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Mechanism of Action of TiO2: Recommendations to Reduce Uncertainties Related to Carcinogenic Potential

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Adverse outcome pathways as a tool for the design of testing strategies to support the safety assessment of emerging advanced materials at the nanoscale

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The hazards and risks of inhaled poorly soluble particles – where do we stand after 30 years of research?

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Different effects of titanium dioxide nanoparticles instillation in young and adult mice on DNA methylation related with lung inflammation and fibrosis

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Pulmonary toxicity in rats following inhalation exposure to poorly soluble particles: The issue of impaired clearance and the relevance for human health hazard and risk assessment

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Gene expression profiling in colon of mice exposed to food additive titanium dioxide (E171)

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Food-grade TiO2 impairs intestinal and systemic immune homeostasis, initiates preneoplastic lesions and promotes aberrant crypt development in the rat colon

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Food-grade titanium dioxide exposure exacerbates tumor formation in colitis associated cancer model

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Development of linear and threshold no significant risk levels for inhalation exposure to titanium dioxide using systematic review and mode of action considerations

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Relevance of the rat lung tumor response to particle overload for human risk assessment—Update and interpretation of new data since ILSI 2000

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Inhalation of titanium dioxide induces endoplasmic reticulum stress-mediated autophagy and inflammation in mice

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Acute and subchronic oral toxicity studies in rats with nanoscale and pigment grade titanium dioxide particles

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Risk assessment strategies for nanoscale and fine-sized titanium dioxide particles: Recognizing hazard and exposure issues

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Lung carcinogenicity of inhaled multi-walled carbon nanotube in rats

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Development of a new multi-walled carbon nanotube (MWCNT) aerosol generation and exposure system and confirmation of suitability for conducting a single-exposure inhalation study of MWCNT in rats

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Titanium dioxide nanoparticles: a review of current toxicological data

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(2013) David B. Warheit   TOXICOLOGY LETTERS

TiO2 photocatalysis: Design and applications

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Alveolar Type II Cells Possess the Capability of Initiating Lung Tumor Development

(2012) Chuwen Lin et al.   PLoS One

Evidence for type II cells as cells of origin of K-Ras-induced distal lung adenocarcinoma

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Differential Mouse Pulmonary Dose and Time Course Responses to Titanium Dioxide Nanospheres and Nanobelts

(2012) Dale W. Porter et al.   TOXICOLOGICAL SCIENCES

Pulmonary response to surface-coated nanotitanium dioxide particles includes induction of acute phase response genes, inflammatory cascades, and changes in microRNAs: A toxicogenomic study

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Genotoxicity of inhaled nanosized TiO2 in mice

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Adverse outcome pathways: A conceptual framework to support ecotoxicology research and risk assessment

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Proliferative and Nonproliferative Lesions of the Rat and Mouse Respiratory Tract

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