Directed Evolution of Flavin-Dependent Halogenases for Site- and Atroposelective Halogenation of 3-Aryl-4(3H)-Quinazolinones via Kinetic or Dynamic Kinetic Resolution

Biocatalytic oxidative cross-coupling reactions for biaryl bond formation

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Atropisomers beyond the C–C axial chirality: Advances in catalytic asymmetric synthesis

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Illuminating the dark conformational space of macrocycles using dominant rotors

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Highly accurate protein structure prediction with AlphaFold

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Flavin-dependent halogenases catalyze enantioselective olefin halocyclization

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Biocatalytic synthesis of planar chiral macrocycles

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4(3H)-Quinazolinone derivatives: Promising antibacterial drug leads

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Site-Selective C–H Halogenation Using Flavin-Dependent Halogenases Identified via Family-Wide Activity Profiling

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Discovery of a Covalent Inhibitor of KRASG12C (AMG 510) for the Treatment of Solid Tumors

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Understanding and Improving the Activity of Flavin-Dependent Halogenases via Random and Targeted Mutagenesis

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Halogenases: powerful tools for biocatalysis (mechanisms applications and scope)

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Enantioselective Desymmetrization of Methylenedianilines via Enzyme-Catalyzed Remote Halogenation

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Peptide-Based Catalysts Reach the Outer Sphere through Remote Desymmetrization and Atroposelectivity

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Understanding Flavin-Dependent Halogenase Reactivity via Substrate Activity Profiling

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Specific Enzymatic Halogenation-From the Discovery of Halogenated Enzymes to Their Applications In Vitro and In Vivo

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Discovery of 6-Fluoro-5-(R)-(3-(S)-(8-fluoro-1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)-2-methylphenyl)-2-(S)-(2-hydroxypropan-2-yl)-2,3,4,9-tetrahydro-1H-carbazole-8-carboxamide (BMS-986142): A Reversible Inhibitor of Bruton’s Tyrosine Kinase (BTK) Conformationally Constrained by Two Locked Atropisomers

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Enzymatic approaches for the preparation of optically active non-centrochiral compounds

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Directed evolution of RebH for catalyst-controlled halogenation of indole C–H bonds

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Directed Evolution of RebH for Site-Selective Halogenation of Large Biologically Active Molecules

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Recent advances and new concepts for the synthesis of axially stereoenriched biaryls

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Cytochrome P450-Catalyzed Regio- and Stereoselective Phenol Coupling of Fungal Natural Products

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Enantioselective Synthesis of 3-Arylquinazolin-4(3H)-ones via Peptide-Catalyzed Atroposelective Bromination

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Regioselective Derivatizations of a Tribrominated Atropisomeric Benzamide Scaffold

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Regioselective Arene Halogenation using the FAD-Dependent Halogenase RebH

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Enantioselective Synthesis of Atropisomeric Benzamides through Peptide-Catalyzed Bromination

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Development of α-glucosidase inhibitors by room temperature C–C cross couplings of quinazolinones

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Synthesis of Atropisomerically Defined, Highly Substituted Biaryl Scaffolds through Catalytic Enantioselective Bromination and Regioselective Cross-Coupling

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Assessing Atropisomer Axial Chirality in Drug Discovery and Development

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Atroposelective Total Synthesis of Axially Chiral Biaryl Natural Products

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Dynamic Kinetic Resolution of Biaryl Atropisomers via Peptide-Catalyzed Asymmetric Bromination

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AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading

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Scalable Total Synthesis and Biological Evaluation of Haouamine A and Its Atropisomer

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New Insights into the Mechanism of Enzymatic Chlorination of Tryptophan

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