Aurora A regulation by reversible cysteine oxidation reveals evolutionarily conserved redox control of Ser/Thr protein kinase activity

A Quantitative Tissue-Specific Landscape of Protein Redox Regulation during Aging

(2020) Haopeng Xiao et al.   CELL

A redox-sensitive thiol in Wis1 modulates the fission yeast MAPK response to H2O2 and is the target of a small molecule

(2020) Johanna J. Sjölander et al.   MOLECULAR AND CELLULAR BIOLOGY

Spatial and temporal alterations in protein structure by EGF regulate cryptic cysteine oxidation

(2020) Jessica B. Behring et al.   Science Signaling

ROS and Oxidative Stress Are Elevated in Mitosis during Asynchronous Cell Cycle Progression and Are Exacerbated by Mitotic Arrest

(2019) Jesse C. Patterson et al.   Cell Systems

Covalent Aurora A regulation by the metabolic integrator coenzyme A

(2019) Yugo Tsuchiya et al.   Redox Biology

The Cysteinome of Protein Kinases as a Target in Drug Development

(2018) Apirat Chaikuad et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

New tools for evaluating protein tyrosine sulphation: Tyrosyl Protein Sulphotransferases (TPSTs) are novel targets for RAF protein kinase inhibitors

(2018) Dominic P Byrne et al.   BIOCHEMICAL JOURNAL

Targeting non-small cell lung cancer with small-molecule EGFR tyrosine kinase inhibitors

(2018) Mahaveer Singh et al.   DRUG DISCOVERY TODAY

Mitotic spindle association of TACC3 requires Aurora‐A‐dependent stabilization of a cryptic α‐helix

(2018) Selena G Burgess et al.   EMBO JOURNAL

AGC kinases, mechanisms of regulation ‎and innovative drug development

(2018) Alejandro E. Leroux et al.   SEMINARS IN CANCER BIOLOGY

Proteome-wide analysis of cysteine oxidation reveals metabolic sensitivity to redox stress

(2018) Jiska van der Reest et al.   Nature Communications

A dynamic mechanism for allosteric activation of Aurora kinase A by activation loop phosphorylation

(2018) Emily F Ruff et al.   eLife

Dynamics of human protein kinase Aurora A linked to drug selectivity

(2018) Warintra Pitsawong et al.   eLife

Cysteine-Based Redox Sensing and Its Role in Signaling by Cyclic Nucleotide-Dependent Kinases in the Cardiovascular System

(2018) Friederike Cuello et al.   Annual Review of Physiology

Oxidation of cysteine 117 stimulates constitutive activation of the type Iα cGMP-dependent protein kinase

(2018) Jessica L Sheehe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Covalent inhibitors of EGFR family protein kinases induce degradation of human Tribbles 2 (TRIB2) pseudokinase in cancer cells

(2018) Daniel M. Foulkes et al.   Science Signaling

Aurora kinase A localises to mitochondria to control organelle dynamics and energy production

(2018) Giulia Bertolin et al.   eLife

Quantitative conformational profiling of kinase inhibitors reveals origins of selectivity for Aurora kinase activation states

(2018) Eric W. Lake et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Direct cysteine sulfenylation drives activation of the Src kinase

(2018) David E. Heppner et al.   Nature Communications

Oxidative stress induces mitotic arrest by inhibiting Aurora A-involved mitotic spindle formation

(2017) Guang-Fei Wang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Pseudokinases: update on their functions and evaluation as new drug targets

(2017) Dominic P Byrne et al.   Future Medicinal Chemistry

The activity of cGMP-dependent protein kinase Iα is not directly regulated by oxidation-induced disulfide formation at cysteine 43

(2017) Hema Kalyanaraman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Determining Cysteines Available for Covalent Inhibition Across the Human Kinome

(2017) Zheng Zhao et al.   JOURNAL OF MEDICINAL CHEMISTRY

A role for 2-Cys peroxiredoxins in facilitating cytosolic protein thiol oxidation

(2017) Sarah Stöcker et al.   Nature Chemical Biology

Playing polo during mitosis: PLK1 takes the lead

(2017) G Combes et al.   ONCOGENE

Local protein kinase A action proceeds through intact holoenzymes

(2017) F. Donelson Smith et al.   SCIENCE

Tribbles in the 21st Century: The Evolving Roles of Tribbles Pseudokinases in Biology and Disease

(2017) Patrick A. Eyers et al.   TRENDS IN CELL BIOLOGY

The structure-guided discovery of osimertinib: the first U.S. FDA approved mutant selective inhibitor of EGFR T790M

(2017) Sam Butterworth et al.   MedChemComm

cAMP-dependent protein kinase (PKA) complexes probed by complementary differential scanning fluorimetry and ion mobility-mass spectrometry

(2016) D. P. Byrne et al.   BIOCHEMICAL JOURNAL

Mitochondrial Biology and Neurological Diseases

(2016) Siddharth Arun et al.   Current Neuropharmacology

KinView: a visual comparative sequence analysis tool for integrated kinome research

(2016) Daniel Ian McSkimming et al.   Molecular BioSystems

Cy-preds: An algorithm and a web service for the analysis and prediction of cysteine reactivity

(2016) İnanç Soylu et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Mitotic phosphotyrosine network analysis reveals that tyrosine phosphorylation regulates Polo-like kinase 1 (PLK1)

(2016) D. Caron et al.   Science Signaling

How Do Protein Kinases Take a Selfie (Autophosphorylate)?

(2016) Jonah Beenstock et al.   TRENDS IN BIOCHEMICAL SCIENCES

Hydrophobic Core Variations Provide a Structural Framework for Tyrosine Kinase Evolution and Functional Specialization

(2016) Smita Mohanty et al.   PLoS Genetics

Mitotic phosphotyrosine network analysis reveals that tyrosine phosphorylation regulates Polo-like kinase 1 (PLK1)

(2016) D. Caron et al.   Science Signaling

The cysteine proteome

(2015) Young-Mi Go et al.   FREE RADICAL BIOLOGY AND MEDICINE

The basics of thiols and cysteines in redox biology and chemistry

(2015) Leslie B. Poole   FREE RADICAL BIOLOGY AND MEDICINE

A proton relay enhances H2O2 sensitivity of GAPDH to facilitate metabolic adaptation

(2015) David Peralta et al.   Nature Chemical Biology

The structure of C290A:C393A Aurora A provides structural insights into kinase regulation

(2015) Selena G. Burgess et al.   Acta Crystallographica Section F-Structural Biology Communications

A Redox-Dependent Mechanism for Regulation of AMPK Activation by Thioredoxin1 during Energy Starvation

(2014) Dan Shao et al.   Cell Metabolism

UniProt: a hub for protein information

(2014)   NUCLEIC ACIDS RESEARCH

MELK is an oncogenic kinase essential for mitotic progression in basal-like breast cancer cells

(2014) Yubao Wang et al.   eLife

Molecular mechanism of Aurora A kinase autophosphorylation and its allosteric activation by TPX2

(2014) Adelajda Zorba et al.   eLife

Biochemical methods for monitoring protein thiol redox states in biological systems

(2014) Olena Rudyk et al.   Redox Biology

A robust methodology to subclassify pseudokinases based on their nucleotide-binding properties

(2013) James M. Murphy et al.   BIOCHEMICAL JOURNAL

Sulfenic acid chemistry, detection and cellular lifetime

(2013) Vinayak Gupta et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Developing Irreversible Inhibitors of the Protein Kinase Cysteinome

(2013) Qingsong Liu et al.   CHEMISTRY & BIOLOGY

Cysteine Oxidative Posttranslational Modifications

(2013) Heaseung S. Chung et al.   CIRCULATION RESEARCH

Redox regulation of protein kinases

(2013) Thu H. Truong et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Redox regulation of protein kinases

(2013) Aoife Corcoran et al.   FEBS Journal

Causes and Consequences of CysteineS-Glutathionylation

(2013) Christina L. Grek et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Basis for the Regulation of Maternal Embryonic Leucine Zipper Kinase

(2013) Lu-Sha Cao et al.   PLoS One

Hydrogen Peroxide Sensing and Signaling by Protein Kinases in the Cardiovascular System

(2012) Joseph R. Burgoyne et al.   ANTIOXIDANTS & REDOX SIGNALING

Redox Regulation of Epidermal Growth Factor Receptor Signaling through Cysteine Oxidation

(2012) Thu H. Truong et al.   BIOCHEMISTRY

Peroxiredoxin 1 functions as a signal peroxidase to receive, transduce, and transmit peroxide signals in mammalian cells

(2012) Reagan M. Jarvis et al.   FREE RADICAL BIOLOGY AND MEDICINE

Single atom substitution in mouse protein kinase G eliminates oxidant sensing to cause hypertension

(2012) Oleksandra Prysyazhna et al.   NATURE MEDICINE

Redox control of cell proliferation

(2012) Joyce Chiu et al.   TRENDS IN CELL BIOLOGY

Structural and evolutionary divergence of eukaryotic protein kinases in Apicomplexa

(2011) Eric Talevich et al.   BMC EVOLUTIONARY BIOLOGY

Multistep regulation of protein kinase A in its localization, phosphorylation and binding with a regulatory subunit in fission yeast

(2011) Dipali Rani Gupta et al.   CURRENT GENETICS

Activation of Aurora-A Kinase by Protein Partner Binding and Phosphorylation Are Independent and Synergistic

(2011) Charlotte A. Dodson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Aurora A and Aurora B jointly coordinate chromosome segregation and anaphase microtubule dynamics

(2011) Nadia Hégarat et al.   JOURNAL OF CELL BIOLOGY

Signal transduction by reactive oxygen species

(2011) Toren Finkel   JOURNAL OF CELL BIOLOGY

Chemistry and biology of reactive oxygen species in signaling or stress responses

(2011) Bryan C Dickinson et al.   Nature Chemical Biology

Peroxide-dependent sulfenylation of the EGFR catalytic site enhances kinase activity

(2011) Candice E Paulsen et al.   Nature Chemical Biology

Investigation of tumor hypoxia using a two-enzyme system for in vitro generation of oxygen deficiency

(2011) Vasileios Askoxylakis et al.   Radiation Oncology

Glyceraldehyde 3-Phosphate Dehydrogenase is Unlikely to Mediate Hydrogen Peroxide Signaling: Studies with a Novel Anti-Dimedone Sulfenic Acid Antibody

(2010) Claire Maller et al.   ANTIOXIDANTS & REDOX SIGNALING

Inactivation of Ca2+/calmodulin-dependent protein kinase I byS-glutathionylation of the active-site cysteine residue

(2010) Toshie Kambe et al.   FEBS LETTERS

Hydrogen Peroxide-sensitive Cysteines in the Sty1 MAPK Regulate the Transcriptional Response to Oxidative Stress

(2010) Alison M. Day et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exposure to Hydrogen Peroxide Induces Oxidation and Activation of AMP-activated Protein Kinase

(2010) Jaroslaw W. Zmijewski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Peroxiredoxin IV protects cells from oxidative stress by removing H2O2 produced during disulphide formation

(2010) T. J. Tavender et al.   JOURNAL OF CELL SCIENCE

Oxidation-induced intramolecular disulfide bond inactivates mitogen-activated protein kinase kinase 6 by inhibiting ATP binding

(2010) Y. Diao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Orchestrating Redox Signaling Networks through Regulatory Cysteine Switches

(2009) Candice E. Paulsen et al.   ACS Chemical Biology

The regulation and function of mammalian AMPK-related kinases

(2009) N. J. Bright et al.   Acta Physiologica

The GOX/CAT system: A novel enzymatic method to independently control hydrogen peroxide and hypoxia in cell culture

(2009) S Mueller et al.   Advances in Medical Sciences

Rapid detection, classification and accurate alignment of up to a million or more related protein sequences

(2009) Andrew F. Neuwald   BIOINFORMATICS

The cell cycle is a redox cycle: Linking phase-specific targets to cell fate

(2009) William C. Burhans et al.   FREE RADICAL BIOLOGY AND MEDICINE

Discovery and Exploitation of Inhibitor-resistant Aurora and Polo Kinase Mutants for the Analysis of Mitotic Networks

(2009) Paul J. Scutt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

REDOX Reaction at ASK1-Cys250 Is Essential for Activation of JNK and Induction of Apoptosis

(2009) Philippe J. Nadeau et al.   MOLECULAR BIOLOGY OF THE CELL

The nuts and bolts of AGC protein kinases

(2009) Laura R. Pearce et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Pfam protein families database

(2009) Robert D. Finn et al.   NUCLEIC ACIDS RESEARCH

Direct and specific inactivation of protein tyrosine kinases in the Src and FGFR families by reversible cysteine oxidation

(2009) D. J. Kemble et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Profiling protein thiol oxidation in tumor cells using sulfenic acid-specific antibodies

(2009) Y. H. Seo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fragmentation of intra-peptide and inter-peptide disulfide bonds of proteolytic peptides by nanoESI collision-induced dissociation

(2008) Michael Mormann et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Thiol-Based Redox Switches in Eukaryotic Proteins

(2008) Nicolas Brandes et al.   ANTIOXIDANTS & REDOX SIGNALING

A Dynamic Pathway for Calcium-Independent Activation of CaMKII by Methionine Oxidation

(2008) Jeffrey R. Erickson et al.   CELL

Polo-like kinase-1 is activated by aurora A to promote checkpoint recovery

(2008) Libor Macůrek et al.   NATURE

Database resources of the National Center for Biotechnology Information

(2008) E. W. Sayers et al.   NUCLEIC ACIDS RESEARCH