A saturated map of common genetic variants associated with human height

Portability of 245 polygenic scores when derived from the UK Biobank and applied to 9 ancestry groups from the same cohort

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Assessing the contribution of rare variants to complex trait heritability from whole-genome sequence data

(2022) Pierrick Wainschtein et al.   NATURE GENETICS

The sequences of 150,119 genomes in the UK Biobank

(2022) Bjarni V. Halldorsson et al.   NATURE

Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program

(2021) Daniel Taliun et al.   NATURE

Quantifying genetic heterogeneity between continental populations for human height and body mass index

(2021) Jing Guo et al.   Scientific Reports

Why are rare variants hard to impute? Coalescent models reveal theoretical limits in existing algorithms

(2021) Yichen Si et al.   GENETICS

Long-read sequencing of 3,622 Icelanders provides insight into the role of structural variants in human diseases and other traits

(2021) Doruk Beyter et al.   NATURE GENETICS

The distribution of common-variant effect sizes

(2021) Luke J. O’Connor   NATURE GENETICS

Protein-coding repeat polymorphisms strongly shape diverse human phenotypes

(2021) Ronen E. Mukamel et al.   SCIENCE

The power of genetic diversity in genome-wide association studies of lipids

(2021) Sarah E. Graham et al.   NATURE

Exome sequencing and analysis of 454,787 UK Biobank participants

(2021) Joshua D. Backman et al.   NATURE

Probabilistic inference of the genetic architecture underlying functional enrichment of complex traits

(2021) Marion Patxot et al.   Nature Communications

Incorporating functional priors improves polygenic prediction accuracy in UK Biobank and 23andMe data sets

(2021) Carla Márquez-Luna et al.   Nature Communications

Ancestry deconvolution and partial polygenic score can improve susceptibility predictions in recently admixed individuals

(2020) Davide Marnetto et al.   Nature Communications

Theoretical and empirical quantification of the accuracy of polygenic scores in ancestry divergent populations

(2020) Ying Wang et al.   Nature Communications

The GTEx Consortium atlas of genetic regulatory effects across human tissues

(2020)   SCIENCE

LDpred2: better, faster, stronger

(2020) Florian Privé et al.   BIOINFORMATICS

Clinical use of current polygenic risk scores may exacerbate health disparities

(2019) Alicia R. Martin et al.   NATURE GENETICS

Polygenic prediction via Bayesian regression and continuous shrinkage priors

(2019) Tian Ge et al.   Nature Communications

Polygenic adaptation on height is overestimated due to uncorrected stratification in genome-wide association studies

(2019) Mashaal Sohail et al.   eLife

Reduced signal for polygenic adaptation of height in UK Biobank

(2019) Jeremy J Berg et al.   eLife

Analysis of polygenic risk score usage and performance in diverse human populations

(2019) L. Duncan et al.   Nature Communications

Improved polygenic prediction by Bayesian multiple regression on summary statistics

(2019) Luke R. Lloyd-Jones et al.   Nature Communications

The great hairball gambit

(2019) Jonathan Flint et al.   PLoS Genetics

Multi-trait analysis of genome-wide association summary statistics using MTAG

(2018) Patrick Turley et al.   NATURE GENETICS

Integrative analysis of omics summary data reveals putative mechanisms underlying complex traits

(2018) Yang Wu et al.   Nature Communications

Identifying gene targets for brain-related traits using transcriptomic and methylomic data from blood

(2018) Ting Qi et al.   Nature Communications

Meta-analysis of genome-wide association studies for height and body mass index in ∼700000 individuals of European ancestry

(2018) Loic Yengo et al.   HUMAN MOLECULAR GENETICS

Estimating cross-population genetic correlations of causal effect sizes

(2018) Kevin J. Galinsky et al.   GENETIC EPIDEMIOLOGY

The UK Biobank resource with deep phenotyping and genomic data

(2018) Clare Bycroft et al.   NATURE

Rare and low-frequency coding variants alter human adult height

(2017) Eirini Marouli et al.   NATURE

Linkage disequilibrium–dependent architecture of human complex traits shows action of negative selection

(2017) Steven Gazal et al.   NATURE GENETICS

Statistical correction of the Winner’s Curse explains replication variability in quantitative trait genome-wide association studies

(2017) Cameron Palmer et al.   PLoS Genetics

RVTESTS: an efficient and comprehensive tool for rare variant association analysis using sequence data: Table 1.

(2016) Xiaowei Zhan et al.   BIOINFORMATICS

Next-generation genotype imputation service and methods

(2016) Sayantan Das et al.   NATURE GENETICS

Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets

(2016) Zhihong Zhu et al.   NATURE GENETICS

Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores

(2015) Bjarni J. Vilhjálmsson et al.   AMERICAN JOURNAL OF HUMAN GENETICS

A global reference for human genetic variation

(2015) Richard A. Gibbs et al.   NATURE

Partitioning heritability by functional annotation using genome-wide association summary statistics

(2015) Hilary K Finucane et al.   NATURE GENETICS

An atlas of genetic correlations across human diseases and traits

(2015) Brendan Bulik-Sullivan et al.   NATURE GENETICS

LD Score regression distinguishes confounding from polygenicity in genome-wide association studies

(2015) Brendan K Bulik-Sullivan et al.   NATURE GENETICS

Biological interpretation of genome-wide association studies using predicted gene functions

(2015) Tune H. Pers et al.   Nature Communications

MAGMA: Generalized Gene-Set Analysis of GWAS Data

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RAREMETAL: fast and powerful meta-analysis for rare variants

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Fast and accurate imputation of summary statistics enhances evidence of functional enrichment

(2014) Bogdan Pasaniuc et al.   BIOINFORMATICS

Defining the role of common variation in the genomic and biological architecture of adult human height

(2014) Andrew R Wood et al.   NATURE GENETICS

Quality control and conduct of genome-wide association meta-analyses

(2014) Thomas W Winkler et al.   Nature Protocols

Estimating and interpreting FST: The impact of rare variants

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Synthesizing genome-wide association studies and expression microarray reveals novel genes that act in the human growth plate to modulate height

(2012) Julian C. Lui et al.   HUMAN MOLECULAR GENETICS

Multiple enhancers associated with ACAN suggest highly redundant transcriptional regulation in cartilage

(2012) Gui Hu et al.   MATRIX BIOLOGY

Conditional and joint multiple-SNP analysis of GWAS summary statistics identifies additional variants influencing complex traits

(2012) Jian Yang et al.   NATURE GENETICS

Genome partitioning of genetic variation for complex traits using common SNPs

(2011) Jian Yang et al.   NATURE GENETICS

GCTA: A Tool for Genome-wide Complex Trait Analysis

(2010) Jian Yang et al.   AMERICAN JOURNAL OF HUMAN GENETICS

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(2010) Kiran Musunuru et al.   Circulation-Cardiovascular Genetics

Integrating common and rare genetic variation in diverse human populations

(2010)   NATURE

Hundreds of variants clustered in genomic loci and biological pathways affect human height

(2010) Hana Lango Allen et al.   NATURE

Common SNPs explain a large proportion of the heritability for human height

(2010) Jian Yang et al.   NATURE GENETICS

Bias-reduced estimators and confidence intervals for odds ratios in genome-wide association studies

(2008) H. Zhong et al.   BIOSTATISTICS