Spike mutations contributing to the altered entry preference of SARS-CoV-2 omicron BA.1 and BA.2

Mutations in SARS-CoV-2 variants of concern link to increased spike cleavage and virus transmission

(2022) Alba Escalera et al.   Cell Host & Microbe

Altered TMPRSS2 usage by SARS-CoV-2 Omicron impacts tropism and fusogenicity

(2022) Bo Meng et al.   NATURE

Activity of convalescent and vaccine serum against SARS-CoV-2 Omicron

(2022) Juan Manuel Carreño et al.   NATURE

Attenuated replication and pathogenicity of SARS-CoV-2 B.1.1.529 Omicron

(2022) Huiping Shuai et al.   NATURE

Omicron extensively but incompletely escapes Pfizer BNT162b2 neutralization

(2022) Sandile Cele et al.   NATURE

Rapid epidemic expansion of the SARS-CoV-2 Omicron variant in southern Africa

(2022) Raquel Viana et al.   NATURE

Attenuated fusogenicity and pathogenicity of SARS-CoV-2 Omicron variant

(2022) Rigel Suzuki et al.   NATURE

SARS-CoV-2 Omicron virus causes attenuated disease in mice and hamsters

(2022) Peter J. Halfmann et al.   NATURE

Omicron escapes the majority of existing SARS-CoV-2 neutralizing antibodies

(2022) Yunlong Cao et al.   NATURE

Striking antibody evasion manifested by the Omicron variant of SARS-CoV-2

(2022) Lihong Liu et al.   NATURE

Virological characteristics of the SARS-CoV-2 Omicron BA.2 spike

(2022) Daichi Yamasoba et al.   CELL

Characterization and antiviral susceptibility of SARS-CoV-2 Omicron/BA.2

(2022) Ryuta Uraki et al.   NATURE

Characterization of SARS-CoV-2 Variants B.1.617.1 (Kappa), B.1.617.2 (Delta), and B.1.618 by Cell Entry and Immune Evasion

(2022) Wenlin Ren et al.   mBio

VPS29 Exerts Opposing Effects on Endocytic Viral Entry

(2022) Daniel Poston et al.   mBio

Delta spike P681R mutation enhances SARS-CoV-2 fitness over Alpha variant

(2022) Yang Liu et al.   Cell Reports

Bacillus Calmette–Guérin-induced trained immunity protects against SARS-CoV-2 challenge in K18-hACE2 mice

(2022) Bao-Zhong Zhang et al.   JCI Insight

Determinants of Spike infectivity, processing, and neutralization in SARS-CoV-2 Omicron subvariants BA.1 and BA.2

(2022) Chiara Pastorio et al.   Cell Host & Microbe

Augmented neutralisation resistance of emerging omicron subvariants BA.2.12.1, BA.4, and BA.5

(2022) Prerna Arora et al.   LANCET INFECTIOUS DISEASES

Coronaviruses exploit a host cysteine-aspartic protease for replication

(2022) Hin Chu et al.   NATURE

Neutralization Escape by SARS-CoV-2 Omicron Subvariants BA.2.12.1, BA.4, and BA.5

(2022) Nicole P. Hachmann et al.   NEW ENGLAND JOURNAL OF MEDICINE

Loss of furin cleavage site attenuates SARS-CoV-2 pathogenesis

(2021) Bryan A. Johnson et al.   NATURE

Host and viral determinants for efficient SARS-CoV-2 infection of the human lung

(2021) Hin Chu et al.   Nature Communications

Syncytia formation by SARS‐CoV‐2‐infected cells

(2021) Julian Buchrieser et al.   EMBO JOURNAL

TMPRSS11D and TMPRSS13 Activate the SARS-CoV-2 Spike Protein

(2021) Mai Kishimoto et al.   Viruses-Basel

Lessons learned one year after SARS-CoV-2 emergence leading to COVID-19 pandemic

(2021) Kelvin Kai-Wang To et al.   Emerging Microbes & Infections

Camostat mesylate inhibits SARS-CoV-2 activation by TMPRSS2-related proteases and its metabolite GBPA exerts antiviral activity

(2021) Markus Hoffmann et al.   EBioMedicine

The SARS-CoV-2 and other human coronavirus spike proteins are fine-tuned towards temperature and proteases of the human airways

(2021) Manon Laporte et al.   PLoS Pathogens

The furin cleavage site in the SARS-CoV-2 spike protein is required for transmission in ferrets

(2021) Thomas P. Peacock et al.   Nature Microbiology

TMPRSS2 expression dictates the entry route used by SARS‐CoV‐2 to infect host cells

(2021) Jana Koch et al.   EMBO JOURNAL

A CRISPR/Cas9 genetically engineered organoid biobank reveals essential host factors for coronaviruses

(2021) Joep Beumer et al.   Nature Communications

Recurrent emergence of SARS-CoV-2 spike deletion H69/V70 and its role in the Alpha variant B.1.1.7

(2021) Bo Meng et al.   Cell Reports

Neutralization of Severe Acute Respiratory Syndrome Coronavirus 2 Omicron Variant by Sera From BNT162b2 or CoronaVac Vaccine Recipients

(2021) Lu Lu et al.   CLINICAL INFECTIOUS DISEASES

Enhanced fusogenicity and pathogenicity of SARS-CoV-2 Delta P681R mutation

(2021) Akatsuki Saito et al.   NATURE

SARS-CoV-2 Delta Variant Displays Moderate Resistance to Neutralizing Antibodies and Spike Protein Properties of Higher Soluble ACE2 Sensitivity, Enhanced Cleavage and Fusogenic Activity

(2021) Sabari Nath Neerukonda et al.   Viruses-Basel

SARS-CoV-2 Omicron variant shows less efficient replication and fusion activity when compared with Delta variant in TMPRSS2-expressed cells

(2021) Hanjun Zhao et al.   Emerging Microbes & Infections

Emerging SARS-CoV-2 variants expand species tropism to murines

(2021) Huiping Shuai et al.   EBioMedicine

A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster

(2020) Jasper Fuk-Woo Chan et al.   LANCET

A pneumonia outbreak associated with a new coronavirus of probable bat origin

(2020) Peng Zhou et al.   NATURE

Genomic characterization of the 2019 novel human-pathogenic coronavirus isolated from a patient with atypical pneumonia after visiting Wuhan

(2020) Jasper Fuk-Woo Chan et al.   Emerging Microbes & Infections

The spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade

(2020) B. Coutard et al.   ANTIVIRAL RESEARCH

Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein

(2020) Alexandra C. Walls et al.   CELL

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

A Multibasic Cleavage Site in the Spike Protein of SARS-CoV-2 Is Essential for Infection of Human Lung Cells

(2020) Markus Hoffmann et al.   MOLECULAR CELL

Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV

(2020) Xiuyuan Ou et al.   Nature Communications

TMPRSS2 and TMPRSS4 promote SARS-CoV-2 infection of human small intestinal enterocytes

(2020) Ruochen Zang et al.   Science Immunology

TMPRSS2 and furin are both essential for proteolytic activation of SARS-CoV-2 in human airway cells

(2020) Dorothea Bestle et al.   Life Science Alliance

Proteolytic processing of Middle East respiratory syndrome coronavirus spikes expands virus tropism

(2016) Jung-Eun Park et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Versatile protein tagging in cells with split fluorescent protein

(2016) Daichi Kamiyama et al.   Nature Communications

Host cell entry of Middle East respiratory syndrome coronavirus after two-step, furin-mediated activation of the spike protein

(2014) Jean Kaoru Millet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA