Extracellular fluid viscosity enhances cell migration and cancer dissemination

Membrane ruffling is a mechanosensor of extracellular fluid viscosity

(2022) Matthew Pittman et al.   Nature Physics

Noninvasive Cancer Diagnosis In Vivo Based on a Viscosity-Activated Near-Infrared Fluorescent Probe

(2021) Junling Yin et al.   ANALYTICAL CHEMISTRY

Neuropathy-causing TRPV4 mutations disrupt TRPV4-RhoA interactions and impair neurite extension

(2021) Brett A. McCray et al.   Nature Communications

Hydraulic resistance induces cell phenotypic transition in confinement

(2021) Runchen Zhao et al.   Science Advances

The fluid shear stress sensor TRPM7 regulates tumor cell intravasation

(2021) Christopher L. Yankaskas et al.   Science Advances

Collective durotaxis along a self-generated stiffness gradient in vivo

(2021) Adam Shellard et al.   NATURE

Dorsoventral polarity directs cell responses to migration track geometries

(2020) Emily O. Wisniewski et al.   Science Advances

The Effects of Stiffness, Fluid Viscosity, and Geometry of Microenvironment in Homeostasis, Aging, and Diseases: A Brief Review

(2020) Seungman Park et al.   JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME

The importance of water and hydraulic pressure in cell dynamics

(2020) Yizeng Li et al.   JOURNAL OF CELL SCIENCE

A microfluidic cell-migration assay for the prediction of progression-free survival and recurrence time of patients with glioblastoma

(2020) Bin Sheng Wong et al.   Nature Biomedical Engineering

Nuclear positioning facilitates amoeboid migration along the path of least resistance

(2019) Jörg Renkawitz et al.   NATURE

A microfluidic assay for the quantification of the metastatic propensity of breast cancer specimens

(2019) Christopher L. Yankaskas et al.   Nature Biomedical Engineering

Cell sensing and decision-making in confinement: The role of TRPM7 in a tug of war between hydraulic pressure and cross-sectional area

(2019) Runchen Zhao et al.   Science Advances

Tissue Architectural Cues Drive Organ Targeting of Tumor Cells in Zebrafish

(2019) Colin D. Paul et al.   Cell Systems

Confinement hinders motility by inducing RhoA-mediated nuclear influx, volume expansion, and blebbing

(2019) Panagiotis Mistriotis et al.   JOURNAL OF CELL BIOLOGY

On the energy efficiency of cell migration in diverse physical environments

(2019) Yizeng Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fate-mapping post-hypoxic tumor cells reveals a ROS-resistant phenotype that promotes metastasis

(2019) Inês Godet et al.   Nature Communications

Extracellular fluid viscosity enhances liver cancer cell mechanosensing and migration

(2018) Jordi Gonzalez-Molina et al.   BIOMATERIALS

Transition from Actin-Driven to Water-Driven Cell Migration Depends on External Hydraulic Resistance

(2018) Yizeng Li et al.   BIOPHYSICAL JOURNAL

Piezo2 channel regulates RhoA and actin cytoskeleton to promote cell mechanobiological responses

(2018) Carlos Pardo-Pastor et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The TRPV4 channel links calcium influx to DDX3X activity and viral infectivity

(2018) P. Doñate-Macián et al.   Nature Communications

TrackMate: An open and extensible platform for single-particle tracking

(2017) Jean-Yves Tinevez et al.   METHODS

Super-resolution microscopy with DNA-PAINT

(2017) Joerg Schnitzbauer et al.   Nature Protocols

FMNL formins boost lamellipodial force generation

(2017) Frieda Kage et al.   Nature Communications

Focal Adhesion–Independent Cell Migration

(2016) Ewa K. Paluch et al.   Annual Review of Cell and Developmental Biology

Force Feedback Controls Motor Activity and Mechanical Properties of Self-Assembling Branched Actin Networks

(2016) Peter Bieling et al.   CELL

Transcript-level expression analysis of RNA-seq experiments with HISAT, StringTie and Ballgown

(2016) Mihaela Pertea et al.   Nature Protocols

VRACs and other ion channels and transporters in the regulation of cell volume and beyond

(2016) Thomas J. Jentsch   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Confinement Sensing and Signal Optimization via Piezo1/PKA and Myosin II Pathways

(2016) Wei-Chien Hung et al.   Cell Reports

Confinement and Low Adhesion Induce Fast Amoeboid Migration of Slow Mesenchymal Cells

(2015) Yan-Jun Liu et al.   CELL

Feedback regulation through myosin II confers robustness on RhoA signalling at E-cadherin junctions

(2015) Rashmi Priya et al.   NATURE CELL BIOLOGY

Water Permeation Drives Tumor Cell Migration in Confined Microenvironments

(2014) Kimberly M. Stroka et al.   CELL

Simulation of Interstitial Fluid Flow in Ligaments: Comparison among Stokes, Brinkman and Darcy Models

(2013) Wei Yao et al.   International Journal of Biological Sciences

Physical confinement alters tumor cell adhesion and migration phenotypes

(2012) Eric M. Balzer et al.   FASEB JOURNAL

Cell mechanics control rapid transitions between blebs and lamellipodia during migration

(2012) M. Bergert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Imaging Intracellular pH in Live Cells with a Genetically Encoded Red Fluorescent Protein Sensor

(2011) Mathew Tantama et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Role of YAP/TAZ in mechanotransduction

(2011) Sirio Dupont et al.   NATURE

Moesin1 and Ve-cadherin are required in endothelial cells during in vivo tubulogenesis

(2010) Y. Wang et al.   DEVELOPMENT

Ultra-rapid activation of TRPV4 ion channels by mechanical forces applied to cell surface β1 integrins

(2010) Benjamin D. Matthews et al.   Integrative Biology

Myosin II contributes to cell-scale actin network treadmilling through network disassembly

(2010) Cyrus A. Wilson et al.   NATURE

Anillin Is a Scaffold Protein That Links RhoA, Actin, and Myosin during Cytokinesis

(2008) Alisa J. Piekny et al.   CURRENT BIOLOGY

Traction stress in focal adhesions correlates biphasically with actin retrograde flow speed

(2008) Margaret L. Gardel et al.   JOURNAL OF CELL BIOLOGY

Functional coupling of TRPV4 cationic channel and large conductance, calcium-dependent potassium channel in human bronchial epithelial cell lines

(2008) José M. Fernández-Fernández et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

TRPV4 channel participates in receptor-operated calcium entry and ciliary beat frequency regulation in mouse airway epithelial cells

(2008) I. M. Lorenzo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA