A dimer-monomer switch controls CHIP-dependent substrate ubiquitylation and processing

A heterotypic assembly mechanism regulates CHIP E3 ligase activity

(2022) Aniruddha Das et al.   EMBO JOURNAL

CHIP-dependent regulation of the actin cytoskeleton is linked to neuronal cell membrane integrity

(2021) Catarina Dias et al.   iScience

CHIP ubiquitylates NOXA and induces its lysosomal degradation in response to DNA damage

(2020) Marie-Christine Albert et al.   Cell Death & Disease

WormCat: An Online Tool for Annotation and Visualization of Caenorhabditis elegans Genome-Scale Data

(2019) Amy D. Holdorf et al.   GENETICS

Ubiquitylation Pathways In Insulin Signaling and Organismal Homeostasis

(2018) Vishnu Balaji et al.   BIOESSAYS

Most mutations that cause spinocerebellar ataxia autosomal recessive type 16 (SCAR16) destabilize the protein quality-control E3 ligase CHIP

(2018) Adam J. Kanack et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

UbiSite approach for comprehensive mapping of lysine and N-terminal ubiquitination sites

(2018) Vyacheslav Akimov et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

SWISS-MODEL: homology modelling of protein structures and complexes

(2018) Andrew Waterhouse et al.   NUCLEIC ACIDS RESEARCH

UbiSite approach for comprehensive mapping of lysine and N-terminal ubiquitination sites

(2018) Vyacheslav Akimov et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Disrupted structure and aberrant function of CHIP mediates the loss of motor and cognitive function in preclinical models of SCAR16

(2018) Chang-he Shi et al.   PLoS Genetics

The PRIDE database and related tools and resources in 2019: improving support for quantification data

(2018) Yasset Perez-Riverol et al.   NUCLEIC ACIDS RESEARCH

Symmetry breaking during homodimeric assembly activates an E3 ubiquitin ligase

(2017) Zhaofeng Ye et al.   Scientific Reports

CHIP as a membrane-shuttling proteostasis sensor

(2017) Yannick Kopp et al.   eLife

E2 enzymes: more than just middle men

(2016) Mikaela D Stewart et al.   CELL RESEARCH

The Perseus computational platform for comprehensive analysis of (prote)omics data

(2016) Stefka Tyanova et al.   NATURE METHODS

Structural insights into the catalysis and regulation of E3 ubiquitin ligases

(2016) Lori Buetow et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

WormExp: a web-based application for aCaenorhabditis elegans-specific gene expression enrichment analysis

(2015) Wentao Yang et al.   BIOINFORMATICS

ff14SB: Improving the Accuracy of Protein Side Chain and Backbone Parameters from ff99SB

(2015) James A. Maier et al.   Journal of Chemical Theory and Computation

Protein–Protein Interactions Modulate the Docking-Dependent E3-Ubiquitin Ligase Activity of Carboxy-Terminus of Hsc70-Interacting Protein (CHIP)

(2015) Vikram Narayan et al.   MOLECULAR & CELLULAR PROTEOMICS

A Bipartite Interaction between Hsp70 and CHIP Regulates Ubiquitination of Chaperoned Client Proteins

(2015) Huaqun Zhang et al.   STRUCTURE

Uncovering global SUMOylation signaling networks in a site-specific manner

(2014) Ivo A Hendriks et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Interaction of Glutaric Aciduria Type 1-Related glutaryl-CoA Dehydrogenase with Mitochondrial Matrix Proteins

(2014) Jessica Schmiesing et al.   PLoS One

The E3 Ligase CHIP: Insights into Its Structure and Regulation

(2014) Indranil Paul et al.   Biomed Research International

The ubiquitin proteasome system in Caenorhabditis elegans and its regulation

(2014) Nikoletta Papaevgeniou et al.   Redox Biology

The Ubiquitin Code

(2012) David Komander et al.   Annual Review of Biochemistry

Structural Insights into the Conformation and Oligomerization of E2∼Ubiquitin Conjugates

(2012) Richard C. Page et al.   BIOCHEMISTRY

Routine Microsecond Molecular Dynamics Simulations with AMBER on GPUs. 1. Generalized Born

(2012) Andreas W. Götz et al.   Journal of Chemical Theory and Computation

A genomic bias for genotype–environment interactions in C. elegans

(2012) Vladislav Grishkevich et al.   Molecular Systems Biology

Ubiquitination of E3 ligases: self-regulation of the ubiquitin system via proteolytic and non-proteolytic mechanisms

(2011) P de Bie et al.   CELL DEATH AND DIFFERENTIATION

Molecular Mechanism of the Negative Regulation of Smad1/5 Protein by Carboxyl Terminus of Hsc70-interacting Protein (CHIP)

(2011) Le Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

E2 Conjugating Enzyme Selectivity and Requirements for Function of the E3 Ubiquitin Ligase CHIP

(2011) Sarah E. Soss et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ube2w and Ataxin-3 Coordinately Regulate the Ubiquitin Ligase CHIP

(2011) K. Matthew Scaglione et al.   MOLECULAR CELL

The Machado-Joseph disease deubiquitylase ATX-3 couples longevity and proteostasis

(2011) Kirsten Kuhlbrodt et al.   NATURE CELL BIOLOGY

RINGs hold the key to ubiquitin transfer

(2011) Rhesa Budhidarmo et al.   TRENDS IN BIOCHEMICAL SCIENCES

K11-Linked Polyubiquitination in Cell Cycle Control Revealed by a K11 Linkage-Specific Antibody

(2010) Marissa L. Matsumoto et al.   MOLECULAR CELL

Ubiquitin ligase complexes: from substrate selectivity to conjugational specificity

(2009) Vanja Nagy et al.   BIOLOGICAL CHEMISTRY

The family of ubiquitin-conjugating enzymes (E2s): deciding between life and death of proteins

(2009) Sjoerd J. L. van Wijk et al.   FASEB JOURNAL

Insights into Ubiquitin Transfer Cascades from a Structure of a UbcH5B∼Ubiquitin-HECTNEDD4L Complex

(2009) Hari B. Kamadurai et al.   MOLECULAR CELL

CHIP deletion reveals functional redundancy of E3 ligases in promoting degradation of both signaling proteins and expanded glutamine proteins

(2008) Y. Morishima et al.   HUMAN MOLECULAR GENETICS

CHIP Deficiency Decreases Longevity, with Accelerated Aging Phenotypes Accompanied by Altered Protein Quality Control

(2008) J.-N. Min et al.   MOLECULAR AND CELLULAR BIOLOGY