Heterogeneity, inherent and acquired drug resistance in patient-derived organoid models of primary liver cancer

Discoidin domain receptor 1 promotes hepatocellular carcinoma progression through modulation of SLC1A5 and the mTORC1 signaling pathway

(2022) Yonglong Pan et al.   CELLULAR ONCOLOGY

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2021) Hyuna Sung et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Isolated cancer stem cells from human liver cancer: morphological and functional characteristics in primary culture

(2021) M. Hu et al.   Clinical & Translational Oncology

A positive feedback loop between Periostin and TGFβ1 induces and maintains the stemness of hepatocellular carcinoma cells via AP-2α activation

(2021) Gang Chen et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Nivolumab Versus Regorafenib in Patients With Hepatocellular Carcinoma After Sorafenib Failure

(2021) Yuan-Hung Kuo et al.   Frontiers in Oncology

Trends in cancer mortality in China from 2004 to 2018: A nationwide longitudinal study

(2021) Dongming Jiang et al.   Cancer Communications

Identification of an Immune-Related Prognostic Gene CLEC5A Based on Immune Microenvironment and Risk Modeling of Ovarian Cancer

(2021) Jiacheng Shen et al.   Frontiers in Cell and Developmental Biology

Recapitulating Cholangiopathy-Associated Necroptotic Cell Death In Vitro Using Human Cholangiocyte Organoids

(2021) Shaojun Shi et al.   Cellular and Molecular Gastroenterology and Hepatology

Uncovering biological factors that regulate hepatocellular carcinoma growth using patient derived xenograft assays

(2020) Min Zhu et al.   HEPATOLOGY

Hedgehog signaling promotes sorafenib resistance in hepatocellular carcinoma patient-derived organoids

(2020) Siqi Wang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Optogenetic control of mRNA localization and translation in live cells

(2020) Na Yeon Kim et al.   NATURE CELL BIOLOGY

Human Hepatic Cancer Stem Cells (HCSCs) Markers Correlated With Immune Infiltrates Reveal Prognostic Significance of Hepatocellular Carcinoma

(2020) Xiaopu Sang et al.   Frontiers in Genetics

Differential effectiveness of tyrosine kinase inhibitors in 2D/3D culture according to cell differentiation, p53 status and mitochondrial respiration in liver cancer cells

(2020) María A. Rodríguez-Hernández et al.   Cell Death & Disease

Haprolid Inhibits Tumor Growth of Hepatocellular Carcinoma through Rb/E2F and Akt/mTOR Inhibition

(2020) Jun Xing et al.   Cancers

hnRNPU Functions as a Novel Therapeutic Target of c‐Myc in the Progression of Hepatocellular Carcinoma

(2020) Biao Zhang et al.   FEBS LETTERS

TP53INP2 Modulates Epithelial-to-Mesenchymal Transition via the GSK-3β/β-Catenin/Snail1 Pathway in Bladder Cancer Cells

(2020) Zhengtao Zhou et al.   OncoTargets and Therapy

Translation of Human β-Actin mRNA is Regulated by mTOR Pathway

(2019) Irina Eliseeva et al.   Genes

Blocking TREM-1+ Tumor-associated macrophages induced by hypoxia reverses immunosuppression and anti-PD-L1 resistance in liver cancer

(2019) Qinchuan Wu et al.   HEPATOLOGY

The Dual PI3K/mTOR Pathway Inhibitor GDC-0084 Achieves Antitumor Activity in PIK3CA-Mutant Breast Cancer Brain Metastases

(2019) Franziska M. Ippen et al.   CLINICAL CANCER RESEARCH

Contribution of Hepatitis B Virus Infection to the Aggressiveness of Primary Liver Cancer: A Clinical Epidemiological Study in Eastern China

(2019) Fan Yang et al.   Frontiers in Oncology

Targeting mechanoresponsive proteins in pancreatic cancer: 4-hydroxyacetophenone blocks dissemination and invasion by activating MYH14

(2019) Alexandra Surcel et al.   CANCER RESEARCH

DEPTOR induces a partial epithelial-to-mesenchymal transition and metastasis via autocrine TGFβ1 signaling and is associated with poor prognosis in hepatocellular carcinoma

(2019) Jin Chen et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Overriding adaptive resistance to sorafenib via combination therapy with SHP2 blockade in hepatocellular carcinoma

(2019) Carmen Oi Ning Leung et al.   HEPATOLOGY

Phenformin-Induced Mitochondrial Dysfunction Sensitizes Hepatocellular Carcinoma for Dual Inhibition of mTOR

(2018) Sónia R. Veiga et al.   CLINICAL CANCER RESEARCH

MCM6 promotes metastasis of hepatocellular carcinoma via MEK/ERK pathway and serves as a novel serum biomarker for early recurrence

(2018) Mingyu Liu et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Identification of the tumour transition states occurring during EMT

(2018) Ievgenia Pastushenko et al.   NATURE

Organoid Models of Human Liver Cancers Derived from Tumor Needle Biopsies

(2018) Sandro Nuciforo et al.   Cell Reports

LncRNA CRNDE promotes the epithelial‐mesenchymal transition of hepatocellular carcinoma cells via enhancing the Wnt/β‐catenin signaling pathway

(2018) Liying Zhu et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

EMT Transition States during Tumor Progression and Metastasis

(2018) Ievgenia Pastushenko et al.   TRENDS IN CELL BIOLOGY

Current status and perspectives of patient-derived xenograft models in cancer research

(2017) Yunxin Lai et al.   Journal of Hematology & Oncology

Human primary liver cancer–derived organoid cultures for disease modeling and drug screening

(2017) Laura Broutier et al.   NATURE MEDICINE

Knockdown of RRS1 by lentiviral-mediated RNAi promotes apoptosis and suppresses proliferation of human hepatocellular carcinoma cells

(2017) Jitao Wang et al.   ONCOLOGY REPORTS

Patient-derived xenograft mouse models of pseudomyxoma peritonei recapitulate the human inflammatory tumor microenvironment

(2016) Murali R. Kuracha et al.   Cancer Medicine

Keratin 19, a Cancer Stem Cell Marker in Human Hepatocellular Carcinoma

(2015) T. Kawai et al.   CLINICAL CANCER RESEARCH

Tumour initiating cells and IGF/FGF signalling contribute to sorafenib resistance in hepatocellular carcinoma

(2015) Victoria Tovar et al.   GUT

StringTie enables improved reconstruction of a transcriptome from RNA-seq reads

(2015) Mihaela Pertea et al.   NATURE BIOTECHNOLOGY

HISAT: a fast spliced aligner with low memory requirements

(2015) Daehwan Kim et al.   NATURE METHODS

Trimmomatic: a flexible trimmer for Illumina sequence data

(2014) Anthony M. Bolger et al.   BIOINFORMATICS

Alternative Mammalian Target of Rapamycin (mTOR) Signal Activation in Sorafenib-resistant Hepatocellular Carcinoma Cells Revealed by Array-based Pathway Profiling

(2014) Mari Masuda et al.   MOLECULAR & CELLULAR PROTEOMICS

A new transcriptional role for matrix metalloproteinase-12 in antiviral immunity

(2014) David J Marchant et al.   NATURE MEDICINE

Gene expression profiling-derived immunohistochemistry signature with high prognostic value in colorectal carcinoma

(2013) Wenjun Chang et al.   GUT

Effect of Antiviral Treatment With Nucleotide/Nucleoside Analogs on Postoperative Prognosis of Hepatitis B Virus–Related Hepatocellular Carcinoma: A Two-Stage Longitudinal Clinical Study

(2013) Jianhua Yin et al.   JOURNAL OF CLINICAL ONCOLOGY

Claudin-1 as a promoter of EMT in hepatocellular carcinoma

(2013) J Stebbing et al.   ONCOGENE

Streaming fragment assignment for real-time analysis of sequencing experiments

(2012) Adam Roberts et al.   NATURE METHODS

Fast gapped-read alignment with Bowtie 2

(2012) Ben Langmead et al.   NATURE METHODS

Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks

(2012) Cole Trapnell et al.   Nature Protocols

Differential expression analysis of multifactor RNA-Seq experiments with respect to biological variation

(2012) Davis J. McCarthy et al.   NUCLEIC ACIDS RESEARCH

NGS QC Toolkit: A Toolkit for Quality Control of Next Generation Sequencing Data

(2012) Ravi K. Patel et al.   PLoS One

Sorafenib in Advanced Hepatocellular Carcinoma

(2008) Josep M. Llovet et al.   NEW ENGLAND JOURNAL OF MEDICINE