thin, Stubby or Mushroom: Spine Pathology in Alzheimers Disease

(2009) C. Tackenberg et al.   Current Alzheimer Research

Screening of anti-glioma effects induced by sigma-1 receptor ligands: Potential new use for old anti-psychiatric medicines

(2009) Véronique Mégalizzi et al.   EUROPEAN JOURNAL OF CANCER

σ-1 receptors in major depression and anxiety

(2009) Shrinivas K Kulkarni et al.   Expert Review of Neurotherapeutics

High occupancy of σ1 receptors in the human brain after single oral administration of donepezil: a positron emission tomography study using [11C]SA4503

(2009) Masatomo Ishikawa et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Anti-amnesic properties of (±)-PPCC, a novel sigma receptor ligand, on cognitive dysfunction induced by selective cholinergic lesion in rats

(2009) Vuokko Antonini et al.   JOURNAL OF NEUROCHEMISTRY

Regulation of  -1 Receptors and Endoplasmic Reticulum Chaperones in the Brain of Methamphetamine Self-Administering Rats

(2009) T. Hayashi et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Sigma-1 Receptors Regulate Bcl-2 Expression by Reactive Oxygen Species-Dependent Transcriptional Regulation of Nuclear Factor  B

(2009) J. Meunier et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Fluvoxamine and sigma-1 receptor agonists dehydroepiandrosterone (DHEA)-sulfate induces the Ser473-phosphorylation of Akt-1 in PC12 cells

(2009) Miho Nakano et al.   LIFE SCIENCES

SA4503, a sigma-1 receptor agonist, prevents cultured cortical neurons from oxidative stress-induced cell death via suppression of MAPK pathway activation and glutamate receptor expression

(2009) Tuerhong Tuerxun et al.   NEUROSCIENCE LETTERS

The pharmacology of sigma-1 receptors

(2009) Tangui Maurice et al.   PHARMACOLOGY & THERAPEUTICS

Molecular Mechanisms of Psychostimulant-induced Structural Plasticity

(2009) D. M. Dietz et al.   PHARMACOPSYCHIATRY

Sigma-1 receptors regulate hippocampal dendritic spine formation via a free radical-sensitive mechanism involving Rac1·GTP pathway

(2009) Shang-Yi Tsai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Hallucinogen N,N-Dimethyltryptamine (DMT) Is an Endogenous Sigma-1 Receptor Regulator

(2009) D. Fontanilla et al.   SCIENCE

MAM: more than just a housekeeper

(2009) Teruo Hayashi et al.   TRENDS IN CELL BIOLOGY

Low density of sigma1 receptors in early Alzheimer’s disease

(2008) Masahiro Mishina et al.   ANNALS OF NUCLEAR MEDICINE

Sigma-1 receptor knockout mice display a depressive-like phenotype

(2008) Valentina Sabino et al.   BEHAVIOURAL BRAIN RESEARCH

ALS-linked mutant SOD1 induces ER stress- and ASK1-dependent motor neuron death by targeting Derlin-1

(2008) H. Nishitoh et al.   GENES & DEVELOPMENT

Sigma receptors suppress multiple aspects of microglial activation

(2008) Aaron A. Hall et al.   GLIA

Juxtaposition of the Steroid Binding Domain-like I and II Regions Constitutes a Ligand Binding Site in the σ-1 Receptor

(2008) Arindam Pal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

 -1 Receptor Modulation of Acid-Sensing Ion Channel a (ASIC1a) and ASIC1a-Induced Ca2+ Influx in Rat Cortical Neurons

(2008) Y. Herrera et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Alterations in Fos-Related Antigen 2 and  1 Receptor Gene and Protein Expression Are Associated with the Development of Cocaine-Induced Behavioral Sensitization: Time Course and Regional Distribution Studies

(2008) Y. Liu et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

The σ-Receptor Antagonist BD-1063 Decreases Ethanol Intake and Reinforcement in Animal Models of Excessive Drinking

(2008) Valentina Sabino et al.   NEUROPSYCHOPHARMACOLOGY

Chronic treatment with a selective ligand for the sigma-1 receptor chaperone, SA4503, up-regulates BDNF protein levels in the rat hippocampus

(2008) Kazue Kikuchi-Utsumi et al.   NEUROSCIENCE LETTERS

Fluvoxamine as a sigma-1 receptor agonist improved cognitive impairments in a patient with schizophrenia

(2008) Masaomi Iyo et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Protection of cellular and mitochondrial functions against liver ischemia by N-benzyl-N′-(2-hydroxy-3,4-dimethoxybenzyl)-piperazine (BHDP), a sigma1 ligand

(2007) Anis Klouz et al.   EUROPEAN JOURNAL OF PHARMACOLOGY