Article
Pharmacology & Pharmacy
Christine N. Habib, Mohamed R. Mohamed, Mariane G. Tadros, Mai F. Tolba, Esther T. Menze, Somia Masoud
Summary: The study found that diosmin (DM) has neuroprotective effects in Parkinson's disease (PD) and can act through various mechanisms such as anti-inflammatory and antioxidative properties. These findings suggest that DM may be a promising candidate for managing the neuropathological course of PD.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Aya S. Sayed, Nesrine S. El Sayed, Barbara Budzynska, Krystyna Skalicka-Wozniak, Mariam K. Ahmed, Esraa A. Kandil
Summary: This study revealed the neuroprotective effect of xanthotoxin in a rotenone-induced PD model in rats, which could be attributed to its antioxidant, anti-inflammatory activities as well as its ability to maintain the function of the MAPK signaling pathway and attenuate apoptosis.
Article
Pharmacology & Pharmacy
Neha Sharma, Navneet Khurana, Arunachalam Muthuraman, Puneet Utreja
Summary: In this study, it was found that vanillic acid has anti-Parkinson's effects in rats induced with rotenone, reducing muscle rigidity and motor defects while lowering oxidative stress levels and providing neuroprotection for neurons.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Lu Zou, Zhen Che, Kun Ding, Chao Zhang, Xia Liu, Luman Wang, Aiping Li, Jianwei Zhou
Summary: Parkinson's disease (PD) is a rapidly growing neurodegenerative disease characterized by loss of dopaminergic neurons. The JWA gene has been shown to play a role in resisting aging, oxidative stress, and inflammation, and its activator JAC4 has potential for PD prevention. This study demonstrated that JAC4 improved motor dysfunction and dopaminergic neuron loss in mouse models, likely through reducing oxidative stress damage and inflammation activation.
Article
Behavioral Sciences
Ming Li, Shiying Luo, Ying Li, Yixian Li, Bo Ma, Feng Liu, Hongjie Wang, Jiguang Guo, Li Ling
Summary: It has been estimated that there will be 930 million Parkinson's disease (PD) patients in the world by 2030. However, no effective therapy for PD has been found so far, except for levodopa which only treats motor symptoms. Developing new drugs to slow down PD progression and improve patients' quality of life is therefore an urgent task. In this study, dyclonine, a commonly used local anesthetic with antioxidant activity, was found to improve motor ability and prevent loss of dopaminergic neurons in a PD model in fruit flies. It also upregulated the Nrf2/HO pathway, reduced ROS and MDA levels, and inhibited neuron apoptosis. Dyclonine may be a promising FDA-approved drug for further exploration in PD therapy.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Neurosciences
Shubhendu M. Shirgadwar, Rahul Kumar, Kumari Preeti, Dharmendra Kumar Khatri, Shashi Bala Singh
Summary: This study evaluated the neuroprotective potential of phloretin (PLT) in Parkinson's disease (PD) by modulating the autophagy-antioxidant axis. The results showed that PLT improved locomotive activity and anxiety-like behavior in mice, reduced apoptosis and α-Synuclein expression, and improved the expression of TH and antioxidant proteins. This study provides evidence for PLT as a potential disease-modifying drug for PD management.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Pharmacology & Pharmacy
Yingjie Han, Tian Wang, Chunyan Li, Zhenhua Wang, Yue Zhao, Jie He, Li Fu, Bing Han
Summary: The study demonstrates that ginsenoside Rg3 can significantly improve neuroprotective effects in rotenone-induced Parkinson's disease mice, manifested in enhanced motor function and regulation of oxidative stress.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Neurosciences
Jing-Yi He, Dai-Di Li, Qian Wen, Ting-Yang Qin, Hong Long, Shi-Bin Zhang, Feng Zhang
Summary: The etiology of Parkinson's disease (PD) is still unknown, but oxidative stress and neuroinflammation play a crucial role in its pathogenesis. This study found that lipopolysaccharide (LPS)-induced neuroinflammation and rotenone (ROT)-induced oxidative stress synergistically aggravated motor dysfunction, dopamine neuron damage, glial cell activation, release of related mediators, activation of Nrf2 signaling, and disruption of oxidative balance in the rat brain. Furthermore, oxidative stress followed by neuroinflammation caused more dopamine neuronal loss than neuroinflammation followed by oxidative stress.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Medicine, Research & Experimental
E. D. Kryl'skii, G. A. Razuvaev, T. N. Potapova, A. I. Akinina, L. E. Nihaev
Summary: The study found that rats with rotenone-induced parkinsonism exhibited dysfunction in the antioxidant system, leading to inhibition of the majority of antioxidant enzymes in the brain and blood serum, which may be attributed to the decompensation of oxidative stress under conditions of prolonged mitochondrial dysfunction. These changes significantly contribute to neuronal degeneration in the cerebral cortex and striatum, as well as motor disorders in experimental animals.
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Marika Cordaro, Sergio Modafferi, Ramona D'Amico, Roberta Fusco, Tiziana Genovese, Alessio Filippo Peritore, Enrico Gugliandolo, Rosalia Crupi, Livia Interdonato, Davide Di Paola, Daniela Impellizzeri, Salvatore Cuzzocrea, Vittorio Calabrese, Rosanna Di Paola, Rosalba Siracusa
Summary: By activating the NF-E2-related factor 2 (Nrf2)/heme oxygenase 1 (HO-1) redox system and increasing lipoxin A4, the combination of Hericium erinaceus and Coriolus versicolor fungi can modulate antioxidant stress and neuroinflammation, showing potential as a nutraceutical choice for preventing Parkinson's disease.
Article
Multidisciplinary Sciences
Richa Singh, Walia Zahra, Saumitra Sen Singh, Hareram Birla, Aaina Singh Rathore, Priyanka Kumari Keshri, Hagera Dilnashin, Shekhar Singh, Surya Pratap Singh
Summary: Major pathological features of Parkinson's disease (PD) include oxidative stress, alpha-synuclein aggregation, mitochondrial dysfunction, apoptosis of dopaminergic neurons, and downregulation of neurotrophic factors. Trophic factor-based neuroprotective medicines have been of interest for treating PD symptoms. Rotenone inhibits mitochondrial complex I, leading to ROS overproduction and alpha-synuclein aggregation. BDNF and TrkB interaction triggers neuronal cell development and differentiation through Akt and GSK-3 beta. The homeostasis of these signaling cascades is compromised in PD. Oleuropein (OLE) from olive leaves shows antioxidative properties and was found to be neuroprotective in a PD mouse model. OLE improved motor impairment, upregulated CREB regulation, phosphorylated Akt and GSK-3 beta, reduced mitochondrial dysfunction, and downregulated proapoptotic markers. OLE may be used as a therapeutic agent for PD by regulating BDNF/CREB/Akt signaling pathway.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Richard L. Jayaraj, Rami Beiram, Sheikh Azimullah, Nagoor M. F. Meeran, Shreesh K. Ojha, Abdu Adem, Fakhreya Yousuf Jalal
Summary: Parkinson's disease is characterized by the loss of dopaminergic neurons and dopamine in the striatum, with oxidative stress and neuroinflammation playing major roles in disease progression. The autophagy lysosome pathway is important for cellular homeostasis and dysfunction can lead to α-synuclein accumulation and neuron loss. Noscapine, traditionally used for cancer and stroke, shows neuroprotective effects in a PD rat model through anti-inflammatory, antioxidant, and anti-α-synuclein mechanisms. Further research is needed for noscapine as a potential therapeutic candidate for PD.
Article
Biochemistry & Molecular Biology
Sachin Kumar, Puneet Kumar
Summary: The study investigated the effect of rice bran extract on rotenone-induced neurotoxicity in rats, showing that it could prevent the adverse behavioral and biochemical changes induced by rotenone.
CURRENT MOLECULAR PHARMACOLOGY
(2021)
Article
Plant Sciences
Syeda Madiha, Zehra Batool, Sidrah Shahzad, Saiqa Tabassum, Laraib Liaquat, Asia Afzal, Sadia Sadir, Irfan Sajid, Bushra Jabeen Mehdi, Saara Ahmad, Saida Haider
Summary: This study investigated the effects of naringenin on a rotenone-induced PD model. The results showed that naringenin supplementation significantly reduced rotenone-induced motor and non-motor impairments, increased antioxidant enzyme activities, and restored changes in neurotransmitter levels.
PLANT FOODS FOR HUMAN NUTRITION
(2023)
Review
Chemistry, Medicinal
Claudia Bento-Pereira, Albena T. Dinkova-Kostova
Summary: Parkinson's disease is a progressive neurodegenerative disorder for which no disease-modifying therapies are available. Factors like age, genetic predisposition, and environmental stressors are known to increase the risk of developing PD. Activation of Nrf2 has shown to be beneficial in cellular and animal models of PD.
MEDICINAL RESEARCH REVIEWS
(2021)
Review
Biochemistry & Molecular Biology
Asif Ahmad Bhat, Gaurav Gupta, Obaid Afzal, Imran Kazmi, Fahad A. Al-Abbasi, Abdulmalik Saleh Alfawaz Altamimi, Waleed Hassan Almalki, Sami I. Alzarea, Sachin Kumar Singh, Kamal Dua
Summary: Risperidone, as an atypical antipsychotic, has been used off-label for treating behavioural and psychological symptoms of dementia, and has shown potential pharmacological interactions in various neurological diseases. However, more research is needed to determine its actual effectiveness and role in different diseases.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Review
Biochemistry & Molecular Biology
Manish Purohit, Gaurav Gupta, Obaid Afzal, Abdulmalik Saleh Alfawaz Altamimi, Sami I. Alzarea, Imran Kazmi, Waleed Hassan Almalki, Monica Gulati, Indu Pal Kaur, Sachin Kumar Singh, Kamal Dua
Summary: The JAK/STAT system is a crucial signaling pathway for the signal transduction of several key cytokines in sepsis. Activation of JAK kinases by cytokine-receptor binding leads to selective phosphorylation of STATs, which play a key role in gene transcription in the nucleus. The JAK/STAT pathway is involved in various biological activities, including hematopoiesis, immunological modulation, cell differentiation, and apoptosis. This review discusses the importance of the JAK/STAT signaling pathway in severe lung inflammation, which is a major public health concern worldwide.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Engineering, Chemical
Sami I. I. Alzarea, Sumera Qasim, Muhammad Afzal, Omar Awad Alsaidan, Hassan H. H. Alhassan, Metab Alharbi, Mohammed Alqinyah, Fahaad S. S. Alenazi
Summary: In this study, an anandamide reuptake inhibitor, VDM11, was selected as a potential candidate for managing post-COVID depression. The results revealed that VDM11 can attenuate neuroinflammation and directly target multiple genes associated with depressive symptoms. Molecular docking analysis showed that VDM11 interacts well with these target genes. The efficacy of VDM11 in alleviating depression was further demonstrated in an LPS-induced depression model. However, further pharmacological studies are required to validate these findings.
Article
Chemistry, Multidisciplinary
Khalid M. Alharthy, Hassan N. Althurwi, Faisal F. Albaqami, Ali Altharawi, Sami I. Alzarea, Fahad A. Al-Abbasi, Muhammad Shahid Nadeem, Imran Kazmi
Summary: This study aimed to investigate the anti-Parkinson's effect of barbigerone, a natural pyranoisoflavone possessing antioxidant activity, in a rotenone-induced rat model of PD. The results demonstrated that barbigerone attenuated rotenone-induced motor deficits and showed improvements in biochemical and neuroinflammatory parameters, suggesting its potential as a therapeutic agent against PD.
Article
Multidisciplinary Sciences
Muhammad Afzal, Khalid Saad Alharbi, Sami I. Alzarea, Najiah M. Alyamani, Imran Kazmi, Emine Gueven
Summary: Through the study of differentially expressed genes (DEGs) in human cortical neurons using non-negative matrix factorization (NMF), shared genes and relationships between Alzheimer's Disease (AD) and Type 2 diabetes (T2D) have been discovered, providing new directions for the treatment of these diseases.
Article
Chemistry, Analytical
Ali Altharawi, Safar M. Alqahtani, Sagar Suman Panda, Majed Alrobaian, Alhumaidi B. Alabbas, Waleed Hassan Almalki, Manal A. Alossaimi, Md. Abul Barkat, Rehan Abdur Rub, Shehla Nasar Mir Najib Ullah, Mahfoozur Rahman, Sarwar Beg
Summary: The study explores the therapeutic benefits of combining neratinib and naringenin for treating early-stage hormone-receptor-positive breast cancers. A validated UPLC-MS/MS method was developed for simultaneous estimation of the drugs in rat plasma. The green method has implications for clinical sample analysis and therapeutic drug monitoring (TDM).
Article
Chemistry, Analytical
Sherif A. Abdel-Gawad, Ali Altharawi
Summary: Monitoring and quantifying active pharmaceutical ingredients (APIs) in the environment is crucial for human health. This study successfully isolated and measured four commonly used fluoroquinolones in pharmaceutical industrial wastewater using capillary zone electrophoresis. Solid-phase extraction was used as an efficient sample pretreatment, and the assay was validated and applied to real wastewater samples.
Article
Polymer Science
Obaid Afzal, Abdulamalik S. A. Altamimi, Mubarak A. Alamri, Ali Altharawi, Manal A. Alossaimi, Md Sayeed Akhtar, Fauzia Tabassum, Waleed H. Almalki, Tanuja Singh
Summary: Natural anti-inflammatory nutraceuticals, such as resveratrol and chia seed oil, can help prevent the worsening of rheumatoid arthritis. This study developed and evaluated a resveratrol-loaded chia seed oil-based nanoemulsion gel for its potential therapeutic benefits in inflammatory arthritic conditions. The optimized gel formulation showed significant reversal of arthritic symptoms in rats, indicating increased topical bioavailability and balancing of pro-inflammatory mediators.
Review
Pathology
Md Sadique Hussain, Obaid Afzal, Gaurav Gupta, Abdulmalik Saleh Alfawaz Altamimi, Waleed Hassan Almalki, Sami I. Alzarea, Imran Kazmi, Neelima Kukreti, Saurabh Gupta, Kunjbihari Sulakhiya, Sachin Kumar Singh, Kamal Dua
Summary: Atherosclerosis, a chronic inflammatory disease, can be influenced by dysregulated lncRNAs that affect the NF-kB signaling pathway, potentially serving as therapeutic targets.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Review
Pathology
Riya Thapa, Obaid Afzal, Gaurav Gupta, Asif Ahmad Bhat, Waleed Hassan Almalki, Sami I. Alzarea, Imran Kazmi, Abdulmalik Saleh Alfawaz Altamimi, Vetriselvan Subramaniyan, Lakshmi Thangavelu, Sachin Kumar Singh, Kamal Dua
Summary: This review explores the interaction between long-chain non-coding RNAs (lncRNAs) and various signaling pathways in breast cancer, including AKT/PI3K/mTOR, Wnt/β-catenin, Notch, DNA damage response, TGF-beta, Hedgehog, and NF-κB. Specific lncRNAs have been found to influence the functioning of these pathways, playing a role in breast cancer development.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Health Care Sciences & Services
Abdulaziz Ibrahim Alzarea, Yusra Habib Khan, Abdullah Salah Alanazi, Nasser Hadal Alotaibi, Sami I. Alzarea, Ziyad Saeed Almalki, Saad S. Alqahtani, Tauqeer Hussain Mallhi
Summary: This study aimed to assess the involvement of community pharmacists in public health services in remote areas of Saudi Arabia, as well as the barriers they face and strategies to improve their role. The results showed that a majority of community pharmacists were involved in public health activities and were willing to provide these services. Education and awareness were found to be the most effective strategies to increase pharmacist involvement.
Article
Toxicology
Suman Rohilla, Mahaveer Singh, Sami I. Alzarea, Waleed Hassan Almalki, Fahad A. Al-Abbasi, Imran Kazmi, Obaid Afzal, Abdulmalik Saleh Alfawaz Altamimi, Sachin Kumar Singh, Dinesh Kumar Chellappan, Kamal Dua, Gaurav Gupta
Summary: Conventional therapies for lung cancer, such as radiation, surgery, and chemotherapy, often lead to undesirable side effects. The major challenge in developing new drug therapies for lung cancer is resistance, which involves mutations and disruptions in signaling pathways. This review article highlights the progress in developing molecularly targeted therapies for non-small cell lung cancer (NSCLC) by studying biomarkers such as EGFR, ALK, MET, ROS-1, KRAS, and B-RAF. However, resistance development limits the clinical benefits of these new drugs.
JOURNAL OF ENVIRONMENTAL PATHOLOGY TOXICOLOGY AND ONCOLOGY
(2023)
Article
Toxicology
Debjyoti Talukdar, Parveen Kumar, Deepak Sharma, Vishal M. Balaramnavar, Obaid Afzal, Abdulmalik Saleh Alfawaz Altamimi, Imran Kazmi, Fahad A. Al-Abbasi, Sami I. Alzarea, Gaurav Gupta, Madan Mohan Gupta
Summary: Phytochemical-based nanoformulations have the potential to treat drug-resistant cancer by delivering phytochemicals to the target site. They demonstrate improved cell cytotoxicity compared to single agents, synergistically inhibiting cancer cell growth through p53 apoptosis and increasing cell death. They also show promise in inhibiting cell proliferation and targeting protein kinase B (Akt)/mammalian target of rapamycin (mTOR) pathways. This review highlights the potential benefits of these nanoformulations in the clinical management of cancer patients, slowing disease progression and reducing chemotherapy-induced toxicities.
JOURNAL OF ENVIRONMENTAL PATHOLOGY TOXICOLOGY AND ONCOLOGY
(2023)
