Endotoxin Tolerance Inhibits Degradation of Tumor Necrosis Factor Receptor–Associated Factor 3 by Suppressing Pellino 1 Expression and the K48 Ubiquitin Ligase Activity of Cellular Inhibitor of Apoptosis Protein 2

SMAD4 is Involved in the Development of Endotoxin Tolerance in Microglia

(2016) Xiaorong Liu et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Sepsis-induced immune dysfunction: can immune therapies reduce mortality?

(2016) Matthew J. Delano et al.   JOURNAL OF CLINICAL INVESTIGATION

Targeting TRAF3 signaling protects against hepatic ischemia/reperfusions injury

(2016) Junfei Hu et al.   JOURNAL OF HEPATOLOGY

LPS/TLR4-mediated stromal cells acquire an invasive phenotype and are implicated in the pathogenesis of adenomyosis

(2016) Jing Guo et al.   Scientific Reports

IRAK-M regulates the inhibition of TLR-mediated macrophage immune response during late in vitroLeishmania donovaniinfection

(2015) Supriya Srivastav et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Molecular and physiological roles of Pellino E3 ubiquitin ligases in immunity

(2015) Fiachra Humphries et al.   IMMUNOLOGICAL REVIEWS

E3 ubiquitin ligases Pellinos as regulators of pattern recognition receptor signaling and immune responses

(2015) Andrei E. Medvedev et al.   IMMUNOLOGICAL REVIEWS

Pellino-1 Positively Regulates Toll-like Receptor (TLR) 2 and TLR4 Signaling and Is Suppressed upon Induction of Endotoxin Tolerance

(2015) Michael Murphy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Coordinated Regulation of miR-155 and miR-146a Genes during Induction of Endotoxin Tolerance in Macrophages

(2015) Christina Doxaki et al.   JOURNAL OF IMMUNOLOGY

Pellino-3 promotes endotoxin tolerance and acts as a negative regulator of TLR2 and TLR4 signaling

(2015) Michael B. Murphy et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Peli1 negatively regulates type I interferon induction and antiviral immunity in the CNS

(2015) Yichuan Xiao et al.   Cell and Bioscience

S-Adenosylmethionine attenuates lipopolysaccharide-induced liver injury by downregulating the Toll-like receptor 4 signal in Kupffer cells

(2014) Peizhi Li et al.   Hepatology International

The Role of the Liver in Sepsis

(2014) Jun Yan et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

Myeloid Cell TRAF3 Regulates Immune Responses and Inhibits Inflammation and Tumor Development in Mice

(2014) Almin I. Lalani et al.   JOURNAL OF IMMUNOLOGY

The liver in sepsis

(2013) Michael Bauer et al.   Current Opinion in Critical Care

An efficient method to isolate and culture mouse Kupffer cells

(2013) Pei-zhi Li et al.   IMMUNOLOGY LETTERS

The Effects of Twist-2 on Liver Endotoxin Tolerance Induced by a Low Dose of Lipopolysaccharide

(2013) Peizhi Li et al.   INFLAMMATION

Macrophage biology in development, homeostasis and disease

(2013) Thomas A. Wynn et al.   NATURE

Peli1 promotes microglia-mediated CNS inflammation by regulating Traf3 degradation

(2013) Yichuan Xiao et al.   NATURE MEDICINE

Prospects of Transcript Profiling for mRNAs and MicroRNAs Using Formalin-Fixed and Paraffin-Embedded Dissected Autoptic Multiple Sclerosis Lesions

(2012) Sylvia Eisele et al.   BRAIN PATHOLOGY

Peli: a family of signal-responsive E3 ubiquitin ligases mediating TLR signaling and T-cell tolerance

(2012) Wei Jin et al.   Cellular & Molecular Immunology

NF-κB-mediated degradation of the coactivator RIP140 regulates inflammatory responses and contributes to endotoxin tolerance

(2012) Ping-Chih Ho et al.   NATURE IMMUNOLOGY

The role of TBK1 and IKKϵ in the expression and activation of Pellino 1

(2011) Hilary Smith et al.   BIOCHEMICAL JOURNAL

Identification of the protein kinases that activate the E3 ubiquitin ligase Pellino 1 in the innate immune system

(2011) Eddy T. H. Goh et al.   BIOCHEMICAL JOURNAL

Roles of tumor necrosis factor receptor associated factor 3 (TRAF3) and TRAF5 in immune cell functions

(2011) Joanne M. Hildebrand et al.   IMMUNOLOGICAL REVIEWS

A Toll-Like Receptor-Responsive Kinase, Protein Kinase R, Is Inactivated in Endotoxin Tolerance through Differential K63/K48 Ubiquitination

(2010) D. J. Perkins et al.   mBio

Endotoxin tolerance dysregulates MyD88- and Toll/IL-1R domain-containing adapter inducing IFN-β-dependent pathways and increases expression of negative regulators of TLR signaling

(2009) Wenji Piao et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Different modes of ubiquitination of the adaptor TRAF3 selectively activate the expression of type I interferons and proinflammatory cytokines

(2009) Ping-Hui Tseng et al.   NATURE IMMUNOLOGY

Glycine attenuates endotoxin-induced liver injury by downregulating TLR4 signaling in Kupffer cells

(2008) Fa Liang Xu et al.   AMERICAN JOURNAL OF SURGERY

The effects of SOCS-1 on liver endotoxin tolerance development induced by a low dose of lipopolysaccharide are related to dampen NF-κB-mediated pathway

(2008) Z.J. Liu et al.   DIGESTIVE AND LIVER DISEASE

Up-Regulation of IRAK-M is Essential for Endotoxin Tolerance Induced by a Low Dose of Lipopolysaccharide in Kupffer Cells

(2008) Zuo-Jin Liu et al.   JOURNAL OF SURGICAL RESEARCH