Natural and engineered inflammasome adapter proteins reveal optimum linker length for self-assembly

Inflammasome regulation by adaptor isoforms, ASC and ASCb, via differential self-assembly

(2022) Pedro Diaz-Parga et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure, Activation and Regulation of NLRP3 and AIM2 Inflammasomes

(2021) Meenakshi Sharma et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

NLRP3 Inflammasome—A Key Player in Antiviral Responses

(2020) Chunyuan Zhao et al.   Frontiers in Immunology

UCSF ChimeraX : Structure visualization for researchers, educators, and developers

(2020) Eric F. Pettersen et al.   PROTEIN SCIENCE

Structure, interactions and self-assembly of ASC-dependent inflammasomes

(2019) Eva de Alba   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Mechanisms of NLRP1-Mediated Autoinflammatory Disease in Humans and Mice

(2018) Chien-Hsiung Yu et al.   JOURNAL OF MOLECULAR BIOLOGY

Same but not alike: Structure, flexibility and energetics of domains in multi-domain proteins are influenced by the presence of other domains

(2018) Sneha Vishwanath et al.   PLoS Computational Biology

Cytosolic Recognition of Microbes and Pathogens: Inflammasomes in Action

(2018) Jenni A. Hayward et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

The inflammasome adapter ASC assembles into filaments with integral participation of its two Death Domains, PYD and CARD

(2018) Reinard Jeffrey T. Nambayan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A histone-mimicking interdomain linker in a multidomain protein modulates multivalent histone binding

(2017) Sebastian Kostrhon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Salt-Mediated Oligomerization of the Mouse Prion Protein Monitored by Real-Time NMR

(2017) Ishita Sengupta et al.   JOURNAL OF MOLECULAR BIOLOGY

Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death

(2017) Jianjin Shi et al.   TRENDS IN BIOCHEMICAL SCIENCES

The Role of Protein Loops and Linkers in Conformational Dynamics and Allostery

(2016) Elena Papaleo et al.   CHEMICAL REVIEWS

ASC Pyrin Domain Self-associates and Binds NLRP3 Protein Using Equivalent Binding Interfaces

(2016) Javier Oroz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The cell biology of inflammasomes: Mechanisms of inflammasome activation and regulation

(2016) Deepika Sharma et al.   JOURNAL OF CELL BIOLOGY

The HADDOCK2.2 Web Server: User-Friendly Integrative Modeling of Biomolecular Complexes

(2016) G.C.P. van Zundert et al.   JOURNAL OF MOLECULAR BIOLOGY

Molecular basis of caspase-1 polymerization and its inhibition by a new capping mechanism

(2016) Alvin Lu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Molecular basis of caspase-1 polymerization and its inhibition by a new capping mechanism

(2016) Alvin Lu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion

(2015) Wan-ting He et al.   CELL RESEARCH

Initiation and perpetuation of NLRP3 inflammasome activation and assembly

(2015) Eric I. Elliott et al.   IMMUNOLOGICAL REVIEWS

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

(2015) Nobuhiko Kayagaki et al.   NATURE

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

Activation and assembly of the inflammasomes through conserved protein domain families

(2014) Tengchuan Jin et al.   APOPTOSIS

Inflammasome activation causes dual recruitment of NLRC4 and NLRP3 to the same macromolecular complex

(2014) S. M. Man et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Length of the Calmodulin Linker Determines the Extent of Transient Interdomain Association and Target Affinity

(2013) Nicholas J. Anthis et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Helical assembly in the death domain (DD) superfamily

(2012) Ryan Ferrao et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Understanding the role of domain–domain linkers in the spatial orientation of domains in multi-domain proteins

(2012) Ramachandra M. Bhaskara et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Water proton spin saturation affects measured protein backbone 15 N spin relaxation rates

(2011) Kang Chen et al.   JOURNAL OF MAGNETIC RESONANCE

A practical guide to protein dynamics from 15N spin relaxation in solution

(2011) Sébastien Morin   PROGRESS IN NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY

Dynamic Allostery: Linkers Are Not Merely Flexible

(2011) Buyong Ma et al.   STRUCTURE

An introduction to NMR-based approaches for measuring protein dynamics

(2010) Ian R. Kleckner et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

The Inflammasomes

(2010) Kate Schroder et al.   CELL

Flexibility between the Protease and Helicase Domains of the Dengue Virus NS3 Protein Conferred by the Linker Region and Its Functional Implications

(2010) Dahai Luo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential splicing of the apoptosis-associated speck like protein containing a caspase recruitment domain (ASC) regulates inflammasomes

(2010) Nicole B Bryan et al.   Journal of Inflammation-London

Kinetics of Amyloid β Monomer-to-Oligomer Exchange by NMR Relaxation

(2010) Nicolas L. Fawzi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structure and Interdomain Dynamics of Apoptosis-associated Speck-like Protein Containing a CARD (ASC)

(2009) Eva de Alba   JOURNAL OF BIOLOGICAL CHEMISTRY

Cutting Edge: NF- B Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression

(2009) F. G. Bauernfeind et al.   JOURNAL OF IMMUNOLOGY

A Splice Variant of ASC Regulates IL-1βRelease and Aggregates Differently from Intact ASC

(2009) Kazuhiko Matsushita et al.   MEDIATORS OF INFLAMMATION