Curcumin Sensitises Cancerous Kidney Cells to TRAIL Induced Apoptosis via Let-7C Mediated Deregulation of Cell Cycle Proteins and Cellular Metabolism

Cancer statistics, 2022

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Dysregulation of let-7c-5p/Tyrosyl-DNA phosphodiesterase 1 axis indicates an unfavorable outcome in gastric cancer

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Curcumin Prevents the Glycation of Tricarboxylic Acid Cycle and Cell Respiration Proteins in the Heart of Mice Fed with a High-Fructose Diet

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The TRAIL in the Treatment of Human Cancer: An Update on Clinical Trials

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let-7c-5p regulates CyclinD1 in fluoride-mediated osteoblast proliferation and activation

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Anticancer Mechanism of Curcumin on Human Glioblastoma

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The Roles of the Let-7 Family of MicroRNAs in the Regulation of Cancer Stemness

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Ring A/B-Modified 17β-Hydroxywithanolide Analogues as Antiproliferative Agents for Prostate Cancer and Potentiators of Immunotherapy for Renal Carcinoma and Melanoma

(2021) E. M. Kithsiri Wijeratne et al.   JOURNAL OF NATURAL PRODUCTS

Bioactivity-guided Isolation of TRAIL-Resistance-Overcoming Activity Compounds From the Leaves of Murraya exotica

(2021) Kritamorn Jitrangsri et al.   Natural Product Communications

Curcumin Sensitizes Kidney Cancer Cells to TRAIL-Induced Apoptosis via ROS Mediated Activation of JNK-CHOP Pathway and Upregulation of DR4

(2020) Ismael Obaidi et al.   Biology-Basel

Turmeric and Its Major Compound Curcumin on Health: Bioactive Effects and Safety Profiles for Food, Pharmaceutical, Biotechnological and Medicinal Applications

(2020) Javad Sharifi-Rad et al.   Frontiers in Pharmacology

Resveratrol, curcumin, paclitaxel and miRNAs mediated regulation of PI3K/Akt/mTOR pathway: go four better to treat bladder cancer

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(2020) Mofei Huang et al.   Cancer Prevention Research

Effect of let‑7c on the PI3K/Akt/FoxO signaling pathway in hepatocellular carcinoma

(2020) Yuehua Li et al.   Oncology Letters

Cellular and molecular mechanisms of curcumin in prevention and treatment of disease

(2019) Sita Sharan Patel et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Mechanisms of apoptosis modulation by curcumin: Implications for cancer therapy

(2019) Keywan Mortezaee et al.   JOURNAL OF CELLULAR PHYSIOLOGY

miR-let-7b and miR-let-7c suppress tumourigenesis of human mucosal melanoma and enhance the sensitivity to chemotherapy

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ARHGAP4 mediates the Warburg effect in pancreatic cancer through the mTOR and HIF-1α signaling pathways

(2019) Yehua Shen et al.   OncoTargets and Therapy

Modeling the Dynamics of Let-7-Coupled Gene Regulatory Networks Linking Cell Proliferation to Malignant Transformation

(2019) Claude Gérard et al.   Frontiers in Physiology

Biological Effects of Ciliary Neurotrophic Factor on hMADS Adipocytes

(2019) Jessica Perugini et al.   Frontiers in Endocrinology

Current Concepts of Non-Coding RNAs in the Pathogenesis of Non-Clear Cell Renal Cell Carcinoma

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Combination of the natural compound Periplocin and TRAIL induce esophageal squamous cell carcinoma apoptosis in vitro and in vivo: Implication in anticancer therapy

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Curcumin induces a fatal energetic impairment in tumor cells in vitro and in vivo by inhibiting ATP-synthase activity

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Identification of the Multifaceted Chemopreventive Activity of Curcumin Against the Carcinogenic Potential of the Food Additive, KBrO3

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Breast cancer stem-like cells are sensitized to tamoxifen induction of self-renewal inhibition with enforced Let-7c dependent on Wnt blocking

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Curcumin induces apoptosis and cell cycle arrest via the activation of reactive oxygen species–independent mitochondrial apoptotic pathway in Smad4 and p53 mutated colon adenocarcinoma HT29 cells

(2018) Ayushi Agarwal et al.   NUTRITION RESEARCH

Let-7c inhibits cholangiocarcinoma growth but promotes tumor cell invasion and growth at extrahepatic sites

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MicroRNA-375 inhibits the proliferation, migration and invasion of kidney cancer cells by triggering apoptosis and modulation of PDK1 expression

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A Combination of Resveratrol and Curcumin is Effective Against Aluminum Chloride-Induced Neuroinflammation in Rats

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Curcumin inhibits cancer progression through regulating expression of microRNAs

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MicroRNA-378 enhances inhibitory effect of curcumin on glioblastoma

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Targeting PDK1 for Chemosensitization of Cancer Cells

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Anti-cancer effects of curcumin on lung cancer through the inhibition of EZH2 and NOTCH1

(2016) Guo-Qing Wu et al.   Oncotarget

Synergistic chemopreventive effects of curcumin and berberine on human breast cancer cells through induction of apoptosis and autophagic cell death

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Cell death mechanisms of plant-derived anticancer drugs: beyond apoptosis

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PDK1-Dependent Metabolic Reprogramming Dictates Metastatic Potential in Breast Cancer

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Targeting TNF-related apoptosis-inducing ligand (TRAIL) receptor by natural products as a potential therapeutic approach for cancer therapy

(2015) Xiaoyun Dai et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Cellular Effect of Curcumin and Citral Combination on Breast Cancer Cells: Induction of Apoptosis and Cell Cycle Arrest

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Cancer metabolism and the Warburg effect: the role of HIF-1 and PI3K

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let-7b and let-7c are determinants of intrinsic chemoresistance in renal cell carcinoma

(2015) Jingtao Peng et al.   World Journal of Surgical Oncology

Withanolide E sensitizes renal carcinoma cells to TRAIL-induced apoptosis by increasing cFLIP degradation

(2015) C J Henrich et al.   Cell Death & Disease

The association between let-7, RAS and HIF-1α in Ewing Sarcoma tumor growth

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Natural Compounds Regulate Glycolysis in Hypoxic Tumor Microenvironment

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Predicting effective microRNA target sites in mammalian mRNAs

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Knocking down CDK4 mediates the elevation of let-7c suppressing cell growth in nasopharyngeal carcinoma

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Getting TRAIL back on track for cancer therapy

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(2014) Kavirayani Priyadarsini   MOLECULES

Lin28/let-7 axis regulates aerobic glycolysis and cancer progression via PDK1

(2014) Xiaoyu Ma et al.   Nature Communications

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(2013) Lawrence Helson   BIOFACTORS

Curcumin, a component of turmeric: From farm to pharmacy

(2013) Subash C. Gupta et al.   BIOFACTORS

MicroRNA let-7c inhibits migration and invasion of human non-small cell lung cancer by targeting ITGB3 and MAP4K3

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(2013) Biyin Cao et al.   CURRENT PHARMACEUTICAL DESIGN

Curcumin enhances TRAIL-induced apoptosis of breast cancer cells by regulating apoptosis-related proteins

(2013) Sojung Park et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Resistance to TRAIL in non-transformed cells is due to multiple redundant pathways

(2013) M van Dijk et al.   Cell Death & Disease

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(2012) Shishir Shishodia   BIOFACTORS

Bortezomib and TRAIL: A perfect match for apoptotic elimination of tumour cells?

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(2012) JIE ZHENG   Oncology Letters

Hsa-let-7a functions as a tumor suppressor in renal cell carcinoma cell lines by targeting c-myc

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Curcumin Analogue CDF Inhibits Pancreatic Tumor Growth by Switching on Suppressor microRNAs and Attenuating EZH2 Expression

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Curcumin induces DNA damage and caffeine-insensitive cell cycle arrest in colorectal carcinoma HCT116 cells

(2011) Jin-Jian Lu et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Specific miRNA signatures are associated with metastasis and poor prognosis in clear cell renal cell carcinoma

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New insights into apoptosis signaling by Apo2L/TRAIL

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Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Modulation of anti-apoptotic and survival pathways by curcumin as a strategy to induce apoptosis in cancer cells

(2008) Simone Reuter et al.   BIOCHEMICAL PHARMACOLOGY

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