Article
Nutrition & Dietetics
Katie L. Whytock, Sam O. Shepherd, Matt Cocks, Anton J. M. Wagenmakers, Juliette A. Strauss
Summary: The study found that short-term high-fat, high-calorie diets did not significantly impact insulin sensitivity, metabolic flexibility, or arterial stiffness in young healthy males and females. There were differences in fat distribution between males and females, with males showing a more significant increase in trunk to leg fat mass ratio.
EUROPEAN JOURNAL OF NUTRITION
(2021)
Article
Neurosciences
Marija Sajic, Amy E. Rumora, Anish A. Kanhai, Giacomo Dentoni, Sharlini Varatharajah, Caroline Casey, Ryan D. R. Brown, Fabian Peters, Lucy M. Hinder, Masha G. Savelieff, Eva L. Feldman, Kenneth J. Smith
Summary: Peripheral neuropathy (PN) is a common complication in patients with prediabetes and Type 2 diabetes (T2D) and is often associated with dyslipidemia and mitochondrial dysfunction. Studies on a high-fat diet mouse model of prediabetes showed that dyslipidemia led to reduced mitochondrial membrane potential and impaired nerve impulse conduction. These results suggest that mitochondrial dysfunction may contribute to the pathogenesis of PN in prediabetes.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Behavioral Sciences
Hendrik Hartmann, Lieneke K. Janssen, Nadine Herzog, Filip Morys, Daniel Fangstrom, Sean J. Fallon, Annette Horstmann
Summary: Animal studies suggest that a high-fat/high-sugar diet can affect dopamine signal transmission in the brain, leading to maladaptive behavior and decision-making. This study aimed to investigate the association between diet and dopamine-dependent cognition in humans, and the influence of genetic variations on this association. The findings did not support any significant differences in cognition or neural activation between the low fat/sugar and high fat/sugar diet groups, nor an interaction with specific genetic variants.
Article
Endocrinology & Metabolism
Kirsi-Marja Zitting, Ramalingam Vetrivelan, Robin K. Yuan, Nina Vujovic, Wei Wang, Sathyajit S. Bandaru, Stuart F. Quan, Elizabeth B. Klerman, Frank A. J. L. Scheer, Orfeu M. Buxton, Jonathan S. Williams, Jeanne F. Duffy, Clifford B. Saper, Charles A. Czeisler
Summary: This study examines the effects of circadian disruption on metabolism in both mice and humans. The results show that circadian disruption, even in the absence of significant sleep loss, has a negative impact on glucose metabolism in individuals consuming a high-fat diet. Reducing dietary fat intake may help protect against the metabolic consequences of chronic circadian disruption.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2022)
Article
Biochemistry & Molecular Biology
Xiaojing Wei, Chuanfei Wei, Yutian Tan, Ximing Dong, Zhao Yang, Jianqun Yan, Xiao Luo
Summary: This study aimed to determine the regulation of NAD+-related enzymes in the liver and their relationships with glucose and lipid metabolism. It was found that both high-fat diet feeding and calorie restriction increased hepatic NAD+ levels and the expression of related genes. In addition, high-fat diet feeding and calorie restriction had different effects on hepatic lipogenesis and gluconeogenesis. These findings highlight the importance of hepatic NAD+ metabolism in maintaining metabolic flexibility.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Article
Environmental Sciences
Yong-Wei Xiong, Lu-Lu Tan, Jin Zhang, Hua-Long Zhu, Xin-Mei Zheng, Wei Chang, Lan Gao, Tian Wei, De-Xiang Xu, Hua Wang
Summary: This study investigated the combined effects of high-fat diet (HFD) and environmental cadmium (Cd) exposure on sperm quality and its m6A-dependent mechanism. The results demonstrated that co-exposure to HFD and Cd led to a significant decrease in the number of mature testicular seminiferous tubules and epididymis sperm quantity in mice. Additionally, the expression of genes and proteins related to spermatogenesis was altered, and the degradation of Stra8 was mediated by m6A-YTHDF2 in an ROS-dependent manner.
ENVIRONMENTAL POLLUTION
(2022)
Article
Biochemistry & Molecular Biology
Marija Pinteric, Iva I. Podgorski, Marijana Popovic Hadzija, Ivana Tartaro Bujak, Ana Tadijan, Tihomir Balog, Sandra Sobocanec
Summary: This study found that high fat diet can lead to weight gain, increased expression of NAFLD and oxidative stress-inducing genes, and impaired response of antioxidative system in mice with ovariectomy and Sirt3 depletion. Ovariectomy increases Sirt3 and fatty acid synthesis, maintains mitochondrial function, and decreases levels of lipid hydroperoxides, providing protection against harmful effects of high fat diet.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Physiology
Evan M. Zeitler, J. Charles Jennette, Jennifer E. Flythe, Ronald J. Falk, John S. Poulton
Summary: This study on zebrafish shows that a high-calorie diet, regardless of fat content, can lead to kidney pathology, but these changes can be reversed after 4 weeks of calorie restriction.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Matteo Serano, Cecilia Paolini, Antonio Michelucci, Laura Pietrangelo, Flavia A. Guarnier, Feliciano Protasi
Summary: A high-fat diet may increase the susceptibility of wild type mice to heat stress, resulting in increased heat production and oxidative stress in skeletal muscles, as well as enhanced sensitivity to temperature and caffeine in isolated muscles.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Food Science & Technology
Qian Liu, Jie Fang, Wenqi Huang, Sining Liu, Xueting Zhang, Guiping Gong, Linjuan Huang, Xiaoliang Lin, Zhongfu Wang
Summary: This study investigated the effects of konjac glucomannan with different molecular weights on high-fat and high-fructose diet-induced obese mice. The results showed that konjac glucomannan with higher molecular weight reduced body weight and improved insulin resistance. It also inhibited lipid accumulation in the liver by regulating gene expression. Furthermore, konjac glucomannan at different molecular weights caused changes in gut microbial diversity. These findings provide a scientific basis for the development and utilization of konjac resources.
FOOD RESEARCH INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Laura L. Koekkoek, Margo Slomp, Julien Castel, Michael Mutersbaugh, Ian Linville, Mireille J. Serlie, Serge H. Luquet, Susanne E. la Fleur
Summary: Research shows that glutamatergic neurons in the lateral hypothalamus can differentiate between low-calorie sweeteners and caloric sweeteners, and consuming a high fat diet disrupts their ability to detect calories.
Article
Food Science & Technology
Luis Crisostomo, Romeu A. Videira, Ivana Jarak, Kristina Starcevic, Tomislav Masek, Luis Rato, Joao F. Raposo, Rachel L. Batterham, Pedro F. Oliveira, Marco G. Alves
Summary: Exposure to a high-fat diet in early life can result in abnormal testicular metabolism and impaired sperm parameters up to two generations later in mice. The study also found that descendants of HFD-exposed mice showed a shift towards a pro-inflammatory environment in the testicles, potentially leading to a decrease in sperm counts.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Article
Biology
Nianyi Zeng, Fan Wu, Junqi Lu, Xiang Li, Shaomei Lin, Lang Zhou, Zhongwei Wang, Guangyan Wu, Qingfa Huang, Daowen Zheng, Jie Gao, Shan Wu, Xiaojiao Chen, Muxuan Chen, Fanguo Meng, Haitao Shang, Yan He, Peng Chen, Hong Wei, Zhuang Li, Hongwei Zhou
Summary: Gut barrier disruption is a key event linking gut microbiota dysbiosis and metabolic disorders caused by a high-fat diet. In this study, it was found that a high-fat diet instantly altered the gut microbiota composition and damaged the gut barrier. The high-fat diet induced gut microbiota to produce reactive oxygen species (ROS), which could be transferred to germ-free mice, leading to downregulation of gut barrier tight junctions. The study suggests that extracellular ROS derived from gut microbiota play a pivotal role in high-fat diet-induced gut barrier disruption and have potential as a therapeutic target for metabolic diseases.
SCIENCE CHINA-LIFE SCIENCES
(2023)
Article
Endocrinology & Metabolism
Cheng Lin, YanYan Lin, Ji Luo, JunRu Yu, YaNi Cheng, XiaoYun Wu, Lin Lin, YuanShao Lin
Summary: The study demonstrated that maternal consumption of a high-fat diet during pregnancy and lactation had multigenerational effects on hippocampal synaptic plasticity and cognitive function in male offspring. Central insulin resistance may play a crucial role in the link between maternal diet and cognitive impairment across generations.
Article
Biochemistry & Molecular Biology
Thuy T. P. Nguyen, Do-Young Kim, Yu-Geon Lee, Young-Seung Lee, Xuan T. Truong, Jae-Ho Lee, Dae-Kyu Song, Taeg Kyu Kwon, So-Hyun Park, Chang Hwa Jung, Changjong Moon, Timothy F. Osborne, Seung-Soon Im, Tae-Il Jeon
Summary: The study demonstrates that high-fat-diet induced SREBP-1c impairs autophagic lipid catabolism by altering H2S signaling, leading to hepatic lipid accumulation. This mechanism involves the reduction of CSE via miR-216a, which decreases hepatic H2S levels and sulfhydration-dependent activation of ULK1, contributing to the pathogenesis of NAFLD. The findings highlight a 2-fold mechanism for SREBP-1c-driven hepatic lipid accumulation through regulation of lipid biosynthesis and degradation.
Article
Endocrinology & Metabolism
Jeroen H. P. M. van der Velde, Sebastiaan C. Boone, Esther Winters-van Eekelen, Matthijs K. C. Hesselink, Vera B. Schrauwen-Hinderling, Patrick Schrauwen, Hildo J. Lamb, Frits R. Rosendaal, Renee de Mutsert
Summary: This study found that the number of breaks in sedentary time was not associated with lower liver fat content or reduced insulin resistance. However, engaging in moderate-to-vigorous physical activity in the afternoon or evening was associated with a reduction of up to 25% in insulin resistance. Further research should investigate whether the timing of physical activity also plays an important role in the occurrence of type 2 diabetes.
Review
Radiology, Nuclear Medicine & Medical Imaging
Paul R. Roos, Friso M. Rijnberg, Jos J. M. Westenberg, Hildo J. Lamb
Summary: This article systematically reviews the methods, clinical value, clinical applications, and current developments of particle tracing based on 4D Flow MRI. The results show that particle tracing methods often use an adaptive timestep, fourth order Runge-Kutta integration method, and linear interpolation in the time dimension. Particle tracing is applied in various cardiovascular areas. Further studies are needed to evaluate the clinical value of this technique in different cardiovascular diseases.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Letter
Hematology
Nicolas Stumpe, Tuba Gueden-Silber, Rebekka Schneckmann, Katharina Wolters, Hildo Lamb, Maria Grandoch, Ulrich Floegel
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Biology
Romana Perinajova, Concepcion Borras Alvarez-Cuevas, Joe Juffermans, Jos Westenberg, Hildo Lamb, Sasa Kenjeres
Summary: There is an urgent need to establish new biomarkers for predicting the development of thoracic aortic aneurysm. In addition to hemodynamics, the roles of oxygen and nitric oxide in the pathogenesis of thoracic aortic aneurysm are potentially significant. The relationship between aneurysm presence and species distribution in both the lumen and aortic wall needs to be understood. Computational fluid dynamics can be used to explore this relationship.
COMPUTERS IN BIOLOGY AND MEDICINE
(2023)
Article
Endocrinology & Metabolism
Lushun Yuan, Ruifang Li-Gao, Aswin Verhoeven, Huub J. van Eyk, Maurice B. Bizino, Patrick C. N. Rensen, Martin Giera, Ingrid M. Jazet, Hildo J. Lamb, Ton J. Rabelink, Bernard M. van den Berg
Summary: This study aimed to investigate the association between changes in HDL composition and increased microvascular risk in individuals with type 2 diabetes mellitus. Differences in HDL composition were found between Dutch South Asian and Dutch white Caucasian individuals with diabetes, and these differences were associated with the incidence of microvascular complications. These HDL compositional differences could serve as ethnicity-specific biomarkers for type 2 diabetes.
DIABETES OBESITY & METABOLISM
(2023)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Hildo J. Lamb
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Ilona A. Dekkers, Hildo J. Lamb
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Mitch J. F. G. Ramaekers, Jos J. M. Westenberg, Max F. G. H. M. Venner, Joe F. Juffermans, Hans C. van Assen, Bastiaan J. C. te Kiefte, Bouke P. Adriaans, Hildo J. Lamb, Joachim E. Wildberger, Simon Schalla
Summary: This study compared the influence of static and multiphase segmentation methods on flow-related parameters in aortic 4D flow MRI and assessed the evolution of these parameters during systole. The results showed that static and multiphase segmentation yielded comparable results for flow-related parameters, eliminating the need for time-consuming multiple segmentations. However, multiphase quantification was necessary for assessing peak values of aortic flow-related parameters.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Review
Endocrinology & Metabolism
Marc Foretz, Bruno Guigas, Benoit Viollet
Summary: This Review presents the latest advances in understanding the mechanisms of action of metformin and discusses its potential repurposing for other indications. Metformin is currently the first-line medication for treating type 2 diabetes in most guidelines and is widely used by over 200 million patients. Its therapeutic action involves complex mechanisms that are not fully understood. Although the liver was initially identified as the main organ involved, increasing evidence suggests the involvement of other sites, including the gastrointestinal tract, gut microbial communities, and tissue-resident immune cells. The molecular mechanisms of metformin vary depending on the dose and duration of treatment, and recent studies have revealed a novel action on the lysosome surface at low concentrations. Considering its efficacy and safety in diabetes, attention has been given to using metformin as adjunct therapy for cancer, age-related diseases, inflammatory diseases, and COVID-19.
NATURE REVIEWS ENDOCRINOLOGY
(2023)
Review
Nutrition & Dietetics
Elske L. van den Burg, Petra G. van Peet, Marjolein P. Schoonakker, Dionysia E. van de Haar, Mattijs E. Numans, Hanno Pijl
Summary: This systematic review aims to summarize the effects of intermittent energy restriction (IER) and periodic fasting (PF) on patients with type 2 diabetes (T2D). The review found that IER and PF may improve glucose control in the short term and potentially reduce the need for medication dosage.
Article
Oncology
Rieneke T. Lugtenberg, Stefanie de Groot, Danny Houtsma, Vincent O. Dezentje, Annelie J. E. Vulink, Maarten J. Fischer, Johanneke E. A. Portielje, Jacobus J. M. van der Hoeven, Hans Gelderblom, Hanno Pijl, Judith R. Kroep
Summary: Docetaxel, an anti-cancer agent, can cause hypersensitivity reactions and fluid retention. High-dose corticosteroids, such as dexamethasone, have been used to reduce these adverse effects, but there is little evidence to support this practice and high doses of corticosteroids can have undesirable effects. This study aimed to evaluate the impact of reducing the dose of dexamethasone on the incidence of hypersensitivity reactions and fluid retention in patients with breast or prostate cancer.
Letter
Gastroenterology & Hepatology
Artemiy Kovynev, Zhixiong Ying, Joost M. Lambooij, Hendrik J. P. van der Zande, Bruno Guigas, Patrick C. N. Rensen, Milena Schonke
JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Joe F. Juffermans, Jos J. M. Westenberg, Pieter J. van den Boogaard, Hildo J. Lamb
Summary: This case study examines the effects of aging on aortic hemodynamics and dilation. The results show that aging has marginal effects on aortic hemodynamic parameters and diameter. Furthermore, the study suggests that the rate of aortic dilation remains constant as individuals age.
EUROPEAN HEART JOURNAL-CASE REPORTS
(2023)
Article
Cardiac & Cardiovascular Systems
Michelle Feijen, Meindert Palmen, Hildo J. Lamb, Eleonora P. M. Corssmit, Maria Louisa Antoni
Summary: This is a case report of an intracardiac paraganglioma in a male patient with an SDHD mutation. The presence of the paraganglioma was confirmed using multiple imaging modalities, and surgical removal was recommended to reduce the risk. The surgery was successful without any complications, and histological examination confirmed the diagnosis of a paraganglioma. Therefore, screening and the use of multiple imaging modalities prior to surgery are of major importance.
EUROPEAN HEART JOURNAL-CASE REPORTS
(2023)
Article
Cardiac & Cardiovascular Systems
Tjerry Hut, Arno Roest, Duco Gaillard, Mark Hazekamp, Pieter van den Boogaard, Hildo Lamb, Lucia Kroft, Monique Jongbloed, Jos Westenberg, Jolanda Wentzel, Friso Rijnberg, Sasa Kenjeres
Summary: Virtual expansion of Fontan conduits from 16 mm to 24-32 mm based on patient-specific flow significantly improves TCPC efficiency, while thrombosis risk remains low.
INTERDISCIPLINARY CARDIOVASCULAR AND THORACIC SURGERY
(2023)