The Inflammasome Activity of NLRP3 Is Independent of NEK7 in HEK293 Cells Co-Expressing ASC

Structure of the NLRP3 decamer bound to the cytokine release inhibitor CRID3

(2022) Inga V. Hochheiser et al.   NATURE

Structural basis for the oligomerization-mediated regulation of NLRP3 inflammasome activation

(2022) Umeharu Ohto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sensing low intracellular potassium by NLRP3 results in a stable open structure that promotes inflammasome activation

(2021) Ana Tapia-Abellán et al.   Science Advances

NLRP3 cages revealed by full-length mouse NLRP3 structure control pathway activation

(2021) Liudmila Andreeva et al.   CELL

Crystal Structure of NLRP3 NACHT Domain With an Inhibitor Defines Mechanism of Inflammasome Inhibition

(2021) Carien Dekker et al.   JOURNAL OF MOLECULAR BIOLOGY

NLRP3 phosphorylation in its LRR domain critically regulates inflammasome assembly

(2021) Tingting Niu et al.   Nature Communications

Cellular Models and Assays to Study NLRP3 Inflammasome Biology

(2020) Giovanni Zito et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases

(2020) Marija Buljan et al.   MOLECULAR CELL

Beta-amyloid activates NLRP3 inflammasome via TLR4 in mouse microglia

(2020) Yang Liu et al.   NEUROSCIENCE LETTERS

Detection of viruses by inflammasomes

(2020) Lotte Spel et al.   Current Opinion in Virology

The NLRP3 Inflammasome: An Overview of Mechanisms of Activation and Regulation

(2019) Nathan Kelley et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Structural mechanism for NEK7-licensed activation of NLRP3 inflammasome

(2019) Humayun Sharif et al.   NATURE

Caspase-1 self-cleavage is an intrinsic mechanism to terminate inflammasome activity

(2018) Dave Boucher et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Single-Molecule Fluorescence Reveals the Oligomerization and Folding Steps Driving the Prion-like Behavior of ASC

(2018) Yann Gambin et al.   JOURNAL OF MOLECULAR BIOLOGY

Targeting the NLRP3 inflammasome in inflammatory diseases

(2018) Matthew S. J. Mangan et al.   NATURE REVIEWS DRUG DISCOVERY

PtdIns4P on dispersed trans-Golgi network mediates NLRP3 inflammasome activation

(2018) Jueqi Chen et al.   NATURE

NLRP3 inflammasome assembly is regulated by phosphorylation of the pyrin domain

(2017) Andrea Stutz et al.   JOURNAL OF EXPERIMENTAL MEDICINE

NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux

(2016) Yuan He et al.   NATURE

Mechanism and Regulation of NLRP3 Inflammasome Activation

(2016) Yuan He et al.   TRENDS IN BIOCHEMICAL SCIENCES

A Genome-wide CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) Screen Identifies NEK7 as an Essential Component of NLRP3 Inflammasome Activation

(2015) Jonathan L. Schmid-Burgk et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component

(2015) Hexin Shi et al.   NATURE IMMUNOLOGY

Prion-like Polymerization Underlies Signal Transduction in Antiviral Immune Defense and Inflammasome Activation

(2014) Xin Cai et al.   CELL

Unified Polymerization Mechanism for the Assembly of ASC-Dependent Inflammasomes

(2014) Alvin Lu et al.   CELL

CARD8 is a negative regulator for NLRP3 inflammasome, but mutant NLRP3 in cryopyrin-associated periodic syndromes escapes the restriction

(2014) Sayaka Ito et al.   ARTHRITIS RESEARCH & THERAPY

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

Oxidized Mitochondrial DNA Activates the NLRP3 Inflammasome during Apoptosis

(2012) Kenichi Shimada et al.   IMMUNITY

Cell cycle regulation by the NEK family of protein kinases

(2012) A. M. Fry et al.   JOURNAL OF CELL SCIENCE

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

The Nek6 and Nek7 Protein Kinases Are Required for Robust Mitotic Spindle Formation and Cytokinesis

(2009) L. O'Regan et al.   MOLECULAR AND CELLULAR BIOLOGY