Article
Nanoscience & Nanotechnology
Masamichi Inoue, Taishi Higashi, Yuya Hayashi, Risako Onodera, Kazuya Fujisawa, Toru Taharabaru, Ryoma Yokoyama, Kenta Ouchi, Yohei Misumi, Mitsuharu Ueda, Yasuteru Inoue, Mineyuki Mizuguchi, Takashi Saito, Takaomi C. Saido, Yukio Ando, Hidetoshi Arima, Keiichi Motoyama, Hirofumi Jono
Summary: Amyloidosis is a pathological process involving the production of amyloidogenic proteins, formation of protein aggregates, and their deposition on tissues. A novel multitarget therapeutic drug has been developed that can simultaneously suppress the three critical steps of amyloidosis. This drug has shown therapeutic effects in models of systemic transthyretin amyloidosis and Alzheimer's disease by targeting specific proteins involved in amyloid formation. It has the potential to establish curative treatments for amyloidosis.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Applied
Zehra Irem Yildiz, Fuat Topuz, Mehmet Emin Kilic, Engin Durgun, Tamer Uyar
Summary: In this study, beta-carotene was encapsulated in electrospun cyclodextrin nanofibers to increase its water solubility and photostability. The beta-carotene/CD nanofibers demonstrated antioxidant activity and protection against UV radiation. This work presents a water-borne electrospinning method to stabilize beta-carotene against UV-mediated oxidation.
Article
Chemistry, Physical
Deepika Sharma, Bhabani K. Satapathy
Summary: The paper presents the synthesis and characterization of inclusion complexes (ICs) based on curcumin (CUR) and beta-cyclodextrin (β-CD), with IC-2 showing superior encapsulation efficiency. Nanoparticles (NPs) of IC-2 demonstrated the finest particle diameter and minimal variation, making them suitable for potential biomedical applications with controlled release properties. The study highlights the possibility of using IC-2 for electrospraying on implant and device surfaces to enhance the efficacy and stability of CUR release.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2021)
Article
Chemistry, Physical
Nina Alizadeh, Fatemeh Nazari
Summary: In this study, the inclusion complex of TH/β-CD was synthesized and loaded into CS nanoparticles, resulting in improved solubility and stability of TH. The complexes showed antibacterial effects against Staphylococcus aureus and Escherichia coli, and exhibited better antioxidant activities compared to pure TH.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Chemistry, Physical
Rajaram Rajamohan, Mika Sillanpaa, Angaiah Subramania
Summary: Nanofibrous mats and cyclodextrins are essential components in drug releasing systems, with cyclodextrins playing a key role in enhancing drug release profile by forming inclusion complexes. This study focused on analyzing the drug release profile of benzocaine using electrospun PVdF nanofibrous mats, with and without beta-cyclodextrin, demonstrating enhanced drug release ability with the presence of beta-CD due to increased solubility of benzocaine.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Chemistry, Physical
Shuang Gao, Xiaoming Li, Jingyu Jiang, Lixia Zhao, Ying Fu, Fei Ye
Summary: The electrospun thiophanate methyl/hydroxypropyl-beta-cyclodextrin (TM/HP β CD) inclusion complex nanofibers demonstrated enhanced water solubility, thermal stability, and antifungal activity, offering potential for environmentally safe application of thiophanate methyl (TM).
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Chemistry, Applied
Hao Yin, Chenxiao Wang, Jin Yue, Yun Deng, Shunshan Jiao, Yanyun Zhao, Jie Zhou, Ting Cao
Summary: In this study, cyclodextrin was used to encapsulate 1,8-cineole to enhance the thermal stability of essential oils. The optimal conditions for encapsulation were identified using the response surface methodology, and the release behavior and kinetics of the inclusion complexes were investigated.
FOOD HYDROCOLLOIDS
(2021)
Article
Food Science & Technology
Prakash Chandra Pradhan, Abhishek Mandal, Anirban Dutta, Rohan Sarkar, Aditi Kundu, Supradip Saha
Summary: The inclusion complex of Berberis lycium anthocyanins with beta-cyclodextrin was successfully prepared and demonstrated improved thermal stability and regulated release of anthocyanins. Molecular docking studies revealed the thermodynamic stability of one anthocyanin complex over the other. Molecular dynamics simulations provided insights into the behavior of anthocyanins within the inclusion complex cavity.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Ziyi Li, Jiwei Cai, Miaohan Wei, Juncheng Chen
Summary: This article introduces a shape memory hydrogel with self-healing and dual stimuli-responsive properties. The hydrogel exhibits rapid self-healing and adjustable swelling performance, and shows a dual stimuli-responsive shape memory effect to light and ionic strength.
Article
Spectroscopy
Ye Li, Hongrui Liu, Chunyu Mu, Jiali Gu, Chun Li
Summary: This study investigated the interaction mechanism between ethoxyquin (EQ) and transporter protein before and after beta-cyclodextrin (beta-CD) encapsulation. The results showed that EQ formed complexes with bovine serum albumin (BSA) and affected its structure and environment. However, encapsulation in beta-CD reduced the binding ability of EQ to BSA and prevented adverse effects on BSA conformation.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2024)
Article
Food Science & Technology
Dan Shen, Xia Chang, Liling Zhou, Dandan Hao, Zhongxiang Fang, Yang Shan, Lvhong Huang, Gaoyang Li
Summary: In this study, an inclusion complex of citral within hydroxypropyl-beta-cyclodextrin was prepared using ultrasound technique. The complex showed improved thermal stability and antifungal properties. Additionally, treatment with the complex effectively extended the shelf life of strawberries.
Article
Chemistry, Analytical
Nevena Dajic, Biljana Otasevic, Andelija Malenovic, Mira Zecevic, Ulrike Holzgrabe, Ana Protic
Summary: In RP-HPLC, the binding between CD cavity and guest molecule is a dynamic process. The stability of the complex can be measured by the reduction in analyte's retention time. It was found that under certain conditions, the retention time of some analytes may be prolonged.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2021)
Article
Chemistry, Physical
Shuang Gao, Jingyu Jiang, Xiaoming Li, Fei Ye, Ying Fu, Lixia Zhao
Summary: In this study, an inclusion complex of beta-cyclodextrin and difenoconazole was synthesized to enhance water solubility and antifungal activity. The complex showed increased water solubility and improved fungicidal effect against Gibberella sp., presenting a new formulation idea for the agricultural application of difenoconazole.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Chemistry, Multidisciplinary
Lucia Casali, Valquiria Broll, Stefano Ciurli, Franziska Emmerling, Dario Braga, Fabrizia Grepioni
Summary: The inclusion complex beta-CD center dot NP, prepared via mechanochemical synthesis, shows improved solubility and thermal stability, while still effectively inhibiting the enzymatic activity of AMO. This indicates that the inclusion of NP into beta-CD is a promising approach for creating novel inhibitors with enhanced properties.
CRYSTAL GROWTH & DESIGN
(2021)
Article
Chemistry, Applied
Changyue Deng, Chuan Cao, Yingying Zhang, Jingwei Hu, Yongqiang Gong, Mingming Zheng, Yibin Zhou
Summary: The formation and stabilization mechanisms of inclusion complexes between beta-cyclodextrin and five C10 aroma molecules were investigated using experimental methods and molecular dynamics simulation. The inclusion complexes had a new crystal structure and better thermal stability. The aroma molecules induced conformational changes in the inclusion complexes, with van der Waals interactions being the main driving force for their spontaneous entry into the cavity.
FOOD HYDROCOLLOIDS
(2022)
Article
Engineering, Chemical
Asghar Bakravi, Yashar Ahamadian, Hamed Hashemi, Hassan Namazi
ADVANCES IN POLYMER TECHNOLOGY
(2018)
Article
Materials Science, Multidisciplinary
Hamed Hashemi, Hassan Namazi
APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING
(2018)
Article
Chemistry, Applied
Siamak Javanbakht, Naser Nazari, Rasul Rakhshaei, Hassan Namazi
CARBOHYDRATE POLYMERS
(2018)
Article
Electrochemistry
Amin Goljanian Tabrizi, Nasser Arsalani, Abdolkhaled Mohammadi, Laleh Saleh Ghadimi, Iraj Ahadzadeh, Hassan Namazi
ELECTROCHIMICA ACTA
(2018)
Article
Biochemistry & Molecular Biology
Monireh Rasoulzadehzali, Hassan Namazi
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2018)
Article
Environmental Sciences
N. Alipour, H. Namazi
INTERNATIONAL JOURNAL OF ENVIRONMENTAL SCIENCE AND TECHNOLOGY
(2019)
Article
Materials Science, Multidisciplinary
Alireza Banaei, Mojtaba Farokhi Yaychi, Soheyla Karimi, Hossein Vojoudi, Hassan Namazi, Alireza Badiei, Eslam Pourbasheer
MATERIALS CHEMISTRY AND PHYSICS
(2018)
Article
Materials Science, Multidisciplinary
Malihe Pooresmaeil, Hassan Namazi
MATERIALS CHEMISTRY AND PHYSICS
(2018)
Article
Materials Science, Biomaterials
Siamak Javanbakht, Hassan Namazi
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2018)
Article
Acoustics
Hamed Hashemi, Hassan Namazi
ULTRASONICS SONOCHEMISTRY
(2018)
Article
Biophysics
Malihe Pooresmaeil, Hassan Namazi
COLLOIDS AND SURFACES B-BIOINTERFACES
(2018)
Article
Biochemistry & Molecular Biology
Siamak Javanbakht, Malihe Pooresmaeil, Hamed Hashemi, Hassan Namazi
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2018)
Article
Polymer Science
Yashar Ahmadian, Asghar Bakravi, Hamed Hashemi, Hassan Namazi
Article
Pharmacology & Pharmacy
Hassan Namazi, Elnaz Abdollahzadeh
Article
Chemistry, Applied
Rahim Ghadari, Hassan Namazi, Mohammad Aghazadeh
APPLIED ORGANOMETALLIC CHEMISTRY
(2018)
Review
Chemistry, Applied
Xingran Kou, Dongdong Su, Fei Pan, Xiwei Xu, Qingran Meng, Qinfei Ke
Summary: This review provides a systematic discussion of the application of molecular dynamics (MD) simulations in aroma compounds (ACs)/cyclodextrins (CDs) inclusion complexes (ICs). It covers the establishment of the simulation process, parameter selection, model evaluation, and various application cases, summarizing the major achievements and challenges of this method.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Haoyu Yu, Quanbin Zhang, Ammad Ahmad Farooqi, Jing Wang, Yang Yue, Lihua Geng, Ning Wu
Summary: Brown algae are rich in fucoidan, which has been found to have anti-cancer and anti-metastasis effects. Fucoidan inhibits tumor cell growth, proliferation, and metastasis, and also promotes immune responses in the tumor microenvironment.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Liang Dong, Yanan Li, Hailin Cong, Bing Yu, Youqing Shen
Summary: Gene therapy is a revolutionary treatment that requires suitable vectors for protecting and releasing exogenous nucleic acids in target cells. Chitosan, as a non-viral vector, has gained attention due to its good biocompatibility and ability to load large amounts of nucleic acids. This paper summarizes the potential of chitosan and its derivatives as gene delivery vector materials, discusses factors influencing transfection efficiency, performance evaluation, ways to optimize infectious efficiency, and current research development directions. It also provides an outlook on the future prospects of chitosan.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ana Iglesias-Mejuto, Beatriz Magarinos, Tania Ferreira-Goncalves, Ricardo Starbird-Perez, Carmen Alvarez-Lorenzo, Catarina Pinto Reis, Ines Ardao, Carlos A. Garcia-Gonzalez
Summary: This study developed a novel processing strategy to manufacture drug-loaded and personalized aerogels with nanostructures. The aerogels demonstrated bioactivity and antimicrobial effects, promoting bone regeneration and preventing infections in bone tissue engineering.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Zhenxu Shi, Dimei Yang, Yan Zhou, Xinyu Chen, Lin Gan, Jin Huang
Summary: This study proposes a micro-assembly method to improve the photoluminescent properties of crystalline cellulose nanocrystals (CNCs) by organizing them within a sub-micrometer-sized metal-organic framework and coating with TiO2. The TiO2 coating prevents CNC assembly breakdown and allows information to be revealed using screenprinted labels for anti-counterfeiting purposes.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Xuejiao Liu, Bin Fu, Jierong Chen, Zhenyu Sun, Dongdong Zheng, Zhonghua Li, Bing Gu, Ying Zhang, Haojie Lu
Summary: Liver disease is a major cause of global mortality, and identifying biomarkers for diagnosing its progression is crucial for improving outcomes. Targeted mass spectrometry is a powerful tool for verifying biomarker candidates and clinical applications, particularly for glycoproteins translation. However, the limitation of analyzing only one sample per run has become apparent. In this study, a high-throughput intact N-glycopeptides quantification strategy was developed, allowing the validation of 20 samples per run with an average analysis time of 3 minutes per sample. The strategy was applied in a cohort of 461 serum samples and identified a panel of 10 IgG N-glycopeptides that have strong clinical utility in evaluating the severity of liver disease.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Qian Wang, Hao Jiang, Hongli Zhang, Weiqiao Lu, Xiao Wang, Wenfeng Xu, Jia Li, Youjing Lv, Guoyun Li, Chao Cai, Guangli Yu
Summary: This study proposes a novel strategy of antibody-beta-glucan conjugates (AGC) to enhance the antitumor immune response to immune checkpoint blockade (ICB) therapy. AGC demonstrated powerful tumor suppression and promoted interaction between tumor cells and dendritic cells (DCs), thereby enhancing immunotherapeutic benefits.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Chaeyeon Lee, Sojeong Lee, Sang Wook Kang
Summary: The study aims to enhance the properties of porous membranes by addressing the limitations associated with phase separation. By using cellulose acetate and citric acid, the researchers were able to fabricate membranes with improved mechanical strength and thermal stability. The cross-linking effect of citric acid resulted in a more uniform pore structure and higher porosity.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Tejaswini Kolipaka, Giriraj Pandey, Noella Abraham, Dadi A. Srinivasarao, Rajeev Singh Raghuvanshi, P. S. Rajinikanth, Vidya Tickoo, Saurabh Srivastava
Summary: This review focuses on the design and application of polysaccharide-based hydrogel wound dressings, highlighting aspects such as biocompatibility, biodegradability, drug entrapment, moisturizing ability, swelling, and mechanical properties. Additionally, various crosslinking methods and recent developments in stimuli-responsive hydrogels are discussed.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Anqi Xu, Nan Zhang, Shixing Su, Hongyu Shi, Daoqiang Lu, Xifeng Li, Xin Zhang, Xin Feng, Zhuohua Wen, Gengwu Ma, Mengshi Huang, Chi Huang, Yuqi Hu, Hao Yuan, Qinwen Liu, Daogang Guan, Jun Wang, Chuanzhi Duan
Summary: The study presents a one-pot radical polymerization method to fabricate a hydrogel with adhesive properties, which can effectively treat bacterial-infected diabetic wounds and accelerate wound healing.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Montarop Yamabhai, Munthipha Khamphio, Thae Thae Min, Chai Noy Soem, Nguyen Cao Cuong, Waheni Rizki Aprilia, Krisanai Luesukprasert, Karsidete Teeranitayatarn, Atthaphon Maneedaeng, Tina R. Tuveng, Silje B. Lorentzen, Simen Antonsen, Paiboon Jitprasertwong, Vincent G. H. Eijsink
Summary: The study investigates the bioconversion of chitosan into soluble anti-inflammatory chitosan oligosaccharides (CHOS) using an enzyme. The results show that the generated CHOS have anti-inflammatory activity, but the magnitude of the activity depends on the substrate and production process. Different methods of dissolving chitosan also affect the properties of CHOS. The study highlights the importance of quality assurance in CHOS preparations.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Wen Cao, Jiangping Wu, Xinya Zhao, Zixu Li, Jie Yu, Taili Shao, Xuefeng Hou, Lutan Zhou, Chunfei Wang, Guodong Wang, Jun Han
Summary: In this study, a water-soluble polysaccharide (PLP1) was successfully isolated and purified from Pueraria lobata. It was found that PLP1 was composed of specific glycosidic units and exhibited a better free radical-scavenging ability. Moreover, PLP1 effectively protected the liver against acute alcoholic liver disease (ALD) in mice.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ya Su, Yaqian Liu, Xueyan Hu, Yueqi Lu, Jinyuan Zhang, Wenbo Jin, Wang Liu, Yan Shu, Yuen Yee Cheng, Wenfang Li, Yi Nie, Bo Pan, Kedong Song
Summary: A 3D printed scaffold based on carbon dots-curcumin nano-drug release has been developed for drug delivery after breast cancer surgery. The scaffold showed effective inhibition of tumor growth, antibacterial activity, and promotion of wound healing, making it a promising approach for preventing tumor recurrence.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ekaterina Sokolova, Diane Jouanneau, Antonin Chevenier, Murielle Jam, Nathalie Desban, Pierre Colas, Elizabeth Ficko-Blean, Gurvan Michel
Summary: Carrageenans, a compound synthesized in red algae, have various biological properties and are valuable in the pharmaceutical and cosmetic industries. Their fine structure affects wound healing, oxidative processes, hemostasis, and inflammation. Enzymatic modification of carrageenans produces oligosaccharides that bind to natural human serum antibodies and specific antibodies, showing potential for therapeutic applications.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Yan Shi, Miao Yu, Kaijin Qiu, Tiantian Kong, Chunjing Guo, Wenxue Zhang, Daquan Chen, Ming Kong
Summary: In this study, functionalized transfersomes were developed to co-deliver doxorubicin and 1MT towards primary tumors and tumor draining lymph nodes via transdermal administration using microneedles. The results showed that the nano-complexed microneedles exhibited a stronger suppression in tumor growth compared to the intravenous group.
CARBOHYDRATE POLYMERS
(2024)