Dietary Supplement 4-Methylumbelliferone: An Effective Chemopreventive and Therapeutic Agent for Prostate Cancer

Recent advances in bone-targeted therapies of metastatic prostate cancer

(2014) Xiyun Deng et al.   CANCER TREATMENT REVIEWS

Active surveillance for clinically localized prostate cancer--A systematic review

(2014) Frederik B. Thomsen et al.   JOURNAL OF SURGICAL ONCOLOGY

Hyaluronan: Towards novel anti-cancer therapeutics

(2014) Michał S. Karbownik et al.   Pharmacological Reports

Activator or inhibitor? GSK-3 as a new drug target

(2013) Fumi Takahashi-Yanaga   BIOCHEMICAL PHARMACOLOGY

Hyaluronan synthases (HAS1–3) in stromal and malignant cells correlate with breast cancer grade and predict patient survival

(2013) Päivi Auvinen et al.   BREAST CANCER RESEARCH AND TREATMENT

Cancer Stem–like Cell Marker CD44 Promotes Bone Metastases by Enhancing Tumorigenicity, Cell Motility, and Hyaluronan Production

(2013) Toru Hiraga et al.   CANCER RESEARCH

Aberrant Splicing, Hyaluronan Synthases and Intracellular Hyaluronan as Drivers of Oncogenesis and Potential Drug Targets

(2013) Sophia Adamia et al.   CURRENT CANCER DRUG TARGETS

CD44 integrates signaling in normal stem cell, cancer stem cell and (pre)metastatic niches

(2013) Karin Williams et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Curcumin analogue identified as hyaluronan export inhibitor by virtual docking to the ABC transporter MRP5

(2013) Peter Prehm   FOOD AND CHEMICAL TOXICOLOGY

Pharmacological modulation of beta-catenin and its applications in cancer therapy

(2013) Ravi Thakur et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Dishevelled-2 silencing reduces androgen-dependent prostate tumor cell proliferation and migration and expression of Wnt-3a and matrix metalloproteinases

(2013) Yinhui Yang et al.   MOLECULAR BIOLOGY REPORTS

Germline Genetic Variation Modulates Tumor Progression and Metastasis in a Mouse Model of Neuroendocrine Prostate Carcinoma

(2013) Shashank J. Patel et al.   PLoS One

Genomic insights into WNT/β-catenin signaling

(2013) Joseph Rosenbluh et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Mannose reduces hyaluronan and leukocytes in wound granulation tissue and inhibits migration and hyaluronan-dependent monocyte binding

(2013) Tiina A. Jokela et al.   WOUND REPAIR AND REGENERATION

PTENgenomic deletion predicts prostate cancer recurrence and is associated with low AR expression and transcriptional activity

(2012) Khalil Choucair et al.   BMC CANCER

C-X-C chemokine receptor 7

(2012) Travis J. Yates et al.   CANCER

Dietary Supplement Hymecromone and Sorafenib: A Novel Combination for the Control of Renal Cell Carcinoma

(2012) Anaid Benitez et al.   JOURNAL OF UROLOGY

The  -Catenin Destruction Complex

(2012) J. L. Stamos et al.   Cold Spring Harbor Perspectives in Biology

Inhibition of hyaluronan retention by 4-methylumbelliferone suppresses osteosarcoma cells in vitro and lung metastasis in vivo

(2011) E Arai et al.   BRITISH JOURNAL OF CANCER

Molecular characterization of kidney cancer

(2011) Andrew Chi et al.   CANCER

Targeting Hyaluronidase for Cancer Therapy: Antitumor Activity of Sulfated Hyaluronic Acid in Prostate Cancer Cells

(2011) A. Benitez et al.   CANCER RESEARCH

Hyaluronan Synthase HAS2 Promotes Tumor Progression in Bone by Stimulating the Interaction of Breast Cancer Stem-Like Cells with Macrophages and Stromal Cells

(2011) H. Okuda et al.   CANCER RESEARCH

Antitumor effects of hyaluronic acid inhibitor 4-methylumbelliferone in an orthotopic hepatocellular carcinoma model in mice

(2011) F. Piccioni et al.   GLYCOBIOLOGY

Inhibition of hyaluronan synthesis in breast cancer cells by 4-methylumbelliferone suppresses tumorigenicity in vitro and metastatic lesions of bone in vivo

(2011) Hiroshi Urakawa et al.   INTERNATIONAL JOURNAL OF CANCER

Regulation of neuroendocrine differentiation by AKT/hnRNPK/AR/β-catenin signaling in prostate cancer cells

(2011) Monica Ciarlo et al.   INTERNATIONAL JOURNAL OF CANCER

Involvement of hyaluronidases in colorectal cancer

(2010) Helen Bouga et al.   BMC CANCER

Association of hyaluronic acid family members (HAS1, HAS2, and HYAL-1) with bladder cancer diagnosis and prognosis

(2010) Mario W. Kramer et al.   CANCER

Antitumor Activity of Hyaluronic Acid Synthesis Inhibitor 4-Methylumbelliferone in Prostate Cancer Cells

(2010) Vinata B. Lokeshwar et al.   CANCER RESEARCH

Hyaluronan in human malignancies

(2010) R.K. Sironen et al.   EXPERIMENTAL CELL RESEARCH

Hyaluronan-CD44 Interaction Promotes c-Src-mediated Twist Signaling, MicroRNA-10b Expression, and RhoA/RhoC Up-regulation, Leading to Rho-kinase-associated Cytoskeleton Activation and Breast Tumor Cell Invasion

(2010) Lilly Y. W. Bourguignon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Spontaneous Metastasis of Prostate Cancer Is Promoted by Excess Hyaluronan Synthesis and Processing

(2009) Alamelu G. Bharadwaj et al.   AMERICAN JOURNAL OF PATHOLOGY

Androgen-Stimulated UDP-Glucose Dehydrogenase Expression Limits Prostate Androgen Availability without Impacting Hyaluronan Levels

(2009) Q. Wei et al.   CANCER RESEARCH

4-Methylumbelliferone inhibits hyaluronan synthesis by depletion of cellular UDP-glucuronic acid and downregulation of hyaluronan synthase 2 and 3

(2009) Anne Kultti et al.   EXPERIMENTAL CELL RESEARCH

Aberrant Splice Variants of HAS1 (Hyaluronan Synthase 1) Multimerize with and Modulate Normally Spliced HAS1 Protein

(2009) Anirban Ghosh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hyaluronic Acid and HYAL-1 in Prostate Biopsy Specimens: Predictors of Biochemical Recurrence

(2009) Christopher S. Gomez et al.   JOURNAL OF UROLOGY

Hyaluronic Acid Synthase-1 Expression Regulates Bladder Cancer Growth, Invasion, and Angiogenesis through CD44

(2008) R. Golshani et al.   CANCER RESEARCH

Key Amino Acid Residues Responsible for the Differences in Substrate Specificity of Human UDP-Glucuronosyltransferase (UGT)1A9 and UGT1A8

(2008) R. Fujiwara et al.   DRUG METABOLISM AND DISPOSITION