Alterations in Systemic Extracellular Heme and Hemopexin Are Associated With Adverse Clinical Outcomes in Ugandan Children With Severe Malaria

Acute Kidney Injury Is Common in Pediatric Severe Malaria and Is Associated With Increased Mortality

(2016) Andrea L. Conroy et al.   Open Forum Infectious Diseases

Multifaceted Role of Heme during Severe Plasmodium falciparum Infections in India

(2015) Esther Dalko et al.   INFECTION AND IMMUNITY

Inhaled nitric oxide as adjunctive therapy for severe malaria: a randomized controlled trial

(2015) Michael T. Hawkes et al.   MALARIA JOURNAL

Dysregulation of the haem-haemopexin axis is associated with severe malaria in a case–control study of Ugandan children

(2015) Robyn E. Elphinstone et al.   MALARIA JOURNAL

Red Blood Cells Preconditioned with Hemin Are Less Permissive to Plasmodium Invasion In Vivo and In Vitro

(2015) Véronique Gaudreault et al.   PLoS One

Elevated Soluble VEGF Receptor sFlt-1 Correlates with Endothelial Injury in IgA Nephropathy

(2014) Ya-Ling Zhai et al.   PLoS One

Severe Malaria

(2014)   TROPICAL MEDICINE & INTERNATIONAL HEALTH

The epidemiology of chronic kidney disease in sub-Saharan Africa: a systematic review and meta-analysis

(2014) John W Stanifer et al.   Lancet Global Health

Complement activation by heme as a secondary hit for atypical hemolytic uremic syndrome

(2013) M. Frimat et al.   BLOOD

Heme triggers TLR4 signaling leading to endothelial cell activation and vaso-occlusion in murine sickle cell disease

(2013) J. D. Belcher et al.   BLOOD

Hemopexin induces neuroprotection in the rat subjected to focal cerebral ischemia

(2013) Beibei Dong et al.   BMC NEUROSCIENCE

Hemopexin Therapy Improves Cardiovascular Function by Preventing Heme-Induced Endothelial Toxicity in Mouse Models of Hemolytic Diseases

(2013) Francesca Vinchi et al.   CIRCULATION

Mechanisms of neuroprotection by hemopexin: modeling the control of heme and iron homeostasis in brain neurons in inflammatory states

(2013) Peter Hahl et al.   JOURNAL OF NEUROCHEMISTRY

Malaria biology and disease pathogenesis: insights for new treatments

(2013) Louis H Miller et al.   NATURE MEDICINE

Preconditioning with Hemin Decreases Plasmodium chabaudi adami Parasitemia and Inhibits Erythropoiesis in BALB/c Mice

(2013) Esther Dalko et al.   PLoS One

Contrasting pediatric and adult cerebral malaria

(2013) Michael Hawkes et al.   Virulence

Predicting the Clinical Outcome of Severe Falciparum Malaria in African Children: Findings From a Large Randomized Trial

(2012) L. von Seidlein et al.   CLINICAL INFECTIOUS DISEASES

Predicting progression to chronic kidney disease after recovery from acute kidney injury

(2012) Michael Heung et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

Prolonged Neutrophil Dysfunction after Plasmodium falciparum Malaria Is Related to Hemolysis and Heme Oxygenase-1 Induction

(2012) A. J. Cunnington et al.   JOURNAL OF IMMUNOLOGY

Clinical Features of Severe Malaria Associated with Death: A 13-Year Observational Study in The Gambia

(2012) Muminatou Jallow et al.   PLoS One

Notice

(2012)   Kidney International Supplements

Endothelial activation and dysregulation in malaria: a potential target for novel therapeutics

(2011) Hani Kim et al.   CURRENT OPINION IN HEMATOLOGY

Soluble VEGF receptor 1 promotes endothelial injury in children and adolescents with lupus nephritis

(2011) Monika Edelbauer et al.   PEDIATRIC NEPHROLOGY

Combinations of Host Biomarkers Predict Mortality among Ugandan Children with Severe Malaria: A Retrospective Case-Control Study

(2011) Laura K. Erdman et al.   PLoS One

A Role for Hemopexin in Oligodendrocyte Differentiation and Myelin Formation

(2011) Noemi Morello et al.   PLoS One

Activation of GPR4 by Acidosis Increases Endothelial Cell Adhesion through the cAMP/Epac Pathway

(2011) Aishe Chen et al.   PLoS One

Synergistic Inflammation Is Induced by Blood Degradation Products with Microbial Toll‐Like Receptor Agonists and Is Blocked by Hemopexin

(2010) Tian Lin et al.   JOURNAL OF INFECTIOUS DISEASES

Artesunate versus quinine in the treatment of severe falciparum malaria in African children (AQUAMAT): an open-label, randomised trial

(2010) Arjen M Dondorp et al.   LANCET

A Central Role for Free Heme in the Pathogenesis of Severe Sepsis

(2010) R. Larsen et al.   Science Translational Medicine

Angiopoietin-2 in patients requiring renal replacement therapy in the ICU: relation to acute kidney injury, multiple organ dysfunction syndrome and outcome

(2009) Philipp Kümpers et al.   INTENSIVE CARE MEDICINE

Heme–Hemopexin Complex Attenuates Neuronal Cell Death and Stroke Damage

(2009) Rung-chi Li et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Hemozoin (Malarial Pigment) Directly Promotes Apoptosis of Erythroid Precursors

(2009) Abigail A. Lamikanra et al.   PLoS One

A central role for free heme in the pathogenesis of severe malaria: the missing link?

(2008) Ana Ferreira et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Long Term Outcome of Severe Anaemia in Malawian Children

(2008) Kamija S. Phiri et al.   PLoS One