The TRAIL in the Treatment of Human Cancer: An Update on Clinical Trials
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Title
The TRAIL in the Treatment of Human Cancer: An Update on Clinical Trials
Authors
Keywords
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Journal
Frontiers in Molecular Biosciences
Volume 8, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2021-03-10
DOI
10.3389/fmolb.2021.628332
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Note: Only part of the references are listed.- The history and advances in cancer immunotherapy: understanding the characteristics of tumor-infiltrating immune cells and their therapeutic implications
- (2020) Yuanyuan Zhang et al. Cellular & Molecular Immunology
- Human cancers express TRAILshort, a dominant negative TRAIL splice variant, which impairs immune effector cell killing of tumor cells.
- (2020) Fatma Aboulnasr et al. CLINICAL CANCER RESEARCH
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- (2019) Juliane Medler et al. Cell Death & Disease
- An introduction to chimeric antigen receptor (CAR) T-cell immunotherapy for human cancer
- (2019) Steven Feins et al. AMERICAN JOURNAL OF HEMATOLOGY
- Phase 1, first-in-human study of TRAIL receptor agonist fusion protein ABBV-621.
- (2019) Mark J. Ratain et al. JOURNAL OF CLINICAL ONCOLOGY
- Impact of p53 status on TRAIL-mediated apoptotic and non-apoptotic signaling in cancer cells
- (2019) Anna Willms et al. PLoS One
- Molecular Mode of Action of TRAIL Receptor Agonists—Common Principles and Their Translational Exploitation
- (2019) Wajant Cancers
- Novel Apoptosis-Inducing Agents for the Treatment of Cancer, a New Arsenal in the Toolbox
- (2019) Lim et al. Cancers
- 457PFirst-in-human study of ABBV-621 in patients (pts) with previously treated sold tumours: Dose-optimization cohorts
- (2019) E Calvo et al. ANNALS OF ONCOLOGY
- Integrated drug profiling and CRISPR screening identify essential pathways for CAR T-cell cytotoxicity
- (2019) Olli Dufva et al. BLOOD
- Developing TRAIL/TRAIL death receptor-based cancer therapies
- (2018) Xun Yuan et al. CANCER AND METASTASIS REVIEWS
- CAR-T Cell Therapy for Acute Lymphoblastic Leukemia: Transforming the Treatment of Relapsed and Refractory Disease
- (2018) Katherine C. Pehlivan et al. Current Hematologic Malignancy Reports
- Phase III study of dulanermin (recombinant human tumor necrosis factor-related apoptosis-inducing ligand/Apo2 ligand) combined with vinorelbine and cisplatin in patients with advanced non-small-cell lung cancer
- (2017) Xuenong Ouyang et al. INVESTIGATIONAL NEW DRUGS
- Tumor Microenvironment and Differential Responses to Therapy
- (2017) Eishu Hirata et al. Cold Spring Harbor Perspectives in Medicine
- Cancer prevention from the perspective of global cancer burden patterns
- (2017) Hiroki Nagai et al. Journal of Thoracic Disease
- Onto better TRAILs for cancer treatment
- (2016) D de Miguel et al. CELL DEATH AND DIFFERENTIATION
- Melanoma-Directed Activation of Apoptosis Using a Bispecific Antibody Directed at MCSP and TRAIL Receptor-2/Death Receptor-5
- (2016) Yuan He et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Programmed Death Ligand 1 (PD-L1)-targeted TRAIL combines PD-L1-mediated checkpoint inhibition with TRAIL-mediated apoptosis induction
- (2016) Djoke Hendriks et al. OncoImmunology
- The tetravalent anti-DR5 antibody without cross-linking direct induces apoptosis of cancer cells
- (2015) Fengtao Liu et al. BIOMEDICINE & PHARMACOTHERAPY
- Mitochondrial apoptosis: killing cancer using the enemy within
- (2015) J Lopez et al. BRITISH JOURNAL OF CANCER
- Unexpected hepatotoxicity in a phase I study of TAS266, a novel tetravalent agonistic Nanobody® targeting the DR5 receptor
- (2015) Kyriakos P. Papadopoulos et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- Targeting TNF-related apoptosis-inducing ligand (TRAIL) receptor by natural products as a potential therapeutic approach for cancer therapy
- (2015) Xiaoyun Dai et al. EXPERIMENTAL BIOLOGY AND MEDICINE
- Hetero-modification of TRAIL trimer for improved drug delivery and in vivo antitumor activities
- (2015) Li-Qiang Pan et al. Scientific Reports
- Dulanermin with rituximab in patients with relapsed indolent B-cell lymphoma: an open-label phase 1b/2 randomised study
- (2015) Chan Yoon Cheah et al. Lancet Haematology
- A chimeric antigen receptor for TRAIL-receptor 1 induces apoptosis in various types of tumor cells
- (2014) Eiji Kobayashi et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Getting TRAIL back on track for cancer therapy
- (2014) J Lemke et al. CELL DEATH AND DIFFERENTIATION
- AD-O53.2—a novel recombinant fusion protein combining the activities of TRAIL/Apo2L and Smac/Diablo, overcomes resistance of human cancer cells to TRAIL/Apo2L
- (2014) Jerzy S. Pieczykolan et al. INVESTIGATIONAL NEW DRUGS
- High-level production of Fc-fused kringle domain in Pichia pastoris
- (2014) Gu Min Jeong et al. JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY
- A randomized, placebo-controlled phase 2 study of ganitumab or conatumumab in combination with FOLFIRI for second-line treatment of mutant KRAS metastatic colorectal cancer†
- (2013) A. L. Cohn et al. ANNALS OF ONCOLOGY
- Death receptors as targets in cancer
- (2013) O Micheau et al. BRITISH JOURNAL OF PHARMACOLOGY
- TRAIL receptor agonist conatumumab with modified FOLFOX6 plus bevacizumab for first-line treatment of metastatic colorectal cancer
- (2013) Charles S. Fuchs et al. CANCER
- TRAIL-Based Therapeutic Approaches for the Treatment of Pediatric Malignancies
- (2013) C. Gasparini et al. CURRENT MEDICINAL CHEMISTRY
- A randomized, double-blind, placebo-controlled phase 2 study of tigatuzumab (CS-1008) in combination with carboplatin/paclitaxel in patients with chemotherapy-naïve metastatic/unresectable non-small cell lung cancer
- (2013) Martin Reck et al. LUNG CANCER
- Phase 2, multicenter, open-label study of tigatuzumab (CS-1008), a humanized monoclonal antibody targeting death receptor 5, in combination with gemcitabine in chemotherapy-naive patients with unresectable or metastatic pancreatic cancer
- (2013) Andres Forero-Torres et al. Cancer Medicine
- A randomized, placebo-controlled phase 2 study of ganitumab (AMG 479) or conatumumab (AMG 655) in combination with gemcitabine in patients with metastatic pancreatic cancer
- (2012) H. L. Kindler et al. ANNALS OF ONCOLOGY
- Cell Death via DR5, but not DR4, Is Regulated by p53 in Myeloma Cells
- (2012) S. Surget et al. CANCER RESEARCH
- A novel anti-DR5 chimeric antibody and epirubicin synergistically suppress tumor growth
- (2012) Yuhe Qiu et al. IUBMB LIFE
- Randomized Phase II Study of Dulanermin in Combination With Paclitaxel, Carboplatin, and Bevacizumab in Advanced Non–Small-Cell Lung Cancer
- (2011) Jean-Charles Soria et al. JOURNAL OF CLINICAL ONCOLOGY
- A Phase 1b/2 trial of mapatumumab in patients with relapsed/refractory non-Hodgkin's lymphoma
- (2010) A Younes et al. BRITISH JOURNAL OF CANCER
- Tumor-targeted delivery of biologically active TRAIL protein
- (2010) H-Y Zhang et al. CANCER GENE THERAPY
- Human monomeric antibody fragments to TRAIL-R1 and TRAIL-R2 that display potent in vitro agonism
- (2010) Claire L. Dobson et al. mAbs
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