DNA Damage Inducible Transcript 4 Gene: The Switch of the Metabolism as Potential Target in Cancer

Genetic effects on gene expression across human tissues

(2017) François Aguet et al.   NATURE

In silico evaluation of DNA Damage Inducible Transcript 4 gene (DDIT4) as prognostic biomarker in several malignancies

(2017) Joseph A. Pinto et al.   Scientific Reports

Emerging role for regulated in development and DNA damage 1 (REDD1) in the regulation of skeletal muscle metabolism

(2016) Bradley S. Gordon et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Ezrin Inhibition Up-regulates Stress Response Gene Expression

(2016) Haydar Çelik et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A prognostic signature based on three-genes expression in triple-negative breast tumours with residual disease

(2016) Joseph A Pinto et al.   npj Genomic Medicine

REDD1/DDIT4-Independent mTORC1 Inhibition and Apoptosis by Glucocorticoids in Thymocytes

(2014) Nicholas C. Wolff et al.   MOLECULAR CANCER RESEARCH

Self-consumption: the interplay of autophagy and apoptosis

(2014) Guillermo Mariño et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

RTP801/REDD1: a stress coping regulator that turns into a troublemaker in neurodegenerative disorders

(2014) Mercè Canal et al.   Frontiers in Cellular Neuroscience

MiR-630 inhibits proliferation by targeting CDC7 kinase, but maintains the apoptotic balance by targeting multiple modulators in human lung cancer A549 cells

(2014) J-X Cao et al.   Cell Death & Disease

Targeting PI3K/Akt/mTOR Signaling in Cancer

(2014) Camillo Porta et al.   Frontiers in Oncology

Sustained overexpression of Redd1 leads to Akt activation involved in cell survival

(2013) Hyeon-Ok Jin et al.   CANCER LETTERS

Regulated in DNA damage and development 1 (REDD1) promotes cell survival during serum deprivation by sustaining repression of signaling through the mechanistic target of rapamycin in complex 1 (mTORC1)

(2013) Michael D. Dennis et al.   CELLULAR SIGNALLING

p53/TAp63 and AKT Regulate Mammalian Target of Rapamycin Complex 1 (mTORC1) Signaling through Two Independent Parallel Pathways in the Presence of DNA Damage

(2013) Maren Cam et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

mTORC1 Dependent Regulation of REDD1 Protein Stability

(2013) Chia Yee Tan et al.   PLoS One

Targeting the PI3K-AKT-mTOR signaling network in cancer

(2013) Khurum H. Khan et al.   Chinese Journal of Cancer

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

The mTOR Signalling Pathway in Human Cancer

(2012) Helena Pópulo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Nuclear factor of activated T-cell c3 inhibition of mammalian target of rapamycin signaling through induction of regulated in development and DNA damage response 1 in human intestinal cells

(2012) Yuning Zhou et al.   MOLECULAR BIOLOGY OF THE CELL

Micro-RNA30c Negatively Regulates REDD1 Expression in Human Hematopoietic and Osteoblast Cells after Gamma-Irradiation

(2012) Xiang Hong Li et al.   PLoS One

REDD1 Expression in Placenta During Human Gestation

(2012) Ya Yi Hu et al.   Reproductive Sciences

REDD1 is required for RAS-mediated transformation of human ovarian epithelial cells

(2011) Bin Chang et al.   CELL CYCLE

REDD1, a new Ras oncogenic effector

(2011) Elizabeth R. Smith et al.   CELL CYCLE

The p53 target Plk2 interacts with TSC proteins impacting mTOR signaling, tumor growth, and chemosensitivity under hypoxic conditions

(2011) Elizabeth M. Matthew et al.   CELL CYCLE

The dynamic nature of autophagy in cancer

(2011) A. C. Kimmelman   GENES & DEVELOPMENT

Glucocorticoid Elevation of Dexamethasone-induced Gene 2 (Dig2/RTP801/REDD1) Protein Mediates Autophagy in Lymphocytes

(2011) Jason K. Molitoris et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RTP801/REDD1 Regulates the Timing of Cortical Neurogenesis and Neuron Migration

(2011) C. Malagelada et al.   JOURNAL OF NEUROSCIENCE

Feedback Control of p53 Translation by REDD1 and mTORC1 Limits the p53-Dependent DNA Damage Response

(2011) D. D. Vadysirisack et al.   MOLECULAR AND CELLULAR BIOLOGY

miR-495 is upregulated by E12/E47 in breast cancer stem cells and promotes oncogenesis and hypoxia resistance via downregulation of E-cadherin and REDD1

(2011) W W Hwang-Verslues et al.   ONCOGENE

Alteration of REDD1-Mediated Mammalian Target of Rapamycin Pathway and Hypoxia-Inducible Factor-1α Regulation in Human Breast Cancer

(2011) Ja Seung Koo et al.   PATHOBIOLOGY

Structural Analysis and Functional Implications of the Negative mTORC1 Regulator REDD1,

(2010) Silvia Vega-Rubin-de-Celis et al.   BIOCHEMISTRY

MicroRNA: Biogenesis, Function and Role in Cancer

(2010) Leigh-Ann MacFarlane et al.   CURRENT GENOMICS

mTOR regulation of autophagy

(2010) Chang Hwa Jung et al.   FEBS LETTERS

mTOR: from growth signal integration to cancer, diabetes and ageing

(2010) Roberto Zoncu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Rapamycin inhibits mTORC1, but not completely

(2009) Carson C. Thoreen et al.   Autophagy

REDD1, an inhibitor of mTOR signalling, is regulated by the CUL4A–DDB1 ubiquitin ligase

(2009) Samiksha Katiyar et al.   EMBO REPORTS

MicroRNAs in Cancer: Small Molecules With a Huge Impact

(2009) Marilena V. Iorio et al.   JOURNAL OF CLINICAL ONCOLOGY

miR-221 overexpression contributes to liver tumorigenesis

(2009) P. Pineau et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ATF4 is necessary and sufficient for ER stress-induced upregulation of REDD1 expression

(2008) Michael L. Whitney et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

p53 Target Genes Sestrin1 and Sestrin2 Connect Genotoxic Stress and mTOR Signaling

(2008) Andrei V. Budanov et al.   CELL

Hypoxia regulates TSC1/2 mTOR signaling and tumor suppression through REDD1-mediated 14 3 3 shuttling

(2008) M. P. DeYoung et al.   GENES & DEVELOPMENT