GABAergic Interneurons in Seizures: Investigating Causality With Optogenetics

Holographic imaging and photostimulation of neural activity

(2018) Weijian Yang et al.   CURRENT OPINION IN NEUROBIOLOGY

Optogenetic dissection of roles of specific cortical interneuron subtypes in GABAergic network synchronization

(2018) Andrew S. Bohannon et al.   JOURNAL OF PHYSIOLOGY-LONDON

Brief activation of GABAergic interneurons initiates the transition to ictal events through post-inhibitory rebound excitation

(2018) Michael Chang et al.   NEUROBIOLOGY OF DISEASE

Update on the mechanisms and roles of high-frequency oscillations in seizures and epileptic disorders

(2017) Premysl Jiruska et al.   EPILEPSIA

Interneuronal Network Activity at the Onset of Seizure-Like Events in Entorhinal Cortex Slices

(2017) Laura Librizzi et al.   JOURNAL OF NEUROSCIENCE

Optogenetic Low-Frequency Stimulation of Specific Neuronal Populations Abates Ictogenesis

(2017) Zahra Shiri et al.   JOURNAL OF NEUROSCIENCE

Fully integrated silicon probes for high-density recording of neural activity

(2017) James J. Jun et al.   NATURE

Dynamic, Cell-Type-Specific Roles for GABAergic Interneurons in a Mouse Model of Optogenetically Inducible Seizures

(2017) Sattar Khoshkhoo et al.   NEURON

Depolarized GABAergic Signaling in Subicular Microcircuits Mediates Generalized Seizure in Temporal Lobe Epilepsy

(2017) Yi Wang et al.   NEURON

GABAergic networks jump-start focal seizures

(2016) Marco de Curtis et al.   EPILEPSIA

The antiepileptic and ictogenic effects of optogenetic neurostimulation of PV-expressing interneurons

(2016) Fadi Assaf et al.   JOURNAL OF NEUROPHYSIOLOGY

GABAergic Interneurons in the Neocortex: From Cellular Properties to Circuits

(2016) Robin Tremblay et al.   NEURON

Convulsive seizures from experimental focal cortical dysplasia occur independently of cell misplacement

(2016) Lawrence S. Hsieh et al.   Nature Communications

The ictal wavefront is the spatiotemporal source of discharges during spontaneous human seizures

(2016) Elliot H. Smith et al.   Nature Communications

Interneuron activity leads to initiation of low-voltage fast-onset seizures

(2015) Zahra Shiri et al.   ANNALS OF NEUROLOGY

Single unit action potentials in humans and the effect of seizure activity

(2015) Edward M. Merricks et al.   BRAIN

GABAergic inhibition shapes interictal dynamics in awake epileptic mice

(2015) Sarah Feldt Muldoon et al.   BRAIN

Seizure reduction through interneuron-mediated entrainment using low frequency optical stimulation

(2015) Thomas P. Ladas et al.   EXPERIMENTAL NEUROLOGY

Selective activation of parvalbumin- or somatostatin-expressing interneurons triggers epileptic seizurelike activity in mouse medial entorhinal cortex

(2015) Latefa Yekhlef et al.   JOURNAL OF NEUROPHYSIOLOGY

The Contribution of Raised Intraneuronal Chloride to Epileptic Network Activity

(2015) H. Alfonsa et al.   JOURNAL OF NEUROSCIENCE

Parvalbumin-Positive Inhibitory Interneurons Oppose Propagation But Favor Generation of Focal Epileptiform Activity

(2015) M. Sessolo et al.   JOURNAL OF NEUROSCIENCE

Principles of connectivity among morphologically defined cell types in adult neocortex

(2015) X. Jiang et al.   SCIENCE

Initiation, Propagation, and Termination of Partial (Focal) Seizures

(2015) Marco de Curtis et al.   Cold Spring Harbor Perspectives in Medicine

Physiological sharp wave-ripples and interictal events in vitro: what’s the difference?

(2014) Mária R. Karlócai et al.   BRAIN

Seizure Suppression by High Frequency Optogenetic Stimulation Using In Vitro and In Vivo Animal Models of Epilepsy

(2014) Chia-Chu Chiang et al.   Brain Stimulation

Global Optogenetic Activation of Inhibitory Interneurons during Epileptiform Activity

(2014) M. Ledri et al.   JOURNAL OF NEUROSCIENCE

Excitatory Effects of Parvalbumin-Expressing Interneurons Maintain Hippocampal Epileptiform Activity via Synchronous Afterdischarges

(2014) T. J. Ellender et al.   JOURNAL OF NEUROSCIENCE

Chemical–genetic attenuation of focal neocortical seizures

(2014) Dennis Kätzel et al.   Nature Communications

Inhibition of inhibition in visual cortex: the logic of connections between molecularly distinct interneurons

(2013) Carsten K Pfeffer et al.   NATURE NEUROSCIENCE

Neocortical Somatostatin-Expressing GABAergic Interneurons Disinhibit the Thalamorecipient Layer 4

(2013) Han Xu et al.   NEURON

On-demand optogenetic control of spontaneous seizures in temporal lobe epilepsy

(2013) Esther Krook-Magnuson et al.   Nature Communications

Transition to Seizure: Ictal Discharge Is Preceded by Exhausted Presynaptic GABA Release in the Hippocampal CA3 Region

(2012) Z. J. Zhang et al.   JOURNAL OF NEUROSCIENCE

Cortical inhibition, pH and cell excitability in epilepsy: what are optimal targets for antiepileptic interventions?

(2012) Ivan Pavlov et al.   JOURNAL OF PHYSIOLOGY-LONDON

Fast spiking interneuron control of seizure propagation in a cortical slice model of focal epilepsy

(2012) Mario Cammarota et al.   JOURNAL OF PHYSIOLOGY-LONDON

Closed-loop optogenetic control of thalamus as a tool for interrupting seizures after cortical injury

(2012) Jeanne T Paz et al.   NATURE NEUROSCIENCE

Pyramidal cells accumulate chloride at seizure onset

(2012) Kyle P. Lillis et al.   NEUROBIOLOGY OF DISEASE

How inhibition influences seizure propagation

(2012) Andrew J. Trevelyan et al.   NEUROPHARMACOLOGY

Optogenetic and Potassium Channel Gene Therapy in a Rodent Model of Focal Neocortical Epilepsy

(2012) R. C. Wykes et al.   Science Translational Medicine

Evidence of an inhibitory restraint of seizure activity in humans

(2012) Catherine A. Schevon et al.   Nature Communications

GABAergic drugs in the treatment of epilepsy: modern or outmoded?

(2011) Marco Mula   Future Medicinal Chemistry

State-Dependent Function of Neocortical Chandelier Cells

(2011) A. R. Woodruff et al.   JOURNAL OF NEUROSCIENCE

A disinhibitory microcircuit for associative fear learning in the auditory cortex

(2011) Johannes J. Letzkus et al.   NATURE

Glutamatergic pre-ictal discharges emerge at the transition to seizure in human epilepsy

(2011) Gilles Huberfeld et al.   NATURE NEUROSCIENCE

A Resource of Cre Driver Lines for Genetic Targeting of GABAergic Neurons in Cerebral Cortex

(2011) Hiroki Taniguchi et al.   NEURON

Interictal spikes: Harbingers or causes of epilepsy?

(2011) Kevin J. Staley et al.   NEUROSCIENCE LETTERS

GABAergic synchronization in the limbic system and its role in the generation of epileptiform activity

(2011) Massimo Avoli et al.   PROGRESS IN NEUROBIOLOGY

The K+-Cl−cotransporter KCC2 promotes GABAergic excitation in the mature rat hippocampus

(2010) Tero Viitanen et al.   JOURNAL OF PHYSIOLOGY-LONDON

Regulation of cortical microcircuits by unitary GABA-mediated volume transmission

(2009) Szabolcs Oláh et al.   NATURE

Dendritic encoding of sensory stimuli controlled by deep cortical interneurons

(2009) Masanori Murayama et al.   NATURE

Parvalbumin neurons and gamma rhythms enhance cortical circuit performance

(2009) Vikaas S. Sohal et al.   NATURE

Driving fast-spiking cells induces gamma rhythm and controls sensory responses

(2009) Jessica A. Cardin et al.   NATURE

Interneurons hyperpolarize pyramidal cells along their entire somatodendritic axis

(2008) Lindsey L Glickfeld et al.   NATURE NEUROSCIENCE

Petilla terminology: nomenclature of features of GABAergic interneurons of the cerebral cortex

(2008)   NATURE REVIEWS NEUROSCIENCE