The Roles of Mitophagy and Autophagy in Ineffective Erythropoiesis in β-Thalassemia

ATG4A regulates human erythroid maturation and mitochondrial clearance

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Safety and efficacy of mitapivat, an oral pyruvate kinase activator, in adults with non-transfusion dependent α-thalassaemia or β-thalassaemia: an open-label, multicentre, phase 2 study

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β-Thalassemias

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A Phase 3 Trial of Luspatercept in Patients with Transfusion-Dependent β-Thalassemia

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Mitophagy regulates mitochondrial network signaling, oxidative stress, and apoptosis during myoblast differentiation

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BNIP3L/NIX and FUNDC1-mediated mitophagy is required for mitochondrial network remodeling during cardiac progenitor cell differentiation

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Safety and Efficacy of Mitapivat in Pyruvate Kinase Deficiency

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The autophagy-activating kinase ULK1 mediates clearance of free α-globin in β-thalassemia

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The regulation of autophagy by calcium signals: Do we have a consensus?

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Hematopoietic Stem Cell Transplantation in Thalassemia

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Iron Chelation Therapy as a Modality of Management

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Gene Therapy and Genome Editing

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Sotatercept, a novel transforming growth factor beta ligand trap, improves anemia in beta-thalassemia: a phase 2, open-label, dose-finding study

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The mammalian ULK1 complex and autophagy initiation

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Short-term administration of JAK2 inhibitors reduces splenomegaly in mouse models of β-thalassemia intermedia and major

(2017) Carla Casu et al.   HAEMATOLOGICA

Short-term administration of JAK2 inhibitors reduces splenomegaly in mouse models of β-thalassemia intermedia and major

(2017) Carla Casu et al.   HAEMATOLOGICA

Ferroptosis is an autophagic cell death process

(2016) Minghui Gao et al.   CELL RESEARCH

Mitophagy is increased during erythroid differentiation in β-thalassemia

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Mitophagy is required for mitochondrial biogenesis and myogenic differentiation of C2C12 myoblasts

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Severe bacterial infections in patients with non-transfusion-dependent thalassemia: prevalence and clinical risk factors

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Thalassaemia and risk of cancer: a population-based cohort study

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An activin receptor IIA ligand trap corrects ineffective erythropoiesis in β-thalassemia

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Transforming growth factor-β superfamily ligand trap ACE-536 corrects anemia by promoting late-stage erythropoiesis

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Autophagy—a key player in cellular and body metabolism

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Crosstalk between apoptosis, necrosis and autophagy

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Prevalence and risk factors for pulmonary hypertension in patients with hemoglobin E/β-thalassemia disease

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Integrated protein quality-control pathways regulate free  -globin in murine  -thalassemia

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GSK3-TIP60-ULK1 Signaling Pathway Links Growth Factor Deprivation to Autophagy

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Regulation of TGF-β receptor activity

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Enhanced activation of autophagy in β-thalassemia/Hb E erythroblasts during erythropoiesis

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How I treat thalassemia

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Increased oxidative metabolism is associated with erythroid precursor expansion in β0-thalassaemia/Hb E disease

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The WD40 Repeat PtdIns(3)P-Binding Protein EPG-6 Regulates Progression of Omegasomes to Autophagosomes

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Nonredundant role of Atg7 in mitochondrial clearance during erythroid development

(2010) Monika Mortensen et al.   Autophagy

Mammalian Atg18 (WIPI2) localizes to omegasome-anchored phagophores and positively regulates LC3 lipidation

(2010) Hannah E.J. Polson et al.   Autophagy

FIP200 is required for the cell-autonomous maintenance of fetal hematopoietic stem cells

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Observations on the relationship between γ-globin chain content and globin chain precipitation in thalassaemic erythroblasts and on the composition of erythroblastic inclusions in HbE/β-thalassaemia

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Effect of hydroxyurea on the transfusion requirements in patients with severe HbE- -thalassaemia: a genotypic and phenotypic study

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Splenectomy and thrombosis: the case of thalassemia intermedia

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Regulation Mechanisms and Signaling Pathways of Autophagy

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Mitochondrial clearance is regulated by Atg7-dependent and independent mechanisms during reticulocyte maturation

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Increased erythropoiesis of β-thalassaemia/Hb E proerythroblasts is mediated by high basal levels of ERK1/2 activation

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A mechanism of ineffective erythropoiesis in  -thalassemia/Hb E disease

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Imbalanced globin chain synthesis determines erythroid cell pathology in thalassemic mice

(2009) K. Srinoun et al.   HAEMATOLOGICA

Nutrient-dependent mTORC1 Association with the ULK1–Atg13–FIP200 Complex Required for Autophagy

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An Atg1/Atg13 Complex with Multiple Roles in TOR-mediated Autophagy Regulation

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ULK-Atg13-FIP200 Complexes Mediate mTOR Signaling to the Autophagy Machinery

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Regulation of Autophagy by Reactive Oxygen Species (ROS): Implications for Cancer Progression and Treatment

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Erythroblastic islands: niches for erythropoiesis

(2008) J. A. Chasis et al.   BLOOD

Ulk1 plays a critical role in the autophagic clearance of mitochondria and ribosomes during reticulocyte maturation

(2008) M. Kundu et al.   BLOOD

Global epidemiology of haemoglobin disorders and derived service indicators

(2008) Bernadette Modell   BULLETIN OF THE WORLD HEALTH ORGANIZATION

Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum

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Essential role for Nix in autophagic maturation of erythroid cells

(2008) Hector Sandoval et al.   NATURE