The Crystal Structure of Mouse Ces2c, a Potential Ortholog of Human CES2, Shows Structural Similarities in Substrate Regulation and Product Release to Human CES1

Human Safety, Tolerability, and Pharmacokinetics of Molnupiravir, a Novel Broad-Spectrum Oral Antiviral Agent with Activity Against SARS-CoV-2

(2021) Wendy P. Painter et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Metabolic Spectrum of Liver Failure in Type 2 Diabetes and Obesity: From NAFLD to NASH to HCC

(2021) Hyunmi Kim et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Key Metabolic Enzymes Involved in Remdesivir Activation in Human Lung Cells

(2021) Ruidong Li et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Mechanism of molnupiravir-induced SARS-CoV-2 mutagenesis

(2021) Florian Kabinger et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A phase 2a clinical trial of molnupiravir in patients with COVID-19 shows accelerated SARS-CoV-2 RNA clearance and elimination of infectious virus

(2021) William A. Fischer et al.   Science Translational Medicine

The role of metabolic lipases in the pathogenesis and management of liver disease

(2020) Matteo Tardelli et al.   HEPATOLOGY

The Lipolysome—A Highly Complex and Dynamic Protein Network Orchestrating Cytoplasmic Triacylglycerol Degradation

(2020) Peter Hofer et al.   Metabolites

Obesity as a risk factor for COVID-19: an overview

(2020) Ricardo Wesley Alberca et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Design, synthesis and biological evaluation of water-soluble phenytoin prodrugs considering the substrate recognition ability of human carboxylesterase 1

(2020) Masato Takahashi et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Hepatocyte-specific Expression of Human Carboxylesterase 2 Attenuates Non-alcoholic Steatohepatitis in Mice

(2020) Yanyong Xu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

ATSAS 3.0: expanded functionality and new tools for small-angle scattering data analysis

(2020) Karen Manalastas-Cantos et al.   JOURNAL OF APPLIED CRYSTALLOGRAPHY

Protein-protein interactions regulate the activity of Adipose Triglyceride Lipase in intracellular lipolysis

(2019) Natalia Kulminskaya et al.   BIOCHIMIE

The modular structure of α/β‐hydrolases

(2019) Tabea L. Bauer et al.   FEBS Journal

Discovery of a highly specific and efficacious inhibitor of human carboxylesterase 2 by large-scale screening

(2019) Yun-Qing Song et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Orally Efficacious Broad-Spectrum Ribonucleoside Analog Inhibitor of Influenza and Respiratory Syncytial Viruses

(2018) Jeong-Joong Yoon et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Pharmacological intervention of liver triacylglycerol lipolysis: The good, the bad and the ugly

(2018) Ariel D. Quiroga et al.   BIOCHEMICAL PHARMACOLOGY

ISOLDE: a physically realistic environment for model building into low-resolution electron-density maps

(2018) Tristan Ian Croll   Acta Crystallographica Section D-Structural Biology

Distributed computing for macromolecular crystallography

(2018) Evgeny Krissinel et al.   Acta Crystallographica Section D-Structural Biology

Human carboxylesterases: a comprehensive review

(2018) Dandan Wang et al.   Acta Pharmaceutica Sinica B

MolProbity: More and better reference data for improved all-atom structure validation

(2017) Christopher J. Williams et al.   PROTEIN SCIENCE

Human Carboxylesterase 2 Reverses Obesity-Induced Diacylglycerol Accumulation and Glucose Intolerance

(2017) Maxwell A. Ruby et al.   Cell Reports

Carboxylesterases in lipid metabolism: from mouse to human

(2017) Jihong Lian et al.   Protein & Cell

Carboxylesterase 2 prevents liver steatosis by modulating lipolysis, endoplasmic reticulum stress, and lipogenesis and is regulated by hepatocyte nuclear factor 4 alpha in mice

(2016) Yuanyuan Li et al.   HEPATOLOGY

The role of obesity measures in the development and persistence of major depressive disorder

(2016) Deborah Gibson-Smith et al.   JOURNAL OF AFFECTIVE DISORDERS

Tissue-based map of the human proteome

(2015) M. Uhlen et al.   SCIENCE

Comparison of the Structure and Activity of Glycosylated and Aglycosylated Human Carboxylesterase 1

(2015) Victoria Arena de Souza et al.   PLoS One

Presenting your structures: theCCP4mgmolecular-graphics software

(2011) S. McNicholas et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

The Phenix software for automated determination of macromolecular structures

(2011) Paul D. Adams et al.   METHODS

XDS

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Recommended nomenclature for five mammalian carboxylesterase gene families: human, mouse, and rat genes and proteins

(2010) Roger S. Holmes et al.   MAMMALIAN GENOME

Human Carboxylesterase 1 Stereoselectively Binds the Nerve Agent Cyclosarin and Spontaneously Hydrolyzes the Nerve Agent Sarin

(2010) A. C. Hemmert et al.   MOLECULAR PHARMACOLOGY