Thiazole in the targeted anticancer drug discovery

In vitro antioxidant activity of thiazolidinone derivatives of 1,3-thiazole and 1,3,4-thiadiazole

(2018) Mirjana Djukic et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Nanoparticles in Cancer Treatment: Opportunities and Obstacles

(2018) Rajendra Awasthi et al.   CURRENT DRUG TARGETS

Synthesis, molecular modeling studies and evaluation of antifungal activity of a novel series of thiazole derivatives

(2018) Cleudiomar Inácio Lino et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, anticancer activity and mechanism of action of new thiazole derivatives

(2018) Temístocles Italo de Santana et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and biological evaluation of 4-amino-5-cinnamoylthiazoles as chalcone-like anticancer agents

(2018) Adileh Ayati et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and biological evaluation of new coumarins bearing 2,4-diaminothiazole-5-carbonyl moiety

(2018) Adileh Ayati et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and evaluation of thiazolidinone–pyrazole conjugates as anticancer and antimicrobial agents

(2018) Mahima Bhat et al.   Future Medicinal Chemistry

New thiazolyl-coumarin hybrids: Design, synthesis, characterization, X-ray crystal structure, antibacterial and antiviral evaluation

(2018) Hasnah Osman et al.   JOURNAL OF MOLECULAR STRUCTURE

Clinical Pharmacokinetics and Pharmacodynamics of Dabrafenib

(2018) Alicja Puszkiel et al.   CLINICAL PHARMACOKINETICS

Overcoming ABC transporter-mediated multidrug resistance: The dual role of tyrosine kinase inhibitors as multitargeting agents

(2017) Giovanni Luca Beretta et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of piperazine-based thiazolidinones as VEGFR2 tyrosine kinase inhibitors inducing apoptosis

(2017) Mostafa MM El-Miligy et al.   Future Medicinal Chemistry

Synthesis and antitumor activity of novel N-(5-benzyl-4-(tert-butyl)thiazol-2-yl)-2-(piperazin-1-yl)acetamides

(2017) Zhilin Wu et al.   RESEARCH ON CHEMICAL INTERMEDIATES

Anti-liver cancer activity in vitro and in vivo induced by 2-pyridyl 2,3-thiazole derivatives

(2017) Thiago David dos Santos Silva et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

RITA Mimics: Synthesis and Mechanistic Evaluation of Asymmetric Linked Trithiazoles

(2017) Adrian L. Pietkiewicz et al.   ACS Medicinal Chemistry Letters

Antitumor and immunomodulatory activities of thiosemicarbazones and 1,3-Thiazoles in Jurkat and HT-29 cells

(2016) Thiago André R. dos Santos et al.   BIOMEDICINE & PHARMACOTHERAPY

Synthesis, antitumor activity and mechanism of action of novel 1,3-thiazole derivatives containing hydrazide–hydrazone and carboxamide moiety

(2016) Haifeng He et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Dasatinib: A Review in Chronic Myeloid Leukaemia and Ph+ Acute Lymphoblastic Leukaemia

(2016) Gillian M. Keating   DRUGS

Recent advances of cytotoxic chalconoids targeting tubulin polymerization: Synthesis and biological activity

(2016) Hassan Mirzaei et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

1-Piperazinylphthalazines as potential VEGFR-2 inhibitors and anticancer agents: Synthesis and in vitro biological evaluation

(2016) Sahar M. Abou-Seri et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and anticancer effects evaluation of 1-alkyl-3-(6-(2-methoxy-3-sulfonylaminopyridin-5-yl)benzo[d]thiazol-2-yl)urea as anticancer agents with low toxicity

(2015) Xiao-Xiao Xie et al.   BIOORGANIC & MEDICINAL CHEMISTRY

2-(3′-Indolyl)-N-arylthiazole-4-carboxamides: Synthesis and evaluation of antibacterial and anticancer activities

(2015) Mukund P. Tantak et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Identification and optimisation of 4,5-dihydrobenzo[1,2-d:3,4-d]bisthiazole and 4,5-dihydrothiazolo[4,5-h]quinazoline series of selective phosphatidylinositol-3 kinase alpha inhibitors

(2015) Robin A. Fairhurst et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Identification and optimisation of a 4′,5-bisthiazole series of selective phosphatidylinositol-3 kinase alpha inhibitors

(2015) Robin A. Fairhurst et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Thiazole: A promising heterocycle for the development of potent CNS active agents

(2015) Chandra Bhushan Mishra et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design and optimization of hybrid of 2,4-diaminopyrimidine and arylthiazole scaffold as anticancer cell proliferation and migration agents

(2015) Wenbo Zhou et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Recent applications of 1,3-thiazole core structure in the identification of new lead compounds and drug discovery

(2015) Adile Ayati et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Discovery, Development, and SAR of Aminothiazoles as LIMK Inhibitors with Cellular Anti-Invasive Properties

(2015) Mark D. Charles et al.   JOURNAL OF MEDICINAL CHEMISTRY

CRISPR-Cas9–based target validation for p53-reactivating model compounds

(2015) Michael Wanzel et al.   Nature Chemical Biology

Preparation and optimization of new 4-(2-(indolin-1-yl)-2-oxoethyl)-2-morpholinothiazole-5-carboxylic acid and amide derivatives as potent and selective PI3Kβ inhibitors

(2014) Victor Certal et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and biological evaluation of compounds which contain pyrazole, thiazole and naphthalene ring as antitumor agents

(2014) Ji-Wen Yuan et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Efficacy of biological agents in metastatic triple-negative breast cancer

(2014) Annalisa Bramati et al.   CANCER TREATMENT REVIEWS

Novel Inhibitors of the MDM2-p53 Interaction Featuring Hydrogen Bond Acceptors as Carboxylic Acid Isosteres

(2014) Ana Z. Gonzalez et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of N-{5-[3-(3-hydroxypiperidin-1-yl)-1,2,4-oxadiazol-5-yl]-4-methyl-1,3-thiazol-2-yl}acetamide (TASP0415914) as an orally potent phosphoinositide 3-kinase γ inhibitor for the treatment of inflammatory diseases

(2013) Yusuke Oka et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Discovery of NVP-BYL719 a potent and selective phosphatidylinositol-3 kinase alpha inhibitor selected for clinical evaluation

(2013) Pascal Furet et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis of some new 2-(3-pyridyl)-4,5-disubstituted thiazoles as potent antimicrobial agents

(2013) Samir Bondock et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, structure–activity relationship and biological evaluation of 2,4,5-trisubstituted pyrimidine CDK inhibitors as potential anti-tumour agents

(2013) Hao Shao et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and biological evaluation of 3-(trimethoxyphenyl)-2(3H)-thiazole thiones as combretastatin analogs

(2013) Mandana Banimustafa et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Novel thiazole derivatives: a patent review (2008 – 2012; Part 1)

(2013) Alberto Leoni et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Development of Highly Potent and Selective Diaminothiazole Inhibitors of Cyclin-Dependent Kinases

(2013) Ernst Schonbrunn et al.   JOURNAL OF MEDICINAL CHEMISTRY

Autocrine functions of VEGF in breast tumor cells

(2013) Martine Perrot-Applanat et al.   Cell Adhesion & Migration

Indeno[1,2-b]indole derivatives as a novel class of potent human protein kinase CK2 inhibitors

(2012) Claas Hundsdörfer et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and biological evaluation of 2-substituted-4-(3′,4′,5′-trimethoxyphenyl)-5-aryl thiazoles as anticancer agents

(2012) Romeo Romagnoli et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Molecular hybridization of bioactives: Synthesis and antitubercular evaluation of novel dibenzofuran embodied homoisoflavonoids via Baylis–Hillman reaction

(2012) Thirumal Yempala et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery and optimization of a series of 2-aminothiazole-oxazoles as potent phosphoinositide 3-kinase γ inhibitors

(2012) Yusuke Oka et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Modulation of cofilin phosphorylation by inhibition of the Lim family kinases

(2012) Liqi He et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Development of isoform selective PI3-kinase inhibitors as pharmacological tools for elucidating the PI3K pathway

(2012) Ian Bruce et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A Small Molecule Inhibitor of Ubiquitin-Specific Protease-7 Induces Apoptosis in Multiple Myeloma Cells and Overcomes Bortezomib Resistance

(2012) Dharminder Chauhan et al.   CANCER CELL

Discovery of Specific Inhibitors of Human USP7/HAUSP Deubiquitinating Enzyme

(2012) Céline Reverdy et al.   CHEMISTRY & BIOLOGY

Discovery and Optimization of a Series of 2-Aryl-4-Amino-5-(3′,4′,5′-trimethoxybenzoyl)Thiazoles as Novel Anticancer Agents

(2012) Romeo Romagnoli et al.   JOURNAL OF MEDICINAL CHEMISTRY

Role of VEGF/VEGFR in the pathogenesis of leukemias and as treatment targets (Review)

(2012) GUANHUA SONG et al.   ONCOLOGY REPORTS

An Overview of Tubulin Inhibitors That Interact with the Colchicine Binding Site

(2012) Yan Lu et al.   PHARMACEUTICAL RESEARCH

Synthesis, molecular docking and evaluation of thiazolyl-pyrazoline derivatives as EGFR TK inhibitors and potential anticancer agents

(2011) Peng-Cheng Lv et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

1-[(2-Arylthiazol-4-yl)methyl]azoles as a New Class of Anticonvulsants: Design, Synthesis, In vivo Screening, and In silico Drug-like Properties

(2011) Nematollah Ahangar et al.   Chemical Biology & Drug Design

Activity-Based Chemical Proteomics Accelerates Inhibitor Development for Deubiquitylating Enzymes

(2011) Mikael Altun et al.   CHEMISTRY & BIOLOGY

Thiazolyl N-benzyl-substituted acetamide derivatives: Synthesis, Src kinase inhibitory and anticancer activities

(2011) Asal Fallah-Tafti et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

One-pot synthesis and biological evaluation of 2-pyrrolidinyl-4-amino-5-(3′,4′,5′-trimethoxybenzoyl)thiazole: A unique, highly active antimicrotubule agent

(2011) Romeo Romagnoli et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Convergent Synthesis and Biological Evaluation of 2-Amino-4-(3′,4′,5′-trimethoxyphenyl)-5-aryl Thiazoles as Microtubule Targeting Agents

(2011) Romeo Romagnoli et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, molecular modeling, and biological evaluation of cinnamic acid metronidazole ester derivatives as novel anticancer agents

(2010) Yong Qian et al.   BIOORGANIC & MEDICINAL CHEMISTRY

2-Anilino-4-aryl-1,3-thiazole inhibitors of valosin-containing protein (VCP or p97)

(2010) Matthew G. Bursavich et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Autocrine VEGF Signaling Synergizes with EGFR in Tumor Cells to Promote Epithelial Cancer Development

(2010) Beate M. Lichtenberger et al.   CELL

Synthesis and biological evaluation of 2-phenylthiazole-4-carboxamide derivatives as anticancer agents

(2010) Alireza Aliabadi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

LIM kinases are required for invasive path generation by tumor and tumor-associated stromal cells

(2010) Rebecca W. Scott et al.   JOURNAL OF CELL BIOLOGY

Design, Synthesis, and Evaluation of 2-Methyl- and 2-Amino-N-aryl-4,5-dihydrothiazolo[4,5-h]quinazolin-8-amines as Ring-Constrained 2-Anilino-4-(thiazol-5-yl)pyrimidine Cyclin-Dependent Kinase Inhibitors

(2010) Neil A. McIntyre et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis and biological evaluation of thiazolidinone derivatives as potential EGFR and HER-2 kinase inhibitors

(2009) Peng-Cheng Lv et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis of 4-benzyl-1,3-thiazole derivatives as potential anti-inflammatory agents: An analogue-based drug design approach

(2009) Ritesh N. Sharma et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

2-Arylamino-4-Amino-5-Aroylthiazoles. “One-Pot” Synthesis and Biological Evaluation of a New Class of Inhibitors of Tubulin Polymerization

(2009) Romeo Romagnoli et al.   JOURNAL OF MEDICINAL CHEMISTRY

A diaminocyclohexyl analog of SNS-032 with improved permeability and bioavailability properties

(2008) Ingrid C. Choong et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Apoptosis and non-apoptotic deaths in cancer development and treatment response

(2008) Elza C. de Bruin et al.   CANCER TREATMENT REVIEWS

Protein Kinase CK2 in Human Diseases

(2008) Barbara Guerra et al.   CURRENT MEDICINAL CHEMISTRY

AAA ATPase p97/VCP: cellular functions, disease and therapeutic potential

(2008) Neeraj Vij   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE