Xanthotoxin modulates oxidative stress, inflammation, and MAPK signaling in a rotenone-induced Parkinson's disease model

Crosstalk between PI3K/AKT/KLF4 signaling and microglia M1/M2 polarization as a novel mechanistic approach towards flibanserin repositioning in parkinson's disease

(2022) Nancy K. El-Deeb et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Xanthotoxin and umbelliferone attenuate cognitive dysfunction in a streptozotocin-induced rat model of sporadic Alzheimer's disease: The role of JAK2/STAT3 and Nrf2/HO-1 signalling pathway modulation

(2020) Merhan O. Hindam et al.   PHYTOTHERAPY RESEARCH

Xanthotoxin reverses Parkinson’s disease-like symptoms in zebrafish larvae and mice models: a comparative study

(2020) Ewelina Kozioł et al.   Pharmacological Reports

Edaravone-caffeine combination for the effective management of rotenone induced Parkinson’s disease in rats: An evidence based affirmative from a comparative analysis of behavior and biomarker expression

(2019) Maria Bandookwala et al.   NEUROSCIENCE LETTERS

Scopolamine-Induced Memory Impairment Is Alleviated by Xanthotoxin: Role of Acetylcholinesterase and Oxidative Stress Processes

(2018) Krystyna Skalicka-Wozniak et al.   ACS Chemical Neuroscience

Neuroprotective effect of agmatine (decarboxylated l-arginine) against oxidative stress and neuroinflammation in rotenone model of Parkinson’s disease

(2018) E K El-Sayed et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

Xanthotoxin suppresses LPS-induced expression of iNOS, COX-2, TNF-α, and IL-6 via AP-1, NF-κB, and JAK-STAT inactivation in RAW 264.7 macrophages

(2017) Seung-Bin Lee et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

High BAX/BCL2 mRNA ratio predicts favorable prognosis in laryngeal squamous cell carcinoma, particularly in patients with negative lymph nodes at the time of diagnosis

(2016) Aris I. Giotakis et al.   CLINICAL BIOCHEMISTRY

Influence of xanthotoxin (8-methoxypsoralen) on the anticonvulsant activity of various novel antiepileptic drugs against maximal electroshock-induced seizures in mice

(2016) Mirosław Zagaja et al.   FITOTERAPIA

Role of neuroinflammation in neurodegenerative diseases (Review)

(2016) WEI-WEI CHEN et al.   Molecular Medicine Reports

In vivo modulation of the behavioral effects of nicotine by the coumarins xanthotoxin, bergapten, and umbelliferone

(2016) Barbara Budzynska et al.   PSYCHOPHARMACOLOGY

Phytic acid attenuates inflammatory responses and the levels of NF-κB and p-ERK in MPTP-induced Parkinson’s disease model of mice

(2015) Yuqiang Lv et al.   NEUROSCIENCE LETTERS

Parkinson’s disease-implicated kinases in the brain; insights into disease pathogenesis

(2014) Nicolas Dzamko et al.   Frontiers in Molecular Neuroscience

Anti-tumor effects of various furocoumarins isolated from the roots, seeds and fruits of Angelica and Cnidium species under ultraviolet A irradiation

(2013) Maho Sumiyoshi et al.   Journal of Natural Medicines

Neural and Immune Mechanisms in the Pathogenesis of Parkinson’s Disease

(2013) Fabio Blandini   Journal of Neuroimmune Pharmacology

Neuroinflammation and oxidative stress: Co-conspirators in the pathology of Parkinson’s disease

(2013) Juliet M. Taylor et al.   NEUROCHEMISTRY INTERNATIONAL

Nitric oxide synthase inhibitors protect against rotenone-induced, oxidative stress mediated parkinsonism in rats

(2013) K.S. Madathil et al.   NEUROCHEMISTRY INTERNATIONAL

p38MAPK/p53-Mediated Bax induction contributes to neurons degeneration in rotenone-induced cellular and rat models of Parkinson’s disease

(2013) Feng Wu et al.   NEUROCHEMISTRY INTERNATIONAL

Quercetin up-regulates mitochondrial complex-I activity to protect against programmed cell death in rotenone model of Parkinson’s disease in rats

(2013) S.S. Karuppagounder et al.   NEUROSCIENCE

Rotenone Directly Induces BV2 Cell Activation via the p38 MAPK Pathway

(2013) Feng Gao et al.   PLoS One

Contributions of central and systemic inflammation to the pathophysiology of Parkinson's disease

(2012) Louise M. Collins et al.   NEUROPHARMACOLOGY

Anti-inflammatory properties rather than anti-oxidant capability is the major mechanism of neuroprotection by sodium salicylate in a chronic rotenone model of Parkinson’s disease

(2012) P. Thakur et al.   NEUROSCIENCE

Kinases and kinase signaling pathways: Potential therapeutic targets in Parkinson's disease

(2012) Gang Wang et al.   PROGRESS IN NEUROBIOLOGY

Neuroinflammation is a key player in Parkinson’s disease and a prime target for therapy

(2010) Li Qian et al.   JOURNAL OF NEURAL TRANSMISSION

An experimental study on intracerebroventricular transplantation of human amniotic epithelial cells in a rat model of Parkinson's disease

(2010) Xinxin Yang et al.   NEUROLOGICAL RESEARCH

Activation of p38 MAPK in the substantia nigra leads to nuclear translocation of NF-κB in MPTP-treated mice: implication in Parkinson’s disease

(2009) S. Karunakaran et al.   JOURNAL OF NEUROCHEMISTRY

Neuroinflammation in Parkinson’s Disease

(2009) Jae-Kyung Lee et al.   Journal of Neuroimmune Pharmacology

Gene therapy using lactoferrin-modified nanoparticles in a rotenone-induced chronic Parkinson model

(2009) Rongqin Huang et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Small peptide inhibitor of JNKs protects against MPTP-induced nigral dopaminergic injury via inhibiting the JNK-signaling pathway

(2009) Jing Pan et al.   LABORATORY INVESTIGATION

Oxidative modifications, mitochondrial dysfunction, and impaired protein degradation in Parkinson's disease: how neurons are lost in the Bermuda triangle

(2009) Kristen A Malkus et al.   Molecular Neurodegeneration

Neuroinflammation in Parkinson's disease: Its role in neuronal death and implications for therapeutic intervention

(2009) Malú G. Tansey et al.   NEUROBIOLOGY OF DISEASE

Blockade of the translocation and activation of c-Jun N-terminal kinase 3 (JNK3) attenuates dopaminergic neuronal damage in mouse model of Parkinson's disease

(2009) Jing Pan et al.   NEUROCHEMISTRY INTERNATIONAL

Oxidative and Inflammatory Pathways in Parkinson’s Disease

(2008) Rebecca L. Miller et al.   NEUROCHEMICAL RESEARCH

α-Synuclein activates stress signaling protein kinases in THP-1 cells and microglia

(2006) Andis Klegeris et al.   NEUROBIOLOGY OF AGING