The m6A demethylase ALKBH5-mediated upregulation of DDIT4-AS1 maintains pancreatic cancer stemness and suppresses chemosensitivity by activating the mTOR pathway
Published 2022 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
The m6A demethylase ALKBH5-mediated upregulation of DDIT4-AS1 maintains pancreatic cancer stemness and suppresses chemosensitivity by activating the mTOR pathway
Authors
Keywords
-
Journal
Molecular Cancer
Volume 21, Issue 1, Pages -
Publisher
Springer Science and Business Media LLC
Online
2022-09-02
DOI
10.1186/s12943-022-01647-0
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Female erectile tissues and sexual dysfunction after pelvic radiotherapy: A scoping review
- (2022) Deborah C. Marshall et al. CA-A CANCER JOURNAL FOR CLINICIANS
- Development of a core measurement set for research in degenerative cervical myelopathy: a study protocol (AO Spine RECODE-DCM CMS)
- (2022) Benjamin M Davies et al. BMJ Open
- Cancer Statistics, 2021
- (2021) Rebecca L. Siegel et al. CA-A CANCER JOURNAL FOR CLINICIANS
- MEDAG enhances breast cancer progression and reduces epirubicin sensitivity through the AKT/AMPK/mTOR pathway
- (2021) Zhiyu Li et al. Cell Death & Disease
- PRKAR1B-AS2 Long Noncoding RNA Promotes Tumorigenesis, Survival, and Chemoresistance via the PI3K/AKT/mTOR Pathway
- (2021) Abdelrahman M. Elsayed et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- lncRNA C2dat2 facilitates autophagy and apoptosis via the miR-30d-5p/DDIT4/mTOR axis in cerebral ischemia-reperfusion injury
- (2021) Qian Xu et al. Aging-US
- PIK3C3 Inhibition Promotes Sensitivity to Colon Cancer Therapy by Inhibiting Cancer Stem Cells
- (2021) Balawant Kumar et al. Cancers
- Non-coding Natural Antisense Transcripts: Analysis and Application
- (2021) Julian C. Krappinger et al. JOURNAL OF BIOTECHNOLOGY
- The pseudogene PRELID1P6 promotes glioma progression via the hnHNPH1-Akt/mTOR axis
- (2021) Shaoyan Xi et al. ONCOGENE
- N6-Methylandenosine-Related lncRNA Signature Is a Novel Biomarkers of Prognosis and Immune Response in Colon Adenocarcinoma Patients
- (2021) Peiling Zhang et al. Frontiers in Cell and Developmental Biology
- m6A demethylase ALKBH5 inhibits pancreatic cancer tumorigenesis by decreasing WIF-1 RNA methylation and mediating Wnt signaling
- (2020) Bo Tang et al. Molecular Cancer
- A Key Role of DNA Damage-Inducible Transcript 4 (DDIT4) Connects Autophagy and GLUT3-Mediated Stemness To Desensitize Temozolomide Efficacy in Glioblastomas
- (2020) Kuo-Hao Ho et al. Neurotherapeutics
- Atractylenolide I inhibits colorectal cancer cell proliferation by affecting metabolism and stemness via AKT/mTOR signaling
- (2020) Kuilong Wang et al. PHYTOMEDICINE
- Silencing of microRNA-135b inhibits invasion, migration, and stemness of CD24+CD44+ pancreatic cancer stem cells through JADE-1-dependent AKT/mTOR pathway
- (2020) Jingyang Zhou et al. Cancer Cell International
- RNA Demethylase ALKBH5 Selectively Promotes Tumorigenesis and Cancer Stem Cell Self-Renewal in Acute Myeloid Leukemia
- (2020) Chao Shen et al. Cell Stem Cell
- REDD1 loss reprograms lipid metabolism to drive progression of RAS mutant tumors
- (2020) Shuxi Qiao et al. GENES & DEVELOPMENT
- FTO-Dependent N6-Methyladenosine Modifications Inhibit Ovarian Cancer Stem Cell Self-Renewal by Blocking cAMP Signaling
- (2020) Hao Huang et al. CANCER RESEARCH
- DDIT4 licenses only healthy cells to proliferate during injury-induced metaplasia
- (2020) Zhi-Feng Miao et al. GASTROENTEROLOGY
- MNAT1 promotes proliferation and the chemo-resistance of osteosarcoma cell to cisplatin through regulating PI3K/Akt/mTOR pathway
- (2020) Chensheng Qiu et al. BMC CANCER
- Loss of miR-100 and miR-125b results in cancer stem cell properties through IGF2 upregulation in hepatocellular carcinoma
- (2020) Hyang Sook Seol et al. Scientific Reports
- Free fatty acids rewire cancer metabolism in obesity-associated breast cancer via estrogen receptor and mTOR signaling
- (2019) Zeynep Madak-Erdogan et al. CANCER RESEARCH
- Where, When, and How: Context-Dependent Functions of RNA Methylation Writers, Readers, and Erasers
- (2019) Hailing Shi et al. MOLECULAR CELL
- Role of the PI3K/AKT/mTOR signaling pathway in ovarian cancer: Biological and therapeutic significance
- (2019) Meran Keshawa Ediriweera et al. SEMINARS IN CANCER BIOLOGY
- LncRNA SATB2-AS1 inhibits tumor metastasis and affects the tumor immune cell microenvironment in colorectal cancer by regulating SATB2
- (2019) Mu Xu et al. Molecular Cancer
- RNA N6-methyladenosine modification in cancers: current status and perspectives
- (2018) Xiaolan Deng et al. CELL RESEARCH
- Recognition of RNA N6-methyladenosine by IGF2BP proteins enhances mRNA stability and translation
- (2018) Huilin Huang et al. NATURE CELL BIOLOGY
- DNA Damage Inducible Transcript 4 Gene: The Switch of the Metabolism as Potential Target in Cancer
- (2018) Indira Tirado-Hurtado et al. Frontiers in Oncology
- LAT2 regulates glutamine-dependent mTOR activation to promote glycolysis and chemoresistance in pancreatic cancer
- (2018) Mengyu Feng et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Nuclear mTOR acts as a transcriptional integrator of the androgen signaling pathway in prostate cancer
- (2017) Étienne Audet-Walsh et al. GENES & DEVELOPMENT
- Upf proteins: highly conserved factors involved in nonsense mRNA mediated decay
- (2017) Puneet Gupta et al. MOLECULAR BIOLOGY REPORTS
- Long non-coding antisense RNA KRT7-AS is activated in gastric cancers and supports cancer cell progression by increasing KRT7 expression
- (2016) B Huang et al. ONCOGENE
- Sleep deprivation and false confessions
- (2016) Steven J. Frenda et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Adjuvant Chemotherapy With Gemcitabine and Long-term Outcomes Among Patients With Resected Pancreatic Cancer
- (2013) Helmut Oettle et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- The mTOR Signalling Pathway in Human Cancer
- (2012) Helena Pópulo et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Metformin, Independent of AMPK, Induces mTOR Inhibition and Cell-Cycle Arrest through REDD1
- (2011) I. Ben Sahra et al. CANCER RESEARCH
- AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
- (2011) Joungmok Kim et al. NATURE CELL BIOLOGY
- N- and C-terminal Upf1 phosphorylations create binding platforms for SMG-6 and SMG-5:SMG-7 during NMD
- (2011) Yukiko Okada-Katsuhata et al. NUCLEIC ACIDS RESEARCH
- TXNIP potentiates Redd1-induced mTOR suppression through stabilization of Redd1
- (2011) H-O Jin et al. ONCOGENE
- Rtp801, a suppressor of mTOR signaling, is an essential mediator of cigarette smoke–induced pulmonary injury and emphysema
- (2010) Toshinori Yoshida et al. NATURE MEDICINE
- Negative feedback control of HIF-1 through REDD1-regulated ROS suppresses tumorigenesis
- (2010) P. Horak et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Nonsense-mediated mRNA decay in human cells: mechanistic insights, functions beyond quality control and the double-life of NMD factors
- (2009) Pamela Nicholson et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Hypoxia regulates TSC1/2 mTOR signaling and tumor suppression through REDD1-mediated 14 3 3 shuttling
- (2008) M. P. DeYoung et al. GENES & DEVELOPMENT
- Pancreatic Cancer Stem Cells
- (2008) Cheong J. Lee et al. JOURNAL OF CLINICAL ONCOLOGY
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExplorePublish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn More