Tryptophan mutations in G3BP1 tune the stability of a cellular signaling hub by weakening transient interactions with Caprin1 and USP10

Modulating binding affinity, specificity, and configurations by multivalent interactions

(2022) Yunxin Deng et al.   BIOPHYSICAL JOURNAL

Human-type sialic acid receptors contribute to avian influenza A virus binding and entry by hetero-multivalent interactions

(2022) Mengying Liu et al.   Nature Communications

Co‐purification of nitrate reductase 1 with components of the cytochrome bcc‐aa 3 oxidase supercomplex from spores of Streptomyces coelicolor A3(2)

(2021) Dörte Falke et al.   FEBS Open Bio

SARS-CoV-2 nucleocapsid protein phase separates with G3BPs to disassemble stress granules and facilitate viral production

(2021) Lingling Luo et al.   Science Bulletin

Resveratrol and related stilbene-derivatives induce Stress Granules with distinct clearance kinetics

(2021) Triana Amen et al.   MOLECULAR BIOLOGY OF THE CELL

In silico identification of MicroRNAs targeting the key nucleator of stress granules, G3BP: Promising therapeutics for SARS-CoV-2 infection

(2021) Bjad K. Almutairy et al.   SAUDI JOURNAL OF BIOLOGICAL SCIENCES

Competing Protein-RNA Interaction Networks Control Multiphase Intracellular Organization

(2020) David W. Sanders et al.   CELL

G3BP1 Is a Tunable Switch that Triggers Phase Separation to Assemble Stress Granules

(2020) Peiguo Yang et al.   CELL

RNA-Induced Conformational Switching and Clustering of G3BP Drive Stress Granule Assembly by Condensation

(2020) Jordina Guillén-Boixet et al.   CELL

Mammalian stress granules and P bodies at a glance

(2020) Claire L. Riggs et al.   JOURNAL OF CELL SCIENCE

Dance with the Devil: Stress Granules and Signaling in Antiviral Responses

(2020) Nina Eiermann et al.   Viruses-Basel

When the chains do not break: the role of USP10 in physiology and pathology

(2020) Udayan Bhattacharya et al.   Cell Death & Disease

USP10 is a critical factor for Tau-positive stress granule formation in neuronal cells

(2019) Svetlana Piatnitskaia et al.   Scientific Reports

Enhancer Features that Drive Formation of Transcriptional Condensates

(2019) Krishna Shrinivas et al.   MOLECULAR CELL

Phospho-dependent phase separation of FMRP and CAPRIN1 recapitulates regulation of translation and deadenylation

(2019) Tae Hun Kim et al.   SCIENCE

Macromolecular structure determination using X-rays, neutrons and electrons: recent developments in Phenix

(2019) Dorothee Liebschner et al.   Acta Crystallographica Section D-Structural Biology

Stress granules and neurodegeneration

(2019) Benjamin Wolozin et al.   NATURE REVIEWS NEUROSCIENCE

Context-Dependent and Disease-Specific Diversity in Protein Interactions within Stress Granules

(2018) Sebastian Markmiller et al.   CELL

Deubiquitylases USP5 and USP13 are recruited to and regulate heat-induced stress granules through their deubiquitylating activities

(2018) Xuan Xie et al.   JOURNAL OF CELL SCIENCE

Rasputin a decade on and more promiscuous than ever? A review of G3BPs

(2018) Umber Alam et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

COSMIC: the Catalogue Of Somatic Mutations In Cancer

(2018) John G Tate et al.   NUCLEIC ACIDS RESEARCH

The Autophagy Inhibitor Spautin-1 Antagonizes Rescue of Mutant CFTR Through an Autophagy-Independent and USP13-Mediated Mechanism

(2018) Emanuela Pesce et al.   Frontiers in Pharmacology

Inhibition of USP10 induces degradation of oncogenic FLT3

(2017) Ellen L Weisberg et al.   Nature Chemical Biology

G3BP–Caprin1–USP10 complexes mediate stress granule condensation and associate with 40S subunits

(2016) Nancy Kedersha et al.   JOURNAL OF CELL BIOLOGY

Principles and Properties of Stress Granules

(2016) David S.W. Protter et al.   TRENDS IN CELL BIOLOGY

Combined structural, biochemical and cellular evidence demonstrates that both FGDF motifs in alphavirus nsP3 are required for efficient replication

(2016) Tim Schulte et al.   Open Biology

The Ki-67 and RepoMan mitotic phosphatases assemble via an identical, yet novel mechanism

(2016) Ganesan Senthil Kumar et al.   eLife

Crystal structure of the G3BP2 NTF2-like domain in complex with a canonical FGDF motif peptide

(2015) Ole Kristensen   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Intrinsically disordered proteins in cellular signalling and regulation

(2015) Peter E. Wright et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Targeting a ribonucleoprotein complex containing the caprin-1 protein and the c-Myc mRNA suppresses tumor growth in mice: an identification of a novel oncotarget

(2015) Ya-Qi Qiu et al.   Oncotarget

Viral and Cellular Proteins Containing FGDF Motifs Bind G3BP to Block Stress Granule Formation

(2015) Marc D. Panas et al.   PLoS Pathogens

The C-Terminal Repeat Domains of nsP3 from the Old World Alphaviruses Bind Directly to G3BP

(2014) M. D. Panas et al.   JOURNAL OF VIROLOGY

Resveratrol induces apoptosis by directly targeting Ras-GTPase-activating protein SH3 domain-binding protein 1

(2014) N Oi et al.   ONCOGENE

RasGAP-derived peptide GAP159 enhances cisplatin-induced cytotoxicity and apoptosis in HCT116 cells

(2014) Hao Zhang et al.   Acta Pharmaceutica Sinica B

Downregulation of G3BPs inhibits the growth, migration and invasion of human lung carcinoma H1299 cells by suppressing the Src/FAK-associated signaling pathway

(2013) H Zhang et al.   CANCER GENE THERAPY

Crystal Structures of the Human G3BP1 NTF2-Like Domain Visualize FxFG Nup Repeat Specificity

(2013) Tina Vognsen et al.   PLoS One

Stereochemical Preferences Modulate Affinity and Selectivity among Five PDZ Domains that Bind CFTR: Comparative Structural and Sequence Analyses

(2013) Jeanine F. Amacher et al.   STRUCTURE

USP10 Antagonizes c-Myc Transcriptional Activation through SIRT6 Stabilization to Suppress Tumor Formation

(2013) Zhenghong Lin et al.   Cell Reports

GAP161 targets and downregulates G3BP to suppress cell growth and potentiate cisplaitin-mediated cytotoxicity to colon carcinoma HCT116 cells

(2012) Hao Zhang et al.   CANCER SCIENCE

Stereochemical Determinants of C-terminal Specificity in PDZ Peptide-binding Domains

(2012) Jeanine F. Amacher et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chikungunya Virus nsP3 Blocks Stress Granule Assembly by Recruitment of G3BP into Cytoplasmic Foci

(2012) J. J. Fros et al.   JOURNAL OF VIROLOGY

Correction: Fragile Mental Retardation Protein Interacts with the RNA-Binding Protein Caprin1 in Neuronal RiboNucleoProtein Complexes

(2012) Rachid El Fatimy et al.   PLoS One

Computational Design of a PDZ Domain Peptide Inhibitor that Rescues CFTR Activity

(2012) Kyle E. Roberts et al.   PLoS Computational Biology

Beclin1 Controls the Levels of p53 by Regulating the Deubiquitination Activity of USP10 and USP13

(2011) Junli Liu et al.   CELL

A Pseudomonas aeruginosa Toxin that Hijacks the Host Ubiquitin Proteolytic System

(2011) Jennifer M. Bomberger et al.   PLoS Pathogens

XDS

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

A Stabilizing Influence: CAL PDZ Inhibition Extends the Half-Life of ΔF508-CFTR

(2010) Patrick R. Cushing et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

USP10 Regulates p53 Localization and Stability by Deubiquitinating p53

(2010) Jian Yuan et al.   CELL

The Deubiquitinating Enzyme USP10 Regulates the Post-endocytic Sorting of Cystic Fibrosis Transmembrane Conductance Regulator in Airway Epithelial Cells

(2009) Jennifer M. Bomberger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Long-Distance Delivery of Bacterial Virulence Factors by Pseudomonas aeruginosa Outer Membrane Vesicles

(2009) Jennifer M. Bomberger et al.   PLoS Pathogens

The role of disorder in interaction networks: a structural analysis

(2008) Philip M Kim et al.   Molecular Systems Biology