Interferon regulatory factor 4 (IRF4) controls myeloid-derived suppressor cell (MDSC) differentiation and function

Soluble NKG2D ligand promotes MDSC expansion and skews macrophage to the alternatively activated phenotype

(2015) Gang Xiao et al.   Journal of Hematology & Oncology

IFN Regulatory Factor 8 Represses GM-CSF Expression in T Cells To Affect Myeloid Cell Lineage Differentiation

(2015) Amy V. Paschall et al.   JOURNAL OF IMMUNOLOGY

Id1 suppresses anti-tumour immune responses and promotes tumour progression by impairing myeloid cell maturation

(2015) Marianna Papaspyridonos et al.   Nature Communications

Dual mechanisms by which miR-125b represses IRF4 to induce myeloid and B-cell leukemias

(2014) A. Y.-L. So et al.   BLOOD

Transcription factor IRF8 plays a critical role in the development of murine basophils and mast cells

(2014) H. Sasaki et al.   BLOOD

IRF4 at the crossroads of effector T-cell fate decision

(2014) Magdalena Huber et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Phenotypes, accumulation, and functions of myeloid-derived suppressor cells and associated treatment strategies in cancer patients

(2014) Jingwei Jiang et al.   HUMAN IMMUNOLOGY

Proinflammatory S100 Proteins Regulate the Accumulation of Myeloid-Derived Suppressor Cells

(2014) P. Sinha et al.   JOURNAL OF IMMUNOLOGY

Subsets of Myeloid-Derived Suppressor Cells in Tumor-Bearing Mice

(2014) J.-I. Youn et al.   JOURNAL OF IMMUNOLOGY

IRF4 in Dendritic Cells Inhibits IL-12 Production and Controls Th1 Immune Responses against Leishmania major

(2014) M. Akbari et al.   JOURNAL OF IMMUNOLOGY

Pancreatic Cancer Cells Isolated from Muc1-Null Tumors Favor the Generation of a Mature Less Suppressive MDSC Population

(2014) Amritha Kidiyoor et al.   Frontiers in Immunology

Myeloid derived suppressor cells in physiological and pathological conditions: the good, the bad, and the ugly

(2013) Paolo Serafini   IMMUNOLOGIC RESEARCH

Myeloid-derived suppressor cell development is regulated by a STAT/IRF-8 axis

(2013) Jeremy D. Waight et al.   JOURNAL OF CLINICAL INVESTIGATION

Stimulation of Osteoclast Formation by RANKL Requires Interferon Regulatory Factor-4 and Is Inhibited by Simvastatin in a Mouse Model of Bone Loss

(2013) Yoshiki Nakashima et al.   PLoS One

Prostaglandin E2 Suppresses Antifungal Immunity by Inhibiting Interferon Regulatory Factor 4 Function and Interleukin-17 Expression in T Cells

(2012) Patricia A. Valdez et al.   IMMUNITY

Myeloid-derived suppressor cells are implicated in regulating permissiveness for tumor metastasis during mouse gestation

(2011) Laetitia A. Mauti et al.   JOURNAL OF CLINICAL INVESTIGATION

Simvastatin Inhibits IFN Regulatory Factor 4 Expression and Th17 Cell Differentiation in CD4+ T Cells Derived from Patients with Multiple Sclerosis

(2011) X. Zhang et al.   JOURNAL OF IMMUNOLOGY

Shared and Distinct Functions of the Transcription Factors IRF4 and IRF8 in Myeloid Cell Development

(2011) Michio Yamamoto et al.   PLoS One

Cooperation between deficiencies of IRF-4 and IRF-8 promotes both myeloid and lymphoid tumorigenesis

(2010) S.-H. Jo et al.   BLOOD

Regulation of immunity and oncogenesis by the IRF transcription factor family

(2010) David Savitsky et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Early exposure of high-dose interleukin-4 to tumor stroma reverses myeloid cell-mediated T-cell suppression

(2010) J Jiang et al.   GENE THERAPY

Interleukin-4 induced interferon regulatory factor (Irf) 4 participates in the regulation of alternative macrophage priming

(2010) Carol El Chartouni et al.   IMMUNOBIOLOGY

Stat 6-Dependent Induction of Myeloid Derived Suppressor Cells After Physical Injury Regulates Nitric Oxide Response to Endotoxin

(2009) Veronica Munera et al.   ANNALS OF SURGERY

Roles of PU.1 in monocyte- and mast cell-specific gene regulation: PU.1 transactivates CIITA pIV in cooperation with IFN- 

(2009) T. Ito et al.   INTERNATIONAL IMMUNOLOGY

The IRF Family Transcription Factors in Immunity and Oncogenesis

(2008) Tomohiko Tamura et al.   Annual Review of Immunology

Identification of discrete tumor-induced myeloid-derived suppressor cell subpopulations with distinct T cell-suppressive activity

(2008) K. Movahedi et al.   BLOOD

Arginine regulation by myeloid derived suppressor cells and tolerance in cancer: mechanisms and therapeutic perspectives

(2008) Paulo C. Rodríguez et al.   IMMUNOLOGICAL REVIEWS

Untangling the Complex Web of IL-4- and IL-13-Mediated Signaling Pathways

(2008) M. Wills-Karp et al.   Science Signaling